| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Hvidberg, M T Nielsen, J Hilsted, C Orskov, J J Hols. Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man. Metabolism: clinical and experimental. vol 43. issue 1. 1994-02-24. PMID:8289665. |
the newly discovered intestinal hormone, glucagon-like peptide-1 (glp-1) (proglucagon 78-107amide), stimulates insulin secretion and inhibits glucagon secretion in man and may therefore be anticipated to influence hepatic glucose production. |
1994-02-24 |
2023-08-12 |
human |
| A Hvidberg, M T Nielsen, J Hilsted, C Orskov, J J Hols. Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man. Metabolism: clinical and experimental. vol 43. issue 1. 1994-02-24. PMID:8289665. |
to study this, we infused synthetic glp-1 sequentially at rates of 25 and 75 pmol.kg-1.h-1 into eight healthy volunteers after an overnight fast and measured plasma concentrations of glucose, insulin, and glucagon and glucose turnover by a technique involving infusion of 3-3h-glucose. |
1994-02-24 |
2023-08-12 |
human |
| T Fridolf, B Ahré. Effects of glucagon like peptide-1(7-36) amide on the cytoplasmic Ca(2+)-concentration in rat islet cells. Molecular and cellular endocrinology. vol 96. issue 1-2. 1994-02-08. PMID:8276143. |
glucagon like peptide-1(7-36) amide (glp-1(7-36)amide) stimulates both insulin secretion and the efflux of 45ca2+ from 45ca(2+)-preloaded rat islets in a na(+)-dependent manner. |
1994-02-08 |
2023-08-12 |
rat |
| T Yada, K Itoh, M Nakat. Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity. Endocrinology. vol 133. issue 4. 1993-11-03. PMID:8404610. |
glucagon-like peptide-1 (glp-1), in the form of either glp-1-(7-36)amide or glp-1-(7-37), has been shown to potently stimulate insulin release in a glucose-dependent manner and is suggested to be a physiological incretin. |
1993-11-03 |
2023-08-12 |
rat |
| M A Nauck, N Kleine, C Orskov, J J Holst, B Willms, W Creutzfeld. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. vol 36. issue 8. 1993-10-25. PMID:8405741. |
glucagon-like peptide 1 (glp-1) (7-36 amide) is a physiological incretin hormone that is released after nutrient intake from the lower gut and stimulates insulin secretion at elevated plasma glucose concentrations. |
1993-10-25 |
2023-08-12 |
Not clear |
| M A Nauck, N Kleine, C Orskov, J J Holst, B Willms, W Creutzfeld. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. vol 36. issue 8. 1993-10-25. PMID:8405741. |
in all patients, insulin (by 17.4 +/- 4.7 nmol x 1-1 x min; p = 0.0157) and c-peptide (by 228.0 +/- 39.1 nmol x 1-1 x min; p = 0.0019) increased significantly over basal levels, glucagon was reduced (by -1418 +/- 308 pmol x 1-1 x min) and plasma glucose reached normal fasting concentrations (4.9 +/- 0.3 mmol/l) within 4 h of glp-1 (7-36 amide) administration, but not with placebo. |
1993-10-25 |
2023-08-12 |
Not clear |
| M A Nauck, N Kleine, C Orskov, J J Holst, B Willms, W Creutzfeld. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. vol 36. issue 8. 1993-10-25. PMID:8405741. |
when normal fasting plasma glucose concentrations were reached insulin returned towards basal levels and plasma glucose concentrations remained stable despite the ongoing infusion of glp-1 (7-36 amide). |
1993-10-25 |
2023-08-12 |
Not clear |
| B Gallwitz, M Witt, U R Fölsch, W Creutzfeldt, W E Schmid. Binding specificity and signal transduction of receptors for glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide on RINm5F insulinoma cells. Journal of molecular endocrinology. vol 10. issue 3. 1993-10-21. PMID:8396943. |
glucagon-like peptide-1(7-36)amide (glp-1(7-36) amide) and gastric inhibitory polypeptide (gip), peptides of the glucagon family, stimulate insulin secretion in vitro and in vivo. |
1993-10-21 |
2023-08-12 |
Not clear |
| R Göke, H C Fehmann, T Linn, H Schmidt, M Krause, J Eng, B Gök. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. The Journal of biological chemistry. vol 268. issue 26. 1993-10-07. PMID:8396143. |
exendin-4, like glp-1, stimulated dose dependently the glucose-induced insulin secretion in isolated rat islets, and, in mouse insulinoma beta tc-1 cells, both peptides stimulated the proinsulin gene expression at the level of transcription. |
1993-10-07 |
2023-08-12 |
mouse |
| G Waeber, N Thompson, B Waeber, H R Brunner, P Nicod, E Grouzman. Neuropeptide Y expression and regulation in a differentiated rat insulin-secreting cell line. Endocrinology. vol 133. issue 3. 1993-10-06. PMID:8396008. |
