| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H C Fehmann, B Göke, R Göke, M E Trautmann, R Arnol. Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS letters. vol 252. issue 1-2. 1989-09-21. PMID:2668027. |
the interaction of glucagon-like peptide-1 (7-36)amide (glp-1) and glucose-dependent insulin-releasing polypeptide (gip) on insulin release from the perfused rat pancreas was studied. |
1989-09-21 |
2023-08-11 |
rat |
| H C Fehmann, B Göke, R Göke, M E Trautmann, R Arnol. Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS letters. vol 252. issue 1-2. 1989-09-21. PMID:2668027. |
the glp-1 stimulated (0.5 nmol/l), glucose-induced (6.7 mmol/l) insulin secretory answer was enhanced by gip (0.1, 1.0 and 10.0 nmol/l) to the arterial perfusate. |
1989-09-21 |
2023-08-11 |
rat |
| H C Fehmann, B Göke, R Göke, M E Trautmann, R Arnol. Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS letters. vol 252. issue 1-2. 1989-09-21. PMID:2668027. |
our data demonstrate an additive synergistic effect of glp-1 and gip on the glucose-induced insulin release. |
1989-09-21 |
2023-08-11 |
rat |
| C Orskov, M Bersani, A H Johnsen, P Højrup, J J Hols. Complete sequences of glucagon-like peptide-1 from human and pig small intestine. The Journal of biological chemistry. vol 264. issue 22. 1989-09-07. PMID:2753890. |
earlier studies have shown that synthetic glucagon-like peptide-1 (glp-1) synthesized according to the proposed structure (proglucagon 71-108 or because residue 108 is gly, 72-107 amide) had no physiological effects, whereas a truncated from of glp-1, corresponding to proglucagon 78-107 amide, strongly stimulated insulin secretion and depressed glucagon secretion. |
1989-09-07 |
2023-08-11 |
human |
| T Matsuyama, R Komatsu, M Namba, N Watanabe, H Itoh, S Taru. Glucagon-like peptide-1 (7-36 amide): a potent glucagonostatic and insulinotropic hormone. Diabetes research and clinical practice. vol 5. issue 4. 1989-05-02. PMID:3069410. |
glucagon and insulin release were not affected significantly by glp-1 (1-37), irrespective of glucose concentration. |
1989-05-02 |
2023-08-11 |
rat |
| K Shima, M Hirota, C Ohbosh. Effect of glucagon-like peptide-1 on insulin secretion. Regulatory peptides. vol 22. issue 3. 1988-11-15. PMID:3051138. |
these findings suggest that the smaller glp-1 may have a physiologically more important role as a modulator of insulin release. |
1988-11-15 |
2023-08-11 |
rat |
| C Orskov, J J Holst, O V Nielse. Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach. Endocrinology. vol 123. issue 4. 1988-10-27. PMID:2901341. |
insulin secretion from the pancreas (with 7 mmol/liter glucose in the perfusate) increased 2-fold with truncated glp-1 at 10(-10) mol/liter and almost 5-fold at 10(-9) mol/liter. |
1988-10-27 |
2023-08-11 |
Not clear |
| C J Bailey, P R Flat. Glucagon-like peptide-1 and the entero-insular axis in obese hyperglycaemic (ob/ob) mice. Life sciences. vol 40. issue 6. 1987-03-19. PMID:3543585. |
compared with glucagon (100 micrograms/kg ip), which produce an approximately 3-fold increase in basal plasma glucose and insulin concentrations, glp-1 (100 micrograms/kg ip) produce a very small (less than 1 fold) increase in plasma insulin, with no significant change in plasma glucose. |
1987-03-19 |
2023-08-11 |
mouse |