| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juris J Meier, Arnica Gethmann, Michael A Nauck, Oliver Götze, Frank Schmitz, Carolyn F Deacon, Baptist Gallwitz, Wolfgang E Schmidt, Jens J Hols. The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans. American journal of physiology. Endocrinology and metabolism. vol 290. issue 6. 2006-07-13. PMID:16403774. |
blood was drawn for glp-1 (total and intact), glucose, insulin, c-peptide, and glucagon measurements. |
2006-07-13 |
2023-08-12 |
human |
| Juris J Meier, Arnica Gethmann, Michael A Nauck, Oliver Götze, Frank Schmitz, Carolyn F Deacon, Baptist Gallwitz, Wolfgang E Schmidt, Jens J Hols. The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans. American journal of physiology. Endocrinology and metabolism. vol 290. issue 6. 2006-07-13. PMID:16403774. |
the glp-1 metabolite had no influence on insulin or c-peptide concentrations. |
2006-07-13 |
2023-08-12 |
human |
| Juris J Meier, Arnica Gethmann, Michael A Nauck, Oliver Götze, Frank Schmitz, Carolyn F Deacon, Baptist Gallwitz, Wolfgang E Schmidt, Jens J Hols. The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans. American journal of physiology. Endocrinology and metabolism. vol 290. issue 6. 2006-07-13. PMID:16403774. |
the glp-1 metabolite lowers postprandial glycemia independently of changes in insulin and glucagon secretion or in the rate of gastric emptying. |
2006-07-13 |
2023-08-12 |
human |
| Aine M O'Connor, Suresh Pola, Blathnaid M Ward, Davina Fillmore, Keith D Buchanan, John P Kirwa. The gastroenteroinsular response to glucose ingestion during postexercise recovery. American journal of physiology. Endocrinology and metabolism. vol 290. issue 6. 2006-07-13. PMID:16403776. |
during the first 60 min of recovery from exercise alone (expl), plasma vasoactive intestinal peptide (vip), gastrin, and glucagon-like peptide-1 (glp-1) all increased significantly, whereas glucose, insulin, and gastric inhibitory polypeptide (gip) were unchanged from the immediate postexercise value. |
2006-07-13 |
2023-08-12 |
Not clear |
| Aine M O'Connor, Suresh Pola, Blathnaid M Ward, Davina Fillmore, Keith D Buchanan, John P Kirwa. The gastroenteroinsular response to glucose ingestion during postexercise recovery. American journal of physiology. Endocrinology and metabolism. vol 290. issue 6. 2006-07-13. PMID:16403776. |
when glucose was ingested after exercise (exglu), glucose, insulin, vip, gastrin, glp-1, and gip were all increased (p < 0.01). |
2006-07-13 |
2023-08-12 |
Not clear |
| Aine M O'Connor, Suresh Pola, Blathnaid M Ward, Davina Fillmore, Keith D Buchanan, John P Kirwa. The gastroenteroinsular response to glucose ingestion during postexercise recovery. American journal of physiology. Endocrinology and metabolism. vol 290. issue 6. 2006-07-13. PMID:16403776. |
however, when glucose was ingested after resting for 2 h (conglu), vip levels were unaffected, although glucose, insulin, gastrin, glp-1, and gip levels increased (p < 0.05). |
2006-07-13 |
2023-08-12 |
Not clear |
| Verónica Sancho, María V Trigo, Antonio Martín-Duce, Nieves Gonz Lez, Alicia Acitores, Luis Arnés, Isabel Valverde, Willy J Malaisse, María L Villanueva-Peñacarrill. Effect of GLP-1 on D-glucose transport, lipolysis and lipogenesis in adipocytes of obese subjects. International journal of molecular medicine. vol 17. issue 6. 2006-07-10. PMID:16685426. |
basal glut4 expression, d-glucose transport, glycerol release and lipogenesis were measured in cells treated, when required, with 10(-12)-10(-9) m glp-1, insulin, glucagon and the glp-1 structurally related peptides, exendin-4 and exendin-9. |
2006-07-10 |
2023-08-12 |
human |
