| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sungwon Kim, Sung Wan Kim, You Han Ba. Synthesis, bioactivity and specificity of glucagon-like peptide-1 (7-37)/polymer conjugate to isolated rat islets. Biomaterials. vol 26. issue 17. 2005-06-20. PMID:15621250. |
in a static insulin secretion test, the vapg increased insulin secretion up to 200% over a control (no stimulation) at high glucose levels, although the insulinotropic activity of vapg was slightly lower than that of native glp-1. |
2005-06-20 |
2023-08-12 |
rat |
| Nieves González, Alicia Acitores, Verónica Sancho, Isabel Valverde, María L Villanueva-Peñacarrill. Effect of GLP-1 on glucose transport and its cell signalling in human myocytes. Regulatory peptides. vol 126. issue 3. 2005-06-09. PMID:15664668. |
we have investigated the effect of glp-1 in normal human myocytes, and that of its structurally related peptides exendin-4 (ex-4) and its truncated form 9-39 (ex-9) upon glucose uptake, and the participation of cellular enzymes proposed to mediate insulin actions. |
2005-06-09 |
2023-08-12 |
human |
| Nieves González, Alicia Acitores, Verónica Sancho, Isabel Valverde, María L Villanueva-Peñacarrill. Effect of GLP-1 on glucose transport and its cell signalling in human myocytes. Regulatory peptides. vol 126. issue 3. 2005-06-09. PMID:15664668. |
glp-1 and both exendins activated, like insulin, pi3k/pkb and p42/44 mapk enzymes, but p70s6k was activated only by glp-1 and insulin. |
2005-06-09 |
2023-08-12 |
human |
| Nieves González, Alicia Acitores, Verónica Sancho, Isabel Valverde, María L Villanueva-Peñacarrill. Effect of GLP-1 on glucose transport and its cell signalling in human myocytes. Regulatory peptides. vol 126. issue 3. 2005-06-09. PMID:15664668. |
glp-1, ex-4 and ex-9, like insulin, stimulated glucose uptake; wortmannin blocked the action of glp-1, insulin and ex-9, and reduced that of ex-4; pd98059 abolished the effect of all peptides/hormones, while rapamycin blocked that of insulin and partially prevented that of glp-1. |
2005-06-09 |
2023-08-12 |
human |
| Nieves González, Alicia Acitores, Verónica Sancho, Isabel Valverde, María L Villanueva-Peñacarrill. Effect of GLP-1 on glucose transport and its cell signalling in human myocytes. Regulatory peptides. vol 126. issue 3. 2005-06-09. PMID:15664668. |
h-7 abolished the action of glp-1, insulin and ex-4, while ro 31-8220 prevented only the ex-4 and ex-9 effect. |
2005-06-09 |
2023-08-12 |
human |
| Nieves González, Alicia Acitores, Verónica Sancho, Isabel Valverde, María L Villanueva-Peñacarrill. Effect of GLP-1 on glucose transport and its cell signalling in human myocytes. Regulatory peptides. vol 126. issue 3. 2005-06-09. PMID:15664668. |
in conclusion, glp-1, like insulin, stimulates glucose uptake, and this involves activation of pi3k/pkb, p44/42 mapks, partially p70s6k, and possibly pkc; ex-4 and ex-9 both have glp-1-like effect upon glucose transport, in which both share with glp-1 an activation of pi3k/pkb--partially in the case of ex-4--and p44/42 mapks but not p70s6k. |
2005-06-09 |
2023-08-12 |
human |
| Javier Jimenez-Feltstrom, Ingmar Lundquist, Albert Saleh. Glucose stimulates the expression and activities of nitric oxide synthases in incubated rat islets: an effect counteracted by GLP-1 through the cyclic AMP/PKA pathway. Cell and tissue research. vol 319. issue 2. 2005-06-06. PMID:15558323. |
the addition of glucagon-like-peptide 1 (glp-1) or dibutyryl-camp to islets incubated with 20 mmol/l glucose results in a marked suppression of inos expression and activity, a reduction in ncnos activity and increased insulin release. |
2005-06-06 |
2023-08-12 |
rat |
| Javier Jimenez-Feltstrom, Ingmar Lundquist, Albert Saleh. Glucose stimulates the expression and activities of nitric oxide synthases in incubated rat islets: an effect counteracted by GLP-1 through the cyclic AMP/PKA pathway. Cell and tissue research. vol 319. issue 2. 2005-06-06. PMID:15558323. |
the glp-1-induced suppression of glucose-stimulated inos activity and expression and its stimulation of insulin release is, at least in part, pka dependent, since the pka inhibitor h-89 reverses the effects of glp-1. |
2005-06-06 |
2023-08-12 |
rat |
| Takashi Miki, Kohtaro Minami, Hidehiro Shinozaki, Kimio Matsumura, Atsunori Saraya, Hiroki Ikeda, Yuichiro Yamada, Jens Juul Holst, Susumu Sein. Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes. vol 54. issue 4. 2005-06-03. PMID:15793244. |
in contrast, pretreatment with glucagon-like peptide-1 (glp-1) in kir6.2(-/-) mice potentiated insulin secretion and blunted the rise in blood glucose levels. |
2005-06-03 |
2023-08-12 |
mouse |
