| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Y Enç, N Imeryüz, L Akin, T Turoğlu, F Dede, G Haklar, N Tekeşin, N Bekiroğlu, B C Yeğen, J F Rehfeld, J J Holst, N B Uluso. Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release. American journal of physiology. Gastrointestinal and liver physiology. vol 281. issue 3. 2001-09-20. PMID:11518688. |
in meal groups with carbohydrates, acarbose attenuated responses of plasma insulin and glucose-dependent insulinotropic polypeptide (gip) while augmenting responses of cck, glucagon-like peptide-1 (glp-1), and peptide yy (pyy). |
2001-09-20 |
2023-08-12 |
human |
| M B Toft-Nielsen, S Madsbad, J J Hols. Determinants of the effectiveness of glucagon-like peptide-1 in type 2 diabetes. The Journal of clinical endocrinology and metabolism. vol 86. issue 8. 2001-09-06. PMID:11502823. |
to clarify the relation of the effect of glp-1 to obesity, blood glucose, beta-cell function, and insulin sensitivity, glp-1 (1.2 pmol/kg.min) was infused iv for 4-6 h into 50 fasting type 2 diabetic patients with a wide range of age, body mass index, hba1c, and fasting plasma glucose. |
2001-09-06 |
2023-08-12 |
Not clear |
| A Imhof, M Schneemann, A Schaffner, M Brändl. Reactive hypoglycaemia due to late dumping syndrome: successful treatment with acarbose. Swiss medical weekly. vol 131. issue 5-6. 2001-08-09. PMID:11383230. |
concomitantly, high concentrations of insulin (3216 pmol/l at a glucose level of 9.4 mmol/l and 335 pmol/l at a glucose level of 1.8 mmol/l) and glucagon-like peptide 1 (glp-1) (375 pmol/l at a glucose level of 9.4 mmol/l and 85 pmol/l at a glucose level of 1.8 mmol/l) were measured. |
2001-08-09 |
2023-08-12 |
Not clear |
| A Imhof, M Schneemann, A Schaffner, M Brändl. Reactive hypoglycaemia due to late dumping syndrome: successful treatment with acarbose. Swiss medical weekly. vol 131. issue 5-6. 2001-08-09. PMID:11383230. |
insulin and glp-1 levels increased much less, to peak levels of 375 pmol/l and 75 pmol/l respectively, after one hour when plasma glucose was 6.8 mmol/l. |
2001-08-09 |
2023-08-12 |
Not clear |
| A Imhof, M Schneemann, A Schaffner, M Brändl. Reactive hypoglycaemia due to late dumping syndrome: successful treatment with acarbose. Swiss medical weekly. vol 131. issue 5-6. 2001-08-09. PMID:11383230. |
we conclude that in patients with reactive hypoglycaemia due to gastrointestinal surgery, acarbose decreases rapid glucose absorption associated with hyperglycaemia and glp-1 secretion, and thus diminishes excessive insulin release. |
2001-08-09 |
2023-08-12 |
Not clear |
| A Brandt, M Katschinski, R Arnold, K S Polonsky, B Göke, M M Byrn. GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve. American journal of physiology. Endocrinology and metabolism. vol 281. issue 2. 2001-08-09. PMID:11440899. |
these studies demonstrate that physiological levels of glp-1 stimulate glucose-induced insulin secretion in a linear manner, with a consistent increase in isr at each 1 mm glucose interval, and that they have no independent effect on insulin clearance and no priming effect on subsequent insulin secretory response to glucose. |
2001-08-09 |
2023-08-12 |
human |
| M L Villanueva-Peñacarrillo, L Márquez, N González, M Díaz-Miguel, I Valverd. Effect of GLP-1 on lipid metabolism in human adipocytes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 33. issue 2. 2001-08-02. PMID:11294496. |
we have studied the effect of several doses of glp-1, compared to that of insulin and glucagons, on lipogenesis, lipolysis and camp cellular content, in human adipocytes isolated from normal subjects. |
2001-08-02 |
2023-08-12 |
human |
| M L Villanueva-Peñacarrillo, L Márquez, N González, M Díaz-Miguel, I Valverd. Effect of GLP-1 on lipid metabolism in human adipocytes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 33. issue 2. 2001-08-02. PMID:11294496. |
the glp-1 lipogenic effect is equal in magnitude to that of equimolar amounts of insulin; both hormones apparently act synergically, and their respective action is abolished by glucagon. |
2001-08-02 |
2023-08-12 |
human |
| M L Villanueva-Peñacarrillo, L Márquez, N González, M Díaz-Miguel, I Valverd. Effect of GLP-1 on lipid metabolism in human adipocytes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 33. issue 2. 2001-08-02. PMID:11294496. |
the lipolytic effect of glp-1 is comparable to that of glucagon, apparently additive to it, and the stimulated value induced by either one is neutralized by the presence of insulin. |
2001-08-02 |
2023-08-12 |
human |
