| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Dupr. Glycaemic effects of incretins in Type 1 diabetes mellitus: a concise review, with emphasis on studies in humans. Regulatory peptides. vol 128. issue 2. 2005-08-04. PMID:15780434. |
these studies showed substantial reduction of glycaemic excursions after ingestion of mixed nutrients during intravenous infusion of glp-1 without administration of insulin, in subjects with a range of endogenous secretion of insulin in response to meals as demonstrated by blood levels of the insulin-connecting peptide (cp). |
2005-08-04 |
2023-08-12 |
human |
| John Dupr. Glycaemic effects of incretins in Type 1 diabetes mellitus: a concise review, with emphasis on studies in humans. Regulatory peptides. vol 128. issue 2. 2005-08-04. PMID:15780434. |
studies of the effects of glp-1 agonists (glp-1 and exendin-4) given together with established insulin doses before a meal supported the hypothesis. |
2005-08-04 |
2023-08-12 |
human |
| John Dupr. Glycaemic effects of incretins in Type 1 diabetes mellitus: a concise review, with emphasis on studies in humans. Regulatory peptides. vol 128. issue 2. 2005-08-04. PMID:15780434. |
it is suggested that further and more prolonged studies of the use of long-acting glp-1 agonists as congeners with insulin in type 1 diabetes mellitus are indicated. |
2005-08-04 |
2023-08-12 |
human |
| Jens Juul Hols. Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors. Expert opinion on emerging drugs. vol 9. issue 1. 2005-07-21. PMID:15155141. |
glucagon-like peptide-1 (glp-1) is a peptide hormone from the gut that stimulates insulin secretion and protects beta-cells, inhibits glucagon secretion and gastric emptying, and reduces appetite and food intake. |
2005-07-21 |
2023-08-12 |
Not clear |
| Patrice D Cani, Catherine A Daubioul, Brigitte Reusens, Claude Remacle, Grégory Catillon, Nathalie M Delzenn. Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats. The Journal of endocrinology. vol 185. issue 3. 2005-07-20. PMID:15930172. |
we have evaluated the influence of oligofructose (ofs), a fermentable dietary fibre, on glucose homeostasis, insulin production and intestinal glucagon-like peptide-1 (glp-1) in streptozotocin-treated diabetic rats. |
2005-07-20 |
2023-08-12 |
rat |
| Patrice D Cani, Catherine A Daubioul, Brigitte Reusens, Claude Remacle, Grégory Catillon, Nathalie M Delzenn. Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats. The Journal of endocrinology. vol 185. issue 3. 2005-07-20. PMID:15930172. |
we propose that ofs, through its fermentation in the colon, promotes the expression and secretion of colonic peptides, namely glp-1(7-36) amide, with beneficial consequences on glycaemia, insulin secretion and hyperphagia in diabetic rats. |
2005-07-20 |
2023-08-12 |
rat |
| P Gerbe. [Diabetes]. Revue medicale suisse. vol 1. issue 2. 2005-07-19. PMID:15773212. |
we will end this short review discussing the future of the inhibitor of glp-1 degradation which in addition to a modest hypoglycaemic effect seems to be able to prevent apoptosis of insulin producing beta cells. |
2005-07-19 |
2023-08-12 |
Not clear |
| J J Hols. Treatment of Type 2 diabetes mellitus based on glucagon-like peptide-1. Expert opinion on investigational drugs. vol 8. issue 9. 2005-07-19. PMID:15992158. |
physiologically, therefore, glp-1 is thought to act as an incretin hormone (intestinal hormones that enhance meal-related insulin secretion) and as one of the hormones of the ileal brake mechanism (endocrine inhibition of gastrointestinal motility and secretion in the presence of nutrients in the lower small intestine). |
2005-07-19 |
2023-08-12 |
Not clear |
| O Andersen, S B Haugaard, J J Holst, C F Deacon, J Iversen, U B Andersen, J O Nielsen, S Madsba. Enhanced glucagon-like peptide-1 (GLP-1) response to oral glucose in glucose-intolerant HIV-infected patients on antiretroviral therapy. HIV medicine. vol 6. issue 2. 2005-07-18. PMID:15807714. |
we investigated whether the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), which are major regulators of glucose tolerance through the stimulation of insulin secretion, contribute to impaired glucose tolerance (igt) among hiv-infected patients on highly active antiretroviral therapy (haart). |
2005-07-18 |
2023-08-12 |
Not clear |
| J R Lindsay, N A Duffy, A M McKillop, J Ardill, F P M O'Harte, P R Flatt, P M Bel. Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes. Diabetic medicine : a journal of the British Diabetic Association. vol 22. issue 5. 2005-07-18. PMID:15842525. |
glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip) are important insulinotropic hormones that enhance the insulin secretory response to feeding. |
2005-07-18 |
2023-08-12 |
Not clear |
| Hyae Gyeong Cheon, Sung-Soo Kim, Kwang-Rok Kim, Sang-Dal Rhee, Sung-Don Yang, Jin Hee Ahn, Sung-Dae Park, Jae Mok Lee, Won Hoon Jung, Hye Sook Lee, Hee Youn Ki. Inhibition of dipeptidyl peptidase IV by novel inhibitors with pyrazolidine scaffold. Biochemical pharmacology. vol 70. issue 1. 2005-07-15. PMID:15893294. |
inhibition of dipeptidyl peptidase iv (dpp-iv) activity has been reported to improve nutrient-stimulated insulin secretion through the stabilization of glucagon-like peptide (glp-1). |
