| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Ahrén, G Pacin. Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice. The American journal of physiology. vol 277. issue 6. 2000-01-20. PMID:10600787. |
furthermore, the insulin sensitivity index (s(i)) was reduced after administration of glp-1. |
2000-01-20 |
2023-08-12 |
mouse |
| B Ahrén, G Pacin. Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice. The American journal of physiology. vol 277. issue 6. 2000-01-20. PMID:10600787. |
matching plasma insulin levels after glp-1 by exogenous insulin reproduced the influences of glp-1 on auc(glucose), k(g), s(i), and gdi. |
2000-01-20 |
2023-08-12 |
mouse |
| B Ahrén, G Pacin. Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice. The American journal of physiology. vol 277. issue 6. 2000-01-20. PMID:10600787. |
we conclude that glp-1 increases glucose tolerance in the mouse mainly by potently stimulating insulin secretion. |
2000-01-20 |
2023-08-12 |
mouse |
| J F Blicklé, E Andres, N Neyrolles, J M Brogar. [Present status in the treatment of type 2 diabetes mellitus. Insulin-secreting agents]. La Revue de medecine interne. vol 20 Suppl 3. 2000-01-13. PMID:10480186. |
among the other possible approaches suggested by the theoretical data concerning the mechanisms of insulin secretion, glp-1 derivatives probably represent good candidates, if stable analogues are developed. |
2000-01-13 |
2023-08-12 |
Not clear |
| J Zhou, X Wang, M A Pineyro, J M Ega. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes. vol 48. issue 12. 1999-12-13. PMID:10580424. |
in this article, we show that glucagon-like peptide 1 (glp-1) can induce ar42j cells to differentiate into insulin, pancreatic polypeptide, and glucagon-positive cells. |
1999-12-13 |
2023-08-12 |
Not clear |
| J Zhou, X Wang, M A Pineyro, J M Ega. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes. vol 48. issue 12. 1999-12-13. PMID:10580424. |
we found that when these cells were exposed to glp-1 (1 or 10 nmol), a peptide normally released from the gut in response to food and a modulator of insulin release, intracellular camp levels were increased, and proliferation of cells was increased for the first 24 h, followed by inhibition. |
1999-12-13 |
2023-08-12 |
Not clear |
| B Balkan, L Kwasnik, R Miserendino, J J Holst, X L. Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats. Diabetologia. vol 42. issue 11. 1999-12-07. PMID:10550416. |
the potent incretin hormone glucagon-like peptide 1 (glp-1) plays a pivotal role in prandial insulin secretion. |
1999-12-07 |
2023-08-12 |
rat |
| M F Kong, I Chapman, E Goble, J Wishart, G Wittert, H Morris, M Horowit. Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects. Peptides. vol 20. issue 5. 1999-10-26. PMID:10465505. |
venous glucose, insulin and glp-1 were measured. |
1999-10-26 |
2023-08-12 |
human |
| M F Kong, I Chapman, E Goble, J Wishart, G Wittert, H Morris, M Horowit. Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects. Peptides. vol 20. issue 5. 1999-10-26. PMID:10465505. |
whereas glucose and fructose both increased plasma glucose, insulin and glp-1 (p < 0.000)] for all), the response to glucose was much greater (p < 0.005 for all). |
1999-10-26 |
2023-08-12 |
human |
| M F Kong, I Chapman, E Goble, J Wishart, G Wittert, H Morris, M Horowit. Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects. Peptides. vol 20. issue 5. 1999-10-26. PMID:10465505. |
we conclude that oral fructose (75 g) stimulates glp-1 (and insulin) secretion, but the response is less than that to 75 g glucose. |
1999-10-26 |
2023-08-12 |
human |
| M F Kong, I Chapman, E Goble, J Wishart, G Wittert, H Morris, M Horowit. Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects. Peptides. vol 20. issue 5. 1999-10-26. PMID:10465505. |
these observations suggest that neither glp-1 nor insulin play a major role in the regulation of satiation. |
