| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyeung-Jin Jang, Zaza Kokrashvili, Michael J Theodorakis, Olga D Carlson, Byung-Joon Kim, Jie Zhou, Hyeon Ho Kim, Xiangru Xu, Sic L Chan, Magdalena Juhaszova, Michel Bernier, Bedrich Mosinger, Robert F Margolskee, Josephine M Ega. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 38. 2007-11-27. PMID:17724330. |
glucagon-like peptide-1 (glp-1), released from gut endocrine l cells in response to glucose, regulates appetite, insulin secretion, and gut motility. |
2007-11-27 |
2023-08-12 |
mouse |
| Hyeung-Jin Jang, Zaza Kokrashvili, Michael J Theodorakis, Olga D Carlson, Byung-Joon Kim, Jie Zhou, Hyeon Ho Kim, Xiangru Xu, Sic L Chan, Magdalena Juhaszova, Michel Bernier, Bedrich Mosinger, Robert F Margolskee, Josephine M Ega. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 38. 2007-11-27. PMID:17724330. |
ingestion of glucose by alpha-gustducin null mice revealed deficiencies in secretion of glp-1 and the regulation of plasma insulin and glucose. |
2007-11-27 |
2023-08-12 |
mouse |
| Jens Juul Hols. The physiology of glucagon-like peptide 1. Physiological reviews. vol 87. issue 4. 2007-11-20. PMID:17928588. |
the main actions of glp-1 are to stimulate insulin secretion (i.e., to act as an incretin hormone) and to inhibit glucagon secretion, thereby contributing to limit postprandial glucose excursions. |
2007-11-20 |
2023-08-12 |
Not clear |
| Edwin P Kwan, Li Xie, Laura Sheu, Toshihisa Ohtsuka, Herbert Y Gaisan. Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells. Diabetes. vol 56. issue 10. 2007-11-13. PMID:17639022. |
glucagon-like peptide-1 (glp-1) rescues insulin secretory deficiency in type 2 diabetes partly via camp actions on exchange protein directly activated by camp (epac2) and protein kinase a (pka)-activated rab3a-interacting molecule 2 (rim2). |
2007-11-13 |
2023-08-12 |
mouse |
| A J Scheen, R P Radermecker, J C Philips, N Paquo. [Incretin mimetics and incretin enhancers for the treatment of type 2 diabetes]. Revue medicale suisse. vol 3. issue 122. 2007-11-08. PMID:17896662. |
it enhances insulin secretion in a glucose-dependent manner, inhibits glucagon secretion, retards gastric emptying,... two pharmacological approaches have been developed to increase the abnormally low glp-1 levels in type 2 diabetic patients: either to subcutaneously inject an agent closed to glp-1 (exenatide), which is partially resistant to the action of dpp-4, either to orally administer a selective dpp-4 inhibitor (sitagliptin,...). |
2007-11-08 |
2023-08-12 |
Not clear |
| Edwin P Kwan, Xiaodong Gao, Yuk M Leung, Herbert Y Gaisan. Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells. Pancreas. vol 35. issue 3. 2007-11-07. PMID:17895835. |
using fm1-43 epifluorescence imaging and electron microscopy, we recently reported that glucagon-like peptide (glp-1)-mediated cyclic adenosine monophosphate (camp) potentiation of insulin secretion markedly promotes the number of plasma membrane (pm) exocytic sites and insulin secretory granule (sg)-to-granule fusions underlying compound and sequential exocytosis. |
2007-11-07 |
2023-08-12 |
rat |
| Dirk Hagemann, Jens J Holst, Arnica Gethmann, Matthias Banasch, Wolfgang E Schmidt, Juris J Meie. Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion. Regulatory peptides. vol 143. issue 1-3. 2007-11-06. PMID:17434608. |
glucagon-like peptide 1 (glp-1) suppresses ghrelin levels in humans via increased insulin secretion. |
2007-11-06 |
2023-08-12 |
Not clear |
| Bo Ahrén, Maria Sörhede Winzell, Nils Wierup, Frank Sundler, Bryan Burkey, Thomas E Hughe. DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide. Regulatory peptides. vol 143. issue 1-3. 2007-11-06. PMID:17482289. |
dpp-4 inhibition improves glucose tolerance and increases insulin and glp-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide. |
2007-11-06 |
2023-08-12 |
mouse |
| Bo Ahrén, Maria Sörhede Winzell, Nils Wierup, Frank Sundler, Bryan Burkey, Thomas E Hughe. DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide. Regulatory peptides. vol 143. issue 1-3. 2007-11-06. PMID:17482289. |
after eight weeks, a gastric tolerance test showed that vildagliptin improved glucose tolerance and markedly (approximately ten-fold) augmented the insulin response in association with augmented (approximately five-fold) levels of intact glucagon-like peptide-1 (glp-1). |
