| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Reimer, M I McBurne. Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology. vol 137. issue 9. 1996-11-13. PMID:8756571. |
short chain fatty acids stimulate mucosal adaptation and may alter proglucagon messenger rna and release of the insulin secretagogue, glucagon-like peptide-1 (glp-1). |
1996-11-13 |
2023-08-12 |
rat |
| R A Reimer, M I McBurne. Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology. vol 137. issue 9. 1996-11-13. PMID:8756571. |
plasma glp-1, insulin, and c peptide levels 30 min postoral glucose were significantly higher in the 30% fiber group vs. the 0% group (19.8 +/- 1.2 vs. 15.4 +/- 1.2 pg/ml, 2.67 +/- 0.4 vs. 1.29 +/- 0.5 ng/ml, and 964.4 +/- 94.4 vs. 530.2 +/- 120.4 pm, respectively). |
1996-11-13 |
2023-08-12 |
rat |
| R A Reimer, M I McBurne. Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology. vol 137. issue 9. 1996-11-13. PMID:8756571. |
a diet supplemented with fiber is able to significantly alter proglucagon gene expression and modulate glp-1 and insulin secretion. |
1996-11-13 |
2023-08-12 |
rat |
| W O Creutzfeldt, N Kleine, B Willms, C Orskov, J J Holst, M A Nauc. Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients. Diabetes care. vol 19. issue 6. 1996-11-05. PMID:8725855. |
glucagon-like peptide i(7-36) amide (glp-1) is a physiological incretin hormone that, in slightly supraphysiological doses, stimulates insulin secretion, lowers glucagon concentrations, and thereby normalizes elevated fasting plasma glucose concentrations in type ii diabetic patients. |
1996-11-05 |
2023-08-12 |
Not clear |
| M Kato, H T Ma, K Tatemot. GLP-1 depolarizes the rat pancreatic beta cell in a Na(+)-dependent manner. Regulatory peptides. vol 62. issue 1. 1996-10-17. PMID:8738878. |
endocrinol., 96 (1993) 85-90) that glp-1 increased both insulin secretion and the efflux of 45ca2+ in a na(+)-dependent manner. |
1996-10-17 |
2023-08-12 |
rat |
| M Kato, H T Ma, K Tatemot. GLP-1 depolarizes the rat pancreatic beta cell in a Na(+)-dependent manner. Regulatory peptides. vol 62. issue 1. 1996-10-17. PMID:8738878. |
these results indicate: (i) glp-1 depolarizes the beta cell by activating the membrane na+ permeability; (ii) glp-1 slightly modulates the l-type ca2+ channel probably through protein kinase a; and (iii) at least in part, these mechanisms may be involved in the insulin secretion induced by glp-1. |
1996-10-17 |
2023-08-12 |
rat |
| B P Bullock, R S Heller, J F Habene. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology. vol 137. issue 7. 1996-10-10. PMID:8770921. |
the incretin hormone glucagon-like peptide-1 (glp-1) is an important regulator of postprandial insulin secretion. |
1996-10-10 |
2023-08-12 |
rat |
| M P van der Burg, O R Guicherit, M Frölich, H G Goosze. Insulinotropic effects of cholecystokinin, gastric inhibitory polypeptide and glucagon-like peptide-1 during perifusion of short-term cultured canine isolated islets. Regulatory peptides. vol 60. issue 1. 1996-10-08. PMID:8747785. |
glp-1 stimulated insulin output from the 2.5 mm glucose level; and a maximum, 2-fold, increase of insulin output was observed from the 7.5 mm glucose level. |
1996-10-08 |
2023-08-12 |
Not clear |
| G Van Dijk, S Lindskog, J J Holst, A B Steffens, B Ahré. Effects of glucagon-like peptide-I on glucose turnover in rats. The American journal of physiology. vol 270. issue 6 Pt 1. 1996-09-26. PMID:8764187. |
in fed rats, glp-1 reduced plasma glucose (from 7.3 +/- 0.2 to 5.6 +/- 0.3 mmol/l; p = 0.017), increased plasma insulin (from 20 +/- 3 to 89 +/- 11 mu/l; p = 0.002), and reduced plasma glucagon (from 44 +/- 1 to 35 +/- 2 pg/ml; p = 0.009) and glucose appearance rate (ra; from 3.9 +/- 0.2 to 1.7 +/- 0.7 micromol.min-1. |
1996-09-26 |
2023-08-12 |
rat |
| M A Trapote, F Clemente, C Galera, M Morales, A I Alcántara, M I López-Delgado, M L Villanueva-Peñacarrillo, I Valverd. Inositolphosphoglycans are possible mediators of the glucagon-like peptide 1 (7-36)amide action in the liver. Journal of endocrinological investigation. vol 19. issue 2. 1996-09-19. PMID:8778163. |
