| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Miki, M Namba, T Nishimura, I Mineo, T Matsumura, J Miyagawa, H Nakajima, M Kuwajima, T Hanafusa, Y Matsuzaw. Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes. Biochimica et biophysica acta. vol 1312. issue 2. 1996-08-09. PMID:8672535. |
full-sequence glp-1(1-37) at 15 nm in the presence of 1 nm insulin increased glucose uptake by 24.6% as compared with 1 nm insulin alone (p < 0.05). |
1996-08-09 |
2023-08-12 |
rat |
| H Miki, M Namba, T Nishimura, I Mineo, T Matsumura, J Miyagawa, H Nakajima, M Kuwajima, T Hanafusa, Y Matsuzaw. Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes. Biochimica et biophysica acta. vol 1312. issue 2. 1996-08-09. PMID:8672535. |
the combination of 15 nm glp-1(7-36)amide and 1 nm insulin caused a further reduction of camp content. |
1996-08-09 |
2023-08-12 |
rat |
| H Miki, M Namba, T Nishimura, I Mineo, T Matsumura, J Miyagawa, H Nakajima, M Kuwajima, T Hanafusa, Y Matsuzaw. Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes. Biochimica et biophysica acta. vol 1312. issue 2. 1996-08-09. PMID:8672535. |
these data indicate that glp-1(7-36)amide possesses augmentative effects on insulin action in isolated rat adipocytes. |
1996-08-09 |
2023-08-12 |
rat |
| M A Nauck, J Siemsglüss, C Orskov, J J Hols. Release of glucagon-like peptide 1 (GLP-1 [7-36 amide]), gastric inhibitory polypeptide (GIP) and insulin in response to oral glucose after upper and lower intestinal resections. Zeitschrift fur Gastroenterologie. vol 34. issue 3. 1996-07-19. PMID:8650968. |
release of glucagon-like peptide 1 (glp-1 [7-36 amide]), gastric inhibitory polypeptide (gip) and insulin in response to oral glucose after upper and lower intestinal resections. |
1996-07-19 |
2023-08-12 |
Not clear |
| M A Nauck, J Siemsglüss, C Orskov, J J Hols. Release of glucagon-like peptide 1 (GLP-1 [7-36 amide]), gastric inhibitory polypeptide (GIP) and insulin in response to oral glucose after upper and lower intestinal resections. Zeitschrift fur Gastroenterologie. vol 34. issue 3. 1996-07-19. PMID:8650968. |
glp-1[7-36 amide], insulin c-peptide, gip and glucagon (specific (rias) were measured over 240 min. |
1996-07-19 |
2023-08-12 |
Not clear |
| V Leclercq-Meyer, W J Malaiss. Potentiation of glucagon-like peptide 1 insulinotropic action by succinic acid dimethyl ester. Life sciences. vol 58. issue 14. 1996-06-05. PMID:8614271. |
in the absence of any exogenous nutrient, glp-1 failed to affect either insulin or glucagon release. |
1996-06-05 |
2023-08-12 |
rat |
| V Leclercq-Meyer, W J Malaiss. Potentiation of glucagon-like peptide 1 insulinotropic action by succinic acid dimethyl ester. Life sciences. vol 58. issue 14. 1996-06-05. PMID:8614271. |
in the presence of sad, glp-1 still failed to affect glucagon release, but markedly enhanced insulin secretion. |
1996-06-05 |
2023-08-12 |
rat |
| V Leclercq-Meyer, W J Malaiss. Potentiation of glucagon-like peptide 1 insulinotropic action by succinic acid dimethyl ester. Life sciences. vol 58. issue 14. 1996-06-05. PMID:8614271. |
these findings indicate that glp-1 is not truly a glucose-dependent, but rather nutrient-dependent insulin secretagogue. |
1996-06-05 |
2023-08-12 |
rat |
| D M Hargrove, N A Nardone, L M Persson, K M Andrews, K L Shepherd, R W Stevenson, J C Parke. Comparison of the glucose dependency of glucagon-like peptide-1 (7-37) and glyburide in vitro and in vivo. Metabolism: clinical and experimental. vol 45. issue 3. 1996-05-23. PMID:8606650. |
the purpose of the present study was to compare the glucose dependency of the insulin secretagogue activity of the sulfonylurea, glyburide, versus that of glucagon-like peptide-1(7-37) [glp-1(7-37)] in vitro and in vivo. |
1996-05-23 |
2023-08-12 |
rat |
| D M Hargrove, N A Nardone, L M Persson, K M Andrews, K L Shepherd, R W Stevenson, J C Parke. Comparison of the glucose dependency of glucagon-like peptide-1 (7-37) and glyburide in vitro and in vivo. Metabolism: clinical and experimental. vol 45. issue 3. 1996-05-23. PMID:8606650. |
in freshly isolated rat islets, maximally effective concentrations of glyburide (10 micromol/l) and glp-1(7-37) (10 nmol/l) were equally effective in stimulating insulin secretion in the presence of 15 mmol/l glucose (2.4-fold increase relative to 15 nmol/l glucose alone). |
1996-05-23 |
2023-08-12 |
rat |
| D M Hargrove, N A Nardone, L M Persson, K M Andrews, K L Shepherd, R W Stevenson, J C Parke. Comparison of the glucose dependency of glucagon-like peptide-1 (7-37) and glyburide in vitro and in vivo. Metabolism: clinical and experimental. vol 45. issue 3. 1996-05-23. PMID:8606650. |
