| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H A Overton, M C T Fyfe, C Reyne. GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. British journal of pharmacology. vol 153 Suppl 1. 2008-04-28. PMID:18037923. |
in vitro studies have indicated a role for gpr119 in the modulation of insulin release by pancreatic beta-cells and of glp-1 secretion by gut enteroendocrine cells. |
2008-04-28 |
2023-08-12 |
Not clear |
| L R Ranganat. Incretins: pathophysiological and therapeutic implications of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. Journal of clinical pathology. vol 61. issue 4. 2008-04-28. PMID:18375745. |
incretins such as glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) are intestinal postprandial hormones that stimulate insulin release from the pancreas as long as circulating glucose concentrations are raised. |
2008-04-28 |
2023-08-12 |
human |
| L R Ranganat. Incretins: pathophysiological and therapeutic implications of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. Journal of clinical pathology. vol 61. issue 4. 2008-04-28. PMID:18375745. |
in addition to their effect on insulin secretion and consequent glucose lowering, gip and glp-1, especially the latter, have a number of physiological effects such as inhibition of glucagon release, gastric emptying and food intake, as well as a tropic action on pancreatic b-cell mass. |
2008-04-28 |
2023-08-12 |
human |
| Byung-Ju Kim, Kwang-Hyun Park, Chang-Yeol Yim, Shin Takasawa, Hiroshi Okamoto, Mie-Jae Im, Uh-Hyun Ki. Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets. Diabetes. vol 57. issue 4. 2008-04-25. PMID:18184929. |
glucagon-like peptide-1 (glp-1) increases intracellular ca(2+) concentrations ([ca(2+)](i)), resulting in insulin secretion from pancreatic beta-cells. |
2008-04-25 |
2023-08-12 |
mouse |
| A J Scheen, L F Van Gaa. [Sitagliptine (Januvia): incretin enhancer potentiating insulin secretion for the treatment of type 2 diabetes]. Revue medicale de Liege. vol 63. issue 2. 2008-04-22. PMID:18372550. |
sitagliptin increases post-meal insulin secretion ("incretin effect) by enhancing the postprandial glp-1 response ("incretin enhancer"), in a glucose-dependent manner. |
2008-04-22 |
2023-08-12 |
Not clear |
| Lakshminarayan R Ranganat. The entero-insular axis: implications for human metabolism. Clinical chemistry and laboratory medicine. vol 46. issue 1. 2008-04-11. PMID:18020966. |
glp-1, on the other hand, when administered intravenously in t2d is able to increase insulin secretion and improve glucose homeostasis. |
2008-04-11 |
2023-08-12 |
human |
| T Vilsbøll, B Brock, H Perrild, K Levin, H-H Lervang, K Kølendorf, T Krarup, O Schmitz, M Zdravkovic, T Le-Thi, S Madsba. Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus. Diabetic medicine : a journal of the British Diabetic Association. vol 25. issue 2. 2008-04-11. PMID:18201212. |
liraglutide, a once-daily human glp-1 analogue, improves pancreatic b-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with type 2 diabetes mellitus. |
2008-04-11 |
2023-08-12 |
human |
| Anne C Nilsson, Elin M Ostman, Jens J Holst, Inger M E Björc. Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast. The Journal of nutrition. vol 138. issue 4. 2008-04-10. PMID:18356328. |
at breakfast, blood was sampled for 3 h for analysis of blood glucose, serum insulin, serum ffa, serum triacylglycerides, plasma glucagon, plasma gastric-inhibitory peptide, plasma glucagon-like peptide-1 (glp-1), serum interleukin (il)-6, serum il-8, and plasma adiponectin. |
2008-04-10 |
2023-08-12 |
human |
| M de la Higuera López-Frías, S Valdés Hernández, F Soriguer Escofe. [GLP-1. Generalities and incretin-nutrient interaction]. Revista clinica espanola. vol 207. issue 10. 2008-04-04. PMID:17988596. |
glp-1 not only stimulates insulin secretion but also reduces glucagon release, slows gastric emptying, improves insulin sensitivity and increases satiety. |
2008-04-04 |
2023-08-12 |
Not clear |
| Su Young Chae, Cheng-Hao Jin, Han Jong Shin, Yu Seok Youn, Seulki Lee, Kang Choon Le. Preparation, characterization, and application of biotinylated and biotin-PEGylated glucagon-like peptide-1 analogues for enhanced oral delivery. Bioconjugate chemistry. vol 19. issue 1. 2008-04-03. PMID:18078308. |
the in vitro insulinotropic effects of db-glp-1 and dbp-glp-1 showed potent biological activity in a dose-dependent manner, which resembled that of native glp-1 in terms of stimulating insulin secretion in isolated rat islets of langerhans. |
