| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diva D De León, Michael F Crutchlow, Jee-Young Nina Ham, Doris A Stoffer. Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus. The international journal of biochemistry & cell biology. vol 38. issue 5-6. 2006-05-08. PMID:16202636. |
the first recognized and most important action of glp-1 is the potentiation of glucose-stimulated insulin secretion in beta-cells, mediated by activation of its seven transmembrane domain g-protein-coupled receptor. |
2006-05-08 |
2023-08-12 |
Not clear |
| Daniel J Drucke. The biology of incretin hormones. Cell metabolism. vol 3. issue 3. 2006-05-01. PMID:16517403. |
gut peptides, exemplified by glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are secreted in a nutrient-dependent manner and stimulate glucose-dependent insulin secretion. |
2006-05-01 |
2023-08-12 |
human |
| Daniel J Drucke. The biology of incretin hormones. Cell metabolism. vol 3. issue 3. 2006-05-01. PMID:16517403. |
furthermore, glp-1, unlike gip, potently stimulates insulin secretion and reduces blood glucose in human subjects with type 2 diabetes. |
2006-05-01 |
2023-08-12 |
human |
| Joy K Saha, Jinqi Xia, Steven K Engle, Yun-Fei Chen, Wolfgang Glaesner, Joseph A Jakubowsk. A model of controlled acute hyperglycemia in rats: Effects of insulin and glucagon-like peptide-1 analog. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16280413. |
a rodent model of controlled acute hyperglycemia that is sensitive to glucose-lowering agents insulin and glucagon-like peptide-1 (glp-1) analog has been developed. |
2006-04-13 |
2023-08-12 |
rat |
| Joy K Saha, Jinqi Xia, Steven K Engle, Yun-Fei Chen, Wolfgang Glaesner, Joseph A Jakubowsk. A model of controlled acute hyperglycemia in rats: Effects of insulin and glucagon-like peptide-1 analog. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16280413. |
the infusion of insulin (0.1 u/kg/h) or glp-1 analog (10 microg/kg/h) effectively lowered blood glucose from its elevated levels. |
2006-04-13 |
2023-08-12 |
rat |
| Joy K Saha, Jinqi Xia, Steven K Engle, Yun-Fei Chen, Wolfgang Glaesner, Joseph A Jakubowsk. A model of controlled acute hyperglycemia in rats: Effects of insulin and glucagon-like peptide-1 analog. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16280413. |
insulin produced a significant increase in glucagon levels, and glp-1 analog produced a significant increase in insulin levels without any change in other glucoregulatory and stress hormone levels. |
2006-04-13 |
2023-08-12 |
rat |
| Joy K Saha, Jinqi Xia, Steven K Engle, Yun-Fei Chen, Wolfgang Glaesner, Joseph A Jakubowsk. A model of controlled acute hyperglycemia in rats: Effects of insulin and glucagon-like peptide-1 analog. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16280413. |
this model was responsive to insulin and glp-1 analog, both of which were effective in ameliorating hyperglycemia. |
2006-04-13 |
2023-08-12 |
rat |
| Baptist Gallwit. Glucagon-like peptide-1-based therapies for the treatment of type 2 diabetes mellitus. Treatments in endocrinology. vol 4. issue 6. 2006-03-28. PMID:16318402. |
glp-1 does not stimulate insulin secretion at normal glucose levels; therefore, it does not cause hypoglycemia. |
2006-03-28 |
2023-08-12 |
Not clear |
| Baptist Gallwit. Glucagon-like peptide-1-based therapies for the treatment of type 2 diabetes mellitus. Treatments in endocrinology. vol 4. issue 6. 2006-03-28. PMID:16318402. |
the improvement of beta-cell function due to glp-1 can be indirectly observed from the increased insulin secretory capacity of humans receiving such treatment. |
2006-03-28 |
2023-08-12 |
Not clear |
| Michael J Theodorakis, Olga Carlson, Spyros Michopoulos, Máire E Doyle, Magdalena Juhaszova, Kalliopi Petraki, Josephine M Ega. Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP. American journal of physiology. Endocrinology and metabolism. vol 290. issue 3. 2006-03-23. PMID:16219666. |
newly diagnosed type 2 diabetic subjects had increased plasma glp-1 levels between 20 and 80 min, concurrently with rising plasma insulin levels. |
2006-03-23 |
2023-08-12 |
human |
| Anthony H Barnet. Exenatide. Drugs of today (Barcelona, Spain : 1998). vol 41. issue 9. 2006-03-09. PMID:16341288. |
released from cells in the gut in response to food, glp-1 binds to pancreatic beta-cell receptors to stimulate the release of insulin. |
2006-03-09 |
2023-08-12 |
Not clear |
