| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H C Fehmann, R Göke, B Göke, R Arnol. Carbachol priming increases glucose- and glucagon-like peptide-1 (7-36)amide-, but not arginine-induced insulin secretion from the isolated perfused rat pancreas. Zeitschrift fur Gastroenterologie. vol 28. issue 7. 1990-12-27. PMID:2238765. |
the priming effect of carbachol on glucose-, arginine- and glucose plus glp-1 (7-36)amide induced insulin secretion was investigated. |
1990-12-27 |
2023-08-11 |
rat |
| H C Fehmann, R Göke, B Göke, R Arnol. Carbachol priming increases glucose- and glucagon-like peptide-1 (7-36)amide-, but not arginine-induced insulin secretion from the isolated perfused rat pancreas. Zeitschrift fur Gastroenterologie. vol 28. issue 7. 1990-12-27. PMID:2238765. |
after an additional 10 min period at 2.8 mmol/l glucose insulin secretion was stimulated for 44 min with 10 mmol/l glucose, or glucose plus glp-1 (7-36)amide (0.5 nmol/l), or arginine (10 mmol/l). |
1990-12-27 |
2023-08-11 |
rat |
| H C Fehmann, R Göke, B Göke, R Arnol. Carbachol priming increases glucose- and glucagon-like peptide-1 (7-36)amide-, but not arginine-induced insulin secretion from the isolated perfused rat pancreas. Zeitschrift fur Gastroenterologie. vol 28. issue 7. 1990-12-27. PMID:2238765. |
prior exposure of the pancrease to carbachol enhanced the glucose / glp-1 (7-36)amide induced insulin release, but left the arginine stimulated secretion unaltered. |
1990-12-27 |
2023-08-11 |
rat |
| B Gallwitz, W E Schmidt, J M Conlon, W Creutzfeld. Glucagon-like peptide-1(7-36)amide: characterization of the domain responsible for binding to its receptor on rat insulinoma RINm5F cells. Journal of molecular endocrinology. vol 5. issue 1. 1990-10-16. PMID:2168708. |
glucagon-like peptide-1(7-36)amide (glp-1(7-36)amide) is a potent stimulator of insulin secretion. |
1990-10-16 |
2023-08-11 |
rat |
| H C Fehmann, B Göke, V Weber, R Göke, M E Trautmann, G Richter, R Arnol. Interaction of glucagon-like peptide-1 (7-36)amide and cholecystokinin-8 in the endocrine and exocrine rat pancreas. Pancreas. vol 5. issue 3. 1990-06-26. PMID:1693001. |
the insulinotropic action of 0.5 nm glp-1 (7-36)amide, which weakly stimulated the glucose-induced (6.7 mm) insulin release from the isolated perfused rat pancreas, was strongly potentiated by the addition of cck-8 (20, 50, and 100 pm) to the perfusate. |
1990-06-26 |
2023-08-11 |
rat |
| S Suzuki, K Kawai, S Ohashi, H Mukai, K Yamashit. Comparison of the effects of various C-terminal and N-terminal fragment peptides of glucagon-like peptide-1 on insulin and glucagon release from the isolated perfused rat pancreas. Endocrinology. vol 125. issue 6. 1990-01-09. PMID:2684616. |
truncated glucagon-like peptide-1 (glp-1) possesses a potent stimulatory activity for insulin secretion and a slight inhibiting activity for glucagon secretion. |
1990-01-09 |
2023-08-11 |
rat |
| R Göke, H C Fehmann, G Richter, M Trautmann, B Gök. Interaction of glucagon-like peptide-1(7-36)amide and somatostatin-14 in RINm5F cells and in the perfused rat pancreas. Pancreas. vol 4. issue 6. 1989-12-20. PMID:2573056. |
in the present study, the effect of somatostatin-14 on the glp-1(7-36)amide-induced insulin release and camp generation in this cell line was investigated. |
1989-12-20 |
2023-08-11 |
rat |
| R Göke, H C Fehmann, G Richter, M Trautmann, B Gök. Interaction of glucagon-like peptide-1(7-36)amide and somatostatin-14 in RINm5F cells and in the perfused rat pancreas. Pancreas. vol 4. issue 6. 1989-12-20. PMID:2573056. |
the glp-1(7-36)amide-induced insulin release was decreased concentration dependently by somatostatin. |
1989-12-20 |
2023-08-11 |
rat |
| R Göke, H C Fehmann, G Richter, M Trautmann, B Gök. Interaction of glucagon-like peptide-1(7-36)amide and somatostatin-14 in RINm5F cells and in the perfused rat pancreas. Pancreas. vol 4. issue 6. 1989-12-20. PMID:2573056. |
somatostatin, 1 microm reduced the maximally glp-1(7-36)amide-stimulated (0.1 microm) insulin release to basal insulin levels. |
1989-12-20 |
2023-08-11 |
rat |
| R Göke, H C Fehmann, G Richter, M Trautmann, B Gök. Interaction of glucagon-like peptide-1(7-36)amide and somatostatin-14 in RINm5F cells and in the perfused rat pancreas. Pancreas. vol 4. issue 6. 1989-12-20. PMID:2573056. |
