| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Kawai, C Yokota, S Ohashi, Y Watanabe, K Yamashit. Evidence that glucagon stimulates insulin secretion through its own receptor in rats. Diabetologia. vol 38. issue 3. 1995-06-26. PMID:7758872. |
by contrast, when 0.3 nmol/l glp-1 was used in the same experimental setting, exendin (9-39) amide clearly inhibited insulin release. |
1995-06-26 |
2023-08-12 |
rat |
| K Kawai, C Yokota, S Ohashi, Y Watanabe, K Yamashit. Evidence that glucagon stimulates insulin secretion through its own receptor in rats. Diabetologia. vol 38. issue 3. 1995-06-26. PMID:7758872. |
these results indicate that glucagon stimulates insulin release mainly through glucagon receptors but not glp-1 receptors on islet beta cells. |
1995-06-26 |
2023-08-12 |
rat |
| C Herrmann, R Göke, G Richter, H C Fehmann, R Arnold, B Gök. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion. vol 56. issue 2. 1995-06-22. PMID:7750665. |
in response to an intraduodenal infusion of a small glucose load (5.34 g within 120 min) a rapid, short-lasting glp-1 response occurred whereas plasma gip and insulin levels remained unaltered. |
1995-06-22 |
2023-08-12 |
human |
| D J Drucker, T Jin, S L Asa, T A Young, P L Brubake. Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line. Molecular endocrinology (Baltimore, Md.). vol 8. issue 12. 1995-05-09. PMID:7535893. |
the recent demonstration that glucagon-like peptide-1 (glp-1) secreted from the intestine is a potent regulator of insulin secretion and glucose homeostasis has stimulated renewed interest in the factors that control glp-1 synthesis in the intestinal l-cell. |
1995-05-09 |
2023-08-12 |
mouse |
| Y T Kruszynska, M A Ghatei, S R Bloom, N McIntyr. Insulin secretion and plasma levels of glucose-dependent insulinotropic peptide and glucagon-like peptide 1 [7-36 amide] after oral glucose in cirrhosis. Hepatology (Baltimore, Md.). vol 21. issue 4. 1995-05-09. PMID:7705803. |
oral glucose is a better stimulant to insulin secretion than intravenous (iv) glucose in part because of release of gut peptides, notably glucose-dependent insulinotropic peptide (gip) and glucagon-like peptide 1 [7-36 amide] (glp-1 [7-36 amide]). |
1995-05-09 |
2023-08-12 |
human |
| Y T Kruszynska, M A Ghatei, S R Bloom, N McIntyr. Insulin secretion and plasma levels of glucose-dependent insulinotropic peptide and glucagon-like peptide 1 [7-36 amide] after oral glucose in cirrhosis. Hepatology (Baltimore, Md.). vol 21. issue 4. 1995-05-09. PMID:7705803. |
because impaired release of or resistance to these gut peptides could explain impaired insulin secretion after oral glucose, we measured insulin secretion, plasma gip, and glp-1 [7-36 amide] levels, basally and after 75 g oral glucose, in 10 cirrhotics and 10 controls. |
1995-05-09 |
2023-08-12 |
human |
| S Britsch, P Krippeit-Drews, F Lang, M Gregor, G Drew. Glucagon-like peptide-1 modulates Ca2+ current but not K+ATP current in intact mouse pancreatic B-cells. Biochemical and biophysical research communications. vol 207. issue 1. 1995-03-14. PMID:7857285. |
at the threshold concentration for insulin secretion (7 mmol/l glucose) glp-1 did not alter the membrane potential. |
1995-03-14 |
2023-08-12 |
mouse |
| Z Wang, R M Wang, A A Owji, D M Smith, M A Ghatei, S R Bloo. Glucagon-like peptide-1 is a physiological incretin in rat. The Journal of clinical investigation. vol 95. issue 1. 1995-02-09. PMID:7814643. |
in the anaesthetized fasted rat, insulin release after four doses of glp-1 (0.1, 0.2, 0.3, and 0.4 nmol/kg) was tested by a 2-min intravenous infusion. |
1995-02-09 |
2023-08-12 |
rat |
| Z Wang, R M Wang, A A Owji, D M Smith, M A Ghatei, S R Bloo. Glucagon-like peptide-1 is a physiological incretin in rat. The Journal of clinical investigation. vol 95. issue 1. 1995-02-09. PMID:7814643. |
exendin (9-39) (1.5, 3.0, and 4.5 nmol/kg) was administered with glp-1 0.3 nmol/kg, or saline, and only the highest dose fully inhibited insulin release. |
1995-02-09 |
2023-08-12 |
rat |
| F Kolligs, H C Fehmann, R Göke, B Gök. Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide. Diabetes. vol 44. issue 1. 1995-02-07. PMID:7813808. |
in contrast, the glp-1 antagonist left the insulin response after an intravenous glucose or glucose plus gip (60 pmol) load unaltered. |
1995-02-07 |
2023-08-12 |
rat |
