| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Sandhu, S R Wiesenthal, P E MacDonald, R H McCall, V Tchipashvili, S Rashid, M Satkunarajah, D M Irwin, Z Q Shi, P L Brubaker, M B Wheeler, M Vranic, S Efendic, A Giacc. Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs. Diabetes. vol 48. issue 5. 1999-05-27. PMID:10331409. |
in 12 paired experiments with six dogs at the high insulin dose, glp-1 infusion resulted in higher glucose requirements than saline (60.9+/-11.0 vs. 43.6+/-8.3 micromol x kg(-1) x min(-1), p< 0.001), because of greater glucose utilization (72.6+/-11.0 vs. 56.8+/-9.7 micromol x kg(-1) x min(-1), p<0.001), whereas the suppression of glucose production was not affected by glp-1. |
1999-05-27 |
2023-08-12 |
Not clear |
| H Sandhu, S R Wiesenthal, P E MacDonald, R H McCall, V Tchipashvili, S Rashid, M Satkunarajah, D M Irwin, Z Q Shi, P L Brubaker, M B Wheeler, M Vranic, S Efendic, A Giacc. Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs. Diabetes. vol 48. issue 5. 1999-05-27. PMID:10331409. |
in 10 paired experiments with five dogs at the low insulin dose, glp-1 infusion did not affect glucose utilization or ffa and glycerol suppression when compared with saline, suggesting that glp-1's effect on insulin action was dependent on the insulin dose. |
1999-05-27 |
2023-08-12 |
Not clear |
| H Sandhu, S R Wiesenthal, P E MacDonald, R H McCall, V Tchipashvili, S Rashid, M Satkunarajah, D M Irwin, Z Q Shi, P L Brubaker, M B Wheeler, M Vranic, S Efendic, A Giacc. Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs. Diabetes. vol 48. issue 5. 1999-05-27. PMID:10331409. |
in conclusion, in depancreatized dogs, glp-1 potentiates insulin-stimulated glucose utilization, an effect that might be contributed in part by glp-1 potentiation of insulin's antilipolytic action. |
1999-05-27 |
2023-08-12 |
Not clear |
| M A Nauc. Is glucagon-like peptide 1 an incretin hormone? Diabetologia. vol 42. issue 3. 1999-05-17. PMID:10096792. |
a glp-1 receptor antagonist or glp-1 antisera have been shown to reduce meal-stimulated insulin secretion in animals, suggesting that glp-1 has a physiological "incretin" function (augmentation of postprandial insulin secretion due to intestinal hormones) for glp-1. |
1999-05-17 |
2023-08-12 |
human |
| E Blázquez, E Alvarez, M Navarro, I Roncero, F Rodríguez-Fonseca, J A Chowen, J A Zuec. Glucagon-like peptide-1 (7-36) amide as a novel neuropeptide. Molecular neurobiology. vol 18. issue 2. 1999-04-26. PMID:10065878. |
although earlier studies indicated that glp-1 (7-36) amide was an intestinal peptide with a potent effect on glucose-dependent insulin secretion, later on it was found that several biological effects of this peptide occur in the brain, rather than in peripheral tissues. |
1999-04-26 |
2023-08-12 |
human |
| J Fernandez, M Valdeolmillo. Glucose-dependent stimulatory effect of glucagon-like peptide 1(7-36) amide on the electrical activity of pancreatic beta-cells recorded in vivo. Diabetes. vol 48. issue 4. 1999-04-15. PMID:10102691. |
the injection of glp-1 produces a lengthening of the active phase with respect to the silent phase, leading to a stimulation of insulin release, which produces a secondary decrease in blood glucose concentration and eventually, to the hyperpolarization of the membrane at a blood glucose level of approximately 5 mmol/l. |
1999-04-15 |
2023-08-12 |
Not clear |
| J Fernandez, M Valdeolmillo. Glucose-dependent stimulatory effect of glucagon-like peptide 1(7-36) amide on the electrical activity of pancreatic beta-cells recorded in vivo. Diabetes. vol 48. issue 4. 1999-04-15. PMID:10102691. |
these results demonstrate that in vivo, the stimulatory effect of glp-1 on insulin secretion is at least partially mediated by its effect on beta-cell electrical activity. |
1999-04-15 |
2023-08-12 |
Not clear |
| R P Pauly, H U Demuth, F Rosche, J Schmidt, H A White, F Lynn, C H McIntosh, R A Pederso. Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide. Metabolism: clinical and experimental. vol 48. issue 3. 1999-04-13. PMID:10094118. |
the incretins glucose-dependent insulinotropic polypeptide (gip1-42) and truncated forms of glucagon-like peptide-1 (glp-1) are hormones released from the gut in response to ingested nutrients, which act on the pancreas to potentiate glucose-induced insulin secretion. |
1999-04-13 |
2023-08-12 |
rat |
| C Montrose-Rafizadeh, P Avdonin, M J Garant, B D Rodgers, S Kole, H Yang, M A Levine, W Schwindinger, M Bernie. Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells. Endocrinology. vol 140. issue 3. 1999-03-23. PMID:10067836. |
the combination of insulin and glp-1 resulted in an additive response (1.6-fold over insulin alone) that was attenuated by ctx. |
