| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Parker, K S Lavery, N Irwin, B D Green, B Greer, P Harriott, F P M O'Harte, V A Gault, P R Flat. Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. The Journal of endocrinology. vol 191. issue 1. 2006-12-29. PMID:17065392. |
effects of sub-chronic exposure to naturally occurring n-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (gip) and glucagon-like peptide-1 (glp-1), gip(3-42) and glp-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. |
2006-12-29 |
2023-08-12 |
mouse |
| J C Parker, K S Lavery, N Irwin, B D Green, B Greer, P Harriott, F P M O'Harte, V A Gault, P R Flat. Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. The Journal of endocrinology. vol 191. issue 1. 2006-12-29. PMID:17065392. |
glp-1(9-36)amide also had no effect on plasma glucose homeostasis or insulin secretion. |
2006-12-29 |
2023-08-12 |
mouse |
| J C Parker, K S Lavery, N Irwin, B D Green, B Greer, P Harriott, F P M O'Harte, V A Gault, P R Flat. Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. The Journal of endocrinology. vol 191. issue 1. 2006-12-29. PMID:17065392. |
these data indicate that sub-chronic exposure to gip and glp-1 metabolites does not result in physiological impairment of insulin secretion or blood glucose control. |
2006-12-29 |
2023-08-12 |
mouse |
| Raylene A Reime. Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases. The Journal of endocrinology. vol 191. issue 1. 2006-12-29. PMID:17065399. |
glucagon-like peptide-1 (glp-1) is a potent insulin secretagogue released from l-cells in the intestine. |
2006-12-29 |
2023-08-12 |
human |
| Fengming Yue, Li Cui, Kohei Johkura, Naoko Ogiwara, Katsunori Sasak. Glucagon-like peptide-1 differentiation of primate embryonic stem cells into insulin-producing cells. Tissue engineering. vol 12. issue 8. 2006-12-22. PMID:16968152. |
the levels of pancreas-related gene and protein expression and insulin secretion in the glp-1 group were stronger than those in the normal controls. |
2006-12-22 |
2023-08-12 |
mouse |
| Neville H McClenaghan, Peter R Flatt, Andrew J Bal. Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide. The Journal of endocrinology. vol 190. issue 3. 2006-12-18. PMID:17003289. |
this study examined the effects of glucagon-like peptide-1 (glp-1) on insulin secretion alone and in combination with sulphonylureas or nateglinide, with particular attention to k(atp) channel-independent insulin secretion. |
2006-12-18 |
2023-08-12 |
Not clear |
| Neville H McClenaghan, Peter R Flatt, Andrew J Bal. Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide. The Journal of endocrinology. vol 190. issue 3. 2006-12-18. PMID:17003289. |
in depolarised cells, glp-1 significantly augmented glucose-induced k(atp) channel-independent insulin secretion in a glucose concentration-dependent manner. |
2006-12-18 |
2023-08-12 |
Not clear |
| Neville H McClenaghan, Peter R Flatt, Andrew J Bal. Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide. The Journal of endocrinology. vol 190. issue 3. 2006-12-18. PMID:17003289. |
in contrast, glp-1 exhibited a reduced but still significant insulin-releasing effect following pka and pkc downregulation, indicating that glp-1 can modulate k(atp) channel-independent insulin secretion by protein kinase-dependent and -independent mechanisms. |
2006-12-18 |
2023-08-12 |
Not clear |
| Neville H McClenaghan, Peter R Flatt, Andrew J Bal. Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide. The Journal of endocrinology. vol 190. issue 3. 2006-12-18. PMID:17003289. |
the synergistic insulin-releasing effects of combinatorial glp-1 and sulphonylurea/nateglinide were lost following pka- or pkc-desensitisation, despite glp-1 retaining an insulin-releasing effect, demonstrating that glp-1 can induce insulin release under conditions where sulphonylureas and nateglinide are no longer effective. |
2006-12-18 |
2023-08-12 |
Not clear |
| Yoshikazu Miura, Hisao Matsu. Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na+ and Ca2+ and PKA-independent increase of cytosolic Ca2+ associated with insulin secretion in hamster pancreatic beta-cells. Toxicology and applied pharmacology. vol 216. issue 3. 2006-12-06. PMID:16837018. |
moreover, tpt administration significantly reduced the insulin secretion by 2 mm db-camp, glp-1, gip, and 8-pcpt-2'-o-me-camp with and without h-89, and that by 6-bnz-camp and forskolin. |
2006-12-06 |
2023-08-12 |
Not clear |
| Daniel J Drucker, Michael A Nauc. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet (London, England). vol 368. issue 9548. 2006-12-04. PMID:17098089. |
