| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Thoren. [GLP-1 and the control of insulin secretion]. Journees annuelles de diabetologie de l'Hotel-Dieu. 1994-09-06. PMID:8051830. |
[glp-1 and the control of insulin secretion]. |
1994-09-06 |
2023-08-12 |
Not clear |
| C Montrose-Rafizadeh, J M Egan, J Rot. Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action. Endocrinology. vol 135. issue 2. 1994-08-18. PMID:8033807. |
glucagon-like peptide-1-(7-36) amide (glp-1) and glucose-dependent insulinotropic peptide (gip) are known incretin hormones, released from enteroendocrine cells in response to food, that enhance insulin secretion, but only in the presence of elevated blood glucose. |
1994-08-18 |
2023-08-12 |
rat |
| C Montrose-Rafizadeh, J M Egan, J Rot. Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action. Endocrinology. vol 135. issue 2. 1994-08-18. PMID:8033807. |
glp-1 stimulates insulin secretion, with a half-maximal concentration of 34 pm. |
1994-08-18 |
2023-08-12 |
rat |
| C Montrose-Rafizadeh, J M Egan, J Rot. Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action. Endocrinology. vol 135. issue 2. 1994-08-18. PMID:8033807. |
glp-1 stimulates insulin secretion by significantly increasing the maximum rate of insulin secretion from 10.3 +/- 2.25 to 25.2 +/- 2.94 ng insulin/mg protein.h. |
1994-08-18 |
2023-08-12 |
rat |
| C Montrose-Rafizadeh, J M Egan, J Rot. Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action. Endocrinology. vol 135. issue 2. 1994-08-18. PMID:8033807. |
glp-1 acts by recruiting 1.5-fold more cells to secrete insulin as well as enhancing insulin secretion by individual cells. |
1994-08-18 |
2023-08-12 |
rat |
| C Montrose-Rafizadeh, J M Egan, J Rot. Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action. Endocrinology. vol 135. issue 2. 1994-08-18. PMID:8033807. |
combinations of stimuli, such as glucose, cell membrane depolarization, and glp-1, can recruit 90% of rin 1046-38 cells to secrete insulin. |
1994-08-18 |
2023-08-12 |
rat |
| D Elahi, M McAloon-Dyke, N K Fukagawa, G S Meneilly, A L Sclater, K L Minaker, J F Habener, D K Anderse. The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regulatory peptides. vol 51. issue 1. 1994-08-12. PMID:8036284. |
in normal subjects during euglycemia, glp-1(7-37) stimulated insulin release, whereas gip did not. |
1994-08-12 |
2023-08-12 |
human |
| D Elahi, M McAloon-Dyke, N K Fukagawa, G S Meneilly, A L Sclater, K L Minaker, J F Habener, D K Anderse. The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regulatory peptides. vol 51. issue 1. 1994-08-12. PMID:8036284. |
gip at a dose of 1, 2 or 4 pmol/kg/min augmented the 90-120 min insulin response by 69, 841 and 920 pmol/l, while glp-1(7-37), at a dose of 1.5 pmol/kg/min augmented the insulin response by 2106 pmol/l. |
1994-08-12 |
2023-08-12 |
human |
| D Elahi, M McAloon-Dyke, N K Fukagawa, G S Meneilly, A L Sclater, K L Minaker, J F Habener, D K Anderse. The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regulatory peptides. vol 51. issue 1. 1994-08-12. PMID:8036284. |
in the diabetic subjects, gip had no effect, while glp-1(7-37) augmented the insulin response by 929 pmol/l. |
1994-08-12 |
2023-08-12 |
human |
| B van Eyll, B Lankat-Buttgereit, H P Bode, R Göke, B Gök. Signal transduction of the GLP-1-receptor cloned from a human insulinoma. FEBS letters. vol 348. issue 1. 1994-08-09. PMID:7517895. |
glp-1 (glucagon-like peptide 1 (7-36) amide) plays an important role in the regulation of insulin secretion and proinsulin gene expression of pancreatic beta-cells. |
1994-08-09 |
2023-08-12 |
human |
| Y Tanizawa, A C Riggs, S C Elbein, A Whelan, H Donis-Keller, M A Permut. Human glucagon-like peptide-1 receptor gene in NIDDM. Identification and use of simple sequence repeat polymorphisms in genetic analysis. Diabetes. vol 43. issue 6. 1994-06-27. PMID:8194659. |
the hypothesis to be tested in this study was that defects in the islet beta-cell glp-1 receptor gene contribute to the impaired glucose-regulated insulin secretion of non-insulin-dependent diabetes mellitus (niddm). |
1994-06-27 |
2023-08-12 |
human |
