| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Lopes-Rocha, Thiago Ohno Bezerra, Roberta Zanotto, Inda Lages Nascimento, Angela Rodrigues, Cristiane Salu. The Antioxidant N-Acetyl-L-Cysteine Restores the Behavioral Deficits in a Neurodevelopmental Model of Schizophrenia Through a Mechanism That Involves Nitric Oxide. Frontiers in pharmacology. vol 13. 2022-07-29. PMID:35903343. |
analyses of markers involved in the inflammatory response, such as astrocytes (glial fibrillary acid protein, gfap) and microglia (binding adapter molecule 1, iba1), and parvalbumin (pv) positive gabaergic, were conducted in the prefrontal cortex [pfc, medial orbital cortex (mo) and prelimbic cortex (prl)] and dorsal and ventral hippocampus [ca1, ca2, ca3, and dentate gyrus (dg)] in rats under chronic treatment with nac. |
2022-07-29 |
2023-08-14 |
rat |
| b' Barbara Sita\\xc5\\xa1, Mihaela Bobi\\xc4\\x87-Rasonja, Goran Mrak, Sara Trnski, Magdalena Krbot Skori\\xc4\\x87, Darko Ore\\xc5\\xa1kovi\\xc4\\x87, Vinka Knezovi\\xc4\\x87, \\xc5\\xbdeljka Petelin Gad\\xc5\\xbee, Zdravko Petanjek, Goran \\xc5\\xa0imi\\xc4\\x87, Danijela Kolenc, Nata\\xc5\\xa1a Jovanov Milo\\xc5\\xa1evi\\xc4\\x8. Reorganization of the Brain Extracellular Matrix in Hippocampal Sclerosis. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897768.' |
hippocampal sections were immunohistochemically stained for aggrecan, neurocan, versican, chondroitin-sulfate (cs56), fibronectin, wisteria floribunda agglutinin (wfa), a nuclear neuronal marker (neun), parvalbumin (pv), and glial-fibrillary-acidic-protein (gfap). |
2022-07-28 |
2023-08-14 |
Not clear |
| Akshatha Ganne, Meenakshisundaram Balasubramaniam, W Sue T Griffin, Robert J Shmookler Reis, Srinivas Ayyadevar. Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease. Pharmaceutics. vol 14. issue 7. 2022-07-27. PMID:35890250. |
here, we present novel evidence that gfap is markedly overexpressed and differentially phosphorylated in ad hippocampus, especially in ad with the apolipoprotein e [ε4, ε4] genotype, relative to age-matched controls (amcs). |
2022-07-27 |
2023-08-14 |
mouse |
| Mohammad Rumman, Shivani Pandey, Babita Singh, Mrinal Gupta, Abbas Ali Mahd. Genistein suppresses microglial activation and inhibits apoptosis in different brain regions of hypoxia-exposed mice model of amnesia. Metabolic brain disease. 2022-07-27. PMID:35895244. |
we assessed microglial activation in the hippocampus, amygdala, and pre-frontal cortex (pfc) regions by evaluating the iba-1 and gfap transcript levels, and mip-1β, cox-2, and il6 protein levels. |
2022-07-27 |
2023-08-14 |
mouse |
| Ying Wei, Li Xiao, Weihao Fan, Jing Zou, Hong Yang, Bo Liu, Yi Ye, Di Wen, Linchuan Lia. Astrocyte Activation, but not Microglia, Is Associated with the Experimental Mouse Model of Schizophrenia Induced by Chronic Ketamine. Journal of molecular neuroscience : MN. 2022-07-08. PMID:35802289. |
meanwhile, immunofluorescence was used to evaluate the expression levels of iba-1 (a microglial marker) and gfap (an astrocyte marker) in the mouse hippocampus for any change. |
2022-07-08 |
2023-08-14 |
mouse |
| Ying Wei, Li Xiao, Weihao Fan, Jing Zou, Hong Yang, Bo Liu, Yi Ye, Di Wen, Linchuan Lia. Astrocyte Activation, but not Microglia, Is Associated with the Experimental Mouse Model of Schizophrenia Induced by Chronic Ketamine. Journal of molecular neuroscience : MN. 2022-07-08. PMID:35802289. |
moreover, chronic ketamine treatment enhanced gfap expression in ca1 and dg regions of the hippocampus but did not influence the expression of iba-1. |
2022-07-08 |
2023-08-14 |
mouse |
| Liu Xianchu, Peng Huan, Liu Kang, Deng Beiwang, Liu Min. Protective effect of rutin against diabetes-associated cognitive decline in rats. Pakistan journal of pharmaceutical sciences. vol 35. issue 3. 2022-07-06. PMID:35791475. |
in hippocampus, rut markedly inhibited ache, gfap mda, tnf-a and il-1β levels and augmented chat and bdnf, sod, cat, gsh, nrf-2 and ho-1 levels. |
2022-07-06 |
2023-08-14 |
rat |
