| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael C Lawrence, Harshika S Bhatt, Richard A Easo. NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1. Diabetes. vol 51. issue 3. 2002-03-15. PMID:11872668. |
these data suggest that the synergistic action of glucose and glp-1 to promote insulin gene transcription is mediated through nfat via pka- and calcineurin-dependent pathways in pancreatic beta-cells. |
2002-03-15 |
2023-08-12 |
rat |
| Audrey E Brynes, C Mark Edwards, Mohammed A Ghatei, Stephen R Bloom, Gary S Fros. Men at increased risk of coronary heart disease are not different from age- and weight-matched healthy controls in their postprandial triglyceride, nonesterified fatty acid, or incretin responses to sucrose. Metabolism: clinical and experimental. vol 51. issue 2. 2002-03-07. PMID:11833048. |
we measured postprandial tg, nonesterified fatty acids (nefa), insulin, glucose, glucagon-like peptide-1 (glp-1), and gastric inhibitory polypeptide (gip) concentrations in response to a meal containing 75 g glucose or 75 g sucrose with a moderate fat load. |
2002-03-07 |
2023-08-12 |
Not clear |
| Daniel J Drucke. Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology. vol 122. issue 2. 2002-03-01. PMID:11832466. |
glp-1 acts as an incretin to lower blood glucose via stimulation of insulin secretion from islet beta cells. |
2002-03-01 |
2023-08-12 |
human |
| Daniel J Drucke. Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology. vol 122. issue 2. 2002-03-01. PMID:11832466. |
glp-1 also exerts actions independent of insulin secretion, including inhibition of gastric emptying and acid secretion, reduction in food ingestion and glucagon secretion, and stimulation of beta-cell proliferation. |
2002-03-01 |
2023-08-12 |
human |
| J Cancelas, M L Villanueva-Peñacarrillo, I Valverde, W J Malaiss. Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats. International journal of molecular medicine. vol 8. issue 5. 2002-01-15. PMID:11605022. |
provoked a rapid and sustained increase in plasma insulin concentration and augmented the release of insulin caused by glp-1. |
2002-01-15 |
2023-08-12 |
rat |
| G S Meneilly, C H McIntosh, R A Pederson, J F Habener, R Gingerich, J M Egan, D T Finegood, D Elah. Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes. Diabetes care. vol 24. issue 11. 2002-01-11. PMID:11679463. |
in a subsequent control study, insulin was infused using the glucose clamp protocol from 30 to 240 min to match the insulin levels that occurred during the glp-1 infusion study. |
2002-01-11 |
2023-08-12 |
Not clear |
| G S Meneilly, C H McIntosh, R A Pederson, J F Habener, R Gingerich, J M Egan, D Elah. Glucagon-like peptide-1 (7-37) augments insulin-mediated glucose uptake in elderly patients with diabetes. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 56. issue 11. 2001-12-07. PMID:11682575. |
glucagon-like peptide-1 (glp-1) is an intestinal insulinotropic hormone that augments glucose-induced insulin secretion in patients with type 2 diabetes. |
2001-12-07 |
2023-08-12 |
Not clear |
| W Creutzfeld. The entero-insular axis in type 2 diabetes--incretins as therapeutic agents. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 109 Suppl 2. 2001-12-05. PMID:11460578. |
the ratio between the integrated insulin response to an oral glucose load and an isoglycaemic intravenous glucose infusion) is markedly diminished in patients with type 2 diabetes mellitus, while the plasma levels of gip and glp-1 and their responses to nutrients are in the normal range. |
2001-12-05 |
2023-08-12 |
Not clear |
| J A Benson, C K Reynold. Effects of abomasal infusion of long-chain fatty acids on splanchnic metabolism of pancreatic and gut hormones in lactating dairy cows. Journal of dairy science. vol 84. issue 6. 2001-11-01. PMID:11417709. |
we investigated the effects of 7-d abomasal infusions of a rapeseed and sunflower oil mixture providing mostly unsaturated long-chain fatty acids (lcfa) on arterial concentration and splanchnic (portal-drained viscera [pdv] and liver) metabolism of insulin, pancreatic (pan) and gut (gut) glucagon, glucagon-like peptide-1 (7-36) amide (glp-1), and cholecystokinin (cck) in six cows at 55 (elac) and 111 (mlac) d postpartum. |
2001-11-01 |
2023-08-12 |
Not clear |
| J A Benson, C K Reynold. Effects of abomasal infusion of long-chain fatty acids on splanchnic metabolism of pancreatic and gut hormones in lactating dairy cows. Journal of dairy science. vol 84. issue 6. 2001-11-01. PMID:11417709. |