| C Widmann, E Bürki, W Dolci, B Thoren. Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of beta cell lines. Molecular pharmacology. vol 45. issue 5. 1994-06-23. PMID:8190093. |
glucagon-like peptide-1 (glp-1) is a gastrointestinal hormone that potentiates glucose-induced insulin secretion by pancreatic beta cells. |
1994-06-23 |
2023-08-12 |
Not clear |
| C Widmann, E Bürki, W Dolci, B Thoren. Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of beta cell lines. Molecular pharmacology. vol 45. issue 5. 1994-06-23. PMID:8190093. |
together, our data show that interaction between glp-1 and glucose signaling pathways in beta cells may be mediated uniquely by an increase in the intracellular camp concentration, with the consequent activation of protein kinase a and phosphorylation of elements of the glucose-sensing apparatus or of the insulin granule exocytic machinery. |
1994-06-23 |
2023-08-12 |
Not clear |
| D A D'Alessio, S E Kahn, C R Leusner, J W Ensinc. Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. The Journal of clinical investigation. vol 93. issue 5. 1994-06-14. PMID:8182159. |
glucagon-like peptide 1 [7-36 amide] (glp-1) has been shown to enhance insulin secretion in healthy and type ii diabetic humans, and to increase glucose disposal in type i diabetic patients. |
1994-06-14 |
2023-08-12 |
human |
| D A D'Alessio, S E Kahn, C R Leusner, J W Ensinc. Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. The Journal of clinical investigation. vol 93. issue 5. 1994-06-14. PMID:8182159. |
in addition, basal insulin concentrations, the acute insulin response to glucose (airg), plasma glucagon levels, and the glucose disappearance constant (kg) were measured on the days that subjects received glp-1 or saline. |
1994-06-14 |
2023-08-12 |
human |
| D A D'Alessio, S E Kahn, C R Leusner, J W Ensinc. Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. The Journal of clinical investigation. vol 93. issue 5. 1994-06-14. PMID:8182159. |
there was no significant effect of glp-1 on si or basal insulin, and glucagon levels were not different during the glucose tolerance tests with or without glp-1. |
1994-06-14 |
2023-08-12 |
human |
| I Navarro, T W Moo. Glucagon binding to hepatocytes isolated from two teleost fishes, the American eel and the brown bullhead. The Journal of endocrinology. vol 140. issue 2. 1994-06-01. PMID:8169557. |
in competition experiments, insulin did not displace 125i-labelled glucagon binding in the hepatocytes of either species, while glucagon-like peptide-1(7-37) (glp-1) displaced glucagon but only at high concentrations, suggesting separate glucagon- and glp-1-binding sites. |
1994-06-01 |
2023-08-12 |
Not clear |
| J F Habene. The incretin notion and its relevance to diabetes. Endocrinology and metabolism clinics of North America. vol 22. issue 4. 1994-04-08. PMID:8125072. |
glp-1 hormone is released into the circulation from intestinal l cells in response to meals and is the most potent incretin hormone known; glp-1 and gip appear to account for most, if not all, of the intestinal incretin effect in the augmentation of glucose-stimulated insulin secretion. |
1994-04-08 |
2023-08-12 |
rat |
| J F Habene. The incretin notion and its relevance to diabetes. Endocrinology and metabolism clinics of North America. vol 22. issue 4. 1994-04-08. PMID:8125072. |
analyses of the mechanisms of action of glp-1 and of glucose on isolated cultured rat beta cells using patch-clamp techniques to record ion channel activities has led to the glucose competence concept in which the combined glucose-signaling and glp-1/camp-signaling pathways are required to affect depolarization of beta cells and to thereby stimulate insulin secretion. |
1994-04-08 |
2023-08-12 |
rat |
| J F Habene. The incretin notion and its relevance to diabetes. Endocrinology and metabolism clinics of North America. vol 22. issue 4. 1994-04-08. PMID:8125072. |
because of the discoveries that glp-1 stimulates both secretion and production of insulin, and that the actions of glp-1 are entirely glucose-dependent, glp-1 may provide unique advantages over the sulfonylurea drugs in the treatment of niddm. |
1994-04-08 |
2023-08-12 |
rat |