| M Zander, M Taskiran, M B Toft-Nielsen, S Madsbad, J J Hols. Additive glucose-lowering effects of glucagon-like peptide-1 and metformin in type 2 diabetes. Diabetes care. vol 24. issue 4. 2001-08-02. PMID:11315837. |
the incretin hormone glucagon-like peptide-1 (glp-1) reduces plasma glucose in type 2 diabetic patients by stimulating insulin secretion and inhibiting glucagon secretion. |
2001-08-02 |
2023-08-12 |
Not clear |
| H Gappa, M Baudys, J J Koh, S W Kim, Y H Ba. The effect of zinc-crystallized glucagon-like peptide-1 on insulin secretion of macroencapsulated pancreatic islets. Tissue engineering. vol 7. issue 1. 2001-07-26. PMID:11224922. |
this research investigates the use of an insulinotropic factor, glucagon-like peptide-1 (glp-1), to enhance insulin secretion from islets within a macrocapsule. |
2001-07-26 |
2023-08-12 |
rat |
| H Gappa, M Baudys, J J Koh, S W Kim, Y H Ba. The effect of zinc-crystallized glucagon-like peptide-1 on insulin secretion of macroencapsulated pancreatic islets. Tissue engineering. vol 7. issue 1. 2001-07-26. PMID:11224922. |
glp-1 crystals can be an effective form to be entrapped in a bioartificial pancreas to enhance insulin secretion function, especially at high glucose concentrations. |
2001-07-26 |
2023-08-12 |
rat |
| I Valverde, J Cancelas, M L Villanueva-Peñacarrillo, W J Malaiss. Potentiation by methyl pyruvate of GLP-1 insulinotropic action in normal rats. International journal of molecular medicine. vol 7. issue 6. 2001-07-19. PMID:11351275. |
in anaesthetized rats receiving a primed constant infusion of mp, the ester augmented plasma insulin concentration before glp-1 injection and potentiated the insulinotropic action of the intestinal hormone. |
2001-07-19 |
2023-08-12 |
rat |
| C Tourrel, D Bailbé, M J Meile, M Kergoat, B Porth. Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes. vol 50. issue 7. 2001-07-19. PMID:11423477. |
despite such early improved beta-cell mass, which is maintained at adult age, the basal and glucose-stimulated insulin secretion (in vivo after intravenous glucose load or in vitro using perfused pancreas) were not improved in the 2-month-old n0-stz rats previously treated with glp-1 or exendin-4 compared with untreated n0-stz rats. |
2001-07-19 |
2023-08-12 |
rat |
| T Nagakura, N Yasuda, K Yamazaki, H Ikuta, S Yoshikawa, O Asano, I Tanak. Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats. Biochemical and biophysical research communications. vol 284. issue 2. 2001-07-12. PMID:11394909. |
glucagon-like peptide-1 (glp-1) is an incretin, which induces glucose-dependent insulin secretion. |
2001-07-12 |
2023-08-12 |
rat |
| T Nagakura, N Yasuda, K Yamazaki, H Ikuta, S Yoshikawa, O Asano, I Tanak. Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats. Biochemical and biophysical research communications. vol 284. issue 2. 2001-07-12. PMID:11394909. |
enhanced insulin secretion and high plasma active glp-1 levels were detected in an intraduodenal glucose tolerance test. |
2001-07-12 |
2023-08-12 |
rat |
| T Nagakura, N Yasuda, K Yamazaki, H Ikuta, S Yoshikawa, O Asano, I Tanak. Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats. Biochemical and biophysical research communications. vol 284. issue 2. 2001-07-12. PMID:11394909. |
glucose tolerance is improved in dppiv-deficient f344/ducrj rats via enhanced insulin release mediated by high active glp-1 levels. |
2001-07-12 |
2023-08-12 |
rat |
| M Srinivasan, R Aalinkeel, F Song, B Lee, S G Laychock, M S Pate. Adaptive changes in insulin secretion by islets from neonatal rats raised on a high-carbohydrate formula. American journal of physiology. Endocrinology and metabolism. vol 279. issue 6. 2001-06-28. PMID:11093923. |
increases in plasma glucagon-like peptide-1 (glp-1) levels and islet glp-1 receptor mrna supported increased insulin secretion by hc islets. |
2001-06-28 |
2023-08-12 |
rat |
| M Srinivasan, R Aalinkeel, F Song, B Lee, S G Laychock, M S Pate. Adaptive changes in insulin secretion by islets from neonatal rats raised on a high-carbohydrate formula. American journal of physiology. Endocrinology and metabolism. vol 279. issue 6. 2001-06-28. PMID:11093923. |
under stringent ca(2+)-free conditions and in the presence of glucose, glp-1 plus acetylcholine augmented insulin release to a larger extent in hc islets. |
2001-06-28 |
2023-08-12 |
rat |
| Z Ling, D Wu, Y Zambre, D Flamez, D J Drucker, D G Pipeleers, F C Schui. Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice. Virchows Archiv : an international journal of pathology. vol 438. issue 4. 2001-06-07. PMID:11355173. |
glucagon-like peptide 1 (glp-1) amplifies glucose-induced insulin release in vivo and in vitro. |
2001-06-07 |
2023-08-12 |
mouse |