| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Pørksen, B Grøfte, B Nyholm, J J Holst, S M Pincus, J D Veldhuis, O Schmitz, P C Butle. Glucagon-like peptide 1 increases mass but not frequency or orderliness of pulsatile insulin secretion. Diabetes. vol 47. issue 1. 1998-01-22. PMID:9421373. |
the orderliness of the insulin release process was not deteriorated by short-term glp-1 infusion as assessed by approximate entropy (1.19 +/- 0.04 vs. 1.18 +/- 0.04; p = 0.7). |
1998-01-22 |
2023-08-12 |
Not clear |
| D Gefel, Y Barg, R Zimlichma. Glucagon-like peptide-1 structure, function and potential use for NIDDM. Israel journal of medical sciences. vol 33. issue 10. 1997-12-31. PMID:9397146. |
glp-1 and gastric inhibitory peptide (gip) which has also been termed glucose-dependent insulinotropic peptide appear to account for most of the incretin effect in the augmentation of glucose-stimulated insulin secretion. |
1997-12-31 |
2023-08-12 |
Not clear |
| D Gefel, Y Barg, R Zimlichma. Glucagon-like peptide-1 structure, function and potential use for NIDDM. Israel journal of medical sciences. vol 33. issue 10. 1997-12-31. PMID:9397146. |
at pharmacological doses, infusion of glp-1, but not of glp, can improve and enhance postprandial insulin response in niddm patients. |
1997-12-31 |
2023-08-12 |
Not clear |
| D Gefel, Y Barg, R Zimlichma. Glucagon-like peptide-1 structure, function and potential use for NIDDM. Israel journal of medical sciences. vol 33. issue 10. 1997-12-31. PMID:9397146. |
the observations that glp-1 induces both secretion and production of insulin, and that its activities are mainly glucose-dependent, led to the suggestion that glp-1 may present a unique advantage over sulfonylurea drugs in the treatment of niddm. |
1997-12-31 |
2023-08-12 |
Not clear |
| R Gama, F Norris, L Morgan, S Hampton, J Wright, V Mark. Elevated post-prandial gastric inhibitory polypeptide concentrations in hypertriglyceridaemic subjects. Clinical science (London, England : 1979). vol 93. issue 4. 1997-12-29. PMID:9404226. |
serum triglycerides and plasma glucose gip, glp-1 and immunoreactive insulin (iri) concentrations were measured before and after a mixed meal in 15 hypertriglyceridaemic patients and in eight healthy normotriglyceridaemic control subjects. |
1997-12-29 |
2023-08-12 |
human |
| A Perea, C Viñambres, F Clemente, M L Villanueva-Peñacarrillo, I Valverd. GLP-1 (7-36) amide: effects on glucose transport and metabolism in rat adipose tissue. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 29. issue 9. 1997-12-22. PMID:9370107. |
in rat adipocytes, glp-1 (7-36) amide induced an increment in 2-deoxy-glucose uptake, which was additive to that of insulin. |
1997-12-22 |
2023-08-12 |
rat |
| A Perea, C Viñambres, F Clemente, M L Villanueva-Peñacarrillo, I Valverd. GLP-1 (7-36) amide: effects on glucose transport and metabolism in rat adipose tissue. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 29. issue 9. 1997-12-22. PMID:9370107. |
furthermore, in rat fat, glp-1 (7-36) amide provoked a rise in glycogen synthesis, glucose oxidation and utilization and lipogenesis, the increments being lower than those obtained with insulin. |
1997-12-22 |
2023-08-12 |
rat |
| A Perea, C Viñambres, F Clemente, M L Villanueva-Peñacarrillo, I Valverd. GLP-1 (7-36) amide: effects on glucose transport and metabolism in rat adipose tissue. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 29. issue 9. 1997-12-22. PMID:9370107. |
these data support the idea that glp-1 exerts insulin-like effects on glucose metabolism in rat adipose tissue, as it does in rat hepatocytes and skeletal muscle, although with a lower potency than that of insulin. |
1997-12-22 |
2023-08-12 |
rat |
| M A Nauck, U Niedereichholz, R Ettler, J J Holst, C Orskov, R Ritzel, W H Schmiege. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. The American journal of physiology. vol 273. issue 5. 1997-12-17. PMID:9374685. |
in conclusion, 1) glp-1-(7-36) amide or -(7-37) inhibits gastric emptying also in normal subjects, 2) physiological doses (0.4 pmol.kg-1.min-1) still have a significant effect, 3) despite the known insulinotropic actions of glp-1-(7-36) amide and -(7-37), the net effect of administering glp-1 with a meal is no change or a reduction in meal-related insulin responses. |
1997-12-17 |
2023-08-12 |
human |
| M A Hussain, J Lee, C P Miller, J F Habene. POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element. Molecular and cellular biology. vol 17. issue 12. 1997-12-16. PMID:9372951. |
