| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jocelyn de Heer, Jens J Hols. Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1. Diabetes. vol 56. issue 2. 2007-04-09. PMID:17259389. |
however, when glp-1 and tolbutamide were administered simultaneously, insulin secretion increased significantly to 43.7 +/- 6.2 pmol/min (means +/- se), exceeding the sum of the responses to glp-1 (2.0 +/- 0.6 pmol/min; p = 0.019) and tolbutamide (11.3 +/- 3.8; p = 0.005) alone by a factor of 3.3. |
2007-04-09 |
2023-08-12 |
rat |
| Jocelyn de Heer, Jens J Hols. Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1. Diabetes. vol 56. issue 2. 2007-04-09. PMID:17259389. |
at 11 mmol/l glucose, co-infusion of glp-1 and tolbutamide augmented insulin secretion to 141.7 +/- 10.3 vs. 115.36 +/- 14.1 (glp-1) and 42.5 +/- 7.3 pmol/min (tolbutamide). |
2007-04-09 |
2023-08-12 |
rat |
| TracyAnn Perry, Harold W Holloway, Ananda Weerasuriya, Peter R Mouton, Kara Duffy, Julie A Mattison, Nigel H Grei. Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. Experimental neurology. vol 203. issue 2. 2007-03-20. PMID:17125767. |
recent studies have established that glp-1 and ex4, have multiple synergistic effects on glucose-dependent insulin secretion pathways of pancreatic beta-cells and on neural plasticity. |
2007-03-20 |
2023-08-12 |
rat |
| Tanya Hansotia, Adriano Maida, Grace Flock, Yuichiro Yamada, Katsushi Tsukiyama, Yutaka Seino, Daniel J Drucke. Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. The Journal of clinical investigation. vol 117. issue 1. 2007-03-07. PMID:17187081. |
the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) control glucose homeostasis through well-defined actions on the islet beta cell via stimulation of insulin secretion and preservation and expansion of beta cell mass. |
2007-03-07 |
2023-08-12 |
mouse |
| Wen-Jun Shen, Yu Liang, Jenny Wang, Kenji Harada, Shailja Patel, Sara A Michie, Jun-Ichi Osuga, Shun Ishibashi, Fredric B Kraeme. Regulation of hormone-sensitive lipase in islets. Diabetes research and clinical practice. vol 75. issue 1. 2007-03-06. PMID:16765472. |
basal insulin secretion was increased, whereas glp-1 potentiation of gsis was decreased in islets isolated from hsl-/- mice, as compared to islets from wild type mice. |
2007-03-06 |
2023-08-12 |
mouse |
| Khalid Al Ghofaili, Michelle Fung, Ziliang Ao, Mark Meloche, R Jean Shapiro, Garth L Warnock, Dariush Elahi, Graydon S Meneilly, David M Thompso. Effect of exenatide on beta cell function after islet transplantation in type 1 diabetes. Transplantation. vol 83. issue 1. 2007-03-06. PMID:17220786. |
exenatide is a long acting analogue of glucagon-like peptide-1 (glp-1) that augments glucose induced insulin secretion, and may increase beta cell mass. |
2007-03-06 |
2023-08-12 |
Not clear |
| Lotte Bjerre Knudsen, Dan Kiel, Min Teng, Carsten Behrens, Dilip Bhumralkar, János T Kodra, Jens J Holst, Claus B Jeppesen, Michael D Johnson, Johannes Cornelis de Jong, Anker Steen Jorgensen, Tim Kercher, Jarek Kostrowicki, Peter Madsen, Preben H Olesen, Jacob S Petersen, Fritz Poulsen, Ulla G Sidelmann, Jeppe Sturis, Larry Truesdale, John May, Jesper La. Small-molecule agonists for the glucagon-like peptide 1 receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 3. 2007-02-27. PMID:17213325. |
the most potent compound identified stimulates glucose-dependent insulin release from normal mouse islets but, importantly, not from glp-1 receptor knockout mice. |
2007-02-27 |
2023-08-12 |
mouse |
| Lotte Bjerre Knudsen, Dan Kiel, Min Teng, Carsten Behrens, Dilip Bhumralkar, János T Kodra, Jens J Holst, Claus B Jeppesen, Michael D Johnson, Johannes Cornelis de Jong, Anker Steen Jorgensen, Tim Kercher, Jarek Kostrowicki, Peter Madsen, Preben H Olesen, Jacob S Petersen, Fritz Poulsen, Ulla G Sidelmann, Jeppe Sturis, Larry Truesdale, John May, Jesper La. Small-molecule agonists for the glucagon-like peptide 1 receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 3. 2007-02-27. PMID:17213325. |
also, the compound stimulates insulin release from perfused rat pancreas in a manner additive with glp-1 itself. |
2007-02-27 |
2023-08-12 |
mouse |
| Jianguo Chen, Per Bendix Jeppesen, Iver Nordentoft, Kjeld Hermanse. Stevioside counteracts the glyburide-induced desensitization of the pancreatic beta-cell function in mice: studies in vitro. Metabolism: clinical and experimental. vol 55. issue 12. 2007-02-20. PMID:17142143. |
after 24-hour preincubation with gb in combination with svs or glp-1, we measured the basal and glucose-stimulated insulin responses and the total islet insulin content. |
2007-02-20 |
2023-08-12 |
mouse |
