| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander Stark, Rolf Mentlei. Somatostatin inhibits glucagon-like peptide-1-induced insulin secretion and proliferation of RINm5F insulinoma cells. Regulatory peptides. vol 108. issue 2-3. 2003-04-10. PMID:12220732. |
glucagon-like peptide-1 [glp-1; formerly glp-1(7-36)amide] and somatostatin (ss) are two postprandially or paracrine released peptide hormones that regulate insulin secretion from pancreatic islets. |
2003-04-10 |
2023-08-12 |
rat |
| Alexander Stark, Rolf Mentlei. Somatostatin inhibits glucagon-like peptide-1-induced insulin secretion and proliferation of RINm5F insulinoma cells. Regulatory peptides. vol 108. issue 2-3. 2003-04-10. PMID:12220732. |
glp-1 stimulated insulin release, cell proliferation, intracellular camp accumulation and activation of the transcription factor camp-response element binding protein (creb) which all could be reduced to basal values by co-incubation with ss. |
2003-04-10 |
2023-08-12 |
rat |
| Alexander Stark, Rolf Mentlei. Somatostatin inhibits glucagon-like peptide-1-induced insulin secretion and proliferation of RINm5F insulinoma cells. Regulatory peptides. vol 108. issue 2-3. 2003-04-10. PMID:12220732. |
the experiments show that glp-1 and ss are perfect opponents for regulating pancreatic beta-cell insulin secretion. |
2003-04-10 |
2023-08-12 |
rat |
| Lise L Kjems, Jens J Holst, Aage Vølund, Sten Madsba. The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes. vol 52. issue 2. 2003-04-07. PMID:12540611. |
the influence of glp-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. |
2003-04-07 |
2023-08-12 |
human |
| Lise L Kjems, Jens J Holst, Aage Vølund, Sten Madsba. The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes. vol 52. issue 2. 2003-04-07. PMID:12540611. |
the intestinally derived hormone glucagon-like peptide 1 (glp-1) (7-36 amide) has potent effects on glucose-mediated insulin secretion, insulin gene expression, and beta-cell growth and differentiation. |
2003-04-07 |
2023-08-12 |
human |
| Lise L Kjems, Jens J Holst, Aage Vølund, Sten Madsba. The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes. vol 52. issue 2. 2003-04-07. PMID:12540611. |
however, the dose-response relationship between glp-1 and basal and glucose-stimulated prehepatic insulin secretion rate (isr) is currently not known. |
2003-04-07 |
2023-08-12 |
human |
| Lise L Kjems, Jens J Holst, Aage Vølund, Sten Madsba. The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes. vol 52. issue 2. 2003-04-07. PMID:12540611. |
our results show that glp-1 increases insulin secretion in patients with type 2 diabetes and control subjects in a dose-dependent manner and that the beta-cell responsiveness to glucose may be increased to normal levels with a low dose of glp-1 infusion. |
2003-04-07 |
2023-08-12 |
human |
| Joo-Won Lee, Andrew G Swick, Dale R Romso. Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway. Experimental biology and medicine (Maywood, N.J.). vol 228. issue 2. 2003-03-13. PMID:12563024. |
stimulation of insulin secretion with glp-1, forskolin (an activator of adenylyl cyclase), or ibmx (an inhibitor of pde) did not cause hypersecretion of insulin from islets of young lep(ob)/lep(ob)mice, and leptin did not inhibit glp-1-induced insulin secretion from islets of these mice. |
2003-03-13 |
2023-08-12 |
mouse |
| T Vilsbøll, T Krarup, S Madsbad, J J Hols. Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients. Diabetologia. vol 45. issue 8. 2003-02-25. PMID:12189441. |
our investigation evaluated "early" (protocol 1) - and "late phase" (protocol 2) insulin and c-peptide responses to glp-1 and gip stimulation in patients with type ii diabetes. |
2003-02-25 |
2023-08-12 |
Not clear |
| Jens J Hols. Gastric inhibitory polypeptide analogues: do they have a therapeutic role in diabetes mellitus similar to that of glucagon-like Peptide-1? BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 16. issue 3. 2003-02-24. PMID:12102645. |
gastric inhibitory polypeptide (gip, also called glucose-dependent insulinotropic polypeptide) and glucagon-like peptide-1 (glp-1) are peptide hormones from the gut that enhance nutrient-stimulated insulin secretion (the 'incretin' effect). |
2003-02-24 |
2023-08-12 |
mouse |
| Takashi Tsuboi, Gabriela da Silva Xavier, George G Holz, Laurence S Jouaville, Andrew P Thomas, Guy A Rutte. Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells. The Biochemical journal. vol 369. issue Pt 2. 2003-02-21. PMID:12410638. |
