| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Nauck, D Wollschläger, J Werner, J J Holst, C Orskov, W Creutzfeldt, B Willm. Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM. Diabetologia. vol 39. issue 12. 1997-03-28. PMID:8960841. |
in the short term, there appears to be no tachyphylaxis, since insulin stimulation and glucagon suppression were similar upon repeated administrations of glp-1 [7-36 amide]. |
1997-03-28 |
2023-08-12 |
Not clear |
| J Schirra, P Kuwert, U Wank, P Leicht, R Arnold, B Göke, M Katschinsk. Differential effects of subcutaneous GLP-1 on gastric emptying, antroduodenal motility, and pancreatic function in men. Proceedings of the Association of American Physicians. vol 109. issue 1. 1997-03-25. PMID:9010920. |
in this study of eight healthy male volunteers, we investigated the effects of graded doses of subcutaneous glucagon like peptide-1(7-36)amide (glp-1) on: 1) the gastric emptying pattern of a mixed liquid meal (300 kcal); 2) pancreatic enzyme secretion; 3) antroduodenal motility; and 4) the glycemic response as well as releases of insulin, c-peptide, and glucagon. |
1997-03-25 |
2023-08-12 |
human |
| J Schirra, P Kuwert, U Wank, P Leicht, R Arnold, B Göke, M Katschinsk. Differential effects of subcutaneous GLP-1 on gastric emptying, antroduodenal motility, and pancreatic function in men. Proceedings of the Association of American Physicians. vol 109. issue 1. 1997-03-25. PMID:9010920. |
both doses of glp-1 delayed the postprandial insulin peak, enhanced total insulin release, and diminished postprandial responses of glucagon and pancreatic polypeptide. |
1997-03-25 |
2023-08-12 |
human |
| J Schirra, P Kuwert, U Wank, P Leicht, R Arnold, B Göke, M Katschinsk. Differential effects of subcutaneous GLP-1 on gastric emptying, antroduodenal motility, and pancreatic function in men. Proceedings of the Association of American Physicians. vol 109. issue 1. 1997-03-25. PMID:9010920. |
the initial delay of gastric emptying, the enhancement of postprandial insulin release, and the inhibition of postprandial glucagon release were independent determinants (p < .01-.05) of the postprandial glucose response after subcutaneous administration of glp-1. |
1997-03-25 |
2023-08-12 |
human |
| B Ahrén, H Larsson, J J Hols. Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 82. issue 2. 1997-03-11. PMID:9024239. |
glp-1 (1.5 pmol/kg per min iv) increased serum insulin levels at fasting glucose (p = 0.028), at 14 mmol/l glucose (p = 0.028), and at 28 mmol/l glucose (p = 0.028). |
1997-03-11 |
2023-08-12 |
human |
| B Ahrén, H Larsson, J J Hols. Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 82. issue 2. 1997-03-11. PMID:9024239. |
the acute insulin response (air) to 5 g iv arginine was increased by glp-1 at 14 mmol/l glucose (p = 0.028), and the slopeair, i.e., the glucose potentiation of insulin secretion, was markedly increased by glp-1 (p = 0.028). |
1997-03-11 |
2023-08-12 |
human |
| B Ahrén, H Larsson, J J Hols. Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 82. issue 2. 1997-03-11. PMID:9024239. |
in contrast, glp-1 did not affect the low insulin sensitivity during a hyperinsulinemic, euglycemic clamp. |
1997-03-11 |
2023-08-12 |
human |
| B Ahrén, H Larsson, J J Hols. Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 82. issue 2. 1997-03-11. PMID:9024239. |
thus, glp-1 improves islet dysfunction in diabetes, mainly by increasing the glucose-induced potentiation of insulin secretion. |
1997-03-11 |
2023-08-12 |
human |
| C Galera, F Clemente, A Alcantara, M A Trapote, A Perea, M I Lopez-Delgado, M L Villanueva-Penacarrillo, I Valverd. Inositolphosphoglycans and diacyglycerol are possible mediators in the glycogenic effect of GLP-1(7-36)amide in BC3H-1 myocytes. Cell biochemistry and function. vol 14. issue 1. 1997-03-06. PMID:8907253. |
also, glp-1(7-36)amide modulates the cell content of radiolabelled glycosylphosphatidylinositols (gpis) and increases the production of diacylglycerol (dag), in the same manner as insulin acts, indicating hydrolysis of gpis and an immediate and short-lived generation of ipgs. |
1997-03-06 |
2023-08-12 |
rat |
| V Leclercq-Meyer, W J Malaiss. Potentiation of GLP-1 insulinotropic action by a nonglucidic nutrient in the pancreas of diabetic GK rats. Biochemical and molecular medicine. vol 59. issue 1. 1997-02-28. PMID:8902200. |
