| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masayuki Arakawa, Chie Ebato, Tomoya Mita, Yoshio Fujitani, Tomoaki Shimizu, Hirotaka Watada, Ryuzo Kawamori, Takahisa Hiros. Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects. Metabolism: clinical and experimental. vol 57. issue 9. 2008-09-16. PMID:18702958. |
we compared the postprandial effects of a single administration of miglitol and acarbose on glucose and lipid metabolism, on insulin requirement, on glp-1 secretion, and on inflammatory and endothelial markers in viscerally obese subjects. |
2008-09-16 |
2023-08-12 |
human |
| Masayuki Arakawa, Chie Ebato, Tomoya Mita, Yoshio Fujitani, Tomoaki Shimizu, Hirotaka Watada, Ryuzo Kawamori, Takahisa Hiros. Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects. Metabolism: clinical and experimental. vol 57. issue 9. 2008-09-16. PMID:18702958. |
we measured glucose, insulin, lipids, lipoprotein lipase, interleukin 6, intracellular adhesion molecule 1, vascular cell adhesion molecule 1, and active glp-1 at before and various minutes after the meal. |
2008-09-16 |
2023-08-12 |
human |
| A E Relling, C K Reynold. Plasma concentrations of gut peptides in dairy cattle increase after calving. Journal of dairy science. vol 90. issue 1. 2008-09-12. PMID:17183100. |
the objective of the present study was to measure plasma concentrations of glp-1, gip, cck, insulin, glucose, and nonesterified fatty acids in blood plasma obtained from the coccygeal vein of 32 holstein cows at an average of 11 d before, and 5, 12, and 19 d after calving. |
2008-09-12 |
2023-08-12 |
cattle |
| A E Relling, C K Reynold. Feeding rumen-inert fats differing in their degree of saturation decreases intake and increases plasma concentrations of gut peptides in lactating dairy cows. Journal of dairy science. vol 90. issue 3. 2008-09-12. PMID:17297124. |
our objective was to determine the effect of feeding rumen-inert fats differing in their degree of saturation on dry matter intake (dmi), milk production, and plasma concentrations of insulin, glucagon-like peptide 1 (7-36) amide (glp-1), glucose-dependent insulinotropic polypeptide (gip), and cholecystokinin (cck) in lactating dairy cows. |
2008-09-12 |
2023-08-12 |
cattle |
| A E Relling, C K Reynold. Feeding rumen-inert fats differing in their degree of saturation decreases intake and increases plasma concentrations of gut peptides in lactating dairy cows. Journal of dairy science. vol 90. issue 3. 2008-09-12. PMID:17297124. |
decreases in dmi in cows fed fat were associated with increased plasma concentrations of glp-1 and cck and a decreased insulin concentration. |
2008-09-12 |
2023-08-12 |
cattle |
| Akiko Matsuyama-Yokono, Atsuo Tahara, Ryosuke Nakano, Yuka Someya, Itsuro Nagase, Masahiko Hayakawa, Masayuki Shibasak. ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity. Biochemical pharmacology. vol 76. issue 1. 2008-08-19. PMID:18468582. |
in streptozotocin-nicotinamide-induced diabetic mice, asp8497 (3 mg/kg) significantly reduced glucose excursion during the oral glucose tolerance test conducted 0.5 and 8.5 h after administration, with increases in plasma insulin and active glucagon-like peptide-1 (glp-1) levels. |
2008-08-19 |
2023-08-12 |
mouse |
| J-F Gautier, S-P Choukem, J Girar. Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes & metabolism. vol 34 Suppl 2. 2008-08-19. PMID:18640588. |
in humans, the incretin effect is mainly caused by two peptide hormones, glucose-dependent insulin releasing polypeptide (gip), and glucagon-like peptide-1 (glp-1). |
2008-08-19 |
2023-08-12 |
Not clear |
| J-F Gautier, S-P Choukem, J Girar. Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes & metabolism. vol 34 Suppl 2. 2008-08-19. PMID:18640588. |
in addition to its effects on insulin secretion, glp-1 exerts other significant actions, including stimulation of insulin biosynthesis, inhibition of glucagon secretion, inhibition of gastric emptying and acid secretion, reduction of food intake, and trophic effects on the pancreas. |
2008-08-19 |
2023-08-12 |
Not clear |
| J Butea. GLP-1 receptor signaling: effects on pancreatic beta-cell proliferation and survival. Diabetes & metabolism. vol 34 Suppl 2. 2008-08-19. PMID:18640589. |
glp-1 analogs and enhancers constitute a novel class of anti-diabetes medications which address both the insulin secretion defect as well as the decline in beta-cell mass. |
2008-08-19 |
2023-08-12 |
Not clear |
| J Butea. GLP-1 receptor signaling: effects on pancreatic beta-cell proliferation and survival. Diabetes & metabolism. vol 34 Suppl 2. 2008-08-19. PMID:18640589. |
glp-1 improves glucose-stimulated insulin secretion, restores glucose competence in glucose-resistant beta-cells, and stimulates insulin gene expression and biosynthesis. |
