| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raik Wolf, Torsten Hoffmann, Fred Rosche, Hans-Ulrich Demut. Simultaneous determination of incretin hormones and their truncated forms from human plasma by immunoprecipitation and liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 803. issue 1. 2004-11-09. PMID:15026002. |
the incretins, glucose-dependent insulinotropic peptide (gip(1-42)) and glucagon-like peptide 1 (glp-1(7-36)), are involved in regulation of gastric emptying, glucose homeostasis, body fat regulation and the glucose-induced insulin secretion from the endocrine pancreas. |
2004-11-09 |
2023-08-12 |
human |
| Isabel Valverde, Gen-Sheng Wang, Karolina Burghardt, Lisa M Kauri, Araceli Redondo, Alicia Acitores, Maria L Villanueva-Peñacarrillo, Philippe Courtois, Abdullah Sener, Jesús Cancelas, Willy J Malaisse, Fraser W Scot. Bioactive GLP-1 in gut, receptor expression in pancreas, and insulin response to GLP-1 in diabetes-prone rats. Endocrine. vol 23. issue 1. 2004-11-02. PMID:15034199. |
bioactive glp-1 in gut, receptor expression in pancreas, and insulin response to glp-1 in diabetes-prone rats. |
2004-11-02 |
2023-08-12 |
rat |
| Isabel Valverde, Gen-Sheng Wang, Karolina Burghardt, Lisa M Kauri, Araceli Redondo, Alicia Acitores, Maria L Villanueva-Peñacarrillo, Philippe Courtois, Abdullah Sener, Jesús Cancelas, Willy J Malaisse, Fraser W Scot. Bioactive GLP-1 in gut, receptor expression in pancreas, and insulin response to GLP-1 in diabetes-prone rats. Endocrine. vol 23. issue 1. 2004-11-02. PMID:15034199. |
pancreas glp-1r area fraction, glp-1r gene expression, and insulin content were analyzed, as were plasma glp-1, glucose, and insulin. |
2004-11-02 |
2023-08-12 |
rat |
| Isabel Valverde, Gen-Sheng Wang, Karolina Burghardt, Lisa M Kauri, Araceli Redondo, Alicia Acitores, Maria L Villanueva-Peñacarrillo, Philippe Courtois, Abdullah Sener, Jesús Cancelas, Willy J Malaisse, Fraser W Scot. Bioactive GLP-1 in gut, receptor expression in pancreas, and insulin response to GLP-1 in diabetes-prone rats. Endocrine. vol 23. issue 1. 2004-11-02. PMID:15034199. |
when injected iv with glp-1, bbdp rats displayed lower second-phase insulin response (and insulin/glucose ratios) compared with bbc rats. |
2004-11-02 |
2023-08-12 |
rat |
| Isabel Valverde, Gen-Sheng Wang, Karolina Burghardt, Lisa M Kauri, Araceli Redondo, Alicia Acitores, Maria L Villanueva-Peñacarrillo, Philippe Courtois, Abdullah Sener, Jesús Cancelas, Willy J Malaisse, Fraser W Scot. Bioactive GLP-1 in gut, receptor expression in pancreas, and insulin response to GLP-1 in diabetes-prone rats. Endocrine. vol 23. issue 1. 2004-11-02. PMID:15034199. |
thus, young bbdp rats displayed decreased concentrations of bioactive glp-1 in jejunum and ileum, reduced glp-1r in islets, and lower second-phase insulin response to iv glp-1 than controls. |
2004-11-02 |
2023-08-12 |
rat |
| Alberto Patriti, Enrico Facchiano, Andrea Sanna, Nino Gullà, Annibale Donin. The enteroinsular axis and the recovery from type 2 diabetes after bariatric surgery. Obesity surgery. vol 14. issue 6. 2004-10-27. PMID:15318993. |
the secretion of glp-1 influences glucose metabolism by inhibiting glucagon secretion, stimulating insulin secretion, delaying gastric emptying and stimulating glycogenogenesis. |
2004-10-27 |
2023-08-12 |
Not clear |
| Tracy Ann Perry, Nigel H Grei. A new Alzheimer's disease interventive strategy: GLP-1. Current drug targets. vol 5. issue 6. 2004-10-14. PMID:15270203. |
glp-1 receptor stimulation enhances pancreatic islet beta-cell proliferation, glucose-dependent insulin secretion and lowers blood glucose and food intake in patients with type 2 diabetes mellitus. |
2004-10-14 |
2023-08-12 |
mouse |
| B Thoren. [GIP and GLP-1: multiplicity of regulator mechanisms for insulin secretion]. Journees annuelles de diabetologie de l'Hotel-Dieu. 2004-09-23. PMID:15259310. |
[gip and glp-1: multiplicity of regulator mechanisms for insulin secretion]. |
2004-09-23 |
2023-08-12 |
Not clear |
| Brian D Green, Victor A Gault, Nigel Irwin, Mark H Mooney, Clifford J Bailey, Patrick Harriott, Brett Greer, Peter R Flatt, Finbarr P M O'Hart. Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1. Biological chemistry. vol 384. issue 12. 2004-09-20. PMID:14719796. |
in addition, (pro9)glp-1 showed significant ability to moderate the plasma glucose excursion and increase circulating insulin concentrations in severely insulin resistant obese diabetic (ob/ob) mice. |
2004-09-20 |
2023-08-12 |
mouse |
| Loïc Leroux, Béatrice Durel, Valérie Autier, Louise Deltour, Danielle Bucchini, Jacques Jami, Rajiv L Josh. Ins1 gene up-regulated in a beta-cell line derived from Ins2 knockout mice. International journal of experimental diabesity research. vol 4. issue 1. 2004-09-17. PMID:12745665. |
