| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Takahashi, H Manaka, K Suda, N Fukase, A Sekikawa, H Eguchi, M Tominaga, H Sasak. Hyperglycaemia but not hyperinsulinaemia prevents the secretion of glucagon-like peptide-1 (7-36 amide) stimulated by fat ingestion. Scandinavian journal of clinical and laboratory investigation. vol 51. issue 6. 1992-02-18. PMID:1767243. |
the effect of insulin and glucose on fat-induced gastric inhibitory polypeptide (gip) and glucagon-like peptide-1 (7-36 amide) (glp-1 (7-36 amide)) was studied in five healthy subjects during continuous glucose infusion (protocol 1) and during hyperinsulinaemic euglycaemic blood glucose clamp (protocol 2). |
1992-02-18 |
2023-08-11 |
human |
| H Takahashi, H Manaka, K Suda, N Fukase, A Sekikawa, H Eguchi, M Tominaga, H Sasak. Hyperglycaemia but not hyperinsulinaemia prevents the secretion of glucagon-like peptide-1 (7-36 amide) stimulated by fat ingestion. Scandinavian journal of clinical and laboratory investigation. vol 51. issue 6. 1992-02-18. PMID:1767243. |
thus, it is concluded that insulin inhibits fat-induced gip, but not glp-1 (7-36 amide), secretion and that glucose is likely to inhibit glp-1 (7-36 amide) secretion. |
1992-02-18 |
2023-08-11 |
human |
| K Inoue, A Hisatomi, F Umeda, H Nawat. Effects of glucagon-like peptide 1 (7-36) amide and glucagon on amylin release from perfused rat pancreas. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 23. issue 9. 1992-01-15. PMID:1743611. |
the infusion of glp-1 (7-36) amide at a concentration of 10(-9) m elicited a biphasic release of amylin similar to that of insulin. |
1992-01-15 |
2023-08-11 |
rat |
| K Inoue, A Hisatomi, F Umeda, H Nawat. Effects of glucagon-like peptide 1 (7-36) amide and glucagon on amylin release from perfused rat pancreas. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 23. issue 9. 1992-01-15. PMID:1743611. |
these findings suggest that glp-1 (7-36) amide and glucagon stimulate the release of amylin from the pancreas and that the concomitant secretion of amylin and insulin might contribute to glucose homeostasis. |
1992-01-15 |
2023-08-11 |
rat |
| J Miholic, C Orskov, J J Holst, J Kotzerke, H J Meye. Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy. Digestive diseases and sciences. vol 36. issue 10. 1991-11-05. PMID:1914756. |
postprandial glucagon-like peptide-1 (glp-1), pancreatic glucagon, and insulin were measured in 27 tumor-free patients 43 months (median) after total gastrectomy and in four controls using a 99technetium-labeled 100-g carbohydrate solid test meal. |
1991-11-05 |
2023-08-11 |
human |
| J Miholic, C Orskov, J J Holst, J Kotzerke, H J Meye. Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy. Digestive diseases and sciences. vol 36. issue 10. 1991-11-05. PMID:1914756. |
plasma glp-1 concentrations peaked at 15 min, and insulin concentrations at 30 min after the end of the meal. |
1991-11-05 |
2023-08-11 |
human |
| J Miholic, C Orskov, J J Holst, J Kotzerke, H J Meye. Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy. Digestive diseases and sciences. vol 36. issue 10. 1991-11-05. PMID:1914756. |
a close correlation between integrated glp-1 responses and integrated insulin responses (r = 0.68) was observed. |
1991-11-05 |
2023-08-11 |
human |
| J Miholic, C Orskov, J J Holst, J Kotzerke, H J Meye. Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy. Digestive diseases and sciences. vol 36. issue 10. 1991-11-05. PMID:1914756. |
there was a close (inverse) relationship of t1/2 with early integrated glp-1 and pancreatic glucagon, but not with insulin. |
1991-11-05 |
2023-08-11 |
human |
| J Oben, L Morgan, J Fletcher, V Mark. Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue. The Journal of endocrinology. vol 130. issue 2. 1991-11-01. PMID:1919397. |
the effect of gastric inhibitory polypeptide (gip), glucagon-like peptide-1(7-36) amide, (glp-1(7-36) amide), glucagon-like peptide-2 (glp-2), glucagon and insulin on fatty acid synthesis in explants of rat adipose tissue from various sites was investigated. |
