| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lazaros A Nikolaidis, Dariush Elahi, Teresa Hentosz, Aaron Doverspike, Rhonda Huerbin, Lee Zourelias, Carol Stolarski, You-tang Shen, Richard P Shanno. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation. vol 110. issue 8. 2005-02-28. PMID:15313949. |
we examined the impact of recombinant glp-1 (rglp-1) on lv and systemic hemodynamics and myocardial substrate uptake in conscious dogs with advanced dilated cardiomyopathy (dcm) as a mechanism for overcoming myocardial insulin resistance and enhancing myocardial glucose uptake. |
2005-02-28 |
2023-08-12 |
Not clear |
| Eva Degerman, Vincent Manganiello, Jens J Holst, Bo Ahré. Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice. European journal of pharmacology. vol 498. issue 1-3. 2005-02-28. PMID:15364011. |
however, the pde3 inhibitor augmented the insulin response to intravenous glp-1 (2.8 nmol/kg). |
2005-02-28 |
2023-08-12 |
mouse |
| Eva Degerman, Vincent Manganiello, Jens J Holst, Bo Ahré. Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice. European journal of pharmacology. vol 498. issue 1-3. 2005-02-28. PMID:15364011. |
we therefore conclude that pde3 inhibition by milrinone augments insulin secretion in vivo in mice after oral but not after intravenous glucose, which may be explained by enhanced response to the camp-dependent insulinotropic action of endogenously released glp-1. |
2005-02-28 |
2023-08-12 |
mouse |
| M A Gülpinar, B C Yege. The physiology of learning and memory: role of peptides and stress. Current protein & peptide science. vol 5. issue 6. 2005-02-08. PMID:15581416. |
arginine vasopressin (avp), oxytocin, angiotensin ii, insulin, growth factors, serotonin (5-ht), melanin concentrating hormone, histamine, bombesin and gastrin-releasing peptide (grp), glucagon-like peptide-1 (glp-1), cholecystokinin (cck), dopamine, corticotropin releasing factor (crf) have modulatory effects on learning and memory. |
2005-02-08 |
2023-08-12 |
Not clear |
| Martin B Brenner, Hans-Juergen Mes. A buffer temperature controlled perifusion system to study temperature dependence and kinetics of insulin secretion in MIN6 pseudoislets. Journal of pharmacological and toxicological methods. vol 50. issue 1. 2005-01-25. PMID:15233968. |
additionally, the influence of small temperature changes, glucagon-like peptide 1 (glp-1) and tolbutamide on insulin release from min6 pseudoislets is examined. |
2005-01-25 |
2023-08-12 |
Not clear |
| Simon A Hinke, Karine Hellemans, Frans C Schui. Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal. The Journal of physiology. vol 558. issue Pt 2. 2005-01-24. PMID:15181163. |
it is well established that the acute rise in plasma glucose and in the incretin hormones glucose-dependent insulinotropic peptide (gip) and glucagon-like peptide-1 (7-36) amide (glp-1), as occurs during a meal, is of pivotal importance in regulating the minute-to-minute output of insulin from pancreatic beta cells. |
2005-01-24 |
2023-08-12 |
Not clear |
| N T Lam, A T Cheung, M J Riedel, P E Light, C I Cheeseman, T J Kieffe. Leptin reduces glucose transport and cellular ATP levels in INS-1 beta-cells. Journal of molecular endocrinology. vol 32. issue 2. 2005-01-11. PMID:15072548. |
the twofold induction of glut2 phosphorylation by glp-1, an insulin secretagogue, was abolished by leptin. |
2005-01-11 |
2023-08-12 |
rat |
| Louisa M A Shepherd, Susan C Campbell, Wendy M Macfarlan. Transcriptional regulation of the IAPP gene in pancreatic beta-cells. Biochimica et biophysica acta. vol 1681. issue 1. 2005-01-11. PMID:15566941. |
in the present study, we have used reporter gene analysis and semi-quantitative rt-pcr to establish that insulin, glucagon, glucagon-like peptide-1 (glp-1) and the glp-1 derivatives glp(7-36)amide and exendin-4 all stimulate iapp promoter activity, as well as endogenous iapp mrna levels in isolated islets of langerhans. |
2005-01-11 |
2023-08-12 |
human |
| Kotaro Takasaki, Miho Iwase, Takao Nakajima, Kimihisa Ueno, Yuji Nomoto, Satoshi Nakanishi, Katsuya Hig. K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent. European journal of pharmacology. vol 486. issue 3. 2005-01-04. PMID:14985056. |
in normal rats, k579 suppressed the blood glucose elevation after an oral glucose tolerance test with the increment of plasma insulin and active forms of glucagon-like peptide-1 (glp-1). |
2005-01-04 |
2023-08-12 |
rat |
| Brian D Green, Victor A Gault, Finbarr P M O'harte, Peter R Flat. Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents. Current pharmaceutical design. vol 10. issue 29. 2004-12-27. PMID:15579061. |
consideration will be given to the effects of n-terminal modification and amino acid substitution of glp-1 and gip either side of the dpp iv cleavage site on (i) susceptibility to enzymatic degradation, (ii) binding to native hormone receptor, (iii) ability to elevate intracellular cyclic amp, (iv) potency as insulin secretagogues, and (v) antihyperglycaemic activity in type 2 diabetes. |
2004-12-27 |
2023-08-12 |
Not clear |
| T Vilsbøll, J J Hols. Incretins, insulin secretion and Type 2 diabetes mellitus. Diabetologia. vol 47. issue 3. 2004-12-22. PMID:14968296. |
this effect, which is called the incretin effect and is estimated to be responsible for 50 to 70% of the insulin response to glucose, is caused mainly by the two intestinal insulin-stimulating hormones, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip). |
2004-12-22 |
2023-08-12 |
Not clear |
| Thomas Nyström, Mark K Gutniak, Qimin Zhang, Fan Zhang, Jens Juul Holst, Bo Ahrén, Ake Sjöhol. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. American journal of physiology. Endocrinology and metabolism. vol 287. issue 6. 2004-12-16. PMID:15353407. |
glp-1 stimulates insulin secretion, suppresses glucagon secretion, delays gastric emptying, and inhibits small bowel motility, all actions contributing to the anti-diabetogenic peptide effect. |
2004-12-16 |
2023-08-12 |
human |
| Thomas Nyström, Mark K Gutniak, Qimin Zhang, Fan Zhang, Jens Juul Holst, Bo Ahrén, Ake Sjöhol. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. American journal of physiology. Endocrinology and metabolism. vol 287. issue 6. 2004-12-16. PMID:15353407. |
we investigated glp-1's effect on endothelial function and insulin sensitivity (s(i)) in two groups: 1) 12 type 2 diabetes patients with stable coronary artery disease and 2) 10 healthy subjects with normal endothelial function and s(i). |
2004-12-16 |
2023-08-12 |
human |
| Thomas Nyström, Mark K Gutniak, Qimin Zhang, Fan Zhang, Jens Juul Holst, Bo Ahrén, Ake Sjöhol. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. American journal of physiology. Endocrinology and metabolism. vol 287. issue 6. 2004-12-16. PMID:15353407. |
we conclude that glp-1 improves endothelial dysfunction but not insulin resistance in type 2 diabetic patients with coronary heart disease. |
2004-12-16 |
2023-08-12 |
human |
| M Bayes, X Rabasseda, J R Prou. Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology. vol 26. issue 6. 2004-11-30. PMID:15349141. |
this issue focuses on the following selection of drugs: abi-007, ad.egr.tnf.11d, adefovir dipivoxil, adpedf.11, aes-14, albumex, alefacept, alemtuzumab, aliskiren fumarate, alvimopan hydrate, aaminolevulinic acid hydrochloride, aminolevulinic acid methyl ester, anakinra, anti-il-12 mab, aprepitant, atazanavir sulfate, atrasentan, avanafil; banoxantrone, bg-12, bimatoprost, bortezomib, bosentan; calcipotriol/betamethasone dipropionate, caspofungin acetate, cbt-1, ciclesonide, clofarabine, conivaptan hydrochloride, cpg-7909, c-vax, cypher; da-8159, dac:glp-1, darbepoetin alfa, darifenacin, duloxetine hydrochloride; eculizumab, efalizumab, efaproxiral sodium, egf vaccine, eletriptan, epratuzumab, erlotinib hydrochloride, escitalopram oxalate, etc-642, etoricoxib, everolimus, exenatide; gefitinib, iv gamma-globulin; human insulin, gamma-hydroxybutyrate sodium; idn-6556, iguratimod, imatinib mesylate, indiplon, ixabepilone; laquinimod, lb-80380, lidocaine/prilocaineliraglutide, lopinavir, lopinavir/ritonavir, lucinactant; mab-14.18, melatonin, mln-591-dm1; nc-531, neridronic acid, nesiritide, neutrophil-inhibitory factor, niacin/lovastatin; oblimersen sodium, olcegepant, oral insulin, orv-105; palonosetron hydrochloride, pamab, pegaptanib sodium, peginterferon alfa-2a, pegvisomant, perifosine, pexelizumab, phenoxodiol, phenserine tartrate, pimecrolimus, pramlintide acetate, pregabalin, pro-542, prostate cancer vaccine, pt-141; ramelteon, rasagiline mesilate, rdna insulin, reslizumab, rh-lactoferrin, ribamidine hydrochloride, rosuvastatin calcium; s-8184l, sc-1, sorafenib, st. john's wort extract, su-11248; taxus, telbivudine, tenofovir disoproxil fumarate, teriparatide, testosterone gel, tezosentan disodium, tipifarnib, tolvaptan, trabectedin, travoprost, travoprost/timolol, treprostinil sodium; vardenafil hydrochloride hydrate; xcellerated t cells, xr-5944; yttrium 90 (90y) ibritumomab tiuxetan; ziconotide. |
2004-11-30 |
2023-08-12 |
human |
| Florian Lippl, Florian Kircher, Johannes Erdmann, Hans-Dieter Allescher, Volker Schusdziarr. Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach. Regulatory peptides. vol 119. issue 1-2. 2004-11-19. PMID:15093702. |
effect of gip, glp-1, insulin and gastrin on ghrelin release in the isolated rat stomach. |
2004-11-19 |
2023-08-12 |
rat |
| Florian Lippl, Florian Kircher, Johannes Erdmann, Hans-Dieter Allescher, Volker Schusdziarr. Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach. Regulatory peptides. vol 119. issue 1-2. 2004-11-19. PMID:15093702. |
to elucidate their potential role, glucagon-like peptide-1 (glp-1), gastric inhibitory polypeptide (gip), insulin, gastrin and somatostatin were examined on isolated rat stomach ghrelin secretion, which offers the advantage of avoiding systemic interactions. |
2004-11-19 |
2023-08-12 |
rat |
| Florian Lippl, Florian Kircher, Johannes Erdmann, Hans-Dieter Allescher, Volker Schusdziarr. Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach. Regulatory peptides. vol 119. issue 1-2. 2004-11-19. PMID:15093702. |
these data demonstrate that glp-1(7-36)amide, insulin, gastrin and somatostatin are potential candidates to contribute to the postprandially observed inhibition of ghrelin secretion with insulin being the most effective inhibitor in this isolated stomach model. |
2004-11-19 |
2023-08-12 |
rat |
| Taner Damci, Serap Yalin, Huriye Balci, Zeynep Osar, Ustun Korugan, Mucahit Ozyazar, Hasan Ilkov. Orlistat augments postprandial increases in glucagon-like peptide 1 in obese type 2 diabetic patients. Diabetes care. vol 27. issue 5. 2004-11-16. PMID:15111524. |
glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic peptide (gip) are gut hormones that are secreted in response to food intake, and they both stimulate insulin secretion. |
2004-11-16 |
2023-08-12 |
Not clear |
| M Diamant, M C M Bunck, R J Hein. [Analogs of glucagon-like peptide-1 (GLP-1): an old concept as a new treatment of patients with diabetes mellitus type 2]. Nederlands tijdschrift voor geneeskunde. vol 148. issue 39. 2004-11-16. PMID:15495988. |
glp-1 and gip stimulate beta-cell proliferation and differentiation, whereas glp-1 only inhibits gastric emptying and glucagon secretion, reduces food intake and improves insulin sensitivity. |
2004-11-16 |
2023-08-12 |
human |