somatostatin (1 nm, 1 microm) inhibited the glucose-induced (6.7 mm) and glp-1(7-36)amide-potentiated (0.05, 0.5, and 5 nm) insulin release dose dependently. |
1989-12-20 |
2023-08-11 |
rat |
| R Göke, H C Fehmann, G Richter, M Trautmann, B Gök. Interaction of glucagon-like peptide-1(7-36)amide and somatostatin-14 in RINm5F cells and in the perfused rat pancreas. Pancreas. vol 4. issue 6. 1989-12-20. PMID:2573056. |
the glp-1(7-36)amide-induced insulin release is potently inhibited by somatostatin-14. |
1989-12-20 |
2023-08-11 |
rat |
| R Göke, M E Trautmann, E Haus, G Richter, H C Fehmann, R Arnold, B Gök. Signal transmission after GLP-1(7-36)amide binding in RINm5F cells. The American journal of physiology. vol 257. issue 3 Pt 1. 1989-10-18. PMID:2551182. |
further studies investigated the involvement of membrane depolarization or changes in the cytosolic free calcium level in the intracellular signaling of glp-1(7-36)amide-induced insulin secretion. |
1989-10-18 |
2023-08-11 |
Not clear |
| H C Fehmann, B Göke, R Göke, M E Trautmann, R Arnol. Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS letters. vol 252. issue 1-2. 1989-09-21. PMID:2668027. |
the interaction of glucagon-like peptide-1 (7-36)amide (glp-1) and glucose-dependent insulin-releasing polypeptide (gip) on insulin release from the perfused rat pancreas was studied. |
1989-09-21 |
2023-08-11 |
rat |
| H C Fehmann, B Göke, R Göke, M E Trautmann, R Arnol. Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS letters. vol 252. issue 1-2. 1989-09-21. PMID:2668027. |
the glp-1 stimulated (0.5 nmol/l), glucose-induced (6.7 mmol/l) insulin secretory answer was enhanced by gip (0.1, 1.0 and 10.0 nmol/l) to the arterial perfusate. |
1989-09-21 |
2023-08-11 |
rat |
| H C Fehmann, B Göke, R Göke, M E Trautmann, R Arnol. Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS letters. vol 252. issue 1-2. 1989-09-21. PMID:2668027. |
our data demonstrate an additive synergistic effect of glp-1 and gip on the glucose-induced insulin release. |
1989-09-21 |
2023-08-11 |
rat |
| C Orskov, M Bersani, A H Johnsen, P Højrup, J J Hols. Complete sequences of glucagon-like peptide-1 from human and pig small intestine. The Journal of biological chemistry. vol 264. issue 22. 1989-09-07. PMID:2753890. |
earlier studies have shown that synthetic glucagon-like peptide-1 (glp-1) synthesized according to the proposed structure (proglucagon 71-108 or because residue 108 is gly, 72-107 amide) had no physiological effects, whereas a truncated from of glp-1, corresponding to proglucagon 78-107 amide, strongly stimulated insulin secretion and depressed glucagon secretion. |
1989-09-07 |
2023-08-11 |
human |
| T Matsuyama, R Komatsu, M Namba, N Watanabe, H Itoh, S Taru. Glucagon-like peptide-1 (7-36 amide): a potent glucagonostatic and insulinotropic hormone. Diabetes research and clinical practice. vol 5. issue 4. 1989-05-02. PMID:3069410. |
glucagon and insulin release were not affected significantly by glp-1 (1-37), irrespective of glucose concentration. |
1989-05-02 |
2023-08-11 |
rat |
| K Shima, M Hirota, C Ohbosh. Effect of glucagon-like peptide-1 on insulin secretion. Regulatory peptides. vol 22. issue 3. 1988-11-15. PMID:3051138. |
these findings suggest that the smaller glp-1 may have a physiologically more important role as a modulator of insulin release. |
1988-11-15 |
2023-08-11 |
rat |
| C Orskov, J J Holst, O V Nielse. Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach. Endocrinology. vol 123. issue 4. 1988-10-27. PMID:2901341. |
insulin secretion from the pancreas (with 7 mmol/liter glucose in the perfusate) increased 2-fold with truncated glp-1 at 10(-10) mol/liter and almost 5-fold at 10(-9) mol/liter. |
1988-10-27 |
2023-08-11 |
Not clear |
| C J Bailey, P R Flat. Glucagon-like peptide-1 and the entero-insular axis in obese hyperglycaemic (ob/ob) mice. Life sciences. vol 40. issue 6. 1987-03-19. PMID:3543585. |
compared with glucagon (100 micrograms/kg ip), which produce an approximately 3-fold increase in basal plasma glucose and insulin concentrations, glp-1 (100 micrograms/kg ip) produce a very small (less than 1 fold) increase in plasma insulin, with no significant change in plasma glucose. |
1987-03-19 |
2023-08-11 |
mouse |