thus, whereas the insulin and glucagon responses to glp-1 in gk rats differ from those previously documented in nondiabetic animals when tested in the absence of exogenous nutrient, the secretory response of the endocrine pancreas to glp-1 is virtually normalized in the gk rats when sad is incorporated into the perfusate. |
1997-02-28 |
2023-08-12 |
rat |
| R Gama, F Norris, J Wright, L Morgan, S Hampton, S Watkins, V Mark. The entero-insular axis in polycystic ovarian syndrome. Annals of clinical biochemistry. vol 33 ( Pt 3). 1997-02-27. PMID:8791980. |
we measured plasma glucose, gastric inhibitory polypeptide (gip), glucagon-like peptide-1 (7-36 amide) (glp-1(7-36) amide), immunoreactive insulin (iri), intact proinsulin (ipi), and c-peptide concentrations during a 75 g oral glucose tolerance test in seven normal weight women with pcos and eight healthy women. |
1997-02-27 |
2023-08-12 |
human |
| L Orskov, J J Holst, J Møller, C Orskov, N Møller, K G Alberti, O Schmit. GLP-1 does not not acutely affect insulin sensitivity in healthy man. Diabetologia. vol 39. issue 10. 1997-02-24. PMID:8897012. |
glp-1 does not not acutely affect insulin sensitivity in healthy man. |
1997-02-24 |
2023-08-12 |
Not clear |
| L Orskov, J J Holst, J Møller, C Orskov, N Møller, K G Alberti, O Schmit. GLP-1 does not not acutely affect insulin sensitivity in healthy man. Diabetologia. vol 39. issue 10. 1997-02-24. PMID:8897012. |
previous studies have suggested that glucagon-like peptide-1 (glp-1) (7-36 amide) may have the direct effect of increasing insulin sensitivity in healthy man. |
1997-02-24 |
2023-08-12 |
Not clear |
| L Orskov, J J Holst, J Møller, C Orskov, N Møller, K G Alberti, O Schmit. GLP-1 does not not acutely affect insulin sensitivity in healthy man. Diabetologia. vol 39. issue 10. 1997-02-24. PMID:8897012. |
in conclusion, glp-1 (7-36 amide) administered for 3 h, leading to circulating levels within the physiological range, does not affect insulin sensitivity in healthy man. |
1997-02-24 |
2023-08-12 |
Not clear |
| B Gallwitz, M Witt, C Morys-Wortmann, U R Fölsch, W E Schmid. GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1. Regulatory peptides. vol 63. issue 1. 1997-02-13. PMID:8795084. |
the gastrointestinal hormones glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip) strongly stimulate insulin release. |
1997-02-13 |
2023-08-12 |
Not clear |
| C A Leech, G G Holz, J F Habene. Signal transduction of PACAP and GLP-1 in pancreatic beta cells. Annals of the New York Academy of Sciences. vol 805. 1997-02-10. PMID:8993395. |
pacap and glp-1 depolarize pancreatic beta cells and stimulate insulin secretion in the presence of glucose. |
1997-02-10 |
2023-08-12 |
human |
| C A Leech, G G Holz, J F Habene. Signal transduction of PACAP and GLP-1 in pancreatic beta cells. Annals of the New York Academy of Sciences. vol 805. 1997-02-10. PMID:8993395. |
given that pacap and glp-1 are proven to be exceptionally potent insulin secretagogues, it is of considerable interest to determine their usefulness as blood glucose-lowering agents. |
1997-02-10 |
2023-08-12 |
human |
| S M Hampton, L M Morgan, N Lawrence, T Anastasiadou, F Norris, S Deacon, D Ribeiro, J Arend. Postprandial hormone and metabolic responses in simulated shift work. The Journal of endocrinology. vol 151. issue 2. 1997-01-02. PMID:8958786. |
plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (gip), glucagon-like peptide-1 (glp-1), triacylglycerol (tag) and non-esterified fatty acids (nefas) were determined at intervals for 6 h after each test meal. |
1997-01-02 |
2023-08-12 |
human |
| S M Hampton, L M Morgan, N Lawrence, T Anastasiadou, F Norris, S Deacon, D Ribeiro, J Arend. Postprandial hormone and metabolic responses in simulated shift work. The Journal of endocrinology. vol 151. issue 2. 1997-01-02. PMID:8958786. |
postprandial plasma glucose, insulin, gip and glp-1 profiles were evaluated by calculating areas under the curve (auc) for the first 2 h and the last 4 h of the sampling together with total auc. |
1997-01-02 |
2023-08-12 |
human |
| A A Vaag, J J Holst, A Vølund, H B Beck-Nielse. Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM)--evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins. European journal of endocrinology. vol 135. issue 4. 1996-12-30. PMID:8921824. |
gender was identified as the major independent covariate for incremental glucose, insulin, gip and glp-1 responses, with higher values of all parameters in females. |
1996-12-30 |
2023-08-12 |
Not clear |