| B Göke, C Herrmann, R Göke, H C Fehmann, P Berghöfer, G Richter, R Arnol. Intestinal effects of alpha-glucosidase inhibitors: absorption of nutrients and enterohormonal changes. European journal of clinical investigation. vol 24 Suppl 3. 1995-01-25. PMID:8001623. |
glucose) absorption by therapeutic means (for example, acarbose) could supplement a new approach in the treatment of type 2 diabetics which would utilize the well-preserved insulinotropic activity of glp-1 in these patients, its glucagon-lowering effect, and its possible inhibition of gastric emptying rates, the latter helping to reduce the requirement for rapid insulin secretory responses as is intended while using alpha-glucosidase inhibitor treatment. |
1995-01-25 |
2023-08-12 |
Not clear |
| b' M K Gutniak, B Linde, J J Holst, S Efendi\\xc4\\x8. Subcutaneous injection of the incretin hormone glucagon-like peptide 1 abolishes postprandial glycemia in NIDDM. Diabetes care. vol 17. issue 9. 1995-01-11. PMID:7988303.' |
to investigate the effect of subcutaneously injected glucagon-like peptide 1 (glp-1) (7-36)amide on postprandial plasma glucose, insulin, and c-peptide levels in patients with non-insulin-dependent diabetes mellitus (niddm) and a secondary failure to sulfonylureas. |
1995-01-11 |
2023-08-12 |
Not clear |
| Y Tanizawa, K Kak. [Human glucagon-like peptide-1 receptor gene in NIDDM]. Nihon rinsho. Japanese journal of clinical medicine. vol 52. issue 10. 1995-01-04. PMID:7983806. |
glucagon-like peptide-1 (glp-1) stimulate glucose dependent insulin secretion from beta-cells. |
1995-01-04 |
2023-08-12 |
human |
| J J Hols. Glucagonlike peptide 1: a newly discovered gastrointestinal hormone. Gastroenterology. vol 107. issue 6. 1994-12-27. PMID:7958701. |
it has been suggested that activation of the beta cells by glp-1 is a prerequisite for glucose-induced insulin secretion. |
1994-12-27 |
2023-08-12 |
Not clear |
| J M Egan, C Montrose-Rafizadeh, Y Wang, M Bernier, J Rot. Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action. Endocrinology. vol 135. issue 5. 1994-12-16. PMID:7956929. |
moreover, neither glycogen synthesis nor insulin binding to its receptor were affected by glp-1. |
1994-12-16 |
2023-08-12 |
rat |
| J M Egan, C Montrose-Rafizadeh, Y Wang, M Bernier, J Rot. Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action. Endocrinology. vol 135. issue 5. 1994-12-16. PMID:7956929. |
this study indicates that glp-1, in addition to its well known effect of stimulating insulin secretion, may improve insulin responsiveness by promoting fatty acid synthesis in adipose cells and possibly modulating insulin signaling in other insulin sensitive tissues. |
1994-12-16 |
2023-08-12 |
rat |
| Y Zhang, J T Cook, A T Hattersley, R Firth, P J Saker, M Warren-Perry, M Stoffel, R C Turne. Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young. Diabetologia. vol 37. issue 7. 1994-12-02. PMID:7958545. |
glucagon-like peptide-1 (glp-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal l cells and stimulates insulin secretion from beta cells. |
1994-12-02 |
2023-08-12 |
Not clear |
| Y Zhang, J T Cook, A T Hattersley, R Firth, P J Saker, M Warren-Perry, M Stoffel, R C Turne. Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young. Diabetologia. vol 37. issue 7. 1994-12-02. PMID:7958545. |
the glp-1 receptor is a candidate gene for diabetes mellitus, as mutations may induce the impaired insulin response that is a characteristic feature of niddm. |
1994-12-02 |
2023-08-12 |
Not clear |
| J J Andreasen, C Orskov, J J Hols. Secretion of glucagon-like peptide-1 and reactive hypoglycemia after partial gastrectomy. Digestion. vol 55. issue 4. 1994-09-16. PMID:8063025. |
we subjected 8 patients showing symptoms of early dumping after partial gastrectomy to an oral 100 g glucose load and measured blood glucose and plasma insulin, c-peptide, glucagon, enteroglucagon and glp-1 concentrations for 3.5 h after ingestion. |
1994-09-16 |
2023-08-12 |
Not clear |
| J J Andreasen, C Orskov, J J Hols. Secretion of glucagon-like peptide-1 and reactive hypoglycemia after partial gastrectomy. Digestion. vol 55. issue 4. 1994-09-16. PMID:8063025. |
glp-1 and enteroglucagon responses were grossly elevated in patients compared to controls and insulin and c-peptide levels were higher during the initial 60 min. |
1994-09-16 |
2023-08-12 |
Not clear |