| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Conlon, A M White, J E Plat. Islet hormones from the African bullfrog Pyxicephalus adspersus (Anura:Ranidae): structural characterization and phylogenetic implications. General and comparative endocrinology. vol 119. issue 1. 2000-08-24. PMID:10882553. |
pancreatic polypeptide (pp), insulin, and glucagon-like peptide (glp-1) were isolated from an extract of p. adspersus pancreas and characterized structurally. |
2000-08-24 |
2023-08-12 |
Not clear |
| J M Conlon, A M White, J E Plat. Islet hormones from the African bullfrog Pyxicephalus adspersus (Anura:Ranidae): structural characterization and phylogenetic implications. General and comparative endocrinology. vol 119. issue 1. 2000-08-24. PMID:10882553. |
in contrast, pyxicephalus insulin (a chain, giveqcchsa(10)cslydlenyc(20)n; b-chain, lanqhlcgsh(10)lvealymvcg(20)ergffyypks(30)) and and glp-1 (haegtftsdm(10)tsyleekaak(20)efvdwlikgr(30)pk) resemble more closely the corresponding peptides from the cane toad bufo marinus than the peptides from any species of rana. |
2000-08-24 |
2023-08-12 |
Not clear |
| G Skoglund, M A Hussain, G G Hol. Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element. Diabetes. vol 49. issue 7. 2000-08-09. PMID:10909973. |
glucagon-like peptide 1 (glp-1), a hormonal activator of adenyl cyclase, stimulates insulin gene transcription, an effect mediated by the camp response element (cre) of the rat insulin i gene promoter (rip1). |
2000-08-09 |
2023-08-12 |
rat |
| G Skoglund, M A Hussain, G G Hol. Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element. Diabetes. vol 49. issue 7. 2000-08-09. PMID:10909973. |
here we demonstrate that the signaling mechanism underlying stimulatory effects of glp-1 on insulin gene transcription results from protein kinase a (pka)-independent activation of the rip1 cre. |
2000-08-09 |
2023-08-12 |
rat |
| M Ebinger, D R Jehle, R D Fussgaenger, H C Fehmann, P M Jehl. Glucagon-like peptide-1 improves insulin and proinsulin binding on RINm5F cells and human monocytes. American journal of physiology. Endocrinology and metabolism. vol 279. issue 1. 2000-08-08. PMID:10893327. |
in rinm5f cells, glp-1 increased the capacity and affinity of insulin binding in a time- and concentration-dependent manner. |
2000-08-08 |
2023-08-12 |
human |
| M Ebinger, D R Jehle, R D Fussgaenger, H C Fehmann, P M Jehl. Glucagon-like peptide-1 improves insulin and proinsulin binding on RINm5F cells and human monocytes. American journal of physiology. Endocrinology and metabolism. vol 279. issue 1. 2000-08-08. PMID:10893327. |
in isolated monocytes, 24 h incubation with 100 nm glp-1 significantly (p<0.05) increased the diminished number of high-capacity/low-affinity insulin binding sites per cell in type 1 diabetics (9,000+/-3,200 vs. 18,500+/-3,600) and in type 2 diabetics (15,700+/-2,100 vs. 28,900+/-1,800) compared with nondiabetic control subjects (25,100+/-2,700 vs. 26,200+/-4,200). |
2000-08-08 |
2023-08-12 |
human |
| M Ebinger, D R Jehle, R D Fussgaenger, H C Fehmann, P M Jehl. Glucagon-like peptide-1 improves insulin and proinsulin binding on RINm5F cells and human monocytes. American journal of physiology. Endocrinology and metabolism. vol 279. issue 1. 2000-08-08. PMID:10893327. |
we conclude that, in rinm5f cells and in isolated human monocytes, glp-1 specifically increases the number of high-capacity insulin binding sites that may be functional proinsulin receptors. |
2000-08-08 |
2023-08-12 |
human |
| D A Stoffers, T J Kieffer, M A Hussain, D J Drucker, S Bonner-Weir, J F Habener, J M Ega. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. vol 49. issue 5. 2000-08-07. PMID:10905482. |
concomitantly, glp-1 administered to diabetic mice stimulates insulin secretion and effectively lowers their blood sugar levels. |
2000-08-07 |
2023-08-12 |
mouse |
| D A Stoffers, T J Kieffer, M A Hussain, D J Drucker, S Bonner-Weir, J F Habener, J M Ega. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. vol 49. issue 5. 2000-08-07. PMID:10905482. |
thus, in addition to stimulating insulin secretion, glp-1 stimulates the expression of the transcription factor idx-1 while stimulating beta-cell neogenesis and may thereby be an effective treatment for diabetes. |
2000-08-07 |
2023-08-12 |
mouse |
| D Marguet, L Baggio, T Kobayashi, A M Bernard, M Pierres, P F Nielsen, U Ribel, T Watanabe, D J Drucker, N Wagtman. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 12. 2000-07-13. PMID:10823914. |