| Li-Ping Huang, Xiao-Qin Zhong, Xin-Yu Zhou, Min-Qi Deng, Man-Jing Wu, Min-Zhen Den. [Galangin alleviates learning and memory impairments in APP/PS1 double- transgenic mice by regulating Akt/MEF2D/Beclin-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 10. 2022-06-19. PMID:35718493. |
the levels of p-tau, β-amyloid peptide 1-42(aβ_(42)), acetylcholinesterase(ache), β-site amyloid precursor protein cleaving enzyme 1(bace1), and amyloid precursor protein(app) in hippocampus were detected by elisa, the beclin-1 mrna expression by rt-pcr, the expression of aβ_(42) and glial fibrillary acidic protein(gfap) by immunohistochemistry, and the expression of myocyte enhancer factor 2 d(mef2 d) by immunofluorescence assay. |
2022-06-19 |
2023-08-14 |
mouse |
| Li-Ping Huang, Xiao-Qin Zhong, Xin-Yu Zhou, Min-Qi Deng, Man-Jing Wu, Min-Zhen Den. [Galangin alleviates learning and memory impairments in APP/PS1 double- transgenic mice by regulating Akt/MEF2D/Beclin-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 10. 2022-06-19. PMID:35718493. |
these results showed that compared with the normal group, the model group exhibited prolonged swimming time, increased number of errors and electric shocks, up-regulated p-tau, aβ_(42), app, ache, bace1, gfap, and beclin-1, shortened incubation period, decreased p-akt and mef2 d, and obvious hippocampal injury. |
2022-06-19 |
2023-08-14 |
mouse |
| Li-Ping Huang, Xiao-Qin Zhong, Xin-Yu Zhou, Min-Qi Deng, Man-Jing Wu, Min-Zhen Den. [Galangin alleviates learning and memory impairments in APP/PS1 double- transgenic mice by regulating Akt/MEF2D/Beclin-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 10. 2022-06-19. PMID:35718493. |
compared with the model group, donepezil and galangin shortened the swimming time, reduced the number of errors and electric shocks, down-regulated the expression of p-tau, aβ_(42), app, ache, bace1, gfap, and beclin-1, prolonged the incubation period, up-regulated p-akt and mef2 d, and improved the pathological changes in hippocampus. |
2022-06-19 |
2023-08-14 |
mouse |
| Li-Ping Huang, Xiao-Qin Zhong, Xin-Yu Zhou, Min-Qi Deng, Man-Jing Wu, Min-Zhen Den. [Galangin alleviates learning and memory impairments in APP/PS1 double- transgenic mice by regulating Akt/MEF2D/Beclin-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 10. 2022-06-19. PMID:35718493. |
compared with the autophagy inhibitor group, galangin prolonged the swimming time, elevated the number of errors and electric shocks, enhanced the expression of p-tau, aβ_(42), app, ache, bace1, gfap, and beclin-1, shortened the incubation period, and diminished the expression of p-akt and mef2 d. in conclusion, galangin improves the learning and memory impairments and hippocampal neuron injury of app/ps1 mice, which may be related to its regulation of akt/mef2 d/beclin-1 signaling pathway. |
2022-06-19 |
2023-08-14 |
mouse |
| Lequan Wen, Lirui Tang, Mingming Zhang, Congrui Wang, Shujuan Li, Yuqing Wen, Hongcheng Tu, Haokun Tian, Jingyi Wei, Peiwen Liang, Changsen Yang, Guodong Li, Yun Ga. Gallic Acid Alleviates Visceral Pain and Depression via Inhibition of P2X7 Receptor. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682841. |
furthermore, the distributions of the p2x7 receptor and glial fibrillary acidic protein (gfap) in the hippocampus and drg were investigated in immunofluorescent experiments. |
2022-06-10 |
2023-08-14 |
rat |
| Alana Gomes de Souza, Iardja Stéfane Lopes, Adriano José Maia Chaves Filho, Talita Matias Barbosa Cavalcante, João Victor Souza Oliveira, Michele Albuquerque Jales de Carvalho, Klistenes Alves de Lima, Paloma Marinho Jucá, Sabrina Silva Mendonça, Melina Mottin, Carolina Horta Andrade, Francisca Cléa Florenço de Sousa, Danielle S Macedo, Marta Maria de França Fontele. Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2022-06-06. PMID:35665831. |
cums induced anxiety- and depressive-like behaviors, cognitive deficit, decreased gfap, and increased iba1, tnf-α, and il-iβ expression in the hippocampus. |
