| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Ahré. Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 286. issue 2. 2004-02-27. PMID:14707011. |
nevertheless, at the high dose of 10 nmol/kg, glp-1 augmented the insulin response to glucose in capsaicin-pretreated mice as efficiently as in control mice. |
2004-02-27 |
2023-08-12 |
mouse |
| Bo Ahré. Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 286. issue 2. 2004-02-27. PMID:14707011. |
the insulin response to glp-1 from isolated islets was not affected by neonatal capsaicin, and, furthermore, the in vivo insulin response to glucose was augmented whereas that to arginine was not affected by capsaicin. |
2004-02-27 |
2023-08-12 |
mouse |
| Bo Ahré. Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 286. issue 2. 2004-02-27. PMID:14707011. |
it is concluded that glp-1-induced insulin secretion at a low dose in mice is dependent on intact sensory nerves and therefore indirectly mediated and that this distinguishes glp-1 from other examined insulin secretagogues. |
2004-02-27 |
2023-08-12 |
mouse |
| Marian Dalgaard, Claus Thomsen, Birthe M Rasmussen, Jens J Holst, Kjeld Hermanse. Ethanol with a mixed meal decreases the incretin levels early postprandially and increases postprandial lipemia in type 2 diabetic patients. Metabolism: clinical and experimental. vol 53. issue 1. 2004-02-18. PMID:14681846. |
the incretins, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide 1 (glp-1), are important hormones from the gut that enhance nutrient-stimulated insulin secretion. |
2004-02-18 |
2023-08-12 |
human |
| Patrick E MacDonald, Xiaolin Wang, Fuzhen Xia, Wasim El-kholy, Elisha D Targonsky, Robert G Tsushima, Michael B Wheele. Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways. The Journal of biological chemistry. vol 278. issue 52. 2004-02-10. PMID:14565957. |
antagonism of voltage-dependent k+ (kv) currents in pancreatic beta-cells may contribute to the ability of glucagon-like peptide-1 (glp-1) to stimulate insulin secretion. |
2004-02-10 |
2023-08-12 |
rat |
| W L Hall, D J Millward, P J Rogers, L M Morga. Physiological mechanisms mediating aspartame-induced satiety. Physiology & behavior. vol 78. issue 4-5. 2004-01-16. PMID:12782208. |
plasma cck, glp-1, glucose-dependent insulinotropic polypeptide (gip), glucose, and insulin were measured over 0-120 min. |
2004-01-16 |
2023-08-12 |
human |
| Seungjoon Oh, Minhyung Lee, Kyung Soo Ko, Suna Choi, Sung Wan Ki. GLP-1 gene delivery for the treatment of type 2 diabetes. Molecular therapy : the journal of the American Society of Gene Therapy. vol 7. issue 4. 2004-01-12. PMID:12727110. |
coculture assay of the glp-1 plasmid-transfected cells with isolated rat islet cells demonstrated that glp-1 increased insulin secretion by twofold, compared to controls during a hyperglycemic challenge. |
2004-01-12 |
2023-08-12 |
rat |
| Loredana Farilla, Angela Bulotta, Boaz Hirshberg, Sergio Li Calzi, Nasif Khoury, Houtan Noushmehr, Cristina Bertolotto, Umberto Di Mario, David M Harlan, Riccardo Perfett. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:12960095. |
the peptide hormone, glucagon-like peptide 1 (glp-1), has been shown to increase glucose-dependent insulin secretion, enhance insulin gene transcription, expand islet cell mass, and inhibit beta-cell apoptosis in animal models of diabetes. |
2004-01-05 |
2023-08-12 |
human |
| Loredana Farilla, Angela Bulotta, Boaz Hirshberg, Sergio Li Calzi, Nasif Khoury, Houtan Noushmehr, Cristina Bertolotto, Umberto Di Mario, David M Harlan, Riccardo Perfett. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:12960095. |
human islets were cultured for 5 d in the presence, or absence, of glp-1 (10 nm, added every 12 h) and studied for viability and expression of proapoptotic (caspase-3) and antiapoptotic factors (bcl-2) as well as glucose-dependent insulin production. |
2004-01-05 |
2023-08-12 |
human |
| Loredana Farilla, Angela Bulotta, Boaz Hirshberg, Sergio Li Calzi, Nasif Khoury, Houtan Noushmehr, Cristina Bertolotto, Umberto Di Mario, David M Harlan, Riccardo Perfett. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:12960095. |
intracellular insulin content was markedly enhanced in islets cultured with glp-1 vs. control (p < 0.001, at d 5), and there was a parallel glp-1-dependent potentiation of glucose-dependent insulin secretion (p < 0.01 at d 3; p < 0.05 at d 5). |
2004-01-05 |
2023-08-12 |
human |
| Peter E Light, Jocelyn E Manning Fox, Michael J Riedel, Michael B Wheele. Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism. Molecular endocrinology (Baltimore, Md.). vol 16. issue 9. 2003-12-19. PMID:12198249. |