| Verónica Sancho, María V Trigo, Antonio Martín-Duce, Nieves Gonz Lez, Alicia Acitores, Luis Arnés, Isabel Valverde, Willy J Malaisse, María L Villanueva-Peñacarrill. Effect of GLP-1 on D-glucose transport, lipolysis and lipogenesis in adipocytes of obese subjects. International journal of molecular medicine. vol 17. issue 6. 2006-07-10. PMID:16685426. |
in obese patients, versus normal subjects, a trend towards lower values was found in glut4 protein or mrna, although the differences were not statistically significant; insulin-stimulated glucose uptake was higher and cells did not respond to glp-1, while both exendins (10(-10) and 10(-9) m) exerted an inhibitory action; basal lipolysis was higher and so was the effect of glp-1 and glucagon, whereas insulin abolished the lipolytic action of all peptides; both basal lipogenesis and the response to insulin were higher while glp-1 and exendin-4 were ineffective. |
2006-07-10 |
2023-08-12 |
human |
| Verónica Sancho, María V Trigo, Antonio Martín-Duce, Nieves Gonz Lez, Alicia Acitores, Luis Arnés, Isabel Valverde, Willy J Malaisse, María L Villanueva-Peñacarrill. Effect of GLP-1 on D-glucose transport, lipolysis and lipogenesis in adipocytes of obese subjects. International journal of molecular medicine. vol 17. issue 6. 2006-07-10. PMID:16685426. |
these results document the analogies and dissimilarities between the response to glp-1, exendin-4 and exendin-9, as well as to insulin and glucagon, relative to glucose transport and lipid metabolism of fat tissue from obese patients versus normal subjects, the reduced lipogenic effect and enhanced lipolytic action of glp-1 being, perhaps, adequate for its therapeutic use in obesity. |
2006-07-10 |
2023-08-12 |
human |
| Clark Q Pan, Joanne M Buxton, Stephanie L Yung, Irene Tom, Ling Yang, Hongxing Chen, Margit MacDougall, Andrea Bell, Thomas H Claus, Kevin B Clairmont, James P Whela. Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon receptor antagonist. The Journal of biological chemistry. vol 281. issue 18. 2006-06-28. PMID:16505481. |
glp-1 induces glucose-dependent insulin secretion in the pancreas, whereas glucagon stimulates gluconeogenesis and glycogenolysis in the liver. |
2006-06-28 |
2023-08-12 |
Not clear |
| Tingcun Zhao, Pratik Parikh, Siva Bhashyam, Hakki Bolukoglu, Indu Poornima, You-Tang Shen, Richard P Shanno. Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts. The Journal of pharmacology and experimental therapeutics. vol 317. issue 3. 2006-06-26. PMID:16489128. |
glp-1 increased lv function, myocardial glucose uptake, and glut-1 and glut-4 translocation during reperfusion to an extent similar to that with insulin. |
2006-06-26 |
2023-08-12 |
rat |
| Tingcun Zhao, Pratik Parikh, Siva Bhashyam, Hakki Bolukoglu, Indu Poornima, You-Tang Shen, Richard P Shanno. Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts. The Journal of pharmacology and experimental therapeutics. vol 317. issue 3. 2006-06-26. PMID:16489128. |
glp-1 has direct effects on the normal heart, reducing contractility, but increasing myocardial glucose uptake through a non-akt-1-dependent mechanism, distinct from the actions of insulin. |
2006-06-26 |
2023-08-12 |
rat |
| Tingcun Zhao, Pratik Parikh, Siva Bhashyam, Hakki Bolukoglu, Indu Poornima, You-Tang Shen, Richard P Shanno. Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts. The Journal of pharmacology and experimental therapeutics. vol 317. issue 3. 2006-06-26. PMID:16489128. |
however, glp-1 increased myocardial glucose uptake and enhanced recovery of cardiac function after low-flow ischemia in a fashion similar to that of insulin. |
2006-06-26 |
2023-08-12 |
rat |
