| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Loredana Farilla, Hongxiang Hui, Cristina Bertolotto, Elizabeth Kang, Angela Bulotta, Umberto Di Mario, Riccardo Perfett. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology. vol 143. issue 11. 2002-11-19. PMID:12399437. |
in this study, we investigated the effect of glucagon-like peptide-1 (glp-1) in zucker diabetic rats, an animal model in which the onset of diabetes occurs when the proliferative potential and the rate of beta-cell apoptosis no longer compensate for the increased demand for insulin. |
2002-11-19 |
2023-08-12 |
rat |
| Loredana Farilla, Hongxiang Hui, Cristina Bertolotto, Elizabeth Kang, Angela Bulotta, Umberto Di Mario, Riccardo Perfett. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology. vol 143. issue 11. 2002-11-19. PMID:12399437. |
glp-1 produced a significant increase of insulin secretion, which was paralleled by a decrease in plasma glucose levels (p < 0.001 and p < 0.01, respectively). |
2002-11-19 |
2023-08-12 |
rat |
| Abba J Kastin, Victoria Akerstrom, Weihong Pa. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. Journal of molecular neuroscience : MN. vol 18. issue 1-2. 2002-11-08. PMID:11931352. |
glucagon-like peptide-1 (glp-1) reduces insulin requirement in diabetes mellitus and promotes satiety. |
2002-11-08 |
2023-08-12 |
mouse |
| Abba J Kastin, Victoria Akerstrom, Weihong Pa. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. Journal of molecular neuroscience : MN. vol 18. issue 1-2. 2002-11-08. PMID:11931352. |
lack of modulation by short-term fasting and some other ingestive peptides that may interact with glp-1, including leptin, glucagon, insulin, neuropeptide y, and melanin-concentrating hormone. |
2002-11-08 |
2023-08-12 |
mouse |
| Gunnar Gregersen, J J Holst, A Trankjaer, F Stadil, Anne M Mogense. Case report: somatostatin producing teratoma, causing rapidly alternating extreme hyperglycemia and hypoglycemia, and ovarian somatostatinoma. Metabolism: clinical and experimental. vol 51. issue 9. 2002-09-26. PMID:12200764. |
very high levels of somatostatin and low levels of insulin, c-peptide, gastric inhibitory peptide (gip), and glucagon-like peptide-1 (glp-1) in peripheral blood were constantly present. |
2002-09-26 |
2023-08-12 |
Not clear |
| F A Adatia, L L Baggio, Q Xiao, D J Drucker, P L Brubake. Cellular specificity of proexendin-4 processing in mammalian cells in vitro and in vivo. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193559. |
glucagon-like peptide-1 (glp-1) is a potent stimulator of glucose-dependent insulin secretion. |
2002-09-23 |
2023-08-12 |
mouse |
| Anandwardhan A Hardikar, Xiao Yang Wang, Lindy J Williams, Juliana Kwok, Rose Wong, Mu Yao, Bernard E Tuc. Functional maturation of fetal porcine beta-cells by glucagon-like peptide 1 and cholecystokinin. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193564. |
the incretin hormones glucagon-like peptide 1 (glp-1) and cholecystokinin (cck) are known to be released from the gut in response to oral feeding and enhance insulin secretion from pancreatic beta-cells. |
2002-09-23 |
2023-08-12 |
mouse |
| Anandwardhan A Hardikar, Xiao Yang Wang, Lindy J Williams, Juliana Kwok, Rose Wong, Mu Yao, Bernard E Tuc. Functional maturation of fetal porcine beta-cells by glucagon-like peptide 1 and cholecystokinin. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193564. |
we exposed fetal pig islet-like cell clusters (iccs) to 100 nm glp-1, 5 micro m cck, or 10 mm nicotinamide (nic; a positive control) for 6 h and demonstrated 3- and 1.7-fold increases in glucose-induced insulin secretion for glp-1 and cck, respectively. |
2002-09-23 |
2023-08-12 |
mouse |
| Anandwardhan A Hardikar, Xiao Yang Wang, Lindy J Williams, Juliana Kwok, Rose Wong, Mu Yao, Bernard E Tuc. Functional maturation of fetal porcine beta-cells by glucagon-like peptide 1 and cholecystokinin. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193564. |
in conclusion, glp-1 and cck have a dual effect on fetal pig iccs, causing maturation of glucose-induced insulin secretion from beta-cells as well as enhancement of differentiation from undifferentiated precursors. |
2002-09-23 |
2023-08-12 |
mouse |
| Hongxiang Hui, Run Yu, Corinne Bousquet, Riccardo Perfett. Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193567. |