1999-03-23 |
2023-08-12 |
human |
| G G Holz, J F Habene. Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 121. issue 2. 1999-03-08. PMID:9972293. |
it acts as an agonist at the receptor for glucagon-like peptide-1(7-36)-amide (glp-1), thereby stimulating secretion of insulin from pancreatic beta-cells of the islets of langerhans. |
1999-03-08 |
2023-08-12 |
human |
| G G Holz, J F Habene. Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 121. issue 2. 1999-03-08. PMID:9972293. |
on the basis of this homology, we report the synthesis and initial characterization of a chimeric peptide (black widow glp-1) that stimulates ca2+ signaling and insulin secretion in human beta-cells and min6 insulinoma cells. |
1999-03-08 |
2023-08-12 |
human |
| D G Morgan, R N Kulkarni, J D Hurley, Z L Wang, R M Wang, M A Ghatei, A E Karlsen, S R Bloom, D M Smit. Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells. Diabetologia. vol 41. issue 12. 1999-02-25. PMID:9867216. |
it also blocks insulin secretion stimulated by glp-1, but not by dibutyryl cyclic amp. |
1999-02-25 |
2023-08-12 |
rat |
| N Iritani, T Sugimoto, H Fukuda, M Komiya, H Iked. Oral triacylglycerols regulate plasma glucagon-like peptide-1(7-36) and insulin levels in normal and especially in obese rats. The Journal of nutrition. vol 129. issue 1. 1999-02-23. PMID:9915874. |
in the present study, triacylglycerol-regulation of levels of circulating insulin and glucagon-like peptide-1 (7-36) (glp-1) has been investigated in these rats. |
1999-02-23 |
2023-08-12 |
rat |
| N Iritani, T Sugimoto, H Fukuda, M Komiya, H Iked. Oral triacylglycerols regulate plasma glucagon-like peptide-1(7-36) and insulin levels in normal and especially in obese rats. The Journal of nutrition. vol 129. issue 1. 1999-02-23. PMID:9915874. |
the two plasma glp-1 peaks appeared 15 min and 4 h after intubation of glucose + corn oil similarly to the insulin responses, although the first peak was small and the second peak was very large. |
1999-02-23 |
2023-08-12 |
rat |
| N Iritani, T Sugimoto, H Fukuda, M Komiya, H Iked. Oral triacylglycerols regulate plasma glucagon-like peptide-1(7-36) and insulin levels in normal and especially in obese rats. The Journal of nutrition. vol 129. issue 1. 1999-02-23. PMID:9915874. |
the plasma glp-1 increment in response to oral triacylglycerols was significantly higher in obese rats than in lean rats as was the insulin increment. |
1999-02-23 |
2023-08-12 |
rat |
| N Iritani, T Sugimoto, H Fukuda, M Komiya, H Iked. Oral triacylglycerols regulate plasma glucagon-like peptide-1(7-36) and insulin levels in normal and especially in obese rats. The Journal of nutrition. vol 129. issue 1. 1999-02-23. PMID:9915874. |
thus, oral triacylglycerols (possibly polyunsaturated) appeared to act at the gut lumen to stimulate glp-1 secretion, which may be responsible for the second (4 h) insulin peak. |
1999-02-23 |
2023-08-12 |
rat |
| L Ranganath, I Sedgwick, L Morgan, J Wright, V Mark. The ageing entero-insular axis. Diabetologia. vol 41. issue 11. 1999-02-11. PMID:9833938. |
reduced insulin secretion has been described as part of normal ageing although there is no information on age-related changes in the secretion of the major insulinotropic hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide (7-36 amide) (glp-1). |
1999-02-11 |
2023-08-12 |
human |
| L Ranganath, I Sedgwick, L Morgan, J Wright, V Mark. The ageing entero-insular axis. Diabetologia. vol 41. issue 11. 1999-02-11. PMID:9833938. |
we hypothesise that an age-related impairment of insulin secretion to insulinotropic hormones, gip and glp-1, contributes to a reduction in glucose tolerance in this age group. |
1999-02-11 |
2023-08-12 |
human |
| L Ranganath, I Sedgwick, L Morgan, J Wright, V Mark. The ageing entero-insular axis. Diabetologia. vol 41. issue 11. 1999-02-11. PMID:9833938. |
the pronounced compensatory increase in postprandial secretion of gip and glp-1 provides further evidence not only for the negative feedback relation between incretin and insulin secretion but also for the importance of the entero-insular axis in the regulation of insulin secretion. |
1999-02-11 |
2023-08-12 |
human |
| M A Nauc. Glucagon-like peptide 1 (GLP-1): a potent gut hormone with a possible therapeutic perspective. Acta diabetologica. vol 35. issue 3. 1999-02-05. PMID:9840447. |
glucagon-like peptide 1 (glp-1) is a physiological incretin hormone from the lower gastrointestinal tract, partially explaining the augmented insulin response after oral compared to intravenous glucose administration in normal humans. |
1999-02-05 |
2023-08-12 |
Not clear |