| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| João C Miguel, Yasser H A Abdel-Wahab, Brian D Green, Paulo C F Mathias, Peter R Flat. Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity. Biochemical pharmacology. vol 65. issue 2. 2003-01-24. PMID:12504804. |
glp-1 (20 nm) and ach (100 microm) increased insulin secretion by 24-47%, whereas in combination there was a further 89% enhancement of insulin release. |
2003-01-24 |
2023-08-12 |
Not clear |
| João C Miguel, Yasser H A Abdel-Wahab, Brian D Green, Paulo C F Mathias, Peter R Flat. Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity. Biochemical pharmacology. vol 65. issue 2. 2003-01-24. PMID:12504804. |
effects of selective muscarinic receptor antagonists on the concentration-dependent insulinotropic actions of ach (50 nm-1 mm) on 20 nm glp-1 induced insulin secretion revealed inhibition by rho-fhhsid (m3 antagonist, p<0.05), stimulation with pirenzepine (m1 antagonist, p<0.001) and no significant effects of either methoctramine (m2 antagonist) or mt-3 (m4 antagonist). |
2003-01-24 |
2023-08-12 |
Not clear |
| João C Miguel, Yasser H A Abdel-Wahab, Brian D Green, Paulo C F Mathias, Peter R Flat. Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity. Biochemical pharmacology. vol 65. issue 2. 2003-01-24. PMID:12504804. |
these data indicate an important functional cooperation between the cholinergic neurotransmitter ach and the incretin hormone glp-1 on insulin secretion mediated through the m3 muscarinic receptor subtype. |
2003-01-24 |
2023-08-12 |
Not clear |
| Erik Näslund, Staffan Skogar, Suad Efendic, Per M Hellströ. Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin. Regulatory peptides. vol 106. issue 1-3. 2003-01-23. PMID:12047915. |
plasma insulin concentrations were not different from controls during infusion of ly315902 or glp-1, while somatostatin concentrations were significantly higher during ly315902 and glp-1 compared to saline. |
2003-01-23 |
2023-08-12 |
rat |
| Erik Näslund, Staffan Skogar, Suad Efendic, Per M Hellströ. Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin. Regulatory peptides. vol 106. issue 1-3. 2003-01-23. PMID:12047915. |
ly315902 has a longer duration of inhibitory action on the mmc than glp-1, albeit similar effects on plasma insulin and somatostatin concentrations. |
2003-01-23 |
2023-08-12 |
rat |
| Michael Stumvoll, Andreas Fritsche, Hans-Ulrich Härin. Clinical characterization of insulin secretion as the basis for genetic analyses. Diabetes. vol 51 Suppl 1. 2003-01-17. PMID:11815470. |
we also showed that normal glucose-tolerant carriers of the gly972arg polymorphism in the insulin receptor substrate 1 have significantly reduced insulin secretion in response to glucose and arginine but not to glp-1. |
2003-01-17 |
2023-08-12 |
human |
| Andreas Fritsche, Alexander Madaus, Norbert Stefan, Otto Tschritter, Elke Maerker, Anna Teigeler, Hans Häring, Michael Stumvol. Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans. Diabetes. vol 51 Suppl 1. 2003-01-17. PMID:11815485. |
we studied insulin and proinsulin secretion in nondiabetic subjects during an oral glucose tolerance test (ogtt) using published indexes of beta-cell function (n = 379, age 16--68 years) and a modified hyperglycemic clamp (10 mmol/l, additional glucagon-like peptide [glp-1] infusion, final arginine bolus; n = 50, age 19--68 years). |
2003-01-17 |
2023-08-12 |
human |
| Chantal Simon, Gabrielle Brandenberge. Ultradian oscillations of insulin secretion in humans. Diabetes. vol 51 Suppl 1. 2003-01-17. PMID:11815489. |
also, the latter were not related to either the ultradian oscillations in sympathoagal balance, as inferred from spectral analysis of cardiac r-r intervals, or the plasma fluctuations of glucagon-like peptide-1 (glp-1), an incretin hormone known to potentiate glucose-stimulated insulin. |
2003-01-17 |
2023-08-12 |
Not clear |
| Zhiyong Gao, Robert A Young, Matteo M Trucco, Scott R Greene, Erik L Hewlett, Franz M Matschinsky, Bryan A Wol. Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis. The Biochemical journal. vol 368. issue Pt 2. 2003-01-17. PMID:12180908. |
in conclusion, glucose and glp-1 amplify insulin secretion via camp production and pkabeta activation. |
2003-01-17 |
2023-08-12 |
Not clear |
| Ayako Sato, Pi-Chao Wang, Hisako Ohgawar. Effect of stimulators such as GLP-1, PACAP, and nicotinamide on glucose-stimulated insulin secretion from porcine pancreatic endocrine cells in long-term culture. Pancreas. vol 25. issue 1. 2003-01-10. PMID:12131777. |
effect of stimulators such as glp-1, pacap, and nicotinamide on glucose-stimulated insulin secretion from porcine pancreatic endocrine cells in long-term culture. |
