| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Colin A Leech, Joel F Habene. Regulation of glucagon-like peptide-1 receptor and calcium-sensing receptor signaling by L-histidine. Endocrinology. vol 144. issue 11. 2003-12-03. PMID:12959987. |
receptor-specific agonists of the extracellular calcium-sensing receptor (casr) potentiate glucose-induced insulin secretion, an effect similar to that of glucagon-like peptide-1 (glp-1). |
2003-12-03 |
2023-08-12 |
human |
| Yoshihiro Ikezawa, Keiichi Yamatani, Hiroshi Ohnuma, Makoto Daimon, Hideo Manaka, Hideo Sasak. Glucagon-like peptide-1 inhibits glucagon-induced glycogenolysis in perivenous hepatocytes specifically. Regulatory peptides. vol 111. issue 1-3. 2003-11-21. PMID:12609770. |
glp-1 inhibited 0.1 nm glucagon-induced increase in glucose release from the pvh of fed rats specifically (p < 0.01) and had an additive effect with insulin. |
2003-11-21 |
2023-08-12 |
rat |
| Yoshikazu Miura, Hisao Matsu. Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na+]i associated with insulin secretion in pancreatic beta-cells. American journal of physiology. Endocrinology and metabolism. vol 285. issue 5. 2003-11-20. PMID:14534075. |
glucagon-like peptide-1 (glp-1) elevates the intracellular free calcium concentration ([ca2+]i) and insulin secretion in a na+-dependent manner. |
2003-11-20 |
2023-08-12 |
Not clear |
| Yoshikazu Miura, Hisao Matsu. Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na+]i associated with insulin secretion in pancreatic beta-cells. American journal of physiology. Endocrinology and metabolism. vol 285. issue 5. 2003-11-20. PMID:14534075. |
to investigate a possible role of na ion in the action of glp-1 on pancreatic islet cells, we measured the glucose-and glp-1-induced intracellular na+ concentration ([na+]i), [ca2+]i, and insulin secretion in hamster islet cells in various concentrations of na+. |
2003-11-20 |
2023-08-12 |
Not clear |
| Yoshikazu Miura, Hisao Matsu. Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na+]i associated with insulin secretion in pancreatic beta-cells. American journal of physiology. Endocrinology and metabolism. vol 285. issue 5. 2003-11-20. PMID:14534075. |
in the presence of 135 mm na+ and 8 mm glucose, glp-1 (10 nm) strongly increased the [na+]i, [ca2+]i, and insulin secretion. |
2003-11-20 |
2023-08-12 |
Not clear |
| Yoshikazu Miura, Hisao Matsu. Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na+]i associated with insulin secretion in pancreatic beta-cells. American journal of physiology. Endocrinology and metabolism. vol 285. issue 5. 2003-11-20. PMID:14534075. |
therefore, we conclude that glp-1 increases the camp level via activation of adenylate cyclase, which augments the membrane na+ permeability through pka-dependent and pka-independent mechanisms, thereby increasing the [ca2+]i and promoting insulin secretion from hamster islet cells. |
2003-11-20 |
2023-08-12 |
Not clear |
| T Vilsbøll, F K Knop, T Krarup, A Johansen, S Madsbad, S Larsen, T Hansen, O Pedersen, J J Hols. The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype. The Journal of clinical endocrinology and metabolism. vol 88. issue 10. 2003-11-12. PMID:14557471. |
the effect of the insulinotropic incretin hormone, glucagon-like peptide-1 (glp-1), is preserved in typical middle-aged, obese, insulin-resistant type 2 diabetic patients, whereas a defective amplification of the so-called late-phase plasma insulin response (20-120 min) to glucose by the other incretin hormone, glucose-dependent insulinotropic polypeptide (gip), is seen in these patients. |
2003-11-12 |
2023-08-12 |
human |
| T Vilsbøll, F K Knop, T Krarup, A Johansen, S Madsbad, S Larsen, T Hansen, O Pedersen, J J Hols. The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype. The Journal of clinical endocrinology and metabolism. vol 88. issue 10. 2003-11-12. PMID:14557471. |
the aim of the present investigation was to evaluate plasma insulin and c-peptide responses to glp-1 and gip in five groups of diabetic patients with etiology and phenotype distinct from the obese type 2 diabetic patients. |
2003-11-12 |
2023-08-12 |
human |
| T Vilsbøll, F K Knop, T Krarup, A Johansen, S Madsbad, S Larsen, T Hansen, O Pedersen, J J Hols. The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype. The Journal of clinical endocrinology and metabolism. vol 88. issue 10. 2003-11-12. PMID:14557471. |
the early-phase (0-20 min) plasma insulin response tended to be enhanced by both gip and glp-1, compared with glucose alone, in all five groups. |
2003-11-12 |
2023-08-12 |
human |
| T Vilsbøll, F K Knop, T Krarup, A Johansen, S Madsbad, S Larsen, T Hansen, O Pedersen, J J Hols. The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype. The Journal of clinical endocrinology and metabolism. vol 88. issue 10. 2003-11-12. PMID:14557471. |
in contrast, the late-phase (20-120 min) plasma insulin response to gip was attenuated, compared with the plasma insulin response to glp-1, in all five groups. |
2003-11-12 |
