| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Wang, H K Kole, C Montrose-Rafizadeh, R Perfetti, M Bernier, J M Ega. Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions. Journal of molecular endocrinology. vol 19. issue 3. 1998-03-26. PMID:9460645. |
cells were incubated with glp-1 (10 nm) with or without insulin (10 and 100 nm) for 24 h. under these conditions, glp-1 alone caused an increase in basal and acute insulin-stimulated glucose uptake along with an increase in glut1 and glut4 protein levels. |
1998-03-26 |
2023-08-12 |
Not clear |
| Y Wang, H K Kole, C Montrose-Rafizadeh, R Perfetti, M Bernier, J M Ega. Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions. Journal of molecular endocrinology. vol 19. issue 3. 1998-03-26. PMID:9460645. |
in the absence of glp-1, prolonged exposure to insulin caused a marked reduction in the levels of glut4 mrna and protein, and an inhibition of glucose uptake after an acute exposure to insulin. |
1998-03-26 |
2023-08-12 |
Not clear |
| A Flint, A Raben, A Astrup, J J Hols. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. The Journal of clinical investigation. vol 101. issue 3. 1998-03-18. PMID:9449682. |
plasma glp-1, insulin, glucagon, and blood glucose profiles were affected significantly by the treatment (p < 0.002). |
1998-03-18 |
2023-08-12 |
Not clear |
| A Hareter, E Hoffmann, H P Bode, B Göke, R Gök. The positive charge of the imidazole side chain of histidine7 is crucial for GLP-1 action. Endocrine journal. vol 44. issue 5. 1998-03-16. PMID:9466326. |
since glp-1 potentiates glucose-induced insulin secretion, stimulates insulin biosynthesis and inhibits glucagon release, it is a potential tool for the treatment of diabetes mellitus. |
1998-03-16 |
2023-08-12 |
Not clear |
| J Schirra, P Leicht, P Hildebrand, C Beglinger, R Arnold, B Göke, M Katschinsk. Mechanisms of the antidiabetic action of subcutaneous glucagon-like peptide-1(7-36)amide in non-insulin dependent diabetes mellitus. The Journal of endocrinology. vol 156. issue 1. 1998-03-16. PMID:9496247. |
glp-1 markedly stimulated insulin secretion with an effect lasting for 105 min (solid meal) or 150 min (ogtt). |
1998-03-16 |
2023-08-12 |
Not clear |
| J Schirra, P Leicht, P Hildebrand, C Beglinger, R Arnold, B Göke, M Katschinsk. Mechanisms of the antidiabetic action of subcutaneous glucagon-like peptide-1(7-36)amide in non-insulin dependent diabetes mellitus. The Journal of endocrinology. vol 156. issue 1. 1998-03-16. PMID:9496247. |
the initial and transient delay of gastric emptying, the enhancement of postprandial insulin release, and the inhibition of postprandial glucagon release were independent determinants (p < 0.002) of the postprandial glucose response after subcutaneous glp-1. |
1998-03-16 |
2023-08-12 |
Not clear |
| J Svartberg, J J Holst, M Gutniak, N Adne. The ethanol augmentation of glucose-induced insulin secretion is abolished by calcium antagonism with nifedipine: no evidence for a role of glucagon-like peptide-1 (GLP-1). Pancreas. vol 16. issue 1. 1998-02-11. PMID:9436865. |
the ethanol augmentation of glucose-induced insulin secretion is abolished by calcium antagonism with nifedipine: no evidence for a role of glucagon-like peptide-1 (glp-1). |
1998-02-11 |
2023-08-12 |
human |
| C Drewes, M A Nauck, R Horn, J Holst, W Schmiegel, G Braban. A liquid mixed meal or exogenous glucagon-like peptide 1 (GLP-1) do not alter plasma leptin concentrations in healthy volunteers. Acta diabetologica. vol 34. issue 3. 1998-02-03. PMID:9401646. |
plasma leptin (radioimmunoassay, ria), glucose, insulin (microparticle enzyme immunoassay), c-peptide (enzyme-linked immunosorbent assay) and glp-1 (ria) were measured, and statistical analysis was done with repeated-measures anova and student's t-test. |
1998-02-03 |
2023-08-12 |
human |
| L B Lester, L K Langeberg, J D Scot. Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 26. 1998-02-02. PMID:9405718. |
glp-1 stimulates insulin secretion through several mechanisms including activation of protein kinase a (pka). |
1998-02-02 |
2023-08-12 |
Not clear |
| L B Lester, L K Langeberg, J D Scot. Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 26. 1998-02-02. PMID:9405718. |
disruption of pka anchoring by the introduction of anchoring inhibitor peptides or expression of soluble akap fragments blocks glp-1 action in primary islets and camp-responsive insulin secretion in clonal beta cells (rinm5f). |
1998-02-02 |
2023-08-12 |
Not clear |
| N Dachicourt, P Serradas, D Bailbé, M Kergoat, L Doaré, B Porth. Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies. The Journal of endocrinology. vol 155. issue 2. 1998-02-02. PMID:9415071. |
