| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Guenifi, B Ahrén, S M Abdel-Hali. Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro. Pancreas. vol 22. issue 1. 2001-02-15. PMID:11138972. |
this suggests that a signal generated by nutrient metabolism is required for the potentiation of insulin secretion by glp-1. |
2001-02-15 |
2023-08-12 |
mouse |
| A Guenifi, B Ahrén, S M Abdel-Hali. Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro. Pancreas. vol 22. issue 1. 2001-02-15. PMID:11138972. |
furthermore, glp-1 directly inhibited arginine-induced glucagon release as no concurrent increase in insulin or somatostatin release was noted. |
2001-02-15 |
2023-08-12 |
mouse |
| K Trümper, A Trümper, H Trusheim, R Arnold, B Göke, D Hörsc. Integrative mitogenic role of protein kinase B/Akt in beta-cells. Annals of the New York Academy of Sciences. vol 921. 2001-02-01. PMID:11193829. |
insulin, insulin-like growth factor (igf-1), and glucagon-like peptide-1 (glp-1) act as glucose-dependent growth factors for pancreatic beta-cells. |
2001-02-01 |
2023-08-12 |
Not clear |
| K Trümper, A Trümper, H Trusheim, R Arnold, B Göke, D Hörsc. Integrative mitogenic role of protein kinase B/Akt in beta-cells. Annals of the New York Academy of Sciences. vol 921. 2001-02-01. PMID:11193829. |
insulin, igf-1, and glp-1 induced distinctive time dependent, dose dependent, and glucose dependent phosphorylation of pkb/akt. |
2001-02-01 |
2023-08-12 |
Not clear |
| K Trümper, A Trümper, H Trusheim, R Arnold, B Göke, D Hörsc. Integrative mitogenic role of protein kinase B/Akt in beta-cells. Annals of the New York Academy of Sciences. vol 921. 2001-02-01. PMID:11193829. |
thus, activation pathways of pkb/akt by insulin, igf-1, and glp-1 converge at the level of irs-isoforms and pi 3-k inducing differential activation of pkb/akt. |
2001-02-01 |
2023-08-12 |
Not clear |
| G C Yaney, V N Civelek, A M Richard, J S Dillon, J T Deeney, J A Hamilton, H M Korchak, K Tornheim, B E Corkey, A E Boy. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. vol 50. issue 1. 2001-01-25. PMID:11147795. |
glucagon-like peptide 1 (glp-1) is the most potent physiological incretin for insulin secretion from the pancreatic beta-cell, but its mechanism of action has not been established. |
2001-01-25 |
2023-08-12 |
Not clear |
| G C Yaney, V N Civelek, A M Richard, J S Dillon, J T Deeney, J A Hamilton, H M Korchak, K Tornheim, B E Corkey, A E Boy. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. vol 50. issue 1. 2001-01-25. PMID:11147795. |
because the acute addition of ffas also increases glucose-stimulated insulin secretion, these data suggest that the incretin function of glp-1 may involve a major role for lipolysis in camp-mediated potentiation of secretion. |
2001-01-25 |
2023-08-12 |
Not clear |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
this study investigates the mechanisms responsible for glucagon-like peptide-1 (glp-1)-induced insulin secretion in zucker diabetic fatty (zdf) rats and their lean control (zlc) littermates. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
glucose, and 100 nmol/l glp-1 (7-37 hydroxide) in the presence of stimulatory glucose concentrations, induced insulin secretion in islets from zlc animals. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
in contrast, zdf islets hypersecreted insulin at low glucose (5 mmol/l) and were poorly responsive to 15 mmol/l glucose stimulation, but increased insulin secretion following exposure to glp-1. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
the insulin secretory response to 100 nmol/l glp-1 was reduced by 88% in zlc islets exposed to exendin 9-39. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
the increases in [ca2+]i and insulin secretion in zlc islets induced by glp-1 were attenuated by 1 micromol/l nitrendipine. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
furthermore, insulin secretory responses to glp-1 were not significantly inhibited in zdf islets by nitrendipine. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
however, the insulin secretory response to glp-1 in both zlc and zdf islets was ablated by cholera toxin. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
our findings indicate that in zlc islets, glp-1 induces insulin secretion by a mechanism that depends on ca2+ influx through voltage-dependent ca2+ channels, whereas in zdf islets, the action of glp-1 is mediated by ca2+-independent signaling pathways. |
2001-01-11 |
2023-08-12 |
rat |
| P Huypens, Z Ling, D Pipeleers, F Schui. Glucagon receptors on human islet cells contribute to glucose competence of insulin release. Diabetologia. vol 43. issue 8. 2001-01-05. PMID:10990079. |
this study assessed the importance of an interaction between glucose and camp in the stimulation of insulin secretion from human islet cells by investigating expression and functional activity of receptors recognising glucagon, glucagon-like peptide-1 (7-36)amide (glp-1) and glucose-dependent insulinotropic polypeptide (gip). |
2001-01-05 |
2023-08-12 |
human |
| C A Leech, G G Holz, O Chepurny, J F Habene. Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells. Biochemical and biophysical research communications. vol 278. issue 1. 2001-01-04. PMID:11071853. |
the insulinotropic hormone glucagon-like peptide-1 (glp-1) binds to a gs-coupled receptor on pancreatic beta-cells and potentiates glucose-induced insulin secretion, insulin gene transcription, and beta-cell growth. |
2001-01-04 |
2023-08-12 |
Not clear |
| B Matutte, J M Conlo. Characterization of insulin and atypically processed proglucagon-derived peptides from the surinam toad Pipa pipa (Anura:Pipidae). Peptides. vol 21. issue 9. 2001-01-04. PMID:11072122. |
electrospray mass spectrometry was used to identify insulin, glucagon and two peptides related to glucagon-like peptide-1 (glp-1) in an extract of the pancreas of the surinam toad, pipa pipa, a species belonging to the same family as the african clawed frog, xenopus laevis. |
2001-01-04 |
2023-08-12 |
xenopus_laevis |
| J A García-Martínez, J Cancelas, M L Villanueva-Peñacarrillo, I Valverde, W J Malaiss. Potentiation of the insulinotropic action of GLP-1 by succinic acid dimethyl ester in fed anaesthetized rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 32. issue 8. 2000-12-28. PMID:10983625. |
this study explores whether an ester of succinic acid could be used to potentiate the insulin secretory response to glp-1 in vivo. |
2000-12-28 |
2023-08-12 |
rat |
| J A García-Martínez, J Cancelas, M L Villanueva-Peñacarrillo, I Valverde, W J Malaiss. Potentiation of the insulinotropic action of GLP-1 by succinic acid dimethyl ester in fed anaesthetized rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 32. issue 8. 2000-12-28. PMID:10983625. |
in the sad-infused rats, the increment in plasma insulin concentration caused by glp-1 was more pronounced and more sustained than in saline-infused rats. |
2000-12-28 |
2023-08-12 |
rat |