| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Cancelas, M L Villanueva-Peñacarrillo, I Valverde, W J Malaiss. Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of L-glutamic acid in a type 2 diabetes animal model. Endocrine. vol 16. issue 2. 2002-09-03. PMID:11887931. |
each ester augmented plasma insulin concentration and potentiated and/or prolonged the insulinotropic action of glucagon-like peptide 1 (glp-1) injected intravenously (5 pmol/g of body wt) at min 5 of the test. |
2002-09-03 |
2023-08-12 |
rat |
| José L Soengas, Manuel Aldegund. Energy metabolism of fish brain. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 131. issue 3. 2002-09-03. PMID:11959012. |
furthermore, several studies demonstrate effects of melatonin, insulin, glucagon, glp-1, cortisol or catecholamines on energy parameters of teleost brain, although in most cases the results are quite preliminary being difficult to relate the effects of those hormones to physiological situations. |
2002-09-03 |
2023-08-12 |
Not clear |
| Josephine M Egan, Graydon S Meneilly, Joel F Habener, Dariush Elah. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161508. |
after the glp-1 study, each individual's plasma insulin level was measured. |
2002-08-30 |
2023-08-12 |
human |
| Josephine M Egan, Graydon S Meneilly, Joel F Habener, Dariush Elah. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161508. |
a second study was performed that was identical to the first, with the infusion of regular insulin in place of glp-1. |
2002-08-30 |
2023-08-12 |
human |
| Josephine M Egan, Graydon S Meneilly, Joel F Habener, Dariush Elah. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161508. |
insulin infusion rates were regulated in each individual to simulate plasma insulin levels produced during the glp-1 infusion. |
2002-08-30 |
2023-08-12 |
human |
| Josephine M Egan, Graydon S Meneilly, Joel F Habener, Dariush Elah. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161508. |
in response to the glp-1 infusion, with maintenance of plasma glucose level clamped at fasting level, significant increases in plasma insulin occurred in all subjects (p < 0.001). |
2002-08-30 |
2023-08-12 |
human |
| Josephine M Egan, Graydon S Meneilly, Joel F Habener, Dariush Elah. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161508. |
the insulin levels during the insulin infusion study were similar to that induced by glp-1. |
2002-08-30 |
2023-08-12 |
human |
| Josephine M Egan, Graydon S Meneilly, Joel F Habener, Dariush Elah. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161508. |
the rate of disappearance of glucose (insulin-mediated glucose uptake) progressively increased in response to both the glp-1 and insulin infusion. |
2002-08-30 |
2023-08-12 |
human |
| Josephine M Egan, Graydon S Meneilly, Joel F Habener, Dariush Elah. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161508. |
however, the rate of disappearance of glucose during the glp-1 study was significantly higher (p = 0.033) than during the insulin study. |
2002-08-30 |
2023-08-12 |
human |
| N T Lam, T J Kieffe. The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent. Minerva endocrinologica. vol 27. issue 2. 2002-08-19. PMID:11961501. |
glp-1, released from intestinal l-cells, is renowned for its potent stimulation of insulin biosynthesis and release from pancreatic b-cells. |
2002-08-19 |
2023-08-12 |
human |
| N T Lam, T J Kieffe. The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent. Minerva endocrinologica. vol 27. issue 2. 2002-08-19. PMID:11961501. |
exogenous administration of glp-1 to subjects with type 2 diabetes results in the normalization of plasma glucose concentrations, in part, as a result of augmented glucose-stimulated insulin secretion. |
2002-08-19 |
2023-08-12 |
human |
| N T Lam, T J Kieffe. The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent. Minerva endocrinologica. vol 27. issue 2. 2002-08-19. PMID:11961501. |
glp-1 also reduces plasma glucose levels by suppressing glucagon secretion from pancreatic a-cells and potentially by improving insulin sensitivity in peripheral tissues. |
2002-08-19 |
2023-08-12 |
human |