1999-10-26 |
2023-08-12 |
human |
| H Tammen, W G Forssmann, R Richte. Proteolytic cleavage of glucagon-like peptide-1 by pancreatic beta cells and by fetal calf serum analyzed by mass spectrometry. Journal of chromatography. A. vol 852. issue 1. 1999-10-25. PMID:10480253. |
as insulin is the major secretory product of beta cells depending on glp-1 stimulation, the insulin and insulin fragments of the cell culture supernatants were also analyzed by this method. |
1999-10-25 |
2023-08-12 |
rat |
| T E Hughes, M D Mone, M E Russell, S C Weldon, E B Villhaue. NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry. vol 38. issue 36. 1999-10-21. PMID:10512614. |
n-substituted-glycyl-2-cyanopyrrolidide compounds, typified by nvp-dpp728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(s )-p yrrolidine), inhibit degradation of glucagon-like peptide-1 (glp-1) and thereby potentiate insulin release in response to glucose-containing meals. |
1999-10-21 |
2023-08-12 |
human |
| M E Hill, S L Asa, D J Drucke. Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription. Molecular endocrinology (Baltimore, Md.). vol 13. issue 9. 1999-10-20. PMID:10478839. |
the proglucagon gene is also expressed in enteroendocrine l cells of the intestinal epithelium, which produce glucagon-like peptide 1 (glp-1) and glucagon-like peptide 2 (glp-2), regulators of insulin secretion and intestinal growth, respectively. |
1999-10-20 |
2023-08-12 |
mouse |
| E Näslund, J Bogefors, S Skogar, P Grybäck, H Jacobsson, J J Holst, P M Hellströ. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. The American journal of physiology. vol 277. issue 3. 1999-10-18. PMID:10484511. |
glp-1 slows solid gastric emptying and inhibits insulin, glucagon, and pyy release in humans. |
1999-10-18 |
2023-08-12 |
Not clear |
| E Näslund, J Bogefors, S Skogar, P Grybäck, H Jacobsson, J J Holst, P M Hellströ. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. The American journal of physiology. vol 277. issue 3. 1999-10-18. PMID:10484511. |
concomitantly, plasma concentrations of c- and n-terminal glp-1, glucose, insulin, c-peptide, glucagon, and peptide yy (pyy) were assessed. |
1999-10-18 |
2023-08-12 |
Not clear |
| E Näslund, J Bogefors, S Skogar, P Grybäck, H Jacobsson, J J Holst, P M Hellströ. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. The American journal of physiology. vol 277. issue 3. 1999-10-18. PMID:10484511. |
the insulin and c-peptide responses were lower during infusion with glp-1 than with saline (p < 0.004 and p < 0.001, respectively). |
1999-10-18 |
2023-08-12 |
Not clear |
| E Näslund, J Bogefors, S Skogar, P Grybäck, H Jacobsson, J J Holst, P M Hellströ. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. The American journal of physiology. vol 277. issue 3. 1999-10-18. PMID:10484511. |
infusion of glp-1 inhibits solid gastric emptying with secondary effects on the release of insulin, c-peptide, and glucagon, resulting in lower plasma glucose concentrations. |
1999-10-18 |
2023-08-12 |
Not clear |
| X Wang, C M Cahill, M A Piñeyro, J Zhou, M E Doyle, J M Ega. Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. Endocrinology. vol 140. issue 10. 1999-10-12. PMID:10499550. |
glucagon-like peptide-1 (glp-1) enhances insulin biosynthesis and secretion as well as transcription of the insulin, glut2 and glucokinase genes. |
1999-10-12 |
2023-08-12 |
rat |
| X Wang, C M Cahill, M A Piñeyro, J Zhou, M E Doyle, J M Ega. Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. Endocrinology. vol 140. issue 10. 1999-10-12. PMID:10499550. |
we found that pdx-1 mrna level was significantly increased (p<0.01) after 2 hours and insulin mrna level was subsequently increased (p<0.01) after 3 hours of treatment with glp-1 (10 nm) in rin 1046-38 insulinoma cells. |
1999-10-12 |
2023-08-12 |
rat |