| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Ahrén, K Thomaseth, G Pacin. Reduced insulin clearance contributes to the increased insulin levels after administration of glucagon-like peptide 1 in mice. Diabetologia. vol 48. issue 10. 2005-12-20. PMID:16132949. |
however, whether glp-1 also affects insulin clearance is not known. |
2005-12-20 |
2023-08-12 |
mouse |
| Dominique Dardevet, Mary Courtney Moore, Catherine A DiCostanzo, Ben Farmer, Doss W Neal, Wanda Snead, Margaret Lautz, Alan D Cherringto. Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors. American journal of physiology. Gastrointestinal and liver physiology. vol 289. issue 5. 2005-11-30. PMID:16051922. |
insulin secretion-independent effects of glp-1 on canine liver glucose metabolism do not involve portal vein glp-1 receptors. |
2005-11-30 |
2023-08-12 |
Not clear |
| T J Caperna, A E Shannon, S M Poch, W M Garrett, M P Richard. Hormonal regulation of leptin receptor expression in primary cultures of porcine hepatocytes. Domestic animal endocrinology. vol 29. issue 4. 2005-11-29. PMID:16213991. |
insulin, glucagon and synthetic human proteins (ghrelin and glp-1) at 100 ng/ml had no influence on leptin receptor expression; the addition of t3 was associated with a marked increase (p < 0.001) in expression of total and long forms of the leptin receptor by 1.6 and 2.4-fold, respectively. |
2005-11-29 |
2023-08-12 |
human |
| Edwin P Kwan, Herbert Y Gaisan. Glucagon-like peptide 1 regulates sequential and compound exocytosis in pancreatic islet beta-cells. Diabetes. vol 54. issue 9. 2005-11-21. PMID:16123364. |
glucagon-like peptide 1 (glp-1) has been postulated to potentiate insulin secretion by camp-mediated enhancement of mobilization and priming of secretory granules, but the precise exocytic events are unknown. |
2005-11-21 |
2023-08-12 |
Not clear |
| Edwin P Kwan, Herbert Y Gaisan. Glucagon-like peptide 1 regulates sequential and compound exocytosis in pancreatic islet beta-cells. Diabetes. vol 54. issue 9. 2005-11-21. PMID:16123364. |
we conclude that the potentiation of insulin secretion by glp-1 is contributed by the mobilization of more insulin secretory granules to dock at the plasma membrane and the acceleration of sequential secretory granule-secretory granule fusions. |
2005-11-21 |
2023-08-12 |
Not clear |
| Wan-Chun Li, Marko E Horb, David Tosh, Jonathan M W Slac. In vitro transdifferentiation of hepatoma cells into functional pancreatic cells. Mechanisms of development. vol 122. issue 6. 2005-11-08. PMID:15939230. |
finally, we provided results to suggest that the transdifferentiated cells are functional by detecting: (1) functional markers for pancreatic beta-cells including prohormone convertase 1/3 (pc1/3), insulin c-peptide and glucagon-like peptide 1 receptor (glp-1r), (2) increased insulin mrna expression after treatment of cells with glp-1 and betacellulin, physiological stimuli that regulate pancreatic function and (3) elevated insulin secretion after glucose challenge. |
2005-11-08 |
2023-08-12 |
human |
| B Gallwit. Glucagon-like peptide-1 as a treatment option for type 2 diabetes and its role in restoring beta-cell mass. Diabetes technology & therapeutics. vol 7. issue 4. 2005-11-07. PMID:16120042. |
the improvement of beta-cell function can be indirectly observed from the increased insulin secretory capacity of humans receiving glp-1 or incretin mimetics that act like glp-1. |
2005-11-07 |
2023-08-12 |
Not clear |
| Verónica Sancho, María V Trigo, Nieves González, Isabel Valverde, Willy J Malaisse, María L Villanueva-Peñacarrill. Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats. Journal of molecular endocrinology. vol 35. issue 1. 2005-10-27. PMID:16087719. |
we have investigated, in isolated rat adipocytes, the changes caused by glp-1, ex-4 and ex-9 compared with those provoked by insulin or glucagon, upon the activity of phosphatidylinositol-3-kinase (pi3k), protein kinase b (pkb), p42/44 map kinases (mapks) and p70s6 kinase (p70s6k), and the participation of these kinases and protein kinase c (pkc) in their action upon 2-deoxy-d-glucose uptake, lipolysis and lipogenesis. |
2005-10-27 |
2023-08-12 |
human |
| Verónica Sancho, María V Trigo, Nieves González, Isabel Valverde, Willy J Malaisse, María L Villanueva-Peñacarrill. Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats. Journal of molecular endocrinology. vol 35. issue 1. 2005-10-27. PMID:16087719. |
in normal rat adipocytes, glp-1 and both exendins share with insulin an increasing action upon the activity of all kinases studied (except pkb), pi3k, p44 and p42 mapks and possibly pkc, all being required for their stimulating effect upon glucose uptake. |
2005-10-27 |
2023-08-12 |
human |
| Verónica Sancho, María V Trigo, Nieves González, Isabel Valverde, Willy J Malaisse, María L Villanueva-Peñacarrill. Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats. Journal of molecular endocrinology. vol 35. issue 1. 2005-10-27. PMID:16087719. |
ex-4 and ex-9, like glp-1 and insulin, have lipogenic action, while only ex-4 shares with glp-1 its lipolytic effect which is antagonized by ex-9. |
2005-10-27 |