| N T Lam, T J Kieffe. The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent. Minerva endocrinologica. vol 27. issue 2. 2002-08-19. PMID:11961501. |
further-more, glp-1 upregulates expression of b-cell genes (glut2, glucokinase, insulin, and pdx-1) and promotes b-cell neogenesis and differentiation of ductal cells into insulin secreting cells. |
2002-08-19 |
2023-08-12 |
human |
| L Márquez, N González, J Puente, L Valverde, M L Villanueva-Peñacarrill. GLP-1 effect upon the GPI/IPG system in adipocytes and hepatocytes from diabetic rats. Diabetes, nutrition & metabolism. vol 14. issue 5. 2002-08-15. PMID:11806463. |
glp-1, as insulin, modulates the content of glycosylphosphatidylinositols (gpis)--precursors of inositolphosphoglycans (ipgs), considered mediators of insulin action--in several extrapancreatic cell lines and in normal rat hepatocytes and adipocytes. |
2002-08-15 |
2023-08-12 |
rat |
| L Márquez, N González, J Puente, L Valverde, M L Villanueva-Peñacarrill. GLP-1 effect upon the GPI/IPG system in adipocytes and hepatocytes from diabetic rats. Diabetes, nutrition & metabolism. vol 14. issue 5. 2002-08-15. PMID:11806463. |
in the present paper, we document that in a streptozotocin-induced type 2 diabetic rat model, glp-1, as insulin, provokes a rapid decrease of the [myo-3h-inositol]gpi content in isolated adipocytes--indicative of its hydrolysis and immediate short-lived generation of ipg--as that previously observed in normal animals; in hepatocytes, glp-1, but not insulin, induced a reduction in the cellular gpi, although delayed in relation to normal rats. |
2002-08-15 |
2023-08-12 |
rat |
| L Márquez, N González, J Puente, L Valverde, M L Villanueva-Peñacarrill. GLP-1 effect upon the GPI/IPG system in adipocytes and hepatocytes from diabetic rats. Diabetes, nutrition & metabolism. vol 14. issue 5. 2002-08-15. PMID:11806463. |
in adipocytes from streptozotocin-induced type 1 diabetic rats, glp-1, as insulin, seems to induce a reduction in the cellular gpi content, which was smaller and occurred later than that provoked in the type 2 diabetic model; in the hepatocytes, glp-1 and insulin failed to affect the control gpi content at any time tested. |
2002-08-15 |
2023-08-12 |
rat |
| L Márquez, N González, J Puente, L Valverde, M L Villanueva-Peñacarrill. GLP-1 effect upon the GPI/IPG system in adipocytes and hepatocytes from diabetic rats. Diabetes, nutrition & metabolism. vol 14. issue 5. 2002-08-15. PMID:11806463. |
in type 2 diabetic rat, the hepatocyte retains its response capability to glp-1, but not to insulin, suggesting that the peptide could be bypassing possible defective steps in the insulin signaling pathway in the liver of this diabetic model. |
2002-08-15 |
2023-08-12 |
rat |
| Oleg G Chepurny, George G Hol. Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation. Cell and tissue research. vol 307. issue 2. 2002-08-15. PMID:11845326. |
to develop transplantable beta-cell lines for the treatment of diabetes mellitus, we have taken advantage of the property of ins-1 cells to synthesize and secrete not only insulin, but also small quantities of the insulinotropic hormone glucagon-like peptide-1 (glp-1). |
2002-08-15 |
2023-08-12 |
rat |
| Oleg G Chepurny, George G Hol. Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation. Cell and tissue research. vol 307. issue 2. 2002-08-15. PMID:11845326. |
in ins-1 cells over-expressing the beta-cell glp-1 receptor (glp-1-r), we have shown, by radioimmune assay and bioassay of conditioned medium, that an autocrine signaling mechanism of hormone action exists whereby self-secreted glp-1 acts as a competence factor in support of insulin gene transcription. |
2002-08-15 |
2023-08-12 |
rat |
| Oleg G Chepurny, George G Hol. Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation. Cell and tissue research. vol 307. issue 2. 2002-08-15. PMID:11845326. |
thus, ins-1 cells over-expressing the glp-1-r recapitulate the incretin hormone effect of circulating glp-1, thereby providing a possible strategy by which beta-cell lines may be engineered for efficient glucose-dependent insulin biosynthesis and secretion. |
2002-08-15 |
2023-08-12 |
rat |