| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Bur, Hanno Huwer, Claus-Michael Lehr, Nina Hagen, Mette Guldbrandt, Kwang-Jin Kim, Carsten Ehrhard. Assessment of transport rates of proteins and peptides across primary human alveolar epithelial cell monolayers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 28. issue 3. 2007-08-06. PMID:16533597. |
in this study, we investigated bi-directional fluxes (i.e., in absorptive and secretive directions) of human serum proteins [albumin (hsa), transferrin (tf), and immunoglobulin g (igg)] and peptides/proteins of potential therapeutic relevance [insulin (ins), glucagon-like peptide-1 (glp-1), growth hormone (gh), and parathyroid hormone (pth)] across tight monolayers of human alveolar epithelial cells (haepc) in primary culture. |
2007-08-06 |
2023-08-12 |
human |
| K Thomaseth, A Pavan, G Pacini, B Ahré. Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17311896. |
glucagon-like peptide-1 (glp-1) plays a significant role in glucose homeostasis through its incretin effect on insulin secretion. |
2007-07-30 |
2023-08-12 |
mouse |
| K Thomaseth, A Pavan, G Pacini, B Ahré. Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17311896. |
however, glp-1 also exhibits extrapancreatic actions, and in particular its possible influences on insulin sensitivity are controversial. |
2007-07-30 |
2023-08-12 |
mouse |
| K Thomaseth, A Pavan, G Pacini, B Ahré. Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17311896. |
to study the dynamic action of glp-1 on insulin sensitivity, we applied advanced statistical modeling methods to study glucose disappearance in mice that underwent intravenous glucose tolerance test with administration of glp-1 at various dose levels. |
2007-07-30 |
2023-08-12 |
mouse |
| K Thomaseth, A Pavan, G Pacini, B Ahré. Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17311896. |
minimal model parameters were estimated from glucose and insulin data collected in 209 anesthetized normal mice after intravenous injection of glucose (1 g/kg) alone or with glp-1 (0.03-100 nmol/kg). |
2007-07-30 |
2023-08-12 |
mouse |
| K Thomaseth, A Pavan, G Pacini, B Ahré. Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17311896. |
insulin secretion markedly increased, as expected, with increasing glp-1 dose. |
2007-07-30 |
2023-08-12 |
mouse |
| K Thomaseth, A Pavan, G Pacini, B Ahré. Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17311896. |
however, minimal model-derived indexes, i.e., insulin sensitivity and glucose effectiveness, did not significantly change with glp-1 dose. |
2007-07-30 |
2023-08-12 |
mouse |
| K Thomaseth, A Pavan, G Pacini, B Ahré. Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17311896. |
instead, fractional turnover rate of insulin action [p2 = 0.0207 +/- 24.3% (min) at zero glp-1 dose] increased steadily with administered glp-1 dose, with significant differences at 10.4 nmol/kg (p2 = 0.040 +/- 15.5%, p = 0.0046) and 31.2 nmol/kg (p2 = 0.050 +/- 29.2%, p = 0.01). |
2007-07-30 |
2023-08-12 |
mouse |
| K Thomaseth, A Pavan, G Pacini, B Ahré. Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17311896. |
these results show that glp-1 influences the dynamics of insulin action by accelerating insulin action following glucose challenge. |
2007-07-30 |
2023-08-12 |
mouse |
| Zhi-Liang Chu, Robert M Jones, Hongmei He, Chris Carroll, Veronica Gutierrez, Annette Lucman, Molly Moloney, Hui Gao, Helen Mondala, Didier Bagnol, David Unett, Yin Liang, Keith Demarest, Graeme Semple, Dominic P Behan, James Leonar. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. vol 148. issue 6. 2007-07-24. PMID:17289847. |
injectable peptide agonists of the glucagon-like peptide 1 (glp-1) receptor have shown significant promise as antidiabetic agents by virtue of their ability to amplify glucose-dependent insulin release and preserve pancreatic beta-cell mass. |
2007-07-24 |
2023-08-12 |
mouse |
| Zhi-Liang Chu, Robert M Jones, Hongmei He, Chris Carroll, Veronica Gutierrez, Annette Lucman, Molly Moloney, Hui Gao, Helen Mondala, Didier Bagnol, David Unett, Yin Liang, Keith Demarest, Graeme Semple, Dominic P Behan, James Leonar. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. vol 148. issue 6. 2007-07-24. PMID:17289847. |