levels of glucose-stimulated circulating insulin and the intact insulinotropic form of glp-1 are increased in cd26(-/-) mice. |
2000-07-13 |
2023-08-12 |
mouse |
| A Vella, P Shah, R Basu, A Basu, J J Holst, R A Rizz. Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes. Diabetes. vol 49. issue 4. 2000-07-06. PMID:10871199. |
although it is well established that glucagon-like peptide 1(7-36) amide (glp-1) is a potent stimulator of insulin secretion, its effects on insulin action and glucose effectiveness are less clear. |
2000-07-06 |
2023-08-12 |
human |
| A Vella, P Shah, R Basu, A Basu, J J Holst, R A Rizz. Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes. Diabetes. vol 49. issue 4. 2000-07-06. PMID:10871199. |
to determine whether glp-1 increases insulin action and glucose effectiveness, subjects with type 2 diabetes were studied on two occasions. |
2000-07-06 |
2023-08-12 |
human |
| A Vella, P Shah, R Basu, A Basu, J J Holst, R A Rizz. Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes. Diabetes. vol 49. issue 4. 2000-07-06. PMID:10871199. |
the increase in glucose concentration was virtually identical on the glp-1 and saline study days during both the basal (1.21 +/- 0.15 vs. 1.32 +/- 0.19 mol/l per 6 h) and prandial (0.56 +/- 0.14 vs. 0.56 +/- 0.10 mol/l per 6 h) insulin infusions. |
2000-07-06 |
2023-08-12 |
human |
| A Vella, P Shah, R Basu, A Basu, J J Holst, R A Rizz. Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes. Diabetes. vol 49. issue 4. 2000-07-06. PMID:10871199. |
during both the basal and prandial insulin infusions, glucose disappearance promptly increased after initiation of the glucose infusion to rates that did not differ on the glp-1 and saline study days. |
2000-07-06 |
2023-08-12 |
human |
| A Vella, P Shah, R Basu, A Basu, J J Holst, R A Rizz. Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes. Diabetes. vol 49. issue 4. 2000-07-06. PMID:10871199. |
suppression of endogenous glucose production also was comparable on the glp-1 and saline study days during both the basal (-2.7 +/- 0.3 vs. -3.1 +/- 0.2 micromol/kg) and prandial (-3.1 +/- 0.4 vs. -3.0 +/- 0.6 pmol/kg) insulin infusions. |
2000-07-06 |
2023-08-12 |
human |
| A Vella, P Shah, R Basu, A Basu, J J Holst, R A Rizz. Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes. Diabetes. vol 49. issue 4. 2000-07-06. PMID:10871199. |
we conclude that when insulin and glucagon concentrations are matched, glp-1 has negligible effects on either insulin action or glucose effectiveness in people with type 2 diabetes. |
2000-07-06 |
2023-08-12 |
human |
| A Vella, P Shah, R Basu, A Basu, J J Holst, R A Rizz. Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes. Diabetes. vol 49. issue 4. 2000-07-06. PMID:10871199. |
these data strongly support the concept that glp-1 improves glycemic control in people with type 2 diabetes by increasing insulin secretion, by inhibiting glucagon secretion, and by delaying gastric emptying rather than by altering extrapancreatic glucose metabolism. |
2000-07-06 |
2023-08-12 |
human |
| M Szayna, M E Doyle, J A Betkey, H W Holloway, R G Spencer, N H Greig, J M Ega. Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats. Endocrinology. vol 141. issue 6. 2000-06-15. PMID:10830274. |
exendin-4 induces insulin release through activation of the glp- 1 receptor but is a much more potent insulinotropic agent than glp-1. |
2000-06-15 |
2023-08-12 |
mouse |
| b' A Sj\\xc3\\xb6holm, E Sandberg, C G Ostenson, S Efendi\\xc4\\x8. Peptidergic regulation of maturation of the stimulus-secretion coupling in fetal islet beta cells. Pancreas. vol 20. issue 3. 2000-05-31. PMID:10766455.' |
culture with gastric inhibitory peptide (gip) or glucagon-like peptide i (glp-1), two proposed incretins, did not affect short-term insulin secretion in response to 3.3 or 16.7 mm glucose irrespective of the ambient glucose concentration during culture. |
2000-05-31 |
2023-08-12 |
human |
| b' A Sj\\xc3\\xb6holm, E Sandberg, C G Ostenson, S Efendi\\xc4\\x8. Peptidergic regulation of maturation of the stimulus-secretion coupling in fetal islet beta cells. Pancreas. vol 20. issue 3. 2000-05-31. PMID:10766455.' |
to the contrary, glp-1, but not gip, increased the content of insulin in islets cultured in low glucose. |
2000-05-31 |
2023-08-12 |
human |