| Filip K Knop, Tina Vilsbøll, Steen Larsen, Patricia V Højberg, Aage Vølund, Sten Madsbad, Jens J Holst, Thure Kraru. Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. American journal of physiology. Endocrinology and metabolism. vol 292. issue 1. 2007-02-16. PMID:16954337. |
we aimed to investigate how assimilation of nutrients affects the postprandial responses of glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) and to evaluate the effect of pancreatic enzyme substitution (pes) on insulin secretion in patients with chronic pancreatitis (cp) and pancreatic exocrine insufficiency (pei). |
2007-02-16 |
2023-08-12 |
human |
| Filip K Knop, Tina Vilsbøll, Steen Larsen, Patricia V Højberg, Aage Vølund, Sten Madsbad, Jens J Holst, Thure Kraru. Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. American journal of physiology. Endocrinology and metabolism. vol 292. issue 1. 2007-02-16. PMID:16954337. |
these results suggest that the secretion of glp-1 and gip is under influence of the digestion and absorption of nutrients in the small intestine and that pes increases insulin secretion. |
2007-02-16 |
2023-08-12 |
human |
| Michelle Fung, David Thompson, R Jean Shapiro, Garth L Warnock, Dana K Andersen, Dariush Elahi, Graydon S Meneill. Effect of glucagon-like peptide-1 (7-37) on beta-cell function after islet transplantation in type 1 diabetes. Diabetes research and clinical practice. vol 74. issue 2. 2007-01-29. PMID:16621111. |
glucagon-like peptide-1 (glp-1) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion, and has a trophic effect on beta-cells. |
2007-01-29 |
2023-08-12 |
human |
| Michelle Fung, David Thompson, R Jean Shapiro, Garth L Warnock, Dana K Andersen, Dariush Elahi, Graydon S Meneill. Effect of glucagon-like peptide-1 (7-37) on beta-cell function after islet transplantation in type 1 diabetes. Diabetes research and clinical practice. vol 74. issue 2. 2007-01-29. PMID:16621111. |
we evaluated the effect of glp-1 on insulin secretion after islet transplantation. |
2007-01-29 |
2023-08-12 |
human |
| Brian D Green, Peter R Flatt, Clifford J Baile. Dipeptidyl peptidase IV (DPP IV) inhibitors: A newly emerging drug class for the treatment of type 2 diabetes. Diabetes & vascular disease research. vol 3. issue 3. 2007-01-26. PMID:17160910. |
inhibition of dpp iv prolongs and enhances the activity of endogenous glp-1 and gip, which serve as important prandial stimulators of insulin secretion and regulators of blood glucose control. |
2007-01-26 |
2023-08-12 |
Not clear |
| Jia Duo, Heidi Fletcher, Julie A Stenke. Natural and synthetic affinity agents as microdialysis sampling mass transport enhancers: current progress and future perspectives. Biosensors & bioelectronics. vol 22. issue 3. 2007-01-24. PMID:16797961. |
we present new work focused on the use of antibody-immobilized bead microdialysis sampling enhancement for various endocrine hormones (amylin, glp-1, glucagon, insulin, and leptin). |
2007-01-24 |
2023-08-12 |
cattle |
| Nasser Mikhai. Exenatide: a novel approach for treatment of type 2 diabetes. Southern medical journal. vol 99. issue 11. 2007-01-23. PMID:17195423. |
in addition, glp-1 stimulates insulin synthesis, inhibits glucagon secretion, delays gastric emptying, and may promote satiety. |
2007-01-23 |
2023-08-12 |
Not clear |
| Christoph Beglinger, Lukas Dege. Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY? Physiology & behavior. vol 89. issue 4. 2007-01-04. PMID:16828127. |
both peptides, released from l-cells from the gastrointestinal tract by the local action of digested food, exert various regulatory functions: stimulation of insulin secretion and inhibition of glucagon secretion as typical actions of glp-1, inhibition of gastric emptying, and inhibition of appetite for both glp-1 and pyy. |
2007-01-04 |
2023-08-12 |
Not clear |
| Graydon S Meneilly, Johannes D Veldhuis, Dariush Elah. Pulsatile insulin secretion in elderly patients with diabetes. Diabetes research and clinical practice. vol 73. issue 2. 2007-01-03. PMID:16621106. |
glp-1 increases pulsatile insulin secretion in these patients. |
2007-01-03 |
2023-08-12 |
human |
| Graydon S Meneilly, Johannes D Veldhuis, Dariush Elah. Pulsatile insulin secretion in elderly patients with diabetes. Diabetes research and clinical practice. vol 73. issue 2. 2007-01-03. PMID:16621106. |
we conducted these studies with the hypothesis that glp-1 would enhance pulsatile insulin secretion and alter glucose metabolism in elderly patients with type 2 diabetes. |
2007-01-03 |
2023-08-12 |
human |
| Graydon S Meneilly, Johannes D Veldhuis, Dariush Elah. Pulsatile insulin secretion in elderly patients with diabetes. Diabetes research and clinical practice. vol 73. issue 2. 2007-01-03. PMID:16621106. |
the third was similar except that octreotide (30ng/kg/min) was infused with glp-1 to suppress pulsatile insulin. |
2007-01-03 |
2023-08-12 |
human |