unlike receptors for glp-1 and other peptides that mediate enhanced glucose-dependent insulin release, gpr119 was suitable for the development of potent, orally active, small-molecule agonists. |
2007-07-24 |
2023-08-12 |
mouse |
| Laurie L Baggio, Dianne Holland, Joan Wither, Daniel J Drucke. Lymphocytic infiltration and immune activation in metallothionein promoter-exendin-4 (MT-Exendin) transgenic mice. Diabetes. vol 55. issue 6. 2007-07-23. PMID:16731818. |
glucagon-like peptide 1 (glp-1) exhibits considerable potential for the treatment of type 2 diabetes because of its effects on stimulation of insulin secretion and the inhibition of gastric emptying, appetite, and glucagon secretion. |
2007-07-23 |
2023-08-12 |
mouse |
| P Schlatter, C Beglinger, J Drewe, H Gutman. Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells. Regulatory peptides. vol 141. issue 1-3. 2007-07-17. PMID:17276524. |
the main biological effects of glp-1 include stimulation of glucose dependent insulin secretion and induction of satiety feelings. |
2007-07-17 |
2023-08-12 |
rat |
| Nigel Irwin, Paula L McClean, Peter R Flat. Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice. Journal of peptide science : an official publication of the European Peptide Society. vol 13. issue 6. 2007-07-10. PMID:17486662. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are the two key incretin hormones released from the gastrointestinal tract that regulate blood glucose homeostasis through potent insulin secretion. |
2007-07-10 |
2023-08-12 |
mouse |
| Nigel Irwin, Paula L McClean, Peter R Flat. Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice. Journal of peptide science : an official publication of the European Peptide Society. vol 13. issue 6. 2007-07-10. PMID:17486662. |
subchronic administration of n-acgip, (val8)glp-1 or combined peptide administration had no significant effects on the body weight, food intake and plasma insulin concentrations. |
2007-07-10 |
2023-08-12 |
mouse |
| Nigel Irwin, Paula L McClean, Patrick Harriott, Peter R Flat. Beneficial effects of sub-chronic activation of glucagon-like peptide-1 (GLP-1) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice. Experimental gerontology. vol 42. issue 4. 2007-06-29. PMID:17184947. |
beneficial effects of sub-chronic activation of glucagon-like peptide-1 (glp-1) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice. |
2007-06-29 |
2023-08-12 |
mouse |
| Nigel Irwin, Paula L McClean, Patrick Harriott, Peter R Flat. Beneficial effects of sub-chronic activation of glucagon-like peptide-1 (GLP-1) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice. Experimental gerontology. vol 42. issue 4. 2007-06-29. PMID:17184947. |
daily injection of (val(8))glp-1 (25 n mol/kg body weight) for 12 days had no significant effect on food intake, body weight, non-fasting plasma glucose and insulin concentrations. |
2007-06-29 |
2023-08-12 |
mouse |
| Nigel Irwin, Paula L McClean, Patrick Harriott, Peter R Flat. Beneficial effects of sub-chronic activation of glucagon-like peptide-1 (GLP-1) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice. Experimental gerontology. vol 42. issue 4. 2007-06-29. PMID:17184947. |
these data indicate that sub-chronic activation of the glp-1 receptor by daily treatment with (val(8))glp-1 counters aspects of the age-related impairment of pancreatic beta-cell function and insulin sensitivity. |
2007-06-29 |
2023-08-12 |
mouse |
| Gang Xu, Hideaki Kaneto, D Ross Laybutt, Valerie F Duvivier-Kali, Nitin Trivedi, Kiyoshi Suzuma, George L King, Gordon C Weir, Susan Bonner-Wei. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. vol 56. issue 6. 2007-06-14. PMID:17360984. |
stimulation of insulin secretion by the incretin hormones glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic peptide (gip) has been found to be diminished in type 2 diabetes. |
2007-06-14 |
2023-08-12 |
rat |
| Gang Xu, Hideaki Kaneto, D Ross Laybutt, Valerie F Duvivier-Kali, Nitin Trivedi, Kiyoshi Suzuma, George L King, Gordon C Weir, Susan Bonner-Wei. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. vol 56. issue 6. 2007-06-14. PMID:17360984. |
perifused islets isolated from hyperglycemic px rats showed reduced insulin responses to glp-1 and gip. |
2007-06-14 |
2023-08-12 |
rat |