| Renate E Wachters-Hagedoorn, Marion G Priebe, Janneke A J Heimweg, A Marius Heiner, Klaus N Englyst, Jens J Holst, Frans Stellaard, Roel J Von. The rate of intestinal glucose absorption is correlated with plasma glucose-dependent insulinotropic polypeptide concentrations in healthy men. The Journal of nutrition. vol 136. issue 6. 2006-06-22. PMID:16702313. |
in a crossover study, glucose, insulin, glp-1, and gip concentrations were monitored for 6 h after consumption of glucose, uncooked cornstarch (uccs) or corn pasta in 7 healthy men. |
2006-06-22 |
2023-08-12 |
Not clear |
| J G McCormac. Applying science to drug discovery. Biochemical Society transactions. vol 34. issue Pt 2. 2006-06-16. PMID:16545084. |
the second describes the application of detailed knowledge of insulin structure and action to then use recombinant approaches to design novel molecules to be able to offer the type i (insulin-dependent) diabetic patient therapies allowing a more physiological treatment regime, and also the further application of learned technology to then discover a means of harnessing the potential of glp-1 (glucagon-like polypeptide 1) for treating type ii (non-insulin-dependent) diabetes. |
2006-06-16 |
2023-08-12 |
Not clear |
| D K Arulmozhi, B Porth. GLP-1 based therapy for type 2 diabetes. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 28. issue 1-2. 2006-06-14. PMID:16488579. |
glp-1 glucoregulatory actions include glucose-dependent enhancement of insulin secretion, inhibition of glucagon secretion, slowing of gastric emptying and reduction of food intake. |
2006-06-14 |
2023-08-12 |
Not clear |
| Marzieh Salehi, David A D'Alessi. New therapies for type 2 diabetes based on glucagon-like peptide 1. Cleveland Clinic journal of medicine. vol 73. issue 4. 2006-05-25. PMID:16610399. |
cells in the gastrointestinal tract secrete several hormones that stimulate insulin secretion, one of which is glucagon-like peptide (glp-1). |
2006-05-25 |
2023-08-12 |
Not clear |
| Marzieh Salehi, David A D'Alessi. New therapies for type 2 diabetes based on glucagon-like peptide 1. Cleveland Clinic journal of medicine. vol 73. issue 4. 2006-05-25. PMID:16610399. |
several new drugs act through the glp-1 signaling system to stimulate insulin release and regulate blood glucose levels in patients with diabetes. |
2006-05-25 |
2023-08-12 |
Not clear |
| J Cancelas, P G Prieto, M L Villanueva-Peñacarrillo, I Valverde, W J Malaiss. Effects of an olive oil-enriched diet on glucagon-like peptide 1 release and intestinal content, plasma insulin concentration, glucose tolerance and pancreatic insulin content in an animal model of type 2 diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 38. issue 2. 2006-05-18. PMID:16523410. |
in the light of a recent study conducted in normal rats, the present investigations were aimed at exploring the immediate and long-term effects of an olive oil-enriched diet (oo diet) on glp-1 release and intestinal content, plasma insulin concentration, glucose tolerance and pancreatic insulin content in adult rats that had been injected with streptozotocin during the neonatal period (stz rats). |
2006-05-18 |
2023-08-12 |
rat |
| Joanna Kluz, Rajmund Adamie. [New therapeutic approach in patients with type 2 diabetes based on glucagon-like peptide 1 (GLP-1) and gastric inhibitory peptide (GIP)]. Postepy higieny i medycyny doswiadczalnej (Online). vol 60. 2006-05-16. PMID:16407790. |
apart from their glucose-dependent manner of stimulating insulin secretion, glp-1, its analogues, and gip have been demonstrated to stimulate beta-cell growth, differentiation, proliferation, and survival. |
2006-05-16 |
2023-08-12 |
Not clear |