2007-11-06 |
2023-08-12 |
mouse |
| Shirou Matsumoto, Kenji Okumura, Akira Ogata, Yuichiro Hisatomi, Ayumi Sato, Kiyoko Hattori, Mitsuhito Matsumoto, Yuji Kaji, Masashi Takahashi, Tetsuro Yamamoto, Kimitoshi Nakamura, Fumio End. Isolation of tissue progenitor cells from duct-ligated salivary glands of swine. Cloning and stem cells. vol 9. issue 2. 2007-10-30. PMID:17579551. |
gene expression of insulin and albumin was significantly increased (five-fold) and that of insulin was also increased (3.8-fold) with differentiation medium with nicotinamide and/or glp-1 treatment in spherical culture. |
2007-10-30 |
2023-08-12 |
mouse |
| Olga D Carlson, Jehan D David, Jessica M Schrieder, Dennis C Muller, Hyeung-Jin Jang, Byung-Joon Kim, Josephine M Ega. Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study of Aging. Metabolism: clinical and experimental. vol 56. issue 10. 2007-10-29. PMID:17884459. |
we measured plasma levels of glucose, insulin, c-peptide, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic peptide (gip), ghrelin, leptin, adiponectin, resistin, c-reactive protein, cytokines, and their soluble receptors, as well as nonesterified free fatty acids (nefas). |
2007-10-29 |
2023-08-12 |
human |
| Juris J Meier, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609256. |
therefore, we determined insulin clearance in response to endogenously secreted and exogenously administered gip and glp-1. |
2007-10-24 |
2023-08-12 |
Not clear |
| Juris J Meier, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609256. |
insulin clearance was estimated from the molar c-peptide-to-insulin ratio calculated at basal conditions and from the respective areas under the curve after glucose, gip, or glp-1 administration. |
2007-10-24 |
2023-08-12 |
Not clear |
| Juris J Meier, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609256. |
the endogenous secretion of gip or glp-1 was unrelated to the changes in insulin clearance. |
2007-10-24 |
2023-08-12 |
Not clear |
| Juris J Meier, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609256. |
likewise, infusing glp-1 during a meal course did not alter insulin clearance (p = 0.87). |
2007-10-24 |
2023-08-12 |
Not clear |
| Juris J Meier, Jens J Holst, Wolfgang E Schmidt, Michael A Nauc. Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609256. |
neither gip nor glp-1 has significant effects on insulin extraction. |
2007-10-24 |
2023-08-12 |
Not clear |
| Amelia N Pilichiewicz, Reawika Chaikomin, Ixchel M Brennan, Judith M Wishart, Christopher K Rayner, Karen L Jones, Andre J P M Smout, Michael Horowitz, Christine Feinle-Bisse. Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609258. |
the rises in insulin, glp-1, gip, and cck were related to the glucose load (r > 0.82, p < 0.05). |
2007-10-24 |
2023-08-12 |
human |
| Amelia N Pilichiewicz, Reawika Chaikomin, Ixchel M Brennan, Judith M Wishart, Christopher K Rayner, Karen L Jones, Andre J P M Smout, Michael Horowitz, Christine Feinle-Bisse. Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17609258. |
in conclusion, variations in duodenal glucose loads have differential effects on blood glucose, plasma insulin, glp-1, gip and cck, antropyloroduodenal motility, and energy intake in healthy subjects. |
2007-10-24 |
2023-08-12 |
human |
| Fan Zhang, Åke Sjöholm, Qimin Zhan. Attenuation of insulin secretion by insulin-like growth factor binding protein-1 in pancreatic beta-cells. Biochemical and biophysical research communications. vol 362. issue 1. 2007-10-23. PMID:17693389. |
incubation of dispersed mouse beta-cells with igfbp-1 for 30min inhibited insulin secretion stimulated by glucose, glucagon-like peptide 1 (glp-1) or tolbutamide without changes in basal release of insulin and in cytosolic free ca(2+) concentration ([ca(2+)](i)) and nad(p)h evoked by glucose. |
2007-10-23 |
2023-08-12 |
mouse |
| Nicola A Duffy, Brian D Green, Nigel Irwin, Victor A Gault, Aine M McKillop, Finbarr P M O'Harte, Peter R Flat. Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1. European journal of pharmacology. vol 568. issue 1-3. 2007-10-19. PMID:17573070. |
in vitro nateglinide and glp-1 effects on insulin release were additive. |
2007-10-19 |
2023-08-12 |
mouse |