| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Vilsbøll, T Krarup, J Sonne, S Madsbad, A Vølund, A G Juul, J J Hols. Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 88. issue 6. 2003-07-01. PMID:12788877. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are incretin hormones secreted in response to meal ingestion, thereby enhancing postprandial insulin secretion. |
2003-07-01 |
2023-08-12 |
human |
| T Vilsbøll, T Krarup, J Sonne, S Madsbad, A Vølund, A G Juul, J J Hols. Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 88. issue 6. 2003-07-01. PMID:12788877. |
we conclude: 1) that a decreased glp-1 secretion may contribute to impaired insulin secretion in type 2 diabetes mellitus, whereas gip and glp-1 secretion is normal in type 1 diabetic patients; and 2) that it is possible to modulate the beta-cell sensitivity to glucose in obese healthy subjects, and possibly also in type 2 diabetic patients, by giving them a large meal, compared with a small meal. |
2003-07-01 |
2023-08-12 |
human |
| Juris J Meier, Baptist Gallwitz, Stefan Salmen, Oliver Goetze, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. The Journal of clinical endocrinology and metabolism. vol 88. issue 6. 2003-07-01. PMID:12788879. |
blood was drawn for glucose, insulin, c-peptide, glucagon, and glp-1 determinations. |
2003-07-01 |
2023-08-12 |
Not clear |
| Juris J Meier, Baptist Gallwitz, Stefan Salmen, Oliver Goetze, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. The Journal of clinical endocrinology and metabolism. vol 88. issue 6. 2003-07-01. PMID:12788879. |
insulin and c-peptide concentrations dose-dependently rose during glp-1 infusion in the fasting state (p < 0.05), but were dose-dependently reduced by glp-1 after meal ingestion (p = 0.0031 and 0.0074, respectively). |
2003-07-01 |
2023-08-12 |
Not clear |
| b' Tatjana Radosavljevi\\xc4\\x87, Vera Todorovi\\xc4\\x87, Branka Siki\\xc4\\x8. [Role of glucagon-like peptide 1 (GLP-1) in regulation of insulin secretion]. Srpski arhiv za celokupno lekarstvo. vol 130. issue 11-12. 2003-06-26. PMID:12751170.' |
[role of glucagon-like peptide 1 (glp-1) in regulation of insulin secretion]. |
2003-06-26 |
2023-08-12 |
Not clear |
| Shiue-Cheng Tang, Athanassios Sambani. Development of genetically engineered human intestinal cells for regulated insulin secretion using rAAV-mediated gene transfer. Biochemical and biophysical research communications. vol 303. issue 2. 2003-06-20. PMID:12659868. |
in this work, we established a human cellular model to demonstrate that meat hydrolysate can simultaneously stimulate glucagon-like peptide-1 (glp-1, an enteroendocrine cell-derived incretin hormone) and recombinant insulin secretion from the engineered human nci-h716 intestinal cell line. |
2003-06-20 |
2023-08-12 |
human |
| Shiue-Cheng Tang, Athanassios Sambani. Development of genetically engineered human intestinal cells for regulated insulin secretion using rAAV-mediated gene transfer. Biochemical and biophysical research communications. vol 303. issue 2. 2003-06-20. PMID:12659868. |
a fusion protein of insulin and enhanced green fluorescence protein (egfp) was designed to reveal the compartments of localization of the fusion protein and assess its co-localization with endogenous glp-1. |
2003-06-20 |
2023-08-12 |
human |
| C Beysen, F Karpe, B A Fielding, A Clark, J C Levy, K N Fray. Interaction between specific fatty acids, GLP-1 and insulin secretion in humans. Diabetologia. vol 45. issue 11. 2003-06-16. PMID:12436337. |
interaction between specific fatty acids, glp-1 and insulin secretion in humans. |
2003-06-16 |
2023-08-12 |
Not clear |
| Hiroshi Yamamoto, Toshiro Kishi, Charlotte E Lee, Brian J Choi, Hui Fang, Anthony N Hollenberg, Daniel J Drucker, Joel K Elmquis. Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684481. |
glucagon-like peptide-1 (glp-1) released from the gut is an incretin that stimulates insulin secretion. |
2003-05-30 |
2023-08-12 |
rat |
| Nathalie Pamir, Francis C Lynn, Alison M J Buchan, Jan Ehses, Simon A Hinke, J Andrew Pospisilik, Kazumasa Miyawaki, Yuichiro Yamada, Yutaka Seino, Christopher H S McIntosh, Raymond A Pederso. Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis. American journal of physiology. Endocrinology and metabolism. vol 284. issue 5. 2003-05-21. PMID:12540373. |
the incretins glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) are gut hormones that act via the enteroinsular axis to potentiate insulin secretion from the pancreas in a glucose-dependent manner. |
2003-05-21 |
2023-08-12 |
mouse |
| Nathalie Pamir, Francis C Lynn, Alison M J Buchan, Jan Ehses, Simon A Hinke, J Andrew Pospisilik, Kazumasa Miyawaki, Yuichiro Yamada, Yutaka Seino, Christopher H S McIntosh, Raymond A Pederso. Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis. American journal of physiology. Endocrinology and metabolism. vol 284. issue 5. 2003-05-21. PMID:12540373. |