1991-11-01 |
2023-08-11 |
rat |
| J Oben, L Morgan, J Fletcher, V Mark. Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue. The Journal of endocrinology. vol 130. issue 2. 1991-11-01. PMID:1919397. |
gip, glp-1(7-36) amide and insulin stimulated fatty acid synthesis, as determined by measuring the incorporation of [14c]acetate into saponifiable fat, in a dose-dependent manner, over the concentration range 5-15 ng/ml (0.87-2.61 nmol/l) for insulin and 0.5-7.5 ng/ml for gip (0.10-1.50 nmol/l) and glp-1(7-36) amide (0.15-2.27 nmol/l). |
1991-11-01 |
2023-08-11 |
rat |
| J Oben, L Morgan, J Fletcher, V Mark. Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue. The Journal of endocrinology. vol 130. issue 2. 1991-11-01. PMID:1919397. |
the study indicates that gip and glp-1(7-36)amide, in addition to stimulating insulin secretion, may play a direct physiological role in vivo, in common with insulin, in promoting fatty acid synthesis in adipose tissue. |
1991-11-01 |
2023-08-11 |
rat |
| T Fridolf, G Böttcher, F Sundler, B Ahré. GLP-1 and GLP-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse. Pancreas. vol 6. issue 2. 1991-10-04. PMID:1886889. |
glp-1 and glp-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse. |
1991-10-04 |
2023-08-11 |
mouse |
| T Fridolf, G Böttcher, F Sundler, B Ahré. GLP-1 and GLP-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse. Pancreas. vol 6. issue 2. 1991-10-04. PMID:1886889. |
we studied the cellular distribution of glucagon-like peptide-1 (glp-1) in the pancreas and gut and the effects of glp-1 and its truncated form, glp-1(7-36) amide, on basal and stimulated insulin and glucagon secretion in the mouse. |
1991-10-04 |
2023-08-11 |
mouse |
| T Fridolf, G Böttcher, F Sundler, B Ahré. GLP-1 and GLP-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse. Pancreas. vol 6. issue 2. 1991-10-04. PMID:1886889. |
experiments in vivo revealed that basal insulin secretion was stimulated by glp-1(7-36) amide at the dose levels of 8 and 32 nmol/kg, and by glp-1 at 32 nmol/kg. |
1991-10-04 |
2023-08-11 |
mouse |
| T Fridolf, G Böttcher, F Sundler, B Ahré. GLP-1 and GLP-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse. Pancreas. vol 6. issue 2. 1991-10-04. PMID:1886889. |
in contrast, stimulated insulin secretion was unaffected by glp-1. |
1991-10-04 |
2023-08-11 |
mouse |
| T Fridolf, B Ahré. GLP-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent. Biochemical and biophysical research communications. vol 179. issue 1. 1991-10-02. PMID:1883392. |
glp-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent. |
1991-10-02 |
2023-08-11 |
rat |
| T Fridolf, B Ahré. GLP-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent. Biochemical and biophysical research communications. vol 179. issue 1. 1991-10-02. PMID:1883392. |
it was found that glp-1(7-36)amide stimulated insulin secretion, 45ca(2+)-efflux, and 86rb(+)-efflux from prelabelled islets. |
1991-10-02 |
2023-08-11 |
rat |
| T Fridolf, B Ahré. GLP-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent. Biochemical and biophysical research communications. vol 179. issue 1. 1991-10-02. PMID:1883392. |
this suggests that glp-1(7-36)amide stimulates insulin secretion by depolarizing the beta-cells by increasing their permeability to na+. |
1991-10-02 |
2023-08-11 |
rat |
| P F Blackmore, S Mojsov, J H Exton, J F Habene. Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes. FEBS letters. vol 283. issue 1. 1991-07-02. PMID:1645298. |
it was concluded that in the rat, glp-1(7-37) is a potent insulin secretagogue [1] but is without effect on liver. |
1991-07-02 |
2023-08-11 |
rat |
| A Faulkner, H T Polloc. Effects of truncated glucagon-like peptide-1 on the responses of starved sheep to glucose. The Journal of endocrinology. vol 129. issue 1. 1991-06-18. PMID:2030330. |
giving glp-1 to starved sheep increased the insulin response to the glucose load. |
1991-06-18 |
2023-08-11 |
Not clear |