2003-01-10 |
2023-08-12 |
Not clear |
| Susan C Campbell, Wendy M Macfarlan. Regulation of the pdx1 gene promoter in pancreatic beta-cells. Biochemical and biophysical research communications. vol 299. issue 2. 2003-01-09. PMID:12437983. |
the current study has established the fact that glucose, glp-1, insulin, t(3), hb-egf, and tnf-alpha all positively regulate the pdx1 gene promoter in pancreatic beta-cells. |
2003-01-09 |
2023-08-12 |
Not clear |
| Patrick E MacDonald, Wasim El-Kholy, Michael J Riedel, Anne Marie F Salapatek, Peter E Light, Michael B Wheele. The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes. vol 51 Suppl 3. 2003-01-08. PMID:12475787. |
the multiple actions of glp-1 on the process of glucose-stimulated insulin secretion. |
2003-01-08 |
2023-08-12 |
Not clear |
| Patrick E MacDonald, Wasim El-Kholy, Michael J Riedel, Anne Marie F Salapatek, Peter E Light, Michael B Wheele. The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes. vol 51 Suppl 3. 2003-01-08. PMID:12475787. |
in the pancreas, glp-1 is now known to induce expansion of insulin-secreting beta-cell mass, in addition to its most well-characterized effect: the augmentation of glucose-stimulated insulin secretion. |
2003-01-08 |
2023-08-12 |
Not clear |
| Patrick E MacDonald, Wasim El-Kholy, Michael J Riedel, Anne Marie F Salapatek, Peter E Light, Michael B Wheele. The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes. vol 51 Suppl 3. 2003-01-08. PMID:12475787. |
glp-1 is believed to enhance insulin secretion through mechanisms involving the regulation of ion channels (including atp-sensitive k(+) channels, voltage-dependent ca(2+) channels, voltage-dependent k(+) channels, and nonselective cation channels) and by the regulation of intracellular energy homeostasis and exocytosis. |
2003-01-08 |
2023-08-12 |
Not clear |
| Patrick E MacDonald, Anne Marie F Salapatek, Michael B Wheele. Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism. Diabetes. vol 51 Suppl 3. 2003-01-08. PMID:12475788. |
glucagon-like peptide-1 (glp-1) acts through its g-protein-coupled receptor to enhance glucose-stimulated insulin secretion from pancreatic beta-cells. |
2003-01-08 |
2023-08-12 |
rat |
| Patrick E MacDonald, Anne Marie F Salapatek, Michael B Wheele. Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism. Diabetes. vol 51 Suppl 3. 2003-01-08. PMID:12475788. |
here, we report that glp-1 receptor signaling also regulates the activity of beta-cell voltage-dependent k(+) (k(v)) channels, themselves potent glucose-dependent regulators of insulin secretion. |
2003-01-08 |
2023-08-12 |
rat |
| Mitsuhiro Nakazaki, Ana Crane, Min Hu, Victor Seghers, Susanne Ullrich, Lydia Aguilar-Bryan, Joseph Brya. cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets. Diabetes. vol 51. issue 12. 2002-12-20. PMID:12453898. |
while investigating potential compensatory mechanisms, we found that incretins, specifically glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip), can increase the camp content of sur1ko islets but do not potentiate glucose-stimulated insulin release. |
2002-12-20 |
2023-08-12 |
mouse |
| Chiyo Shiota, Olof Larsson, Kathy D Shelton, Masakazu Shiota, Alexander M Efanov, Marianne Hoy, Jill Lindner, Suwattanee Kooptiwut, Lisa Juntti-Berggren, Jesper Gromada, Per-Olof Berggren, Mark A Magnuso. Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. The Journal of biological chemistry. vol 277. issue 40. 2002-11-20. PMID:12149271. |
because sur1 null mice lack an insulin secretory response to glp-1, even though their islets exhibit a normal rise in camp by glp-1, we tested their response to cholinergic stimulation. |
2002-11-20 |
2023-08-12 |
mouse |
| Linda Härndahl, Xing-Jun Jing, Rosita Ivarsson, Eva Degerman, Bo Ahrén, Vincent C Manganiello, Erik Renström, Lena Stenson Hols. Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin. The Journal of biological chemistry. vol 277. issue 40. 2002-11-20. PMID:12169692. |
cyclic amp potentiates glucose-stimulated insulin release and mediates the stimulatory effects of hormones such as glucagon-like peptide 1 (glp-1) on pancreatic beta-cells. |
2002-11-20 |
2023-08-12 |
rat |
| Linda Härndahl, Xing-Jun Jing, Rosita Ivarsson, Eva Degerman, Bo Ahrén, Vincent C Manganiello, Erik Renström, Lena Stenson Hols. Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin. The Journal of biological chemistry. vol 277. issue 40. 2002-11-20. PMID:12169692. |
further, the ability of glp-1 (100 nm) to augment glucose-stimulated insulin secretion was inhibited by approximately 30% (islets) and 70% (ins-1). |
2002-11-20 |
2023-08-12 |
rat |