we have also shown that lacz expression, as analyzed by determining beta-galactosidase activity, was up-regulated by incubating betains2(-/-lacz) cells with glp-1 and/or ibmx, 2 known stimulators of insulin gene expression. |
2004-09-17 |
2023-08-12 |
mouse |
| Jens Juul Holst, Jesper Gromad. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. American journal of physiology. Endocrinology and metabolism. vol 287. issue 2. 2004-08-30. PMID:15271645. |
on the other hand, the insulintropic effect of glp-1 is preserved, whereas the effect of gip is greatly reduced, mainly because of a complete loss of the normal gip-induced potentiation of second-phase insulin secretion. |
2004-08-30 |
2023-08-12 |
Not clear |
| Jens Juul Holst, Jesper Gromad. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. American journal of physiology. Endocrinology and metabolism. vol 287. issue 2. 2004-08-30. PMID:15271645. |
strong support for the hypothesis that the defect plays an important role in the insulin deficiency of patients is provided by the finding that administration of excess glp-1 to patients may completely restore the glucose-induced insulin secretion as well as the beta-cells' sensitivity to glucose. |
2004-08-30 |
2023-08-12 |
Not clear |
| B D Green, V A Gault, P R Flatt, P Harriott, B Greer, F P M O'Hart. Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid. Archives of biochemistry and biophysics. vol 428. issue 2. 2004-08-16. PMID:15246869. |
comparative effects of glp-1 and gip on camp production, insulin secretion, and in vivo antidiabetic actions following substitution of ala8/ala2 with 2-aminobutyric acid. |
2004-08-16 |
2023-08-12 |
mouse |
| Taro Wasad. [Glucagon-like peptide-1(GLP-1)]. Nihon rinsho. Japanese journal of clinical medicine. vol 62. issue 6. 2004-08-10. PMID:15206160. |
glucagon-like peptide-1(glp-1), an intestinal hormone secreted by l cells in response to luminal nutrients(carbohydrate and fat), enhances glucose-induced insulin secretion. |
2004-08-10 |
2023-08-12 |
Not clear |
| Taro Wasad. [Glucagon-like peptide-1(GLP-1)]. Nihon rinsho. Japanese journal of clinical medicine. vol 62. issue 6. 2004-08-10. PMID:15206160. |
impairment of glucose-induced insulin secretion in patients with type 2 diabetes can be restored to near-normal by glp-1 administration. |
2004-08-10 |
2023-08-12 |
Not clear |
| Taro Wasad. [Glucagon-like peptide-1(GLP-1)]. Nihon rinsho. Japanese journal of clinical medicine. vol 62. issue 6. 2004-08-10. PMID:15206160. |
in addition, glp-1 possesses multiple biological effects which are favorable for the treatment of type 2 diabetes: inhibition of glucagon secretion, slowing of gastric emptying, reduction of appetite and food intake, upregulation of genes essential for insulin secretion(glucokinase, glut-2 etc), and beta cell proliferation and differentiation. |
2004-08-10 |
2023-08-12 |
Not clear |
| Dominique Delmeire, Daisy Flamez, Karen Moens, Simon A Hinke, Chris Van Schravendijk, Daniel Pipeleers, Frans Schui. Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness. Biochemical pharmacology. vol 68. issue 1. 2004-07-19. PMID:15183115. |
glucagon-like peptide-1 (7-36) amide (glp-1) and glucose-dependent insulinotropic peptide (gip) potentiate glucose-induced insulin release when present at the time of nutrient stimulation. |
2004-07-19 |
2023-08-12 |
rat |
| Dominique Delmeire, Daisy Flamez, Karen Moens, Simon A Hinke, Chris Van Schravendijk, Daniel Pipeleers, Frans Schui. Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness. Biochemical pharmacology. vol 68. issue 1. 2004-07-19. PMID:15183115. |
however, when both glp-1 and gip, each at 0.5 nm, were added to the one hour pulses, they not only amplified insulin release during the pulses, as was the case with their single addition, but also increased the secretory response to a subsequent stimulation by glucose and glp-1. |
2004-07-19 |
2023-08-12 |
rat |
| Bo Ahrén, Mona Landin-Olsson, Per-Anders Jansson, Maria Svensson, David Holmes, Anja Schweize. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. The Journal of clinical endocrinology and metabolism. vol 89. issue 5. 2004-07-14. PMID:15126524. |
the stimulation of insulin vs. inhibition of glucagon secretion in relation to the antidiabetic action of glucagon-like peptide-1 (glp-1) is not established. |
2004-07-14 |
2023-08-12 |
human |
| Bo Ahrén, Mona Landin-Olsson, Per-Anders Jansson, Maria Svensson, David Holmes, Anja Schweize. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. The Journal of clinical endocrinology and metabolism. vol 89. issue 5. 2004-07-14. PMID:15126524. |
here, the influence of a 4-wk increase in circulating glp-1 by inhibition of dipeptidyl peptidase-4 (dpp-4) on 24-h glucose and insulin and glucagon responses to breakfast was studied in subjects with dietary controlled diabetes [age: 65 +/- 8 yr (sd), body mass index: 27.3 +/- 3.3 kg/m(2), fasting plasma glucose: 9.0 +/- 1.3 mmol/liter]. |
2004-07-14 |
2023-08-12 |
human |