| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M García-Flores, J A Zueco, E Alvarez, E Blázque. Expression of glucagon-like peptide-1 (GLP-1) receptor and the effect of GLP-1-(7-36) amide on insulin release by pancreatic islets during rat ontogenic development. European journal of biochemistry. vol 268. issue 3. 2001-03-29. PMID:11168389. |
expression of glucagon-like peptide-1 (glp-1) receptor and the effect of glp-1-(7-36) amide on insulin release by pancreatic islets during rat ontogenic development. |
2001-03-29 |
2023-08-12 |
rat |
| M García-Flores, J A Zueco, E Alvarez, E Blázque. Expression of glucagon-like peptide-1 (GLP-1) receptor and the effect of GLP-1-(7-36) amide on insulin release by pancreatic islets during rat ontogenic development. European journal of biochemistry. vol 268. issue 3. 2001-03-29. PMID:11168389. |
the expression of glucagon-like peptide-1 (glp-1) receptor and the effects of glp-1-(7-36) amide (t-glp-1) on glucose metabolism and insulin release by pancreatic islets during rat development were studied. |
2001-03-29 |
2023-08-12 |
rat |
| M García-Flores, J A Zueco, E Alvarez, E Blázque. Expression of glucagon-like peptide-1 (GLP-1) receptor and the effect of GLP-1-(7-36) amide on insulin release by pancreatic islets during rat ontogenic development. European journal of biochemistry. vol 268. issue 3. 2001-03-29. PMID:11168389. |
our findings indicate that glp-1 receptors and the effect of t-glp-1 on insulin release are already present in the fetus, and they therefore exclude the possibility that alterations in the action of t-glp-1 are responsible for the unresponsiveness of pancreatic beta cells to glucose in the fetus, but stimulation of t-glp-1 release by food ingestion in newborns may partially confer glucose competence on beta cells. |
2001-03-29 |
2023-08-12 |
rat |
| R Nesher, N Warwar, A Khan, S Efendic, E Cerasi, N Kaise. Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes. Diabetes. vol 50. issue 2. 2001-03-29. PMID:11272141. |
basal insulin release in islets from diabetes-resistant p. obesus was unaffected by glucagon-like peptide 1 (glp-1) or forskolin, whereas that of islets of the diabetic line was augmented by the drugs. |
2001-03-29 |
2023-08-12 |
Not clear |
| R Nesher, N Warwar, A Khan, S Efendic, E Cerasi, N Kaise. Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes. Diabetes. vol 50. issue 2. 2001-03-29. PMID:11272141. |
glp-1 and forskolin potentiated the insulin response to maximal (11.1 mmol/l) glucose in islets from all groups. |
2001-03-29 |
2023-08-12 |
Not clear |
| R Nesher, N Warwar, A Khan, S Efendic, E Cerasi, N Kaise. Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes. Diabetes. vol 50. issue 2. 2001-03-29. PMID:11272141. |
in summary, we found that 1) p. obesus islets have low oxidative capacity, probably resulting in limited ability to generate atp to initiate and drive the insulin secretion; 2) insulin response potentiated by cyclic amp-dependent protein kinase is intact in p. obesus islets, and increased sensitivity to glp-1 or forskolin in the diabetic line may be secondary to increased sensitivity to glucose; and 3) islets of hyperglycemic p. obesus display reduced expression of alpha-pkc and diminished translocation of lambda-pkc associated with impaired response to pma. |
2001-03-29 |
2023-08-12 |
Not clear |
| R N Bergman, G W Van Citters, S D Mittelman, M K Dea, M Hamilton-Wessler, S P Kim, M Ellmere. Central role of the adipocyte in the metabolic syndrome. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 49. issue 1. 2001-03-22. PMID:11217141. |
the signal(s) resulting in b-cell up-regulation and reduced liver insulin clearance with visceral adiposity is (are) unknown, but it appears that the glucagon-like peptide (glp-1) hormone plays an important role. |
2001-03-22 |
2023-08-12 |
dog |
| B Ahrén, J J Holst, H Mårtensson, B Balka. Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice. European journal of pharmacology. vol 404. issue 1-2. 2001-02-22. PMID:10980284. |
we explored whether inhibition of the enzyme dipeptidyl peptidase iv (dpp iv) increases endogenous levels of glucagon-like peptide-1 (glp-1) and improves glucose tolerance and insulin secretion in mice. |
2001-02-22 |
2023-08-12 |
mouse |
| B Ahrén, J J Holst, H Mårtensson, B Balka. Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice. European journal of pharmacology. vol 404. issue 1-2. 2001-02-22. PMID:10980284. |