also, glp-1(7-36)amide modulates the cell content of radiolabelled glycosylphosphatidylinositols (gpis), in the same manner as insulin, indicating hydrolysis of gpis and an immediate and short-lived generation of ipgs. |
1996-09-19 |
2023-08-12 |
human |
| T Linn, K Schneider, B Göke, K Federli. Glucagon-like-peptide-1 (7-36) amide improves glucose sensitivity in beta-cells of NOD mice. Acta diabetologica. vol 33. issue 1. 1996-09-16. PMID:8777280. |
the effect of the insulinotropic gut hormone glucagon-like-peptide-1 (glp-1) was studied on the residual insulin capacity of prediabetic nonobese diabetic (nod) mice, a model of insulin-dependent diabetes mellitus (type 1). |
1996-09-16 |
2023-08-12 |
mouse |
| T Linn, K Schneider, B Göke, K Federli. Glucagon-like-peptide-1 (7-36) amide improves glucose sensitivity in beta-cells of NOD mice. Acta diabetologica. vol 33. issue 1. 1996-09-16. PMID:8777280. |
in perifused nod islets glp-1, at concentrations already effective in normal islets, left the insulin release unaltered. |
1996-09-16 |
2023-08-12 |
mouse |
| T Linn, K Schneider, B Göke, K Federli. Glucagon-like-peptide-1 (7-36) amide improves glucose sensitivity in beta-cells of NOD mice. Acta diabetologica. vol 33. issue 1. 1996-09-16. PMID:8777280. |
however, a significant rise of glucose-dependent insulin secretion occurred for glp-1 concentrations > 0.1 nm. |
1996-09-16 |
2023-08-12 |
mouse |
| T Linn, K Schneider, B Göke, K Federli. Glucagon-like-peptide-1 (7-36) amide improves glucose sensitivity in beta-cells of NOD mice. Acta diabetologica. vol 33. issue 1. 1996-09-16. PMID:8777280. |
analysis of glucose-insulin dose-response curves revealed a marked improvement of glucose sensitivity of the nod endocrine pancreas in the presence of glp-1 (half-maximal insulin output without glp-1 15.2 mm and with glp-1 9.4 mm, p < 0.002). |
1996-09-16 |
2023-08-12 |
mouse |
| M Furukawa, R Nobusawa, H Shibata, Y Eto, I Kojim. Initiation of insulin secretion in glucose-free medium by activin A. Molecular and cellular endocrinology. vol 113. issue 1. 1996-08-13. PMID:8674816. |
in contrast, glucagon-like peptide-1 (glp-1) had no effect on insulin secretion under the same conditions. |
1996-08-13 |
2023-08-12 |
Not clear |
| M Furukawa, R Nobusawa, H Shibata, Y Eto, I Kojim. Initiation of insulin secretion in glucose-free medium by activin A. Molecular and cellular endocrinology. vol 113. issue 1. 1996-08-13. PMID:8674816. |
however, glp-1 could enhance insulin secretion induced by activin a in glucose-free medium. |
1996-08-13 |
2023-08-12 |
Not clear |
| M Furukawa, R Nobusawa, H Shibata, Y Eto, I Kojim. Initiation of insulin secretion in glucose-free medium by activin A. Molecular and cellular endocrinology. vol 113. issue 1. 1996-08-13. PMID:8674816. |
these results indicate that activin a, but not glp-1, induces insulin secretion in glucose-free medium. |
1996-08-13 |
2023-08-12 |
Not clear |
| H Miki, M Namba, T Nishimura, I Mineo, T Matsumura, J Miyagawa, H Nakajima, M Kuwajima, T Hanafusa, Y Matsuzaw. Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes. Biochimica et biophysica acta. vol 1312. issue 2. 1996-08-09. PMID:8672535. |
glp-1(7-36)amide significantly enhanced glucose uptake in the presence of 1 nm insulin. |
1996-08-09 |
2023-08-12 |
rat |
| H Miki, M Namba, T Nishimura, I Mineo, T Matsumura, J Miyagawa, H Nakajima, M Kuwajima, T Hanafusa, Y Matsuzaw. Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes. Biochimica et biophysica acta. vol 1312. issue 2. 1996-08-09. PMID:8672535. |
glp-1(7-36)amide at 15 nm increased glucose uptake maximally by 56.4% as compared with 1 nm insulin alone (p < 0.01). |
1996-08-09 |
2023-08-12 |
rat |
| H Miki, M Namba, T Nishimura, I Mineo, T Matsumura, J Miyagawa, H Nakajima, M Kuwajima, T Hanafusa, Y Matsuzaw. Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes. Biochimica et biophysica acta. vol 1312. issue 2. 1996-08-09. PMID:8672535. |
in contrast, with less than 1 nm insulin or without insulin glp-1(7-36)amide showed no effect on glucose uptake. |
1996-08-09 |
2023-08-12 |
rat |