| Anthony H Barnet. Exenatide. Drugs of today (Barcelona, Spain : 1998). vol 41. issue 9. 2006-03-09. PMID:16341288. |
exenatide mirrors many of the effects of glp-1, improving glycemic control through a combination of mechanisms, which include glucose-dependent stimulation of insulin secretion, suppression of glucagon secretion, slowing of gastric emptying, reduced appetite and enhanced beta-cell function. |
2006-03-09 |
2023-08-12 |
Not clear |
| Tanja C M Adam, Manuela P G M Lejeune, Margriet S Westerterp-Planteng. Nutrient-stimulated glucagon-like peptide 1 release after body-weight loss and weight maintenance in human subjects. The British journal of nutrition. vol 95. issue 1. 2006-03-09. PMID:16441929. |
at each occasion, following a fasting blood sample the test meal was fed and blood was drawn every 30 min for 2 h relative to ingestion in order to determine plasma glp-1, insulin, glucose and nefa concentrations. |
2006-03-09 |
2023-08-12 |
human |
| George G Holz, Oleg G Chepurn. Diabetes outfoxed by GLP-1? Science's STKE : signal transduction knowledge environment. vol 2005. issue 268. 2006-03-08. PMID:15671479. |
this stke perspective summarizes signaling properties of glp-1 that may explain its ability to increase beta-cell mass, to increase pancreatic insulin secretory capacity, and to lower levels of blood glucose in type 2 diabetic subjects. |
2006-03-08 |
2023-08-12 |
human |
| Eri Tei, Sheilendra Mehta, Sidhartha S Tulachan, Hooi Yew, Mark Hembree, Barry Preuett, Charles L Snyder, Atsuyuki Yamataka, Takeshi Miyano, George K Gitte. Synergistic endocrine induction by GLP-1 and TGF-beta in the developing pancreas. Pancreas. vol 31. issue 2. 2006-03-07. PMID:16025000. |
glucagon-like peptide-1 (glp-1) is known to stimulate glucose-dependent insulin production and secretion by pancreatic beta-cells. |
2006-03-07 |
2023-08-12 |
Not clear |
| B D Green, H K Liu, J T McCluskey, N A Duffy, F P M O'Harte, N H McClenaghan, P R Flat. Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1. Diabetes, obesity & metabolism. vol 7. issue 5. 2006-02-28. PMID:16050949. |
in this study, we determined cell growth, insulin content, insulin accumulation and insulin secretory function of a insulin-secreting cell line cultured for 3 days with either glp-1, glp-1 plus the dpp iv inhibitor diprotin a (dpa) or stable n-acetyl-glp-1. |
2006-02-28 |
2023-08-12 |
human |
| B D Green, H K Liu, J T McCluskey, N A Duffy, F P M O'Harte, N H McClenaghan, P R Flat. Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1. Diabetes, obesity & metabolism. vol 7. issue 5. 2006-02-28. PMID:16050949. |
the results indicate that prevention of dpp iv action is necessary for beneficial effects of glp-1 on pancreatic beta cells and that prolonged exposure to glp-1(9-36)amide may be detrimental to insulin secretory function. |
2006-02-28 |
2023-08-12 |
human |
| Tetsuya Adachi, Toshiki Tanaka, Kazuhisa Takemoto, Taka-aki Koshimizu, Akira Hirasawa, Gozoh Tsujimot. Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin. Biochemical and biophysical research communications. vol 340. issue 1. 2006-02-28. PMID:16356474. |
we found that an unsaturated long-chain ffa, alpha-linolenic acid (alpha-la), resulted in increased plasma glp-1 and insulin levels when administered into the colon. |
2006-02-28 |
2023-08-12 |
mouse |
| Tetsuya Adachi, Toshiki Tanaka, Kazuhisa Takemoto, Taka-aki Koshimizu, Akira Hirasawa, Gozoh Tsujimot. Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin. Biochemical and biophysical research communications. vol 340. issue 1. 2006-02-28. PMID:16356474. |
our results indicate that the in vivo colonic administration of alpha-la promotes secretion of incretin glp-1 by activating the erk pathway in l-cells and thereby enhances the secretion of insulin. |
2006-02-28 |
2023-08-12 |
mouse |
| Wendy A M Blom, Anne Lluch, Sophie Vinoy, Annette Stafleu, Robin van den Berg, Jens J Holst, Frans J Kok, Henk F J Hendrik. Effects of gastric emptying on the postprandial ghrelin response. American journal of physiology. Endocrinology and metabolism. vol 290. issue 2. 2006-02-22. PMID:16188911. |
ghrelin concentrations were only weakly correlated with insulin concentrations (saline r = -0.36; 95% ci = -0.69, 0.09; glp- 1 r = -0.42; 95% ci = -0.73, 0.03), but strongly inversely correlated with gip concentrations (saline r = -0.74; 95% ci= -0.89, -0.45; glp-1 r = -0.63; 95% ci = -0.84, -0.27). |
2006-02-22 |
2023-08-12 |
human |