2023-08-12 |
human |
| Verónica Sancho, María V Trigo, Nieves González, Isabel Valverde, Willy J Malaisse, María L Villanueva-Peñacarrill. Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats. Journal of molecular endocrinology. vol 35. issue 1. 2005-10-27. PMID:16087719. |
in cells from stz-rats the magnitude of the above parameters was, in general, comparable to that in normal animals, with some exceptions: basal pi3k activity and lipogenesis were higher, glp-1, ex-4 and ex-9 failed to modify basal lipogenesis but increased pkb activity, insulin failed to affect the activity of mapks and the insulin-induced glucose uptake was impaired. |
2005-10-27 |
2023-08-12 |
human |
| Verónica Sancho, María V Trigo, Nieves González, Isabel Valverde, Willy J Malaisse, María L Villanueva-Peñacarrill. Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats. Journal of molecular endocrinology. vol 35. issue 1. 2005-10-27. PMID:16087719. |
the impaired insulin effects upon some of the variables in the stz-rat, distinct from those of glp-1 and exendins, adds knowledge to the mechanism of the beneficial action of glp-1 and ex-4 in diabetic states. |
2005-10-27 |
2023-08-12 |
human |
| Máire E Doyle, Patrick McConville, Michael J Theodorakis, Margaret M Goetschkes, Michel Bernier, Richard G S Spencer, Harold W Holloway, Nigel H Greig, Josephine M Ega. In vivo biological activity of exendin (1-30). Endocrine. vol 27. issue 1. 2005-10-26. PMID:16077164. |
activation of the glucagon-like peptide-1 (glp-1) receptor on pancreatic beta cells by glp-1 and exendin-4 increases insulin secretion. |
2005-10-26 |
2023-08-12 |
mouse |
| Jay F Mouse. New drugs for management of diabetes: insulin analogues, inhaled insulin, pramlintide, and novel peptides. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. vol 19. issue 2. 2005-10-25. PMID:16215105. |
intriguingly, glp-1 hormones may have important biologic actions aside from stimulating insulin release, including inhibition of gastric motility and acid secretion, suppression of glucagon secretion, and islet cell proliferation. |
2005-10-25 |
2023-08-12 |
human |
| Masayuki Koizumi, Ryuichiro Doi, Koji Fujimoto, Daisuke Ito, Eiji Toyoda, Tomohiko Mori, Kazuhiro Kami, Yoshiya Kawaguchi, George K Gittes, Masayuki Imamur. Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1. Surgery. vol 138. issue 2. 2005-10-18. PMID:16153418. |
glucagonlike peptide-1 (glp-1) stimulates insulin secretion and proliferation by islet cells in vitro and in vivo, associated with an activation of pancreatic duodenal homeobox gene-1 (pdx-1) function. |
2005-10-18 |
2023-08-12 |
Not clear |
| Hongxiang Hui, Xiaoning Zhao, Riccardo Perfett. Structure and function studies of glucagon-like peptide-1 (GLP-1): the designing of a novel pharmacological agent for the treatment of diabetes. Diabetes/metabolism research and reviews. vol 21. issue 4. 2005-10-04. PMID:15852457. |
the multifaceted actions of glp-1 include the following: (1) the stimulation of insulin secretion and of its gene expression, (2) the inhibition of glucagon secretion, (3) the inhibition of food intake, (4) the proliferation and differentiation of beta cells, and (5) the protection of beta-cells from apoptosis. |
2005-10-04 |
2023-08-12 |
Not clear |
| Mark F McCart. A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk. Medical hypotheses. vol 64. issue 4. 2005-09-27. PMID:15694706. |
the increased production of glp-1 associated with frequent coffee consumption could thus be expected to counteract the adverse impact of chronic free fatty acid overexposure on beta cell function in overweight insulin resistant subjects. |
2005-09-27 |
2023-08-12 |
human |
| Hans-Ulrich Demuth, Christopher H S McIntosh, Raymond A Pederso. Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors. Biochimica et biophysica acta. vol 1751. issue 1. 2005-09-27. PMID:15978877. |
it was published in 1996 for the first time that a specific dp iv inhibitor in a given dose was able to completely block glucagon-like peptide-1 (glp-1) degradation in vivo resulting in improved insulin response accompanied, by accelerated peripheral glucose disposal. |
2005-09-27 |
2023-08-12 |
rat |
| Ewa Bojanowsk. Physiology and pathophysiology of glucagon-like peptide-1 (GLP-1): the role of GLP-1 in the pathogenesis of diabetes mellitus, obesity, and stress. Medical science monitor : international medical journal of experimental and clinical research. vol 11. issue 8. 2005-09-23. PMID:16049395. |
peripherally secreted glp-1 enhances insulin synthesis and release and maintains the normal anatomical status of pancreatic islets. |
2005-09-23 |
2023-08-12 |
human |
| Ewa Bojanowsk. Physiology and pathophysiology of glucagon-like peptide-1 (GLP-1): the role of GLP-1 in the pathogenesis of diabetes mellitus, obesity, and stress. Medical science monitor : international medical journal of experimental and clinical research. vol 11. issue 8. 2005-09-23. PMID:16049395. |
diminished glp-1 response to ingested food, associated with attenuated insulin release and glucose intolerance, was found in non-insulin-dependent diabetes mellitus. |
2005-09-23 |
2023-08-12 |
human |