glucagon-like peptide-1 (glp-1) is a potent regulator of glucose-stimulated insulin secretion whose mechanisms of action are only partly understood. |
2003-02-21 |
2023-08-12 |
Not clear |
| Takashi Tsuboi, Gabriela da Silva Xavier, George G Holz, Laurence S Jouaville, Andrew P Thomas, Guy A Rutte. Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells. The Biochemical journal. vol 369. issue Pt 2. 2003-02-21. PMID:12410638. |
taken together, these results demonstrate that glp-1 potentiates glucose-stimulated insulin release in part via the mobilization of intracellular ca(2+), and the stimulation of mitochondrial atp synthesis. |
2003-02-21 |
2023-08-12 |
Not clear |
| Juris J Meier, Michael A Nauck, Wolfgang E Schmidt, Baptist Gallwit. Gastric inhibitory polypeptide: the neglected incretin revisited. Regulatory peptides. vol 107. issue 1-3. 2003-02-13. PMID:12137960. |
however, the physiological importance of gip in the regulation of insulin secretion has been shown to even exceed that of glp-1. |
2003-02-13 |
2023-08-12 |
Not clear |
| Yazhou Li, Tanya Hansotia, Bernardo Yusta, Frederic Ris, Philippe A Halban, Daniel J Drucke. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. The Journal of biological chemistry. vol 278. issue 1. 2003-02-10. PMID:12409292. |
glucagon-like peptide-1 (glp-1) stimulates insulin secretion and augments beta cell mass via activation of beta cell proliferation and islet neogenesis. |
2003-02-10 |
2023-08-12 |
mouse |
| Yazhou Li, Tanya Hansotia, Bernardo Yusta, Frederic Ris, Philippe A Halban, Daniel J Drucke. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. The Journal of biological chemistry. vol 278. issue 1. 2003-02-10. PMID:12409292. |
mice administered streptozotocin (stz), an agent known to induce beta cell apoptosis, exhibit sustained improvement in glycemic control and increased levels of plasma insulin with concomitant administration of the glp-1 agonist exendin-4 (ex-4). |
2003-02-10 |
2023-08-12 |
mouse |
| Barbara A Cunningham, Ann-Marie T Richard, Joseph S Dillon, Jennifer T Daley, Vildan N Civelek, Jude T Deeney, Gordon C Yaney, Barbara E Corkey, Keith Tornhei. Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets. The Biochemical journal. vol 369. issue Pt 1. 2003-01-31. PMID:12356335. |
glp-1 increased the amplitude of pulses and the magnitude of insulin secretion from the perifused islets, without affecting the average time interval between pulses. |
2003-01-31 |
2023-08-12 |
rat |
| Barbara A Cunningham, Ann-Marie T Richard, Joseph S Dillon, Jennifer T Daley, Vildan N Civelek, Jude T Deeney, Gordon C Yaney, Barbara E Corkey, Keith Tornhei. Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets. The Biochemical journal. vol 369. issue Pt 1. 2003-01-31. PMID:12356335. |
these data show that the physiological incretin glp-1 preserves and enhances normal pulsatile insulin secretion, which may be essential in proposed therapeutic uses of glp-1 or its analogues. |
2003-01-31 |
2023-08-12 |
rat |
| Tadashi Nagakura, Nobuyuki Yasuda, Kazuto Yamazaki, Hironori Ikuta, Isao Tanak. Enteroinsular axis of db/db mice and efficacy of dipeptidyl peptidase IV inhibition. Metabolism: clinical and experimental. vol 52. issue 1. 2003-01-31. PMID:12524666. |
in this study, using c57blks/j-db/db (db/db) mice as a model of type 2 diabetes, we examined the effect of acute dppiv inhibition on glucose tolerance at the early and later stages of diabetes, determining plasma active glp-1 and insulin levels. |
2003-01-31 |
2023-08-12 |
mouse |
| Tadashi Nagakura, Nobuyuki Yasuda, Kazuto Yamazaki, Hironori Ikuta, Isao Tanak. Enteroinsular axis of db/db mice and efficacy of dipeptidyl peptidase IV inhibition. Metabolism: clinical and experimental. vol 52. issue 1. 2003-01-31. PMID:12524666. |
the administration of valine-pyrrolidide, a dppiv inhibitor, resulted in potentiated insulin secretion mediated by increased endogenous glp-1 action, leading to improved glucose tolerance in db/db mice at 6 weeks of age. |
2003-01-31 |
2023-08-12 |
mouse |
| Tadashi Nagakura, Nobuyuki Yasuda, Kazuto Yamazaki, Hironori Ikuta, Isao Tanak. Enteroinsular axis of db/db mice and efficacy of dipeptidyl peptidase IV inhibition. Metabolism: clinical and experimental. vol 52. issue 1. 2003-01-31. PMID:12524666. |
however, although acute dppiv inhibition with valine-pyrrolidide resulted in higher plasma active glp-1 and insulin levels in db/db mice at 23 weeks of age, it did not improve glucose tolerance. |
2003-01-31 |
2023-08-12 |
mouse |