| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Lugari, C Dell'Anna, D Ugolotti, A Dei Cas, A L Barilli, R Zandomeneghi, B Marani, M Iotti, A Orlandini, A Gnud. Effect of nutrient ingestion on glucagon-like peptide 1 (7-36 amide) secretion in human type 1 and type 2 diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 32. issue 10. 2001-05-31. PMID:11069208. |
glp-1 also reduces meal-related insulin requirement in type 1 diabetic patients, suggesting an impairment of the entero-insular axis in both diabetic conditions. |
2001-05-31 |
2023-08-12 |
human |
| R Lugari, C Dell'Anna, D Ugolotti, A Dei Cas, A L Barilli, R Zandomeneghi, B Marani, M Iotti, A Orlandini, A Gnud. Effect of nutrient ingestion on glucagon-like peptide 1 (7-36 amide) secretion in human type 1 and type 2 diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 32. issue 10. 2001-05-31. PMID:11069208. |
in postabsorptive state, a mixed breakfast (230 kcal) was administered to all subjects and blood samples were collected for plasma glucose, insulin, c-peptide and glp-1 determination during the following 3 hours. |
2001-05-31 |
2023-08-12 |
human |
| D G Parkes, R Pittner, C Jodka, P Smith, A Youn. Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro. Metabolism: clinical and experimental. vol 50. issue 5. 2001-05-31. PMID:11319721. |
this study compares in vitro effects of exendin-4 and glucagon-like peptide (glp)-1 on basal and glucose-stimulated insulin release from isolated rat islets and in vivo insulinotropic actions of exendin-4 and glp-1 after an intravenous glucose challenge in rats. |
2001-05-31 |
2023-08-12 |
rat |
| D G Parkes, R Pittner, C Jodka, P Smith, A Youn. Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro. Metabolism: clinical and experimental. vol 50. issue 5. 2001-05-31. PMID:11319721. |
the addition of exendin-4 or glp-1 (1 nmol/l to 1 micromol/l) increased glucose-stimulated insulin secretion up to 5.8 +/- 1.6-fold and 3.3 +/- 1.0-fold, respectively, over basal rates (defined as no hormones added, 3 mmol/l glucose) and 19.6 +/- 2.3-fold and 15.0 +/- 3.1-fold at 10 mmol/l glucose. |
2001-05-31 |
2023-08-12 |
rat |
| D G Parkes, R Pittner, C Jodka, P Smith, A Youn. Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro. Metabolism: clinical and experimental. vol 50. issue 5. 2001-05-31. PMID:11319721. |
in dynamically perfused isolated islets exposed to 7.5 mmol/l glucose, insulin secretion increased 6.4 +/- 1.5-fold, and exendin-4 (20 nmol/l) or glp-1 (20 nmol/l) increased this similarly by up to 13.5 +/- 2.8 and 12.7 +/- 3.9-fold,respectively. |
2001-05-31 |
2023-08-12 |
rat |
| M Dharmalingam, P Kuma. New pharmacological development (alpha glucosidase inhibitors, amylin analogues, GLP-1, thiozolidinediones, short acting insulin analogues). The Journal of the Association of Physicians of India. vol 49 Spec No. 2001-05-24. PMID:11235605. |
new pharmacological development (alpha glucosidase inhibitors, amylin analogues, glp-1, thiozolidinediones, short acting insulin analogues). |
2001-05-24 |
2023-08-12 |
Not clear |
| F C Lynn, N Pamir, E H Ng, C H McIntosh, T J Kieffer, R A Pederso. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334402. |
in type 2 diabetes, there is a decreased responsiveness of the pancreas to gip; however, the insulin response to glp-1 remains intact. |
2001-05-21 |
2023-08-12 |
rat |
| F C Lynn, N Pamir, E H Ng, C H McIntosh, T J Kieffer, R A Pederso. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334402. |
gip also potently stimulated first-phase insulin secretion from isolated perifused islets (10.3 +/- 3.0 x basal), and gip and glp-1 potentiated insulin secretion from the perfused pancreas (6 x control area under the curve [auc]) from lean animals. |
2001-05-21 |
2023-08-12 |
rat |
| F C Lynn, N Pamir, E H Ng, C H McIntosh, T J Kieffer, R A Pederso. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334402. |
gip yielded no significant effect in the vancouver diabetic fatty zucker (vdf) rat pancreases, whereas glp-1 elicited an eightfold increase of insulin secretion from the perfused vdf pancreas. |
