| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Fridolf, B Ahré. GLP-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent. Biochemical and biophysical research communications. vol 179. issue 1. 1991-10-02. PMID:1883392. |
glp-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent. |
1991-10-02 |
2023-08-11 |
rat |
| T Fridolf, B Ahré. GLP-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent. Biochemical and biophysical research communications. vol 179. issue 1. 1991-10-02. PMID:1883392. |
it was found that glp-1(7-36)amide stimulated insulin secretion, 45ca(2+)-efflux, and 86rb(+)-efflux from prelabelled islets. |
1991-10-02 |
2023-08-11 |
rat |
| T Fridolf, B Ahré. GLP-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent. Biochemical and biophysical research communications. vol 179. issue 1. 1991-10-02. PMID:1883392. |
this suggests that glp-1(7-36)amide stimulates insulin secretion by depolarizing the beta-cells by increasing their permeability to na+. |
1991-10-02 |
2023-08-11 |
rat |
| P F Blackmore, S Mojsov, J H Exton, J F Habene. Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes. FEBS letters. vol 283. issue 1. 1991-07-02. PMID:1645298. |
it was concluded that in the rat, glp-1(7-37) is a potent insulin secretagogue [1] but is without effect on liver. |
1991-07-02 |
2023-08-11 |
rat |
| A Faulkner, H T Polloc. Effects of truncated glucagon-like peptide-1 on the responses of starved sheep to glucose. The Journal of endocrinology. vol 129. issue 1. 1991-06-18. PMID:2030330. |
giving glp-1 to starved sheep increased the insulin response to the glucose load. |
1991-06-18 |
2023-08-11 |
Not clear |
| A Faulkner, H T Polloc. Effects of truncated glucagon-like peptide-1 on the responses of starved sheep to glucose. The Journal of endocrinology. vol 129. issue 1. 1991-06-18. PMID:2030330. |
the rise in plasma insulin concentrations in starved sheep given glp-1 was similar to that observed in fed sheep. |
1991-06-18 |
2023-08-11 |
Not clear |
| A Faulkner, H T Polloc. Effects of truncated glucagon-like peptide-1 on the responses of starved sheep to glucose. The Journal of endocrinology. vol 129. issue 1. 1991-06-18. PMID:2030330. |
the data suggest a role for glp-1 in regulating plasma insulin concentrations and hence metabolism in ruminant animals. |
1991-06-18 |
2023-08-11 |
Not clear |
| P R Flatt, O Shiber, S M Hampton, V Mark. Stimulatory effects of glucagon-like peptides on human insulinoma cells and insulin-releasing clonal RINm5F cells. Diabetes research (Edinburgh, Scotland). vol 13. issue 2. 1991-06-10. PMID:1965428. |
insulin release by human insulinoma cells was enhanced at 2 x 10(-7) m by glucagon, glp-1[1-37], glp-1[7-36] and its n- and c-terminal fragments glp-1[7-14] and glp-1[31-37]. |
1991-06-10 |
2023-08-11 |
human |
| P R Flatt, O Shiber, S M Hampton, V Mark. Stimulatory effects of glucagon-like peptides on human insulinoma cells and insulin-releasing clonal RINm5F cells. Diabetes research (Edinburgh, Scotland). vol 13. issue 2. 1991-06-10. PMID:1965428. |
these results suggest that glp-1[7-36] stimulates insulin release by a direct action on human and rat b-cells, partly involving modulation of intracellular cyclic amp. |
1991-06-10 |
2023-08-11 |
human |
| H C Fehmann, R Göke, B Göke, R Bächle, B Wagner, R Arnol. Priming effect of glucagon-like peptide-1 (7-36) amide, glucose-dependent insulinotropic polypeptide and cholecystokinin-8 at the isolated perfused rat pancreas. Biochimica et biophysica acta. vol 1091. issue 3. 1991-04-15. PMID:1705823. |
the priming effect of glucagon-like peptide-1 (7-36) amide (glp-1 (7-36) amide), glucose-dependent insulin-releasing polypeptide (gip) and cholecystokinin-8 (cck-8) on glucose-induced insulin secretion from rat pancreas was investigated. |
1991-04-15 |
2023-08-11 |
rat |
| K Kawai, S Suzuki, S Ohashi, H Mukai, Y Murayma, K Yamashit. Effects of truncated glucagon-like peptide-1 on pancreatic hormone release in normal conscious dogs. Acta endocrinologica. vol 123. issue 6. 1991-03-15. PMID:2284891. |