2008-08-19 |
2023-08-12 |
Not clear |
| A Penfornis, S Borot, D Racca. Therapeutic approach of type 2 diabetes mellitus with GLP-1 based therapies. Diabetes & metabolism. vol 34 Suppl 2. 2008-08-19. PMID:18640590. |
finally, in patients with t2dm inadequately controlled with maximal tolerated oral multi-therapies, glp-1 agonists are a good alternative to insulin therapy, allowing reaching a better glycaemic control together with a weight loss. |
2008-08-19 |
2023-08-12 |
Not clear |
| A Penfornis, S Borot, D Racca. Therapeutic approach of type 2 diabetes mellitus with GLP-1 based therapies. Diabetes & metabolism. vol 34 Suppl 2. 2008-08-19. PMID:18640590. |
however, for patients who do not tolerate glp-1 agonist treatment, and for those not reaching the hba(1c) target, insulin will remain necessary, allowing getting a better metabolic control, with few adverse events. |
2008-08-19 |
2023-08-12 |
Not clear |
| Alejandro E Relling, Christopher K Reynold. Abomasal infusion of casein, starch and soybean oil differentially affect plasma concentrations of gut peptides and feed intake in lactating dairy cows. Domestic animal endocrinology. vol 35. issue 1. 2008-08-15. PMID:18308502. |
our objective was to determine acute (hours) and chronic (1 week) effects of increased abomasal supply of protein, carbohydrate, or fat to the small intestine on dry matter intake (dmi) and plasma concentrations of glp-1, gip, cck, and insulin. |
2008-08-15 |
2023-08-12 |
cattle |
| Alejandro E Relling, Christopher K Reynold. Abomasal infusion of casein, starch and soybean oil differentially affect plasma concentrations of gut peptides and feed intake in lactating dairy cows. Domestic animal endocrinology. vol 35. issue 1. 2008-08-15. PMID:18308502. |
casein infusion tended to increase plasma cck concentration on both days of sampling, and increased plasma glp-1 and insulin concentration on day 1 of infusion. |
2008-08-15 |
2023-08-12 |
cattle |
| Catherine L Marti. Beyond glycemic control: the effects of incretin hormones in type 2 diabetes. The Diabetes educator. vol 34 Suppl 3. 2008-08-13. PMID:18525067. |
first-in-class im exenatide, a glp-1 receptor agonist resistant to dpp-iv inactivation, mimics many beneficial glucoregulatory effects of glp-1, such as suppressing glucagon secretion, regulating gastric emptying and satiety, and increasing glucose-dependent insulin secretion. |
2008-08-13 |
2023-08-12 |
Not clear |
| Pedro A Velásquez-Mieyer, Patricia A Cowan, Sylvia Pérez-Faustinelli, Ramfis Nieto-Martínez, Cesar Villegas-Barreto, Elizabeth A Tolley, Robert H Lustig, Bruce S Alper. Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents. Diabetes care. vol 31. issue 4. 2008-08-06. PMID:18184905. |
we determined the relationship between insulin resistance, beta-cell activity, and subclinical inflammation with glp-1 concentrations and whether racial disparities in glp-1 response were present in 49 obese adolescents (14 +/- 3 years; 76% african american; 71% female). |
2008-08-06 |
2023-08-12 |
Not clear |
| P V Højberg, M Zander, T Vilsbøll, F K Knop, T Krarup, A Vølund, J J Holst, S Madsba. Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes. Diabetologia. vol 51. issue 4. 2008-08-06. PMID:18292985. |
near normalisation of blood glucose improves the potentiating effect of glp-1 on glucose-induced insulin secretion in patients with type 2 diabetes. |
2008-08-06 |
2023-08-12 |
Not clear |
| P V Højberg, M Zander, T Vilsbøll, F K Knop, T Krarup, A Vølund, J J Holst, S Madsba. Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes. Diabetologia. vol 51. issue 4. 2008-08-06. PMID:18292985. |
we investigated whether 4 weeks of near normalisation of blood glucose (bg) improves the potentiation of glucose-stimulated insulin secretion by glp-1. |
2008-08-06 |
2023-08-12 |
Not clear |
| B Gök. Islet cell function: alpha and beta cells--partners towards normoglycaemia. International journal of clinical practice. Supplement. issue 159. 2008-07-31. PMID:18269435. |
the role of the incretin hormone glucagon-like peptide-1 (glp-1) in regulating glucose-dependent beta-cell insulin production and glucose-dependent alpha-cell glucagon production has been used to develop glp-1-based therapies. |
2008-07-31 |
2023-08-12 |
Not clear |
| B Ahrén, J E Fole. The islet enhancer vildagliptin: mechanisms of improved glucose metabolism. International journal of clinical practice. Supplement. issue 159. 2008-07-31. PMID:18269436. |
glp-1 and gip are important for the maintenance of normal glucose homeostasis as they enhance the sensitivity of insulin (beta-cell) and glucagon (alpha-cell) secretion to glucose. |
2008-07-31 |
2023-08-12 |
human |