| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Zhou, J M Ega. SNAP-25 is phosphorylated by glucose and GLP-1 in RIN 1046-38 cells. Biochemical and biophysical research communications. vol 238. issue 2. 1997-10-16. PMID:9299498. |
the addition of glucose and glp-1 to cells that were exposed to the tyrosine kinase inhibitor genistein resulted in a decrease in the extent of phosphorylation of the 18, 25, and 35 kda proteins and a concomitant reduction in insulin secretion, whereas treatment with vanadate, a tyrosine phosphatase inhibitor, led to enhanced responses. |
1997-10-16 |
2023-08-12 |
Not clear |
| K De Ore, N H Greig, H W Holloway, Y Wang, R Perfetti, J M Ega. The effects of GLP-1 on insulin release in young and old rats in the fasting state and during an intravenous glucose tolerance test. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 52. issue 5. 1997-10-16. PMID:9310073. |
the effects of glp-1 on insulin release in young and old rats in the fasting state and during an intravenous glucose tolerance test. |
1997-10-16 |
2023-08-12 |
rat |
| K De Ore, N H Greig, H W Holloway, Y Wang, R Perfetti, J M Ega. The effects of GLP-1 on insulin release in young and old rats in the fasting state and during an intravenous glucose tolerance test. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 52. issue 5. 1997-10-16. PMID:9310073. |
as insulin levels are also positively modulated by incretin hormones, we quantitated the fasting insulin responses of young and old animals to .05, 0.1, 0.2, 0.4, and 0.5 nmol/kg intravenous glucagon-like peptide-1 (glp-1), the most potent incretin known. |
1997-10-16 |
2023-08-12 |
rat |
| K De Ore, N H Greig, H W Holloway, Y Wang, R Perfetti, J M Ega. The effects of GLP-1 on insulin release in young and old rats in the fasting state and during an intravenous glucose tolerance test. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 52. issue 5. 1997-10-16. PMID:9310073. |
glp-1, in conjunction with the ivgtt, restored the acute insulin response to glucose and increased the clearance of glucose in the old animals. |
1997-10-16 |
2023-08-12 |
rat |
| K De Ore, N H Greig, H W Holloway, Y Wang, R Perfetti, J M Ega. The effects of GLP-1 on insulin release in young and old rats in the fasting state and during an intravenous glucose tolerance test. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 52. issue 5. 1997-10-16. PMID:9310073. |
it therefore appears that old animals have an impaired glucose-mediated insulin release but maintain their insulin responsivity to glp-1. |
1997-10-16 |
2023-08-12 |
rat |
| J van Delft, L O Uttenthal, O G Hermida, T Fontela, M Ghiglion. Identification of amidated forms of GLP-1 in rat tissues using a highly sensitive radioimmunoassay. Regulatory peptides. vol 70. issue 2-3. 1997-10-02. PMID:9272633. |
this argues against any role of intrapancreatic glp-1(7-36)amide in the secretion of insulin. |
1997-10-02 |
2023-08-12 |
rat |
| M A Nauck, J J Holst, B Willms, W Schmiege. Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 105. issue 4. 1997-10-02. PMID:9285204. |
glucagon-like peptide 1 (glp-1) is a physiological incretin hormone in normal humans explaining in part the augmented insulin response after oral versus intravenous glucose administration. |
1997-10-02 |
2023-08-12 |
Not clear |
| M A Nauck, J J Holst, B Willms, W Schmiege. Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 105. issue 4. 1997-10-02. PMID:9285204. |
in addition, glp-1 also lowers glucagon concentrations, slows gastric emptying, stimulates (pro)insulin biosynthesis, reduces food intake upon intracerebroventricular administration in animals, and may, in addition, enhance insulin sensitivity. |
1997-10-02 |
2023-08-12 |
Not clear |
| M A Nauck, J J Holst, B Willms, W Schmiege. Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 105. issue 4. 1997-10-02. PMID:9285204. |
therefore, glp-1, in many aspects, opposes the type 2-diabetic phenotype characterized by disturbed glucose-induced insulin secretory capacity, hyperglucagonaemia, moderate insulin deficiency, accelerated gastric emptying, overeating (obesity) and insulin resistance. |
1997-10-02 |
2023-08-12 |
Not clear |
| M A Nauck, J J Holst, B Willms, W Schmiege. Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 105. issue 4. 1997-10-02. PMID:9285204. |
in contrast, glp-1 glucose-dependently stimulates insulin secretion in diet- and sulfonylurea-treated type 2-diabetic patients and also in patients under insulin therapy long after sulfonylurea secondary failure. |
1997-10-02 |
2023-08-12 |
Not clear |
| M A Nauck, J J Holst, B Willms, W Schmiege. Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 105. issue 4. 1997-10-02. PMID:9285204. |