glucagon-like peptide 1 (glp-1) is a gut-derived incretin hormone that stimulates insulin and suppresses glucagon secretion, inhibits gastric emptying, and reduces appetite and food intake. |
2006-12-04 |
2023-08-12 |
Not clear |
| Maria del Pilar Milke Garcí. [Ghrelin: beyond hunger regulation]. Revista de gastroenterologia de Mexico. vol 70. issue 4. 2006-11-30. PMID:17058987. |
satiation biomarkers (stop feeding) are gastric distention and hormones (cck, glp-1) and satiety biomarkers (induce feeding) are food-induced thermogenesis, body temperature, glycaemia and also hormones (insulin, leptin and ghrelin). |
2006-11-30 |
2023-08-12 |
human |
| Yuko Suzuki, Hui Zhang, Naoaki Saito, Itaru Kojima, Tetsumei Urano, Hideo Mogam. Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16870611. |
although the stimulatory effect of glucagon-like peptide 1 (glp-1), a camp-generating agonist, on ca(2+) signal and insulin secretion is well established, the underlying mechanisms remain to be fully elucidated. |
2006-11-27 |
2023-08-12 |
rat |
| Yuko Suzuki, Hui Zhang, Naoaki Saito, Itaru Kojima, Tetsumei Urano, Hideo Mogam. Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16870611. |
thus, glp-1 can activate pkcalpha and pkcepsilon, and these glp-1-activated pkcs may contribute considerably to insulin secretion at a substimulatory concentration of glucose. |
2006-11-27 |
2023-08-12 |
rat |
| Carl Frederik Nagell, André Wettergren, Cathrine Ørskov, Jens Juul Hols. Inhibitory effect of GLP-1 on gastric motility persists after vagal deafferentation in pigs. Scandinavian journal of gastroenterology. vol 41. issue 6. 2006-11-09. PMID:16716964. |
the glp-1 mechanism of action on insulin secretion is at least partly mediated via receptors on the pancreatic islet, but the mechanism by which glp-1 retards gastric emptying is not known and may involve neural interactions, although glp-1 has no effect on vagally stimulated motor activity of the isolated porcine antrum. |
2006-11-09 |
2023-08-12 |
Not clear |
| J Skrh. [Pancreatic hormones and hormonal regulation of insulin secretion]. Casopis lekaru ceskych. vol 145. issue 8. 2006-11-09. PMID:16995414. |
incretin effect of glucose-dependent insulinotropic peptide (gip) and glucagon-like peptide 1 (glp-1) is significantly involved in the insulin secretion which is modulated by many other hormones. |
2006-11-09 |
2023-08-12 |
Not clear |
| María Herminia Navarro, María Teresa Lozano, Blanca Agulleir. Ontogeny of the endocrine pancreatic cells of the gilthead sea bream, Sparus aurata (Teleost). General and comparative endocrinology. vol 148. issue 2. 2006-10-30. PMID:16630618. |
bonito insulin (ins)-, synthetic somatostatin-14 (ss-14)-, salmon somatostatin-25 (ss-25)-, mammalian somatostatin-28 (1-12) (ss-28)-, porcine glucagon (glu)-, glucagon-like peptide-1 (1-19) (glp-1)-, synthetic porcine peptide tyrosine tyrosine (pyy)-, and neuropeptide y (npy)-like immunoreactivities were demonstrated. |
2006-10-30 |
2023-08-12 |
Not clear |
| Viorica Ionut, Idit F Liberty, Katrin Hucking, Maya Lottati, Darko Stefanovski, Dan Zheng, Richard N Bergma. Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action. American journal of physiology. Endocrinology and metabolism. vol 291. issue 4. 2006-10-24. PMID:16720628. |
we also infused systemic glucose plus glp-1, or glucose alone, to simulate the meal test values of these variables and measured insulin response. |
2006-10-24 |
2023-08-12 |
dog |
| Viorica Ionut, Idit F Liberty, Katrin Hucking, Maya Lottati, Darko Stefanovski, Dan Zheng, Richard N Bergma. Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action. American journal of physiology. Endocrinology and metabolism. vol 291. issue 4. 2006-10-24. PMID:16720628. |
the results were as follows: during the meal, we measured a robust insulin response (52 +/- 9 to 136 +/- 14 pmol/l, p < 0.05 vs. basal) with increases in portal glucose and glp-1 but only limited increases in systemic glucose (5.3 +/- 0.1 to 5.7 +/- 0.1 mmol/l, p = 0.1 vs. basal) and glp-1 (6 +/- 0 to 9 +/- 1 pmol/l, p = 0.5 vs. basal). |
2006-10-24 |
2023-08-12 |
dog |
| Viorica Ionut, Idit F Liberty, Katrin Hucking, Maya Lottati, Darko Stefanovski, Dan Zheng, Richard N Bergma. Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action. American journal of physiology. Endocrinology and metabolism. vol 291. issue 4. 2006-10-24. PMID:16720628. |
exogenous infusion of systemic glucose and glp-1 produced a moderate increase in insulin (43 +/- 5 to 84 +/- 15 pmol/l, 43% of the meal insulin). |
2006-10-24 |
2023-08-12 |
dog |