although serum total glp-1 levels in gipr knockout mice were unaltered, insulin responses to glp-1 from pancreas perfusions and static islet incubations were significantly greater (40-60%) in gipr(-/-) than in wild-type (gipr(+/+)) mice. |
2003-05-21 |
2023-08-12 |
mouse |
| Nathalie Pamir, Francis C Lynn, Alison M J Buchan, Jan Ehses, Simon A Hinke, J Andrew Pospisilik, Kazumasa Miyawaki, Yuichiro Yamada, Yutaka Seino, Christopher H S McIntosh, Raymond A Pederso. Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis. American journal of physiology. Endocrinology and metabolism. vol 284. issue 5. 2003-05-21. PMID:12540373. |
in conclusion, gipr(-/-) mice exhibit altered islet structure and topography and increased islet sensitivity to glp-1 despite a decrease in pancreatic insulin content and gene expression. |
2003-05-21 |
2023-08-12 |
mouse |
| Kazuro Yaekura, Richard Julyan, Barton L Wicksteed, Lori B Hays, Cristina Alarcon, Scott Sommers, Vincent Poitout, Denis G Baskin, Yong Wang, Louis H Philipson, Christopher J Rhode. Insulin secretory deficiency and glucose intolerance in Rab3A null mice. The Journal of biological chemistry. vol 278. issue 11. 2003-05-14. PMID:12510060. |
however, in isolated islets, secretagogue-induced insulin release (by glucose, glp-1, glyburide, or fatty acid) was approximately 60-70% lower in rab3a(-/-) islets compared with rab3a(+/+) controls. |
2003-05-14 |
2023-08-12 |
mouse |
| O Schmitz, B Brock, M Hollingdal, C B Juhl, N Pørkse. High-frequency insulin pulsatility and type 2 diabetes: from physiology and pathophysiology to clinical pharmacology. Diabetes & metabolism. vol 28. issue 6 Suppl. 2003-05-14. PMID:12703061. |
the influence of repaglinide, thiazolidinediones and a potential future antidiabetic compound (glp-1) on pulsatile insulin secretion is also discussed briefly. |
2003-05-14 |
2023-08-12 |
human |
| Torsten P Vahl, Breay W Paty, Bradley D Fuller, Ronald L Prigeon, David A D'Alessi. Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans. The Journal of clinical endocrinology and metabolism. vol 88. issue 4. 2003-05-09. PMID:12679472. |
glucagon-like peptide 1 (glp-1) is an insulin secretagogue synthesized in the intestine and released in response to meal ingestion. |
2003-05-09 |
2023-08-12 |
human |
| Torsten P Vahl, Breay W Paty, Bradley D Fuller, Ronald L Prigeon, David A D'Alessi. Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans. The Journal of clinical endocrinology and metabolism. vol 88. issue 4. 2003-05-09. PMID:12679472. |
it is secreted primarily in two forms, glp-1-(7-37) and glp-1-(7-36)nh(2), both of which bind to a specific glp-1 receptor (glp-1r) on the pancreatic beta-cell and augment glucose-stimulated insulin secretion. |
2003-05-09 |
2023-08-12 |
human |
| Torsten P Vahl, Breay W Paty, Bradley D Fuller, Ronald L Prigeon, David A D'Alessi. Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans. The Journal of clinical endocrinology and metabolism. vol 88. issue 4. 2003-05-09. PMID:12679472. |
in a second set of experiments, 10 healthy subjects had glucose-stimulated insulin secretion measured during an infusion of glp-1-(7-36)nh(2) alone or with a simultaneous infusion of glp-1-(9-36)nh(2) that increased plasma levels approximately 10-fold over those produced by unmetabolized glp-1. |
2003-05-09 |
2023-08-12 |
human |
| K Tateishi, N Kitayama, H Ishikawa, A Mitsudome, S Hiros. Effect of growth hormone on high plasma levels of glucagon-like peptide-1 (GLP-1) in hypophysectomized rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 110. issue 7. 2003-04-23. PMID:12397536. |
to examine the influence of pituitary hormones on plasma glp-1 levels, concentrations of plasma glucose, insulin and glp-1 after an oral glucose load to hypox rats that were given either rat growth hormone (rgh) (n = 7), cortisol and thyroxine (n = 7) or no substitution (n = 6) were compared with those of normal rats (n = 7). |
2003-04-23 |
2023-08-12 |
rat |
| K Tateishi, N Kitayama, H Ishikawa, A Mitsudome, S Hiros. Effect of growth hormone on high plasma levels of glucagon-like peptide-1 (GLP-1) in hypophysectomized rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 110. issue 7. 2003-04-23. PMID:12397536. |
insulin levels both in the fasting state and after the glucose ingestion were significantly decreased in hypox rats and the fasting and total glp-1 levels were significantly increased in those rats. |
2003-04-23 |
2023-08-12 |
rat |
| K Tateishi, N Kitayama, H Ishikawa, A Mitsudome, S Hiros. Effect of growth hormone on high plasma levels of glucagon-like peptide-1 (GLP-1) in hypophysectomized rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 110. issue 7. 2003-04-23. PMID:12397536. |
rgh substitution significantly increased the total insulin levels in hypox rats and decreased the fasting and total glp-1 levels closely to levels in normal rats, while substitution with cortisol and thyroxine failed to introduce such a significant effect. |
2003-04-23 |
2023-08-12 |
rat |