glucagon-like peptide-1 (glp-1) elicits a glucose-dependent insulin secretory effect via elevation of camp and activation of protein kinase a (pka). |
2003-12-19 |
2023-08-12 |
Not clear |
| P A Velasquez-Mieyer, P A Cowan, G E Umpierrez, R H Lustig, A K Cashion, G A Burghe. Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 27. issue 11. 2003-12-18. PMID:14574347. |
racial differences in glucagon-like peptide-1 (glp-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects. |
2003-12-18 |
2023-08-12 |
human |
| P A Velasquez-Mieyer, P A Cowan, G E Umpierrez, R H Lustig, A K Cashion, G A Burghe. Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 27. issue 11. 2003-12-18. PMID:14574347. |
we investigated whether differences in glucagon-like peptide-1 (glp-1), the most potent incretin that regulates insulin secretion, might explain racial differences in insulin response. |
2003-12-18 |
2023-08-12 |
human |
| P A Velasquez-Mieyer, P A Cowan, G E Umpierrez, R H Lustig, A K Cashion, G A Burghe. Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 27. issue 11. 2003-12-18. PMID:14574347. |
accordingly, we measured fasting and stimulated glucose, insulin, and glp-1 levels during a 3-h oral glucose tolerance test (ogtt) in 26 obese c (age 38+/-2 y, body mass index 44+/-1 kg/m(2)) and 16 obese aa (age 36+/-2 y, bmi 46+/-2 kg/m(2)) subjects. |
2003-12-18 |
2023-08-12 |
human |
| P A Velasquez-Mieyer, P A Cowan, G E Umpierrez, R H Lustig, A K Cashion, G A Burghe. Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 27. issue 11. 2003-12-18. PMID:14574347. |
corrected insulin response (cir(30)), a measure of beta-cell activity, whole body insulin sensitivity index (wbisi), and area under the curve (auc) for insulin, glp-1, and c-peptide/insulin ratio were computed from the ogtt. |
2003-12-18 |
2023-08-12 |
human |
| P A Velasquez-Mieyer, P A Cowan, G E Umpierrez, R H Lustig, A K Cashion, G A Burghe. Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 27. issue 11. 2003-12-18. PMID:14574347. |
our results indicate that obese aas had higher concentrations of glp-1 both at fasting and during the ogtt than obese c. the increased glp-1 concentration could explain the greater insulin concentration and the increased prevalence of hyperinsulinemia-associated disorders including obesity and type 2 diabetes in aas. |
2003-12-18 |
2023-08-12 |
human |
| Charles P Gilman, TracyAnn Perry, Katsotoshi Furukawa, Nigel H Grieg, Josephine M Egan, Mark P Mattso. Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons. Journal of neurochemistry. vol 87. issue 5. 2003-12-18. PMID:14622093. |
glucagon-like peptide 1 (glp-1) activates receptors coupled to camp production and calcium influx in pancreatic cells, resulting in enhanced glucose sensitivity and insulin secretion. |
2003-12-18 |
2023-08-12 |
rat |
| A Salehi, M Ekelund, I Lundquis. Total parenteral nutrition-stimulated activity of inducible nitric oxide synthase in rat pancreatic islets is suppressed by glucagon-like peptide-1. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 35. issue 1. 2003-12-05. PMID:12669271. |
since nitric oxide (no) has been shown to modulate negatively the insulin response to glucose, we investigated the influence of tpn-treatment on isoforms of islet no-synthase (nos) activities in relation to the effect of glucagon-like peptide-1 (glp-1), a known activator of glucose-stimulated insulin release. |
2003-12-05 |
2023-08-12 |
rat |
| A Salehi, M Ekelund, I Lundquis. Total parenteral nutrition-stimulated activity of inducible nitric oxide synthase in rat pancreatic islets is suppressed by glucagon-like peptide-1. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 35. issue 1. 2003-12-05. PMID:12669271. |
a dose-response study of glp-1 with glucose-stimulated islets showed that glp-1 could overcome and completely restore the impaired insulin release in tpn islets, bringing about a marked increase in islet camp accumulation concomitant with heavy suppression of both glucose-stimulated increase in islet cgmp content and the activities of constitutive nos (cnos) and inos. |
2003-12-05 |
2023-08-12 |
rat |
| A Salehi, M Ekelund, I Lundquis. Total parenteral nutrition-stimulated activity of inducible nitric oxide synthase in rat pancreatic islets is suppressed by glucagon-like peptide-1. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 35. issue 1. 2003-12-05. PMID:12669271. |
the present results show that the impaired insulin response of glucose-stimulated insulin release seen after tpn treatment is normalized by glp-1. |
2003-12-05 |
2023-08-12 |
rat |