2023-08-12 |
human |
| Bo Ahré. Gut peptides and type 2 diabetes mellitus treatment. Current diabetes reports. vol 3. issue 5. 2003-11-07. PMID:12975025. |
this has been most successful for glp-1, which exerts antidiabetogenic properties in subjects with type 2 diabetes by stimulating insulin secretion, increasing beta-cell mass, inhibiting glucagon secretion, delaying gastric emptying, and inducing satiety. |
2003-11-07 |
2023-08-12 |
human |
| Josephine M Egan, Angela Bulotta, Hongxiang Hui, Riccardo Perfett. GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes/metabolism research and reviews. vol 19. issue 2. 2003-10-30. PMID:12673779. |
however, glp-1 also regulates insulin synthesis and proinsulin gene expression, as well as the components of the glucose-sensing machinery. |
2003-10-30 |
2023-08-12 |
Not clear |
| Ronald L Prigeon, Shaista Quddusi, Breay Paty, David A D'Alessi. Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect. American journal of physiology. Endocrinology and metabolism. vol 285. issue 4. 2003-10-30. PMID:12773303. |
glucagon-like peptide-1 (glp-1) is an intestinal hormone that stimulates insulin secretion and decreases glucagon release. |
2003-10-30 |
2023-08-12 |
human |
| Ronald L Prigeon, Shaista Quddusi, Breay Paty, David A D'Alessi. Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect. American journal of physiology. Endocrinology and metabolism. vol 285. issue 4. 2003-10-30. PMID:12773303. |
the effect of glp-1 on glucose appearance (ra) and glucose disposal (rd) was measured in eight men during a pancreatic clamp that was performed by infusing octreotide to suppress secretion of islet hormones, while insulin and glucagon were infused at rates adjusted to maintain blood glucose near fasting levels. |
2003-10-30 |
2023-08-12 |
human |
| Ronald L Prigeon, Shaista Quddusi, Breay Paty, David A D'Alessi. Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect. American journal of physiology. Endocrinology and metabolism. vol 285. issue 4. 2003-10-30. PMID:12773303. |
concentrations of insulin, c-peptide, and glucagon were similar before and during the glp-1 infusion (115 +/- 14 vs. 113 +/- 11 pm; 0.153 +/- 0.029 vs. 0.156 +/- 0.026 nm; and 64.7 +/- 11.5 vs. 65.8 +/- 13.8 ng/l, respectively). |
2003-10-30 |
2023-08-12 |
human |
| A Bulotta, H Hui, E Anastasi, C Bertolotto, L G Boros, U Di Mario, R Perfett. Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1. Journal of molecular endocrinology. vol 29. issue 3. 2003-10-15. PMID:12459036. |
in addition, immunocytochemistry analysis showed that glp-1 induced a time-dependent down-regulation of the ductal marker cytokeratin-20 (ck-20) and a time-dependent induction of insulin expression. |
2003-10-15 |
2023-08-12 |
human |
| A Bulotta, H Hui, E Anastasi, C Bertolotto, L G Boros, U Di Mario, R Perfett. Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1. Journal of molecular endocrinology. vol 29. issue 3. 2003-10-15. PMID:12459036. |
finally, glp-1 promoted a glucose-dependent secretion of insulin, as demonstrated by hplc and ria analyses of the cell culture medium. |
2003-10-15 |
2023-08-12 |
human |
| Lena Eliasson, Xiaosong Ma, Erik Renström, Sebastian Barg, Per-Olof Berggren, Juris Galvanovskis, Jesper Gromada, Xingjun Jing, Ingmar Lundquist, Albert Salehi, Sabine Sewing, Patrik Rorsma. SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. The Journal of general physiology. vol 121. issue 3. 2003-10-14. PMID:12601083. |
measurements of insulin release in response to glp-1 stimulation in isolated islets from sur1(-/-) mice confirmed the complete loss of the pka-independent component. |
2003-10-14 |
2023-08-12 |
mouse |
| Don Arnette, Tara Beers Gibson, Michael C Lawrence, Bridgette January, Shih Khoo, Kathleen McGlynn, Colleen A Vanderbilt, Melanie H Cob. Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells. The Journal of biological chemistry. vol 278. issue 35. 2003-10-02. PMID:12783880. |
the glucose-sensitive mechanism is distinct from that used by phorbol ester or insulin to stimulate erk1/2 but shares common features with that used by glp-1. |
2003-10-02 |
2023-08-12 |
Not clear |
| M Osterhoff, M Möhlig, M Schwanstecher, J Seufert, J Ortmann, H Schatz, A F H Pfeiffe. Ca2+/calmodulin-dependent protein kinase II delta2 regulates gene expression of insulin in INS-1 rat insulinoma cells. Cell calcium. vol 33. issue 3. 2003-09-26. PMID:12600804. |
this caused a loss of ca(2+)/calmodulin-dependent protein kinase ii delta(2) expression at the mrna and protein level, while the expression of the 95% homologous ca(2+)/calmodulin-dependent protein kinase ii gamma and of beta-cell specific proteins such as the homeodomain factor pancreatic-duodenal homeobox factor-1 (pdx-1, also referred to as islet/duodenum homeobox-1, idx-1, insulin promoter factor-1, ipf-1 and somatostatin transactivating factor-1, stf-1), the glucagon-like peptide-1 (glp-1) receptor and k(atp)-channels k(ir)6.2/sur-1 (sulfonylurea receptor-1) was not altered. |
2003-09-26 |
2023-08-12 |
rat |