| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
this study investigates the mechanisms responsible for glucagon-like peptide-1 (glp-1)-induced insulin secretion in zucker diabetic fatty (zdf) rats and their lean control (zlc) littermates. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
glucose, and 100 nmol/l glp-1 (7-37 hydroxide) in the presence of stimulatory glucose concentrations, induced insulin secretion in islets from zlc animals. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
in contrast, zdf islets hypersecreted insulin at low glucose (5 mmol/l) and were poorly responsive to 15 mmol/l glucose stimulation, but increased insulin secretion following exposure to glp-1. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
the insulin secretory response to 100 nmol/l glp-1 was reduced by 88% in zlc islets exposed to exendin 9-39. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
the increases in [ca2+]i and insulin secretion in zlc islets induced by glp-1 were attenuated by 1 micromol/l nitrendipine. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
furthermore, insulin secretory responses to glp-1 were not significantly inhibited in zdf islets by nitrendipine. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
however, the insulin secretory response to glp-1 in both zlc and zdf islets was ablated by cholera toxin. |
2001-01-11 |
2023-08-12 |
rat |
| S K Sreenan, A A Mittal, F Dralyuk, W L Pugh, K S Polonsky, M W Ro. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans. Metabolism: clinical and experimental. vol 49. issue 12. 2001-01-11. PMID:11145120. |
our findings indicate that in zlc islets, glp-1 induces insulin secretion by a mechanism that depends on ca2+ influx through voltage-dependent ca2+ channels, whereas in zdf islets, the action of glp-1 is mediated by ca2+-independent signaling pathways. |
2001-01-11 |
2023-08-12 |
rat |
| P Huypens, Z Ling, D Pipeleers, F Schui. Glucagon receptors on human islet cells contribute to glucose competence of insulin release. Diabetologia. vol 43. issue 8. 2001-01-05. PMID:10990079. |
this study assessed the importance of an interaction between glucose and camp in the stimulation of insulin secretion from human islet cells by investigating expression and functional activity of receptors recognising glucagon, glucagon-like peptide-1 (7-36)amide (glp-1) and glucose-dependent insulinotropic polypeptide (gip). |
2001-01-05 |
2023-08-12 |
human |
| C A Leech, G G Holz, O Chepurny, J F Habene. Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells. Biochemical and biophysical research communications. vol 278. issue 1. 2001-01-04. PMID:11071853. |
the insulinotropic hormone glucagon-like peptide-1 (glp-1) binds to a gs-coupled receptor on pancreatic beta-cells and potentiates glucose-induced insulin secretion, insulin gene transcription, and beta-cell growth. |
2001-01-04 |
2023-08-12 |
Not clear |
| B Matutte, J M Conlo. Characterization of insulin and atypically processed proglucagon-derived peptides from the surinam toad Pipa pipa (Anura:Pipidae). Peptides. vol 21. issue 9. 2001-01-04. PMID:11072122. |
electrospray mass spectrometry was used to identify insulin, glucagon and two peptides related to glucagon-like peptide-1 (glp-1) in an extract of the pancreas of the surinam toad, pipa pipa, a species belonging to the same family as the african clawed frog, xenopus laevis. |
2001-01-04 |
2023-08-12 |
xenopus_laevis |
| J A García-Martínez, J Cancelas, M L Villanueva-Peñacarrillo, I Valverde, W J Malaiss. Potentiation of the insulinotropic action of GLP-1 by succinic acid dimethyl ester in fed anaesthetized rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 32. issue 8. 2000-12-28. PMID:10983625. |
this study explores whether an ester of succinic acid could be used to potentiate the insulin secretory response to glp-1 in vivo. |
2000-12-28 |
2023-08-12 |
rat |
| J A García-Martínez, J Cancelas, M L Villanueva-Peñacarrillo, I Valverde, W J Malaiss. Potentiation of the insulinotropic action of GLP-1 by succinic acid dimethyl ester in fed anaesthetized rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 32. issue 8. 2000-12-28. PMID:10983625. |
in the sad-infused rats, the increment in plasma insulin concentration caused by glp-1 was more pronounced and more sustained than in saline-infused rats. |
2000-12-28 |
2023-08-12 |
rat |
| R Perfetti, J Zhou, M E Doyle, J M Ega. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology. vol 141. issue 12. 2000-12-22. PMID:11108273. |
here, we show that continuous infusion of glucagon-like peptide-1 (7-36) (glp-1; an insulinotropic agent), to young and old animals, had effects on the beta-cell of the pancreas other than simply on the insulin secretory apparatus. |
2000-12-22 |
2023-08-12 |
rat |
| A R Clocquet, J M Egan, D A Stoffers, D C Muller, L Wideman, G A Chin, W L Clarke, J B Hanks, J F Habener, D Elah. Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene). Diabetes. vol 49. issue 11. 2000-11-30. PMID:11078452. |
at a glucose level of 16.8 mmol/l above fasting level, glp-1 augmented insulin secretion equivalently (fold increase) in both groups, but the insulin and c-peptide responses to glp-1 were sevenfold less in the nm subjects than in the nn subjects. |
2000-11-30 |
2023-08-12 |
human |
| K Persson, R L Gingerich, S Nayak, K Wada, E Wada, B Ahré. Reduced GLP-1 and insulin responses and glucose intolerance after gastric glucose in GRP receptor-deleted mice. American journal of physiology. Endocrinology and metabolism. vol 279. issue 5. 2000-11-09. PMID:11052949. |
reduced glp-1 and insulin responses and glucose intolerance after gastric glucose in grp receptor-deleted mice. |
2000-11-09 |
2023-08-12 |
mouse |
| K Persson, R L Gingerich, S Nayak, K Wada, E Wada, B Ahré. Reduced GLP-1 and insulin responses and glucose intolerance after gastric glucose in GRP receptor-deleted mice. American journal of physiology. Endocrinology and metabolism. vol 279. issue 5. 2000-11-09. PMID:11052949. |
the simultaneous increase in plasma insulin correlated to the 10-min glp-1 levels (r = 0.36, p < 0.001; n = 12). |
2000-11-09 |
2023-08-12 |
mouse |
| K Persson, R L Gingerich, S Nayak, K Wada, E Wada, B Ahré. Reduced GLP-1 and insulin responses and glucose intolerance after gastric glucose in GRP receptor-deleted mice. American journal of physiology. Endocrinology and metabolism. vol 279. issue 5. 2000-11-09. PMID:11052949. |
in conclusion, this study has shown that 1) plasma levels of intact glp-1 increase dose dependently on gastric glucose challenge in correlation with increased insulin levels in mice, and 2) intact grp receptors are required for normal glp-1 and insulin responses and glucose tolerance after gastric glucose in mice. |
2000-11-09 |
2023-08-12 |
mouse |
| B Balkan, X L. Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms. American journal of physiology. Regulatory, integrative and comparative physiology. vol 279. issue 4. 2000-11-07. PMID:11004015. |
portal glp-1 administration in rats augments the insulin response to glucose via neuronal mechanisms. |
2000-11-07 |
2023-08-12 |
rat |
| B Balkan, X L. Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms. American journal of physiology. Regulatory, integrative and comparative physiology. vol 279. issue 4. 2000-11-07. PMID:11004015. |
portal glp-1 augmented the insulin response to a portal glucose bolus by 81% (p < 0.01) and markedly improved the glucose disposal rate (p < 0.05). |
2000-11-07 |
2023-08-12 |
rat |