2022-06-06 |
2023-08-14 |
mouse |
| Viridiana Navarrete-Yanez, Antonio Rodriguez-Castaneda, Marcos Ayala, Guillermo Ceballos, Israel Ramirez-Sanchez, Francisco Villarrea. Neurological restorative effects of the flavanol (-)-epicatechin in a rodent model of Gulf War Illness. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-14. PMID:35567443. |
significant increases in markers of hippocampus neuroinflammation (iba1 and gfap) and cell death (caspase activity) were noted with gwi and were significantly reduced with epi. |
2022-05-14 |
2023-08-13 |
human |
| Robert S Gardner, Donna L Korol, Paul E Gol. Hippocampus-sensitive and striatum-sensitive learning one month after morphine or cocaine exposure in male rats. Pharmacology, biochemistry, and behavior. 2022-05-05. PMID:35513118. |
protein levels of glial-fibrillary acidic protein (gfap), an intermediate filament specific to astrocytes, increased significantly in the hippocampus after morphine exposure, but not after cocaine exposure. |
2022-05-05 |
2023-08-13 |
rat |
| Kazuki Hatayama, Sydney Riddick, Fares Awa, Xiaodi Chen, Daniela Virgintino, Barbara S Stonestree. Time Course of Changes in the Neurovascular Unit after Hypoxic-Ischemic Injury in Neonatal Rats. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35456999. |
the right hi and left hypoxic alone sides of the brains were examined by quantitative immunohistochemistry for vascular density (laminin), pericyte vascular coverage (pdgfrβ), astrocyte vascular coverage (gfap), and claudin-5 expression in the microvasculature of the cerebral cortex, white matter, and hippocampus. |
2022-04-23 |
2023-08-13 |
rat |
| Maria Bove, Stefania Schiavone, Paolo Tucci, Vladyslav Sikora, Stefania Dimonte, Anna Laura Colia, Maria Grazia Morgese, Luigia Trabac. Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms. Progress in neuro-psychopharmacology & biological psychiatry. 2022-04-23. PMID:35460811. |
moreover, by using this mouse model, we performed neurochemical and biomolecular analyses, quantifying neurotransmitters belonging to excitatory-inhibitory pathways, such as glutamate, glutamine and gamma-aminobutyric acid (gaba), as well as immune activation biomarkers related to asd, such as cd11b and glial fibrillary acidic protein (gfap), in the hippocampus and amygdala. |
2022-04-23 |
2023-08-13 |
mouse |
| Maria Bove, Stefania Schiavone, Paolo Tucci, Vladyslav Sikora, Stefania Dimonte, Anna Laura Colia, Maria Grazia Morgese, Luigia Trabac. Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms. Progress in neuro-psychopharmacology & biological psychiatry. 2022-04-23. PMID:35460811. |
in addition, we found decreased bdnf and enhanced gfap hippocampal expression levels, accompanied by elevations in glutamate amount, as well as reduction in gaba content in amygdala and hippocampus. |
2022-04-23 |
2023-08-13 |
mouse |
| Mahsa Tashakori-Miyanroudi, Samira Ramazi, Paria Hashemi, Morteza Nazari-Serenjeh, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy. Journal of molecular neuroscience : MN. 2022-03-23. PMID:35320462. |
as well, obtained findings showed that alc can partially reverse hippocampal levels of mda, ros, sod, tnfa, nf-kb, tlr4, gfap, and caspase 1. |
2022-03-23 |
2023-08-13 |
rat |
| Md Mahiuddin Ahmed, Athena Ching-Jung Wang, Mihret Elos, Heidi J Chial, Stefan Sillau, D Adriana Solano, Christina Coughlan, Leila Aghili, Paige Anton, Neil Markham, Vanesa Adame, Katheleen J Gardiner, Timothy D Boyd, Huntington Potte. The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 down syndrome mice and improves learning/memory in wild-type mice. Neurobiology of disease. 2022-03-21. PMID:35307513. |
dp16 mice also showed abnormal astrocyte morphology, increased percent area of gfap staining in the hippocampus, clustering of astrocytes in the hippocampus, and reduced numbers of calretinin-positive interneurons in the entorhinal cortex and subiculum, and all of these brain pathologies were improved by gm-csf treatment. |
2022-03-21 |
2023-08-13 |
mouse |