arterial concentrations of insulin and pan were greater in mlac, whereas arterial concentrations of glp-1 and cck were greater in elac. |
2001-11-01 |
2023-08-12 |
Not clear |
| J A Benson, C K Reynold. Effects of abomasal infusion of long-chain fatty acids on splanchnic metabolism of pancreatic and gut hormones in lactating dairy cows. Journal of dairy science. vol 84. issue 6. 2001-11-01. PMID:11417709. |
abomasal oil infusion increased arterial concentration of gut and glp-1 but decreased arterial insulin concentration. |
2001-11-01 |
2023-08-12 |
Not clear |
| M E Doyle, N H Greig, H W Holloway, J A Betkey, M Bernier, J M Ega. Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent. Endocrinology. vol 142. issue 10. 2001-11-01. PMID:11564711. |
glp-1 aha(8) (10 nm) was equipotent with glp-1 (10 nm) in stimulating insulin secretion in rin 1046-38 cells. |
2001-11-01 |
2023-08-12 |
human |
| M E Doyle, N H Greig, H W Holloway, J A Betkey, M Bernier, J M Ega. Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent. Endocrinology. vol 142. issue 10. 2001-11-01. PMID:11564711. |
they had poor binding affinity for the glp-1 receptor, and none of these compounds stimulated the production of intracellular camp in cho/glp-1r cells or insulin secretion in rin 1046-38 cells. |
2001-11-01 |
2023-08-12 |
human |
| b' R A Reimer, C Darimont, S Gremlich, V Nicolas-M\\xc3\\xa9tral, U T R\\xc3\\xbcegg, K Mac\\xc3\\xa. A human cellular model for studying the regulation of glucagon-like peptide-1 secretion. Endocrinology. vol 142. issue 10. 2001-11-01. PMID:11564718.' |
glp-1 (glucagon-like peptide-1) is a potent insulin secretagogue released from l cells in the intestine. |
2001-11-01 |
2023-08-12 |
human |
| T P Mommsen, T W Moon, E M Plisetskay. Effects of arginine on pancreatic hormones and hepatic metabolism in rainbow trout. Physiological and biochemical zoology : PBZ. vol 74. issue 5. 2001-10-18. PMID:11517452. |
arginine (arg), injected intraperitoneally into rainbow trout (oncorhynchus mykiss), increases plasma concentrations of glucagon, glucagon-like peptide-1 (glp-1), and insulin by three- to 10-fold. |
2001-10-18 |
2023-08-12 |
rabbit |
| T P Mommsen, T W Moon, E M Plisetskay. Effects of arginine on pancreatic hormones and hepatic metabolism in rainbow trout. Physiological and biochemical zoology : PBZ. vol 74. issue 5. 2001-10-18. PMID:11517452. |
resulting ratios of glucagon and glp-1 over insulin are unchanged in 20-d food-deprived fish (saline, 1.28 vs. arg, 0.93; not significant) while slightly increased in feeding trout (saline, 0.70 vs. arg, 0.92; p<0.05). |
2001-10-18 |
2023-08-12 |
rabbit |
| T P Mommsen, T W Moon, E M Plisetskay. Effects of arginine on pancreatic hormones and hepatic metabolism in rainbow trout. Physiological and biochemical zoology : PBZ. vol 74. issue 5. 2001-10-18. PMID:11517452. |
surprisingly, complete removal of insulin does not have immediate altering or detrimental effects on key metabolites and metabolic pathways, even if glucagon and glp-1 concentrations are concurrently several-fold higher than usual. |
2001-10-18 |
2023-08-12 |
rabbit |
| B Gebhard, J J Holst, C Biegelmayer, J Miholi. Postprandial GLP-1, norepinephrine, and reactive hypoglycemia in dumping syndrome. Digestive diseases and sciences. vol 46. issue 9. 2001-10-18. PMID:11575444. |
the plasma concentrations of norepinephrine, glp-1, gip, glucagon, insulin, and glucose were measured following a 1.5 g/kg lean body mass glucose meal. |
2001-10-18 |
2023-08-12 |
Not clear |
| B Gebhard, J J Holst, C Biegelmayer, J Miholi. Postprandial GLP-1, norepinephrine, and reactive hypoglycemia in dumping syndrome. Digestive diseases and sciences. vol 46. issue 9. 2001-10-18. PMID:11575444. |
insulin peaked after 60 min and correlated with early glp-1. |
2001-10-18 |
2023-08-12 |
Not clear |
| J Cancelas, M L Villanueva-Peñacarrillo, I Valverde, W J Malaiss. Synergistic insulinotropic effects of succinic acid dimethyl ester and exendin-4 in anaesthetized rats. International journal of molecular medicine. vol 8. issue 3. 2001-10-04. PMID:11494054. |
in such a perspective, the present study aimed mainly at investigating whether exendin-4 (ex-4), a peptide structurally related to glp-1(7-36)amide, and succinic acid dimethyl ester (sad) also act synergistically upon insulin secretion in anaesthetized rats. |
2001-10-04 |
2023-08-12 |
rat |