2008-04-03 |
2023-08-12 |
mouse |
| Carolyn F Deaco. Incretin-based treatment of type 2 diabetes: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Diabetes, obesity & metabolism. vol 9 Suppl 1. 2008-03-28. PMID:17877544. |
activities of the dominant incretins, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide, include glucose-dependent stimulation of insulin secretion and, in preclinical models, improvement in islet beta-cell mass. |
2008-03-28 |
2023-08-12 |
human |
| Hong Gao, Xinjun Wang, Zhiguo Zhang, Yisheng Yang, Jun Yang, Xiaoying Li, Guang Nin. GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes. Endocrine. vol 32. issue 1. 2008-03-27. PMID:17992607. |
glp-1 amplifies insulin signaling by up-regulation of irbeta, irs-1 and glut4 in 3t3-l1 adipocytes. |
2008-03-27 |
2023-08-12 |
Not clear |
| Hong Gao, Xinjun Wang, Zhiguo Zhang, Yisheng Yang, Jun Yang, Xiaoying Li, Guang Nin. GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes. Endocrine. vol 32. issue 1. 2008-03-27. PMID:17992607. |
glucagon-like peptide-1 (7-36) amide (glp-1) is an insulin secretagogue. |
2008-03-27 |
2023-08-12 |
Not clear |
| Hong Gao, Xinjun Wang, Zhiguo Zhang, Yisheng Yang, Jun Yang, Xiaoying Li, Guang Nin. GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes. Endocrine. vol 32. issue 1. 2008-03-27. PMID:17992607. |
recently, many studies have shown glp-1 can improve insulin resistance in peripheral tissues. |
2008-03-27 |
2023-08-12 |
Not clear |
| Hong Gao, Xinjun Wang, Zhiguo Zhang, Yisheng Yang, Jun Yang, Xiaoying Li, Guang Nin. GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes. Endocrine. vol 32. issue 1. 2008-03-27. PMID:17992607. |
in the present study, we investigated glucose uptake in 3t3-l1 adipocytes in either basal or insulin resistant state and dissected insulin signaling pathway in order to elucidate the molecular mechanisms of glp-1 mediated improvement of insulin resistance. |
2008-03-27 |
2023-08-12 |
Not clear |
| Hong Gao, Xinjun Wang, Zhiguo Zhang, Yisheng Yang, Jun Yang, Xiaoying Li, Guang Nin. GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes. Endocrine. vol 32. issue 1. 2008-03-27. PMID:17992607. |
however, glp-1 and exendin-4 increased insulin mediated glucose uptake in intact and tnf-alpha treated 3t3-l1 adipocytes by up-regulation of phophorylated irbeta, irs-1, akt and gsk-3beta. |
2008-03-27 |
2023-08-12 |
Not clear |
| Hong Gao, Xinjun Wang, Zhiguo Zhang, Yisheng Yang, Jun Yang, Xiaoying Li, Guang Nin. GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes. Endocrine. vol 32. issue 1. 2008-03-27. PMID:17992607. |
these results indicate that glp-1 and its analogue exendin-4 can amplify insulin signaling in 3t3-l1 adipocytes by up-regulation of some crucial insulin signaling molecules. |
2008-03-27 |
2023-08-12 |
Not clear |
| I G Rubio, G Castro, A C Zanini, G Medeiros-Net. Oral ingestion of a hydrolyzed gelatin meal in subjects with normal weight and in obese patients: Postprandial effect on circulating gut peptides, glucose and insulin. Eating and weight disorders : EWD. vol 13. issue 1. 2008-03-17. PMID:18319637. |
subsequently, plasma samples were collected at-30- minute intervals up to 180 minutes and glucose, insulin, pyy, glp-1 and ghrelin were assayed using specific and sensitive immunofluorometric and radioimmunoassays. |
2008-03-17 |
2023-08-12 |
human |
| I G Rubio, G Castro, A C Zanini, G Medeiros-Net. Oral ingestion of a hydrolyzed gelatin meal in subjects with normal weight and in obese patients: Postprandial effect on circulating gut peptides, glucose and insulin. Eating and weight disorders : EWD. vol 13. issue 1. 2008-03-17. PMID:18319637. |
in conclusion, a single gelatin meal induces a rise in plasma glp-1 followed by an increase in serum levels of insulin. |
2008-03-17 |
2023-08-12 |
human |
| Thierry Brun, Kai Hui Hu He, Roberto Lupi, Bernhard Boehm, Anne Wojtusciszyn, Nadine Sauter, Marc Donath, Piero Marchetti, Kathrin Maedler, Benoit R Gauthie. The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1. Human molecular genetics. vol 17. issue 4. 2008-03-12. PMID:17989064. |
in vitro studies on non diabetic islets demonstrated that glucose, betacellulin, activin a, glp-1 and insulin increased pax4 mrna levels. |
2008-03-12 |
2023-08-12 |
mouse |