the effects of truncated glucagon-like peptide-1 (glp-1) on insulin and glucagon release were examined in unanesthetized normal dogs. |
1991-03-15 |
2023-08-11 |
Not clear |
| K Kawai, S Suzuki, S Ohashi, H Mukai, Y Murayma, K Yamashit. Effects of truncated glucagon-like peptide-1 on pancreatic hormone release in normal conscious dogs. Acta endocrinologica. vol 123. issue 6. 1991-03-15. PMID:2284891. |
a bolus injection of glp-1(7-36)amide elicited a transient increase in the plasma insulin level, which brought about a decrease in the plasma glucose level. |
1991-03-15 |
2023-08-11 |
Not clear |
| K Kawai, S Suzuki, S Ohashi, H Mukai, Y Murayma, K Yamashit. Effects of truncated glucagon-like peptide-1 on pancreatic hormone release in normal conscious dogs. Acta endocrinologica. vol 123. issue 6. 1991-03-15. PMID:2284891. |
the degree of increase in plasma insulin levels with glp-1(7-35)oh or glp-1(7-37)oh was less than that induced by glp-1(7-36)amide. |
1991-03-15 |
2023-08-11 |
Not clear |
| K Kawai, S Suzuki, S Ohashi, H Mukai, Y Murayma, K Yamashit. Effects of truncated glucagon-like peptide-1 on pancreatic hormone release in normal conscious dogs. Acta endocrinologica. vol 123. issue 6. 1991-03-15. PMID:2284891. |
the infusion of graded doses of glp-1(7-36)amide (6, 36, 120 ng.kg-1.min-1 every 30 min) did not change the plasma glucose, insulin or glucagon levels significantly. |
1991-03-15 |
2023-08-11 |
Not clear |
| K Kawai, S Suzuki, S Ohashi, H Mukai, Y Murayma, K Yamashit. Effects of truncated glucagon-like peptide-1 on pancreatic hormone release in normal conscious dogs. Acta endocrinologica. vol 123. issue 6. 1991-03-15. PMID:2284891. |
the degree of increase in the plasma glucose level induced by iv glucose infusion (12 mg.kg-1.min-1) was reduced by coinfusion of glp-1(7-36)amide (6 ng.kg-1.min-1), although the degree of increase in the plasma insulin level was the same as that in a control experiment (coinfusion of the vehicle). |
1991-03-15 |
2023-08-11 |
Not clear |
| K Kawai, S Suzuki, S Ohashi, H Mukai, Y Murayma, K Yamashit. Effects of truncated glucagon-like peptide-1 on pancreatic hormone release in normal conscious dogs. Acta endocrinologica. vol 123. issue 6. 1991-03-15. PMID:2284891. |
coinfusion of glp-1(7-36)amide (60 ng.kg-1.min-1) caused an augmented increase in the plasma insulin level and a reduced increase in the plasma glucose level during iv glucose infusion (17 mg.kg-1.min-1) compared with the control experiment. |
1991-03-15 |
2023-08-11 |
Not clear |
| K Kawai, S Suzuki, S Ohashi, H Mukai, Y Murayma, K Yamashit. Effects of truncated glucagon-like peptide-1 on pancreatic hormone release in normal conscious dogs. Acta endocrinologica. vol 123. issue 6. 1991-03-15. PMID:2284891. |
the degree of increase in the plasma glucagon level induced by insulin hypoglycemia and the profile of the plasma glucose level at that time were not affected by the infusion of glp-1(7-36)amide. |
1991-03-15 |
2023-08-11 |
Not clear |
| R Schmid, V Schusdziarra, R Aulehner, N Weigert, M Classe. Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas. Zeitschrift fur Gastroenterologie. vol 28. issue 6. 1990-12-27. PMID:2238756. |
comparison of glp-1 (7-36amide) and gip on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas. |
1990-12-27 |
2023-08-11 |
rat |
| R Schmid, V Schusdziarra, R Aulehner, N Weigert, M Classe. Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas. Zeitschrift fur Gastroenterologie. vol 28. issue 6. 1990-12-27. PMID:2238756. |
the effect of equimolar doses of gip and glp-1 (7-36amide) on insulin and somatostatin secretion in the isolated perfused rat pancreas was compared. |
1990-12-27 |
2023-08-11 |
rat |
| R Schmid, V Schusdziarra, R Aulehner, N Weigert, M Classe. Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas. Zeitschrift fur Gastroenterologie. vol 28. issue 6. 1990-12-27. PMID:2238756. |
at a perfusate glucose concentration of 70 mg/dl glp-1 (7-36amide) 10(-9) and 10(-8) m and gip 10(-9) m elicited a significant stimulation of insulin while gip 10(-8) m and lower doses of both peptides (10(-11) and 10(-10) m) were ineffective. |
1990-12-27 |
2023-08-11 |
rat |