4) induction of npy, a known inhibitor of insulin secretion, may represent a novel counterregulatory mechanism of insulin secretion, limiting the stimulatory effect of glp-1 on insulin secretion. |
1993-10-06 |
2023-08-12 |
rat |
| P A Martin, A Faulkne. Effects of glucagon-like peptide-1(7-36)amide on the concentrations of insulin and glucose in sheep. Comparative biochemistry and physiology. Comparative physiology. vol 105. issue 4. 1993-09-30. PMID:8102959. |
the effects of glucagon-like peptide-1(7-36)amide (glp-1) and/or glucose on the concentration of insulin in fed and starved sheep were studied. |
1993-09-30 |
2023-08-12 |
Not clear |
| P A Martin, A Faulkne. Effects of glucagon-like peptide-1(7-36)amide on the concentrations of insulin and glucose in sheep. Comparative biochemistry and physiology. Comparative physiology. vol 105. issue 4. 1993-09-30. PMID:8102959. |
insulin concentrations in starved sheep increased with increasing doses of glp-1 (0.23-2.27 nmol) when given together with glucose. |
1993-09-30 |
2023-08-12 |
Not clear |
| P A Martin, A Faulkne. Effects of glucagon-like peptide-1(7-36)amide on the concentrations of insulin and glucose in sheep. Comparative biochemistry and physiology. Comparative physiology. vol 105. issue 4. 1993-09-30. PMID:8102959. |
hyperglycaemia was necessary for glp-1 to stimulate increases in serum insulin but the level required was low (0.4 mmol/l or less). |
1993-09-30 |
2023-08-12 |
Not clear |
| P A Martin, A Faulkne. Effects of glucagon-like peptide-1(7-36)amide on the concentrations of insulin and glucose in sheep. Comparative biochemistry and physiology. Comparative physiology. vol 105. issue 4. 1993-09-30. PMID:8102959. |
glp-1 did not augment insulin secretion in response to other known insulin secretagogues. |
1993-09-30 |
2023-08-12 |
Not clear |
| M A Nauck, M Büsing, C Orskov, E G Siegel, J Talartschik, A Baartz, T Baartz, U T Hopt, H D Becker, W Creutzfeld. Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation. Acta diabetologica. vol 30. issue 1. 1993-08-16. PMID:8329730. |
the release of gastric inhibitory polypeptide (gip) and glucagon-like peptide 1 (glp-1) immunoreactivity and b cell secretory responses (ir insulin and c-peptide) to oral (50 g) and "isoglycaemic" intravenous glucose (identical glycaemic profile) were measured by radioimmunoassay. |
1993-08-16 |
2023-08-12 |
Not clear |
| M Stoffel, R Espinosa, M M Le Beau, G I Bel. Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6. Diabetes. vol 42. issue 8. 1993-08-12. PMID:8392011. |
defects in insulin secretion are a common feature of niddm and as such the glp-1 receptor is a candidate for contributing to the development of this clinically and genetically heterogeneous disorder. |
1993-08-12 |
2023-08-12 |
human |
| J Miholic, C Orskov, J J Holst, J Kotzerke, R Pichlmay. Postprandial release of glucagon-like peptide-1, pancreatic glucagon, and insulin after esophageal resection. Digestion. vol 54. issue 2. 1993-08-05. PMID:8319842. |
postprandial concentrations of glucose and the immunoreactivity of insulin, glucagon-like peptide-1 (glp-1), and pancreatic glucagon were measured in 10 patients who had undergone esophageal resection (er) and replacement by the stomach. |
1993-08-05 |
2023-08-12 |
Not clear |
| J Miholic, C Orskov, J J Holst, J Kotzerke, R Pichlmay. Postprandial release of glucagon-like peptide-1, pancreatic glucagon, and insulin after esophageal resection. Digestion. vol 54. issue 2. 1993-08-05. PMID:8319842. |
the early integrated (first 30 min) and total integrated insulin and glp-1 concentrations were significantly higher than in controls. |
1993-08-05 |
2023-08-12 |
Not clear |
| R Göke, B Wagner, H C Fehmann, B Gök. Glucose-dependency of the insulin stimulatory effect of glucagon-like peptide-1 (7-36) amide on the rat pancreas. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. vol 193. issue 2. 1993-07-22. PMID:8516568. |
the glucose-dependent action of glp-1 (7-36) amide (glp-1) on insulin secretion was studied in isolated islets and in the perfused rat pancreas. |
1993-07-22 |
2023-08-12 |
rat |
| R Göke, B Wagner, H C Fehmann, B Gök. Glucose-dependency of the insulin stimulatory effect of glucagon-like peptide-1 (7-36) amide on the rat pancreas. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. vol 193. issue 2. 1993-07-22. PMID:8516568. |
in islet experiments in the presence of non-stimulatory glucose levels (< 3 mmol/l) a glp-1 concentration of 10 nmol/l increased insulin secretion by 83%. |
1993-07-22 |
2023-08-12 |
rat |