glucagon-like peptide-1 (glp-1) is an incretin hormone derived from the proglucagon gene, capable of regulating the transcription of the three major genes that determine the pancreatic beta-cell-specific phenotype: insulin, glut-2, and glucokinase. |
2002-09-23 |
2023-08-12 |
mouse |
| Hongxiang Hui, Run Yu, Corinne Bousquet, Riccardo Perfett. Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193567. |
two constructs were generated: in one, the expression of glp-1 was under the control of the cytomegalovirus (cmv) promoter (cmv/glp-1), and the second was regulated by the rat insulin ii promoter (rip)/glp-1). |
2002-09-23 |
2023-08-12 |
mouse |
| Hongxiang Hui, Run Yu, Corinne Bousquet, Riccardo Perfett. Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193567. |
gene expression studies revealed that although cmv/glp-1 cells did not gain a greater glucose sensitivity as a result of the transfection with glp-1, compared with cells transfected with the plasmid alone, rip/glp-1 was capable of regulating the gene expression of insulin and glp-1 based on the concentration of glucose in the culture medium. |
2002-09-23 |
2023-08-12 |
mouse |
| Hongxiang Hui, Run Yu, Corinne Bousquet, Riccardo Perfett. Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193567. |
detection of the counterpart proteins (insulin and glp-1) in the culture medium paralleled the observation derived from the northern blot analysis. |
2002-09-23 |
2023-08-12 |
mouse |
| Hongxiang Hui, Run Yu, Corinne Bousquet, Riccardo Perfett. Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193567. |
glp-1 action was mediated by an idx-1 (islet/duodenum homeobox-1) dependent transactivation of the endogenous insulin promoter, as demonstrated by gel shift analysis. |
2002-09-23 |
2023-08-12 |
mouse |
| Hongxiang Hui, Run Yu, Corinne Bousquet, Riccardo Perfett. Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193567. |
finally, we observed that although the glp-1-dependent secretion of insulin was mediated by an increase in camp levels, the transcription of the insulin gene, in response to glp-1, was in large part camp independent. |
2002-09-23 |
2023-08-12 |
mouse |
| John A Pospisilik, Sara G Stafford, Hans-Ulrich Demuth, Christopher H S McIntosh, Raymond A Pederso. Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study. Diabetes. vol 51. issue 9. 2002-09-18. PMID:12196458. |
upon release into circulation, the potent insulin secretagogues glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) are rapidly cleaved and inactivated by the enzyme dipeptidyl peptidase iv (dp iv). |
2002-09-18 |
2023-08-12 |
rat |
| C Van Ginneken, K Verlinden, F Van Meir, S Sys, A Weyn. A stereologic evaluation of glucagon-like peptide-1 (GLP-1) mucosal cells in the small intestine of the developing pig. Anatomy and embryology. vol 205. issue 2. 2002-09-12. PMID:12021917. |
the development-related changes of the investigated parameters coincide with dietary changes and the regional differences are in accordance with functional reports that point to glp-1 as a gastrointestinal hormone that ediates the 'ileal brake' and stimulates glucose-dependent pancreatic insulin secretion. |
2002-09-12 |
2023-08-12 |
Not clear |
| Daniel M Kemp, Joel F Habene. Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications. Biochemical pharmacology. vol 64. issue 4. 2002-09-12. PMID:12167488. |
synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (glp-1)-stimulated insulin secretion and gene transcription in ins-1 cells: characterization and implications. |
2002-09-12 |
2023-08-12 |
rat |
| Daniel M Kemp, Joel F Habene. Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications. Biochemical pharmacology. vol 64. issue 4. 2002-09-12. PMID:12167488. |
glp-1 enhances both insulin secretion and insulin gene expression in a glucose-dependent manner via activation of its putative g-protein-coupled receptor on pancreatic beta-cells. |
2002-09-12 |
2023-08-12 |
rat |
| Daniel M Kemp, Joel F Habene. Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications. Biochemical pharmacology. vol 64. issue 4. 2002-09-12. PMID:12167488. |
these data suggest that glp-1 induces insulin gene transcription in a creb, crem, and atf-1-independent manner in beta-cells. |
2002-09-12 |
2023-08-12 |
rat |