2005-07-15 |
2023-08-12 |
mouse |
| J S Dillon, M Lu, S Bowen, L L Homa. The recombinant rat glucagon-like peptide-1 receptor, expressed in an alpha-cell line, is coupled to adenylyl cyclase activation and intracellular calcium release. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 113. issue 3. 2005-07-12. PMID:15789279. |
furthermore, since glp-1 is unable to cause cellular depolarization or activate vdcc in inr1-sf2 cells, these data suggest that glucose-induced membrane depolarization may be crucial for glp-1 to further activate vdcc and potentiate glucose-stimulated insulin release in beta-cells. |
2005-07-12 |
2023-08-12 |
rat |
| C B Juhl, J Sturis, M Hollingdal, O Schmit. Acute insulin responses to intravenous glucose and GLP-1 are independent of preceding high-frequency insulin pulse-defects induced by glucose entrainment in healthy humans. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 37. issue 1. 2005-07-08. PMID:15702438. |
acute insulin responses to intravenous glucose and glp-1 are independent of preceding high-frequency insulin pulse-defects induced by glucose entrainment in healthy humans. |
2005-07-08 |
2023-08-12 |
human |
| C B Juhl, J Sturis, M Hollingdal, O Schmit. Acute insulin responses to intravenous glucose and GLP-1 are independent of preceding high-frequency insulin pulse-defects induced by glucose entrainment in healthy humans. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 37. issue 1. 2005-07-08. PMID:15702438. |
the objective of this study was to test the hypothesis that high-frequency oscillations in insulin release is a part of the mechanistic basis of a prompt and adequate insulin response to iv-glucose and glp-1 exposure. |
2005-07-08 |
2023-08-12 |
human |
| C B Juhl, J Sturis, M Hollingdal, O Schmit. Acute insulin responses to intravenous glucose and GLP-1 are independent of preceding high-frequency insulin pulse-defects induced by glucose entrainment in healthy humans. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 37. issue 1. 2005-07-08. PMID:15702438. |
after 360 min, insulin secretion was assessed by means of a first-phase insulin secretion test (25 g glucose) and injection of glp-1 (9 microg). |
2005-07-08 |
2023-08-12 |
human |
| C B Juhl, J Sturis, M Hollingdal, O Schmit. Acute insulin responses to intravenous glucose and GLP-1 are independent of preceding high-frequency insulin pulse-defects induced by glucose entrainment in healthy humans. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 37. issue 1. 2005-07-08. PMID:15702438. |
we therefore conclude from this short-term experimental setting in healthy subjects that beta-cell response to either iv-glucose or glp-1 is independent of the preceding regularity of oscillations in insulin release. |
2005-07-08 |
2023-08-12 |
human |
| Sang-Heon Lee, Seulki Lee, Yu Seok Youn, Dong Hee Na, Su Young Chae, Youngro Byun, Kang Choon Le. Synthesis, characterization, and pharmacokinetic studies of PEGylated glucagon-like peptide-1. Bioconjugate chemistry. vol 16. issue 2. 2005-06-30. PMID:15769092. |
glucagon-like peptide-1-(7-36) (glp-1) is a hormone derived from the proglucagon molecule, which is considered a highly desirable antidiabetic agent mainly due to its unique glucose-dependent stimulation of insulin secretion profiles. |
2005-06-30 |
2023-08-12 |
rat |
| Sang-Heon Lee, Seulki Lee, Yu Seok Youn, Dong Hee Na, Su Young Chae, Youngro Byun, Kang Choon Le. Synthesis, characterization, and pharmacokinetic studies of PEGylated glucagon-like peptide-1. Bioconjugate chemistry. vol 16. issue 2. 2005-06-30. PMID:15769092. |
the in vitro insulinotropic effect of peg(2k)-lys-glp-1 showed comparable biological activity with native glp-1 (p = 0.11) in stimulating insulin secretion in isolated rat pancreatic islet and was significantly more potent than the peg(2k)-n(ter)-glp-1 (p < 0.05) that showed a marked reduced potency. |
2005-06-30 |
2023-08-12 |
rat |
| T C M Adam, M S Westerterp-Planteng. Nutrient-stimulated GLP-1 release in normal-weight men and women. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 37. issue 2. 2005-06-23. PMID:15778929. |
the aim of the present study was to investigate the effect of a monosaccharide/fiber preload (galactose/guar gum) in combination with a standard breakfast (gg) on plasma glp-1, insulin, glucose, free fatty acid concentrations, and appetite ratings (satiety, hunger, fullness and desire to eat) in 30 normal-weight subjects. |
2005-06-23 |
2023-08-12 |
human |
| Diana Gentilcore, Renuka Visvanathan, Antonietta Russo, Reawika Chaikomin, Julie E Stevens, Judith M Wishart, Anne Tonkin, Michael Horowitz, Karen L Jone. Role of nitric oxide mechanisms in gastric emptying of, and the blood pressure and glycemic responses to, oral glucose in healthy older subjects. American journal of physiology. Gastrointestinal and liver physiology. vol 288. issue 6. 2005-06-21. PMID:15691867. |
ge, bp (systolic and diastolic), heart rate (hr), blood glucose, plasma insulin, and incretin hormones, glucose-dependant insulinotropic-polypeptide (gip), and glucagon-like peptide-1 (glp-1), were measured. |
2005-06-21 |
2023-08-12 |
human |