| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rehab M El-Sayed, Mohamed N Fawzy, Hala F Zaki, Enas A Abd El-Halei. Neuroprotection impact of biochanin A against pentylenetetrazol-kindled mice: Targeting NLRP3 inflammasome/TXNIP pathway and autophagy modulation. International immunopharmacology. vol 115. 2023-01-14. PMID:36640710. |
biochanin a pretreatment significantly reduced the severity of epileptogenesis by 51.7% and downregulated the histological changes in the ca3 region of the hippocampus by 42% along with displaying antioxidant/anti-inflammatory efficacy through upregulated hemeoxygenase-1 (ho-1) and, erythroid 2-related factor 2 (nrf2) levels in the brain by 1.9-fold and 2-fold respectively, parallel to reduction of malondialdehyde (mda), myeloperoxidase (mpo), glial fibrillary acidic protein (gfap) and l-glutamate/il-1β/txnib/nlrp3 axis. |
2023-01-14 |
2023-08-14 |
mouse |
| Shveta V Parekh, Lydia O Adams, Gillian A Barkell, Donald T Lysl. Sex-differences in anxiety, neuroinflammatory markers, and enhanced fear learning following chronic heroin withdrawal. Psychopharmacology. 2023-01-12. PMID:36633660. |
this behavior is associated with an increase in dorsal hippocampal (dh) interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), and glial fibrillary acidic protein (gfap) immunoreactivity. |
2023-01-12 |
2023-08-14 |
human |
| Tosan P Omayone, Faizah T Salami, Oritoke M Aluko, Jannie N Nathanniel, Sikirullai O Jeje, Temitope G Adedeji, Omamuyovwi M Ijomon. Neuroprotective effects of methyl jasmonate in male Wistar rats exposed to delayed acetic acid-induced ulcerative colitis: involvement of antioxidant status, GFAP, and IBA-1 immunoreactivities. Metabolic brain disease. 2023-01-03. PMID:36595156. |
mj reversed these effects and reduced gfap count in the hippocampus and amygdala as well as iba-1 count in the hippocampus, amygdala, and cortex. |
2023-01-03 |
2023-08-14 |
rat |
| Adriana Fernanda K Vizuete, Miriara B Leal, Ana Paula Moreira, Marina Seady, Jéssica Taday, Carlos-Alberto Gonçalve. Arundic acid (ONO-2506) downregulates neuroinflammation and astrocyte dysfunction after status epilepticus in young rats induced by Li-pilocarpine. Progress in neuro-psychopharmacology & biological psychiatry. 2022-12-24. PMID:36565981. |
in se animals, arundic acid was able to prevent the damage induced by li-pilocarpine in the hippocampus, decreasing neuroinflammatory signaling (reducing il-1β, cox2, tlr4 and rage contents), astrogliosis (decreasing gfap and s100