the effects of glucagon-like peptide-1(7-36)-amide (glp-1) on camp content and insulin release were studied in islets isolated from diabetic rats (n0-stz model) which exhibited impaired glucose-induced insulin release. |
1998-02-02 |
2023-08-12 |
rat |
| N Dachicourt, P Serradas, D Bailbé, M Kergoat, L Doaré, B Porth. Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies. The Journal of endocrinology. vol 155. issue 2. 1998-02-02. PMID:9415071. |
we first examined the possibility of re-activating the insulin response to glucose in the beta-cells of the diabetic rats using glp-1 in vitro. |
1998-02-02 |
2023-08-12 |
rat |
| N Dachicourt, P Serradas, D Bailbé, M Kergoat, L Doaré, B Porth. Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies. The Journal of endocrinology. vol 155. issue 2. 1998-02-02. PMID:9415071. |
in static incubation experiments, glp-1 amplified camp accumulation (by 170%) and glucose-induced insulin release (by 140%) in the diabetic islets to the same extent as in control islets. |
1998-02-02 |
2023-08-12 |
rat |
| N Dachicourt, P Serradas, D Bailbé, M Kergoat, L Doaré, B Porth. Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies. The Journal of endocrinology. vol 155. issue 2. 1998-02-02. PMID:9415071. |
using a perifusion procedure, glp-1 amplified the insulin response to 16.7 mm glucose by diabetic islets and generated a clear biphasic pattern of insulin release. |
1998-02-02 |
2023-08-12 |
rat |
| N Dachicourt, P Serradas, D Bailbé, M Kergoat, L Doaré, B Porth. Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies. The Journal of endocrinology. vol 155. issue 2. 1998-02-02. PMID:9415071. |
the incremental insulin response to glucose in the presence of glp-1, although lower than corresponding control values (1.56 +/- 0.37 and 4.53 +/- 0.60 pg/min per ng islet dna in diabetic and control islets respectively), became similar to that of control islets exposed to 16.7 mm glucose alone (1.09 +/- 0.15 pg/min per ng islet dna). |
1998-02-02 |
2023-08-12 |
rat |
| N Dachicourt, P Serradas, D Bailbé, M Kergoat, L Doaré, B Porth. Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies. The Journal of endocrinology. vol 155. issue 2. 1998-02-02. PMID:9415071. |
we investigated the therapeutic effect of in vivo glp-1 administration on glucose tolerance and glucose-induced insulin release by n0-stz rats. |
1998-02-02 |
2023-08-12 |
rat |
| N Dachicourt, P Serradas, D Bailbé, M Kergoat, L Doaré, B Porth. Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies. The Journal of endocrinology. vol 155. issue 2. 1998-02-02. PMID:9415071. |
glucose tolerance and insulin secretion test, it was found to improve (p < 0.05) glucose tolerance and the insulinogenic index, as compared with the respective values of these parameters before glp-1 treatment. |
1998-02-02 |
2023-08-12 |
rat |
| N Pørksen, B Grøfte, B Nyholm, J J Holst, S M Pincus, J D Veldhuis, O Schmitz, P C Butle. Glucagon-like peptide 1 increases mass but not frequency or orderliness of pulsatile insulin secretion. Diabetes. vol 47. issue 1. 1998-01-22. PMID:9421373. |
to assess the effects of glp-1 on the mass, frequency, amplitude, and overall contribution of pulsatile insulin secretion, we used a recently validated deconvolution model to examine these variables before and during infusion of glp-1 in eight healthy men (age 28 +/- 2 years; bmi 24 +/- 2 kg/m2). |
1998-01-22 |
2023-08-12 |
Not clear |
| N Pørksen, B Grøfte, B Nyholm, J J Holst, S M Pincus, J D Veldhuis, O Schmitz, P C Butle. Glucagon-like peptide 1 increases mass but not frequency or orderliness of pulsatile insulin secretion. Diabetes. vol 47. issue 1. 1998-01-22. PMID:9421373. |
after glp-1 infusion, there was an abrupt increase in the peripheral concentrations of serum c-peptide (696 +/- 65 vs. 1,538 +/- 165 pmol/l) and insulin (49 +/- 8 vs. 138 +/- 21 pmol/l) concentrations. |
1998-01-22 |
2023-08-12 |
Not clear |
| N Pørksen, B Grøfte, B Nyholm, J J Holst, S M Pincus, J D Veldhuis, O Schmitz, P C Butle. Glucagon-like peptide 1 increases mass but not frequency or orderliness of pulsatile insulin secretion. Diabetes. vol 47. issue 1. 1998-01-22. PMID:9421373. |
this increase was mainly due to an increase in the pulsatile component of insulin secretion that was achieved by a fourfold increase in secretory burst mass (28.2 +/- 4.4 vs. 100.1 +/- 15.8 pmol x l-1 x pulse-1; p < 0.001), and amplitude (12.7 +/- 2.2 vs. 4.3 +/- 7.7 pmol x l-1 x min-1; p < 0.002), whereas the secretory burst frequency was not affected by glp-1 (11.5 +/- 0.7 vs. 12.6 +/- 0.6 pulses/h; p = 0.4). |
1998-01-22 |
2023-08-12 |
Not clear |