this suggests that valine-pyrrolidide improves insulin secretion and glucose tolerance through indirect action, probably through augmentation of levels of glp-1 and other incretin hormones. |
2001-02-22 |
2023-08-12 |
mouse |
| R Perfetti, P Merke. Glucagon-like peptide-1: a major regulator of pancreatic beta-cell function. European journal of endocrinology. vol 143. issue 6. 2001-02-22. PMID:11124853. |
glp-1 stimulates insulin secretion during hyperglycemia, suppresses glucagon secretion, stimulates (pro)-insulin biosynthesis and decreases the rate of gastric emptying and acid secretion. |
2001-02-22 |
2023-08-12 |
human |
| A Guenifi, B Ahrén, S M Abdel-Hali. Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro. Pancreas. vol 22. issue 1. 2001-02-15. PMID:11138972. |
glp-1 strongly potentiated glucose-stimulated insulin secretion in the perfused rat pancreas and in vivo in mice (p < 0.001). |
2001-02-15 |
2023-08-12 |
mouse |
| A Guenifi, B Ahrén, S M Abdel-Hali. Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro. Pancreas. vol 22. issue 1. 2001-02-15. PMID:11138972. |
in contrast, glp-1 did not enhance arginine-induced insulin release under these experimental conditions. |
2001-02-15 |
2023-08-12 |
mouse |
| A Guenifi, B Ahrén, S M Abdel-Hali. Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro. Pancreas. vol 22. issue 1. 2001-02-15. PMID:11138972. |
in conclusion, glp-1, in contrast to cck, failed to enhance arginine-induced insulin release both in vitro and in vivo. |
2001-02-15 |
2023-08-12 |
mouse |
| A Guenifi, B Ahrén, S M Abdel-Hali. Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro. Pancreas. vol 22. issue 1. 2001-02-15. PMID:11138972. |
this suggests that a signal generated by nutrient metabolism is required for the potentiation of insulin secretion by glp-1. |
2001-02-15 |
2023-08-12 |
mouse |
| A Guenifi, B Ahrén, S M Abdel-Hali. Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro. Pancreas. vol 22. issue 1. 2001-02-15. PMID:11138972. |
furthermore, glp-1 directly inhibited arginine-induced glucagon release as no concurrent increase in insulin or somatostatin release was noted. |
2001-02-15 |
2023-08-12 |
mouse |
| K Trümper, A Trümper, H Trusheim, R Arnold, B Göke, D Hörsc. Integrative mitogenic role of protein kinase B/Akt in beta-cells. Annals of the New York Academy of Sciences. vol 921. 2001-02-01. PMID:11193829. |
insulin, insulin-like growth factor (igf-1), and glucagon-like peptide-1 (glp-1) act as glucose-dependent growth factors for pancreatic beta-cells. |
2001-02-01 |
2023-08-12 |
Not clear |
| K Trümper, A Trümper, H Trusheim, R Arnold, B Göke, D Hörsc. Integrative mitogenic role of protein kinase B/Akt in beta-cells. Annals of the New York Academy of Sciences. vol 921. 2001-02-01. PMID:11193829. |
insulin, igf-1, and glp-1 induced distinctive time dependent, dose dependent, and glucose dependent phosphorylation of pkb/akt. |
2001-02-01 |
2023-08-12 |
Not clear |
| K Trümper, A Trümper, H Trusheim, R Arnold, B Göke, D Hörsc. Integrative mitogenic role of protein kinase B/Akt in beta-cells. Annals of the New York Academy of Sciences. vol 921. 2001-02-01. PMID:11193829. |
thus, activation pathways of pkb/akt by insulin, igf-1, and glp-1 converge at the level of irs-isoforms and pi 3-k inducing differential activation of pkb/akt. |
2001-02-01 |
2023-08-12 |
Not clear |
| G C Yaney, V N Civelek, A M Richard, J S Dillon, J T Deeney, J A Hamilton, H M Korchak, K Tornheim, B E Corkey, A E Boy. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. vol 50. issue 1. 2001-01-25. PMID:11147795. |
glucagon-like peptide 1 (glp-1) is the most potent physiological incretin for insulin secretion from the pancreatic beta-cell, but its mechanism of action has not been established. |
2001-01-25 |
2023-08-12 |
Not clear |
| G C Yaney, V N Civelek, A M Richard, J S Dillon, J T Deeney, J A Hamilton, H M Korchak, K Tornheim, B E Corkey, A E Boy. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. vol 50. issue 1. 2001-01-25. PMID:11147795. |
because the acute addition of ffas also increases glucose-stimulated insulin secretion, these data suggest that the incretin function of glp-1 may involve a major role for lipolysis in camp-mediated potentiation of secretion. |
2001-01-25 |
2023-08-12 |
Not clear |