enprostil, a prostaglandin e2 analogue, fully suppresses gip responses, while only marginally affecting insulin secretion and glucose tolerance after oral glucose, suggesting compensatory hypersecretion of additional insulinotropic peptides, possibly including glp-1. |
1997-10-02 |
2023-08-12 |
Not clear |
| C Montrose-Rafizadeh, Y Wang, A M Janczewski, T E Henderson, J M Ega. Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness. Molecular and cellular endocrinology. vol 130. issue 1-2. 1997-09-29. PMID:9220027. |
glucagon-like peptide-1 (glp-1), secreted from intestine in response to food intake, enhances insulin secretion from pancreatic beta-cells. |
1997-09-29 |
2023-08-12 |
Not clear |
| C Montrose-Rafizadeh, Y Wang, A M Janczewski, T E Henderson, J M Ega. Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness. Molecular and cellular endocrinology. vol 130. issue 1-2. 1997-09-29. PMID:9220027. |
in this study, we evaluated the effects of stably transfecting the glp-1 receptor into an insulinoma cell line, rin 1046-38, on basal and glucose-mediated insulin secretion and on second messenger pathways involved in insulin secretion. |
1997-09-29 |
2023-08-12 |
Not clear |
| C Montrose-Rafizadeh, Y Wang, A M Janczewski, T E Henderson, J M Ega. Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness. Molecular and cellular endocrinology. vol 130. issue 1-2. 1997-09-29. PMID:9220027. |
the glp-1 receptor transfected cells had similar insulin mrna levels but higher insulin content compared with parental cells. |
1997-09-29 |
2023-08-12 |
Not clear |
| C Montrose-Rafizadeh, Y Wang, A M Janczewski, T E Henderson, J M Ega. Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness. Molecular and cellular endocrinology. vol 130. issue 1-2. 1997-09-29. PMID:9220027. |
in glp-1 receptor transfected cells, glucose (0.5 mm)-mediated insulin release was increased compared with parental cells (4.52 +/- 0.79 pmol insulin/l per mg protein x h vs. 2.21 +/- 0.36 pmol insulin/l per mg protein x h; mean +/- s.e., n = 6, p = 0.015, in transfected vs. parental cells, respectively). |
1997-09-29 |
2023-08-12 |
Not clear |
| C Montrose-Rafizadeh, Y Wang, A M Janczewski, T E Henderson, J M Ega. Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness. Molecular and cellular endocrinology. vol 130. issue 1-2. 1997-09-29. PMID:9220027. |
by hemolytic plaque assay measuring single cell insulin secretion, we observed that in the glp-1 receptor transfected cells versus parental cells the increased insulin secretion was due to the presence of more glucose-responsive cells as well as more insulin released in response to glucose per cell. |
1997-09-29 |
2023-08-12 |
Not clear |
| J F Todd, J P Wilding, C M Edwards, F A Khan, M A Ghatei, S R Bloo. Glucagon-like peptide-1 (GLP-1): a trial of treatment in non-insulin-dependent diabetes mellitus. European journal of clinical investigation. vol 27. issue 6. 1997-09-22. PMID:9229235. |
in this group of patients there was no significant increase in postprandial insulin levels with glp-1. |
1997-09-22 |
2023-08-12 |
Not clear |
| C M Edwards, A V Edwards, S R Bloo. Cardiovascular and pancreatic endocrine responses to glucagon-like peptide-1(7-36) amide in the conscious calf. Experimental physiology. vol 82. issue 4. 1997-09-19. PMID:9257113. |
intravenous infusions of glucagon-like peptide-1(7-36) amide (glp-1; 35 pmol min-1 kg-1 for 10 min) produced a significant rise in mean heart rate, without significant change in mean aortic blood pressure, together with a significant rise in mean arterial plasma insulin, but not in plasma pancreatic glucagon or pancreatic polypeptide concentration, in conscious calves given exogenous glucose (30-60 micromol min-1 kg-1 i.v.). |
1997-09-19 |
2023-08-12 |
Not clear |
| C M Edwards, A V Edwards, S R Bloo. Cardiovascular and pancreatic endocrine responses to glucagon-like peptide-1(7-36) amide in the conscious calf. Experimental physiology. vol 82. issue 4. 1997-09-19. PMID:9257113. |
whereas glp-1 produced a statistically significant rise in plasma insulin concentration in these animals, it was much less effective than grp in this respect, when given by continuous i.v. |
1997-09-19 |
2023-08-12 |
Not clear |
| B Ahrén, H Larsson, J J Hols. Reduced gastric inhibitory polypeptide but normal glucagon-like peptide 1 response to oral glucose in postmenopausal women with impaired glucose tolerance. European journal of endocrinology. vol 137. issue 2. 1997-09-17. PMID:9272099. |
the gastrointestinal hormones, gastric inhibitory polypeptide (gip) and glucagon-like peptide 1 (glp-1), are both released from the gut after oral glucose ingestion and stimulate insulin secretion. |
1997-09-17 |
2023-08-12 |
human |