2001-05-21 |
2023-08-12 |
rat |
| B Ahrén, J J Hols. The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334405. |
the preabsorptive insulin response was not accompanied by any increase in circulating levels of gastric inhibitory polypeptide (gip) or glucagon-like peptide 1 (glp-1). |
2001-05-21 |
2023-08-12 |
Not clear |
| B Ahrén, J J Hols. The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334405. |
in conclusion, 1) the early preabsorptive insulin response to meal ingestion in humans can be largely attributed to autonomic activation mediated by noncholinergic and cholinergic mechanisms, 2) this cephalic insulin response is required for a normal postprandial glucose tolerance, and 3) gip and glp-1 do not contribute to the preabsorptive cephalic phase insulin response to meal ingestion. |
2001-05-21 |
2023-08-12 |
Not clear |
| X Wang, J Zhou, M E Doyle, J M Ega. Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism. Endocrinology. vol 142. issue 5. 2001-05-17. PMID:11316746. |
glucagon-like peptide-1 (glp-1) enhances insulin secretion and synthesis. |
2001-05-17 |
2023-08-12 |
Not clear |
| X Wang, J Zhou, M E Doyle, J M Ega. Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism. Endocrinology. vol 142. issue 5. 2001-05-17. PMID:11316746. |
in addition, glp-1 has been shown, both in vitro and in vivo, to be involved in regulation of the transcription factor, pancreatic duodenal homeobox-1 protein (pdx-1), by increasing its total protein levels, its translocation to the nucleus and its binding and resultant increase in activity of the insulin gene promoter in beta-cells of the pancreas. |
2001-05-17 |
2023-08-12 |
Not clear |
| X Wang, J Zhou, M E Doyle, J M Ega. Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism. Endocrinology. vol 142. issue 5. 2001-05-17. PMID:11316746. |
furthermore, forskolin, (which stimulates adenylyl cyclase and insulin secretion), and 8-bromo-camp, (an analog of camp which also stimulates insulin secretion), mimicked the effects of glp-1 on pdx-1. |
2001-05-17 |
2023-08-12 |
Not clear |
| M E Doyle, J M Ega. Glucagon-like peptide-1. Recent progress in hormone research. vol 56. 2001-04-26. PMID:11237222. |
glucagon-like peptide-1 (glp-1) is a potent insulin secretagogue that has multiple synergetic effects on the glucose-dependent insulin secretion pathways of the beta-cell. |
2001-04-26 |
2023-08-12 |
mouse |
| M E Doyle, J M Ega. Glucagon-like peptide-1. Recent progress in hormone research. vol 56. 2001-04-26. PMID:11237222. |
our investigations into the mechanisms of action of glp-1 began by using the reverse hemolytic plaque assay to quantify insulin secretion from individual cells of the rin 1046-38 insulinoma cell line in response to acute treatment with the peptide. |
2001-04-26 |
2023-08-12 |
mouse |
| M E Doyle, J M Ega. Glucagon-like peptide-1. Recent progress in hormone research. vol 56. 2001-04-26. PMID:11237222. |
glp-1 increases both the number of cells secreting insulin and the amount secreted per cell. |
2001-04-26 |
2023-08-12 |
mouse |
| M E Doyle, J M Ega. Glucagon-like peptide-1. Recent progress in hormone research. vol 56. 2001-04-26. PMID:11237222. |
this response to glp-1 is retained even in the beta cell of the old (i.e., 22-month), glucose-intolerant wistar rat, which exhibits a normal, first-phase insulin response to glucose following an acute bolus of glp-1. |
2001-04-26 |
2023-08-12 |
mouse |
| M E Doyle, J M Ega. Glucagon-like peptide-1. Recent progress in hormone research. vol 56. 2001-04-26. PMID:11237222. |
preincubation with glp-1 (24 hours) potentiates glucose- and glp-1-dependent insulin secretion and increases insulin content in the insulinoma cells. |
2001-04-26 |
2023-08-12 |
mouse |
| M E Doyle, J M Ega. Glucagon-like peptide-1. Recent progress in hormone research. vol 56. 2001-04-26. PMID:11237222. |
treatment of old wistar rats for 48 hours with glp-1 leads to normalization of the insulin response and an increase in islet insulin content and mrna levels of glut 2 and glucokinase. |
2001-04-26 |
2023-08-12 |
mouse |