at 5 nmol/l glucose, both agents increased insulin secretion, but the effect for glyburide was threefold greater than for glp-1(7-37) (122% and 41% increase in insulin secretion, respectively). |
1996-05-23 |
2023-08-12 |
rat |
| D M Hargrove, N A Nardone, L M Persson, K M Andrews, K L Shepherd, R W Stevenson, J C Parke. Comparison of the glucose dependency of glucagon-like peptide-1 (7-37) and glyburide in vitro and in vivo. Metabolism: clinical and experimental. vol 45. issue 3. 1996-05-23. PMID:8606650. |
relative to the vehicle control group, glp-1(7-37) infusion produced a transitory increase (30%) in plasma insulin concentration and a modest sustained decrease (10% to 20%) in glucose in both fasted and fed rats, whereas glyburide induced a sustained 2.4- and 1.7-fold increase in plasma insulin concentration in fasted and fed rats, respectively, and a 50% decrease in plasma glucose in both fasted and fed rats. |
1996-05-23 |
2023-08-12 |
rat |
| D M Hargrove, N A Nardone, L M Persson, K M Andrews, K L Shepherd, R W Stevenson, J C Parke. Comparison of the glucose dependency of glucagon-like peptide-1 (7-37) and glyburide in vitro and in vivo. Metabolism: clinical and experimental. vol 45. issue 3. 1996-05-23. PMID:8606650. |
results of these studies demonstrate the higher glucose threshold for the insulin secretagogue activity of glp-1(7-37) relative to glyburide in vitro and in vivo. |
1996-05-23 |
2023-08-12 |
rat |
| W S Zawalich, K C Zawalic. Glucagon-like peptide-1 stimulates insulin secretion but not phosphoinositide hydrolysis from islets desensitized by prior exposure to high glucose or the muscarinic agonist carbachol. Metabolism: clinical and experimental. vol 45. issue 2. 1996-04-18. PMID:8596502. |
in the present series of experiments, the ability of the postulated incretin factor, glucagon-like peptide-1 (glp-1), to stimulate insulin release from desensitized islets was determined. |
1996-04-18 |
2023-08-12 |
Not clear |
| W S Zawalich, K C Zawalic. Glucagon-like peptide-1 stimulates insulin secretion but not phosphoinositide hydrolysis from islets desensitized by prior exposure to high glucose or the muscarinic agonist carbachol. Metabolism: clinical and experimental. vol 45. issue 2. 1996-04-18. PMID:8596502. |
further addition of 10 nmol/l glp-1 together with 20 mmol/l glucose significantly increased insulin output from desensitized islets. |
1996-04-18 |
2023-08-12 |
Not clear |
| W S Zawalich, K C Zawalic. Glucagon-like peptide-1 stimulates insulin secretion but not phosphoinositide hydrolysis from islets desensitized by prior exposure to high glucose or the muscarinic agonist carbachol. Metabolism: clinical and experimental. vol 45. issue 2. 1996-04-18. PMID:8596502. |
we conclude from these studies that the incretin factor glp-1 may play an important role in maintaining insulin output from islets in which phospholipase c (plc)-mediated hydrolysis of islet pi pools in impaired. |
1996-04-18 |
2023-08-12 |
Not clear |
| B Ahrén, R L Gingerich, P J Have. Effects of cholecystokinin and glucagon-like peptide 1 on the secretion of pancreatic polypeptide in mice. Regulatory peptides. vol 59. issue 3. 1996-03-14. PMID:8577934. |
the gut hormones, cholecystokinin (cck) and truncated glucagon-like peptide 1 (glp-1(7-36)amide or glp-1) both stimulate insulin secretion and affect glucagon secretion in mice, but their effects on the secretion of other islet hormones have not been established in rodents. |
1996-03-14 |
2023-08-12 |
mouse |
| B Willms, J Werner, J J Holst, C Orskov, W Creutzfeldt, M A Nauc. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. The Journal of clinical endocrinology and metabolism. vol 81. issue 1. 1996-02-20. PMID:8550773. |
gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (glp-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. |
1996-02-20 |
2023-08-12 |
human |
| D A D'Alessio, R Vogel, R Prigeon, E Laschansky, D Koerker, J Eng, J W Ensinc. Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons. The Journal of clinical investigation. vol 97. issue 1. 1996-02-16. PMID:8550824. |
glucagon-like peptide 1 (glp-1) is an insulinotropic hormone released after nutrient ingestion which is known to augment insulin secretion, inhibit glucagon release, and promote insulin-independent glucose disposition. |
1996-02-16 |
2023-08-12 |
Not clear |
| D A D'Alessio, R Vogel, R Prigeon, E Laschansky, D Koerker, J Eng, J W Ensinc. Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons. The Journal of clinical investigation. vol 97. issue 1. 1996-02-16. PMID:8550824. |
thus, elimination of the action of glp-1 impaired the disposition of an intragastric glucose meal and this was at least partly attributable to diminished early insulin release. |
1996-02-16 |
2023-08-12 |
Not clear |