glp-1 is implicated in the control of insulin secretion, food intake, and satiety signaling, and glp-2 is implicated in regulating small-bowel growth. |
1997-12-16 |
2023-08-12 |
rat |
| H Larsson, J J Holst, B Ahré. Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans. Acta physiologica Scandinavica. vol 160. issue 4. 1997-11-26. PMID:9338524. |
the effect of glucagon-like peptide-1 (glp-1) on hepatic glucose production and peripheral glucose utilization was investigated with or without infusion of somatostatin to inhibit insulin and glucagon secretion in 13 healthy, non-diabetic women aged 59 years. |
1997-11-26 |
2023-08-12 |
human |
| H Larsson, J J Holst, B Ahré. Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans. Acta physiologica Scandinavica. vol 160. issue 4. 1997-11-26. PMID:9338524. |
somatostatin infusion (500 microg h(-1), n = 7) abolished the effects of glp-1 on plasma glucose, serum insulin, insulin to glucagon ratio, ra, rd, mcr and net glucose flow. |
1997-11-26 |
2023-08-12 |
human |
| H Larsson, J J Holst, B Ahré. Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans. Acta physiologica Scandinavica. vol 160. issue 4. 1997-11-26. PMID:9338524. |
the results suggest that glp-1 reduces plasma glucose levels mainly by reducing hepatic glucose production and increasing the metabolic clearance rate of glucose through indirectly increasing the insulin to glucagon ratio in healthy subjects. |
1997-11-26 |
2023-08-12 |
human |
| M P van der Burg, P T van Suylichem, O R Guicherit, M Frölich, H H Lemkes, H G Goosze. Glucoregulation after canine islet transplantation: contribution of insulin secretory capacity, insulin action, and the entero-insular axis. Cell transplantation. vol 6. issue 5. 1997-11-14. PMID:9331501. |
infusion of gip had no effect, but glp-1 nearly doubled glucose-stimulated insulin. |
1997-11-14 |
2023-08-12 |
human |
| M P van der Burg, P T van Suylichem, O R Guicherit, M Frölich, H H Lemkes, H G Goosze. Glucoregulation after canine islet transplantation: contribution of insulin secretory capacity, insulin action, and the entero-insular axis. Cell transplantation. vol 6. issue 5. 1997-11-14. PMID:9331501. |
thus, a hyperglycemia-enhanced insulinotropic effect of glp-1, and perhaps other gut hormones, may account for the difference in the insulin response to the intravenous and oral challenges. |
1997-11-14 |
2023-08-12 |
human |
| R A Reimer, A B Thomson, R V Rajotte, T K Basu, B Ooraikul, M I McBurne. A physiological level of rhubarb fiber increases proglucagon gene expression and modulates intestinal glucose uptake in rats. The Journal of nutrition. vol 127. issue 10. 1997-11-04. PMID:9311946. |
previous work demonstrated that a high fiber diet upregulates proglucagon mrna and secretion of glucagon-like peptide-1 [glp-1(7-37)] and insulin compared with an elemental fiber-free diet. |
1997-11-04 |
2023-08-12 |
rat |
| J Gromada, W G Ding, S Barg, E Renström, P Rorsma. Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors. Pflugers Archiv : European journal of physiology. vol 434. issue 5. 1997-10-23. PMID:9242714. |
the mechanisms by which glucagon-like peptide 1(7-36)amide (glp-1[7-36]amide) potentiates insulin secretion were investigated by measurements of whole-cell k+ and ca2+ currents, membrane potential, the cytoplasmic ca2+ concentration ([ca2+]i) and exocytosis in mouse pancreatic b-cells. |
1997-10-23 |
2023-08-12 |
mouse |
| J Gromada, W G Ding, S Barg, E Renström, P Rorsma. Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors. Pflugers Archiv : European journal of physiology. vol 434. issue 5. 1997-10-23. PMID:9242714. |
we suggest that glp-1(7-36)amide and glucagon stimulate insulin secretion by binding to distinct receptors. |
1997-10-23 |
2023-08-12 |
mouse |
| J Gromada, W G Ding, S Barg, E Renström, P Rorsma. Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors. Pflugers Archiv : European journal of physiology. vol 434. issue 5. 1997-10-23. PMID:9242714. |
the glp-1(7-36)amide-induced stimulation of electrical activity and ca2+ influx can account for (maximally) a doubling of insulin secretion. |
1997-10-23 |
2023-08-12 |
mouse |
| J Zhou, J M Ega. SNAP-25 is phosphorylated by glucose and GLP-1 in RIN 1046-38 cells. Biochemical and biophysical research communications. vol 238. issue 2. 1997-10-16. PMID:9299498. |
at least 4 proteins of 18, 25, 35, and 46 kda size were found to be tyrosine phosphorylated in the presence of glucose and an insulin secretagogue, glucagon-like peptide-1 (glp-1). |
1997-10-16 |
2023-08-12 |
Not clear |