| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Nie, M Nakashima, P L Brubaker, Q L Li, R Perfetti, E Jansen, Y Zambre, D Pipeleers, T C Friedma. Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. The Journal of clinical investigation. vol 105. issue 7. 2000-05-22. PMID:10749575. |
the pancreatic processing enzymes, pc1 and pc2, convert proinsulin to insulin and convert proglucagon to glucagon and glucagon-like peptide 1 (glp-1). |
2000-05-22 |
2023-08-12 |
rat |
| Y Nie, M Nakashima, P L Brubaker, Q L Li, R Perfetti, E Jansen, Y Zambre, D Pipeleers, T C Friedma. Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. The Journal of clinical investigation. vol 105. issue 7. 2000-05-22. PMID:10749575. |
we examined the effect of streptozotocin (stz) treatment on the regulation of these enzymes and the production of insulin, glucagon, and glp-1 in the rat. |
2000-05-22 |
2023-08-12 |
rat |
| Y Nie, M Nakashima, P L Brubaker, Q L Li, R Perfetti, E Jansen, Y Zambre, D Pipeleers, T C Friedma. Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. The Journal of clinical investigation. vol 105. issue 7. 2000-05-22. PMID:10749575. |
this treatment also caused a 2-fold increase in the ratio of amidated forms of glp-1 immunoreactivity to total glucagon immunoreactivity in the pancreas but did not affect the ratio of proinsulin to insulin. |
2000-05-22 |
2023-08-12 |
rat |
| E G Siegel, A Seidenstücker, B Gallwitz, F Schmitz, A Reinecke-Lüthge, G Klöppel, U R Fölsch, W E Schmid. Insulin secretion defects in liver cirrhosis can be reversed by glucagon-like peptide-1. The Journal of endocrinology. vol 164. issue 1. 2000-05-01. PMID:10607933. |
therefore, islets from control and cirrhotic animals were incubated with glp-1 in concentrations from 10(-)(11) to 10(-)(6) m. glp-1 stimulated insulin release in a concentration-dependent manner. |
2000-05-01 |
2023-08-12 |
rat |
| C K Rayner, H S Park, J M Wishart, M Kong, S M Doran, M Horowit. Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 2. 2000-04-07. PMID:10666136. |
antropyloric pressures, blood glucose, and plasma insulin, gastric inhibitory peptide (gip), and glucagon-like peptide-1 (glp-1) were measured concurrently; a buffet meal was offered at the end of the infusion. |
2000-04-07 |
2023-08-12 |
human |
| C K Rayner, H S Park, J M Wishart, M Kong, S M Doran, M Horowit. Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 2. 2000-04-07. PMID:10666136. |
intraduodenal glucose increased blood glucose (p < 0.0005), as well as plasma insulin (p < 0.0005) and gip (p < 0.005) more than intraduodenal fructose, whereas there was no difference in the glp-1 response. |
2000-04-07 |
2023-08-12 |
human |
| C K Rayner, H S Park, J M Wishart, M Kong, S M Doran, M Horowit. Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 2. 2000-04-07. PMID:10666136. |
we conclude that, when infused intraduodenally at 2 kcal/min for 90 min 1) fructose and glucose have comparable effects on antropyloric pressures, 2) fructose tends to suppress food intake more than glucose, despite similar glp-1 and less gip release, and 3) gip, rather than glp-1, probably accounts for the greater insulin response to glucose than fructose. |
2000-04-07 |
2023-08-12 |
human |
| E Simonsson, S Karlsson, B Ahré. The cyclic AMP-protein kinase A pathway restrains islet phospholipase A(2) activation. Biochemical and biophysical research communications. vol 269. issue 1. 2000-03-31. PMID:10694507. |
in parallel with effects on [(3)h]aa, the expected additive insulin secretion induced by mellitin or cck-8 in combination with forskolin or glp-1, respectively, was reduced. |
2000-03-31 |
2023-08-12 |
rat |
| R Mentlei. Dipeptidyl-peptidase IV (CD26)--role in the inactivation of regulatory peptides. Regulatory peptides. vol 85. issue 1. 2000-03-06. PMID:10588446. |
based on these findings the potential clinical uses of selective dpp iv inhibitors or dpp iv-resistant analogues, especially for the insulinotropic hormone glp-1, have been tested to enhance insulin secretion and to improve glucose tolerance in diabetic animals. |
2000-03-06 |
2023-08-12 |
Not clear |
| L Ranganath, F Schaper, R Gama, L Morgan, J Wright, D Teale, V Mark. Effect of glucagon on carbohydrate-mediated secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-36 amide) (GLP-1). Diabetes/metabolism research and reviews. vol 15. issue 6. 2000-02-24. PMID:10634963. |
the insulinotropic hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (7-36 amide) (glp-1), regulate insulin secretion to nutrient intake and constitute the endocrine arm of the entero-insular axis. |
2000-02-24 |
2023-08-12 |
Not clear |
| L Ranganath, F Schaper, R Gama, L Morgan, J Wright, D Teale, V Mark. Effect of glucagon on carbohydrate-mediated secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-36 amide) (GLP-1). Diabetes/metabolism research and reviews. vol 15. issue 6. 2000-02-24. PMID:10634963. |
plasma glucose, gip, glp-1, insulin and paracetamol concentrations were measured before and after a 100 g oral carhohydrate load containing 1.5 g of paracetamol for 6 h during intravenous infusion of either glucagon or saline. |
2000-02-24 |
2023-08-12 |
Not clear |
| B Gallwitz, T Ropeter, C Morys-Wortmann, R Mentlein, E G Siegel, W E Schmid. GLP-1-analogues resistant to degradation by dipeptidyl-peptidase IV in vitro. Regulatory peptides. vol 86. issue 1-3. 2000-02-24. PMID:10672909. |
glucagon-like peptide-1 (glp-1) stimulates insulin secretion and improves glycemic control in type 2 diabetes. |
2000-02-24 |
2023-08-12 |
Not clear |
| C Hedetoft, S P Sheikh, S Larsen, J J Hols. Effect of glucagon-like peptide 1(7-36)amide in insulin-treated patients with diabetes mellitus secondary to chronic pancreatitis. Pancreas. vol 20. issue 1. 2000-02-10. PMID:10630380. |
glucagon-like peptide 1(7-36)amide (glp-1), an intestinally derived insulinotropic hormone, represents a potential therapeutic agent for type 2 diabetes, because exogenous glp-1 has been shown to increase the insulin and reduce the glucagon concentrations in these patients, and thus induce lower blood glucose, but without causing hypoglycemia. |
2000-02-10 |
2023-08-12 |
human |
| C Hedetoft, S P Sheikh, S Larsen, J J Hols. Effect of glucagon-like peptide 1(7-36)amide in insulin-treated patients with diabetes mellitus secondary to chronic pancreatitis. Pancreas. vol 20. issue 1. 2000-02-10. PMID:10630380. |
blood glucose was reduced in all patients with both doses of glp-1; plasma c-peptide increased (p<0.02), and plasma glucagon decreased (p<0.02) compared with basal levels, also in three patients with normoglycemia and high levels of presumably exogenous insulin. |
2000-02-10 |
2023-08-12 |
human |
| S Kesper, J Rucha, H Neye, C Mazenot, E J Verspoh. Galpha(i2)-mRNA and -protein regulation as a mechanism for heterologous sensitization and desensitization of insulin secretion. Cellular signalling. vol 11. issue 10. 2000-01-31. PMID:10574331. |
the insulin inhibitory neuropeptide galanin (50 nm) caused a decrease of alpha(s)- and alpha(i2)-mrna levels, whereas insulinotropic compounds (incretin hormones) such as gip or glp-1 (both 10 nm) led to an increase of alpha(s)- and alpha(i2)-mrna levels. |
2000-01-31 |
2023-08-12 |
Not clear |
| S Kesper, J Rucha, H Neye, C Mazenot, E J Verspoh. Galpha(i2)-mRNA and -protein regulation as a mechanism for heterologous sensitization and desensitization of insulin secretion. Cellular signalling. vol 11. issue 10. 2000-01-31. PMID:10574331. |
the changes in alpha(i2)-mrna levels by either compound were paralleled by inverse changes in insulin secretion: preincubation with uk 14,304 for 8 h led to an increased insulin secretion when challenged by either glp-1, gip or glucose (8.3 mm). |
2000-01-31 |
2023-08-12 |
Not clear |
| S Kesper, J Rucha, H Neye, C Mazenot, E J Verspoh. Galpha(i2)-mRNA and -protein regulation as a mechanism for heterologous sensitization and desensitization of insulin secretion. Cellular signalling. vol 11. issue 10. 2000-01-31. PMID:10574331. |
on the other hand, exposure to the incretins gip or glp-1 for 8 h induced a smaller insulin release when challenged afterwards by either uk 14,304, galanin, gip, glp-1, or glucose. |
2000-01-31 |
2023-08-12 |
Not clear |
| B Ahrén, G Pacin. Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice. The American journal of physiology. vol 277. issue 6. 2000-01-20. PMID:10600787. |
dose-related effects of glp-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice. |
2000-01-20 |
2023-08-12 |
mouse |
| B Ahrén, G Pacin. Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice. The American journal of physiology. vol 277. issue 6. 2000-01-20. PMID:10600787. |
we examined the dose-related net effects of glucagon-like peptide 1 (glp-1) on insulin secretion, insulin sensitivity, and glucose disposal as derived from the minimal model of glucose disappearance in anesthetized mice. |
2000-01-20 |
2023-08-12 |
mouse |
| B Ahrén, G Pacin. Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice. The American journal of physiology. vol 277. issue 6. 2000-01-20. PMID:10600787. |
glp-1 dose dependently potentiated insulin secretion after glucose administration, with the half-maximal effect at 1 nmol/kg. |
2000-01-20 |
2023-08-12 |
mouse |