| Takashi Miki, Kohtaro Minami, Hidehiro Shinozaki, Kimio Matsumura, Atsunori Saraya, Hiroki Ikeda, Yuichiro Yamada, Jens Juul Holst, Susumu Sein. Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes. vol 54. issue 4. 2005-06-03. PMID:15793244. |
perfusion experiments of kir6.2(-/-) mice revealed severely impaired potentiation of insulin secretion by 1 nmol/l gip and substantial potentiation by 1 nmol/l glp-1. |
2005-06-03 |
2023-08-12 |
mouse |
| Takashi Miki, Kohtaro Minami, Hidehiro Shinozaki, Kimio Matsumura, Atsunori Saraya, Hiroki Ikeda, Yuichiro Yamada, Jens Juul Holst, Susumu Sein. Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes. vol 54. issue 4. 2005-06-03. PMID:15793244. |
although both gip and glp-1 increase the intracellular camp concentration and potentiate insulin secretion, these results demonstrate that the glp-1 and gip signaling pathways involve the k(atp) channel differently. |
2005-06-03 |
2023-08-12 |
mouse |
| Ewa Otto Buczkowska, Tomasz Dworzeck. [Glucagon-like peptides--synthesis, biological actions and some clinical implications]. Przeglad lekarski. vol 61. issue 9. 2005-05-26. PMID:15803906. |
glp-1 controls blood glucose following nutrient absorption via stimulation of glucose-dependent insulin secretion, insulin biosynthesis, islet proliferation, and neogenesis and inhibition of glucagon secretion. |
2005-05-26 |
2023-08-12 |
human |
| L B Hays, B Wicksteed, Y Wang, J F McCuaig, L H Philipson, J M Edwardson, C J Rhode. Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells. The Journal of endocrinology. vol 185. issue 1. 2005-05-17. PMID:15817827. |
syncollin expression in isolated rat islets had no effect on basal insulin secretion but significantly inhibited regulated insulin secretion stimulated by glucose (16.7 mm), glucagon-like peptide-1 (glp-1) (10 nm) and glyburide (5 microm). |
2005-05-17 |
2023-08-12 |
rat |
| Kazutaka Nagai, Ken Tsuchiya, Taichi Ezaki, Mariko Tsuchiya, Hisako Ohgawar. Effect of GLP-1 (glucagon-like peptide 1:7-36 amide) on porcine pancreatic endocrine cell proliferation and insulin secretion. Pancreas. vol 28. issue 2. 2005-05-13. PMID:15028945. |
effect of glp-1 (glucagon-like peptide 1:7-36 amide) on porcine pancreatic endocrine cell proliferation and insulin secretion. |
2005-05-13 |
2023-08-12 |
Not clear |
| Kazutaka Nagai, Ken Tsuchiya, Taichi Ezaki, Mariko Tsuchiya, Hisako Ohgawar. Effect of GLP-1 (glucagon-like peptide 1:7-36 amide) on porcine pancreatic endocrine cell proliferation and insulin secretion. Pancreas. vol 28. issue 2. 2005-05-13. PMID:15028945. |
glucagon-like peptide 1 (glp-1), derived from intestinal cells, is one of the substances that may regulate insulin secretion and cell proliferation. |
2005-05-13 |
2023-08-12 |
Not clear |
| S Efendic, N Portwoo. Overview of incretin hormones. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655702. |
in patients with type 2 diabetes, the incretin effect is decreased, mainly due to loss of the gip-regulated second phase of insulin secretion, and because of a decreased secretion of glp-1. |
2005-05-12 |
2023-08-12 |
Not clear |
| B Thoren. Physiology of GLP-1--lessons from glucoincretin receptor knockout mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655706. |
however, a critical role for this hormone and its receptor was demonstrated in the function of the hepatoportal vein glucose sensor, in contrast to that of the pancreatic beta-cells, although absence of both glp-1 and gip receptors leads to a more severe phenotype characterized by a beta-cell-autonomous defect in glucose-stimulated insulin secretion. |
2005-05-12 |
2023-08-12 |
mouse |
| M Sörhede Winzell, B Ahré. Glucagon-like peptide-1 and islet lipolysis. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655711. |
since hsl is expressed in islet beta-cells, this effect could contribute to the stimulation of insulin secretion by glp-1, provided that a lipid signal of importance for insulin secretion is generated. |
2005-05-12 |
2023-08-12 |
mouse |
| M Sörhede Winzell, B Ahré. Glucagon-like peptide-1 and islet lipolysis. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655711. |
to examine this hypothesis, we have studied the acute effect of glp-1 on isolated mouse islets from normal mice and from mice with high-fat diet induced insulin resistance. |
2005-05-12 |
2023-08-12 |
mouse |
| M Sörhede Winzell, B Ahré. Glucagon-like peptide-1 and islet lipolysis. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655711. |
we found, however, that although glp-1 (100 nm) markedly potentiated glucose-stimulated insulin secretion from islets of both feeding groups, the peptide was not able to stimulate islet palmitate oxidation or increase lipolysis measured as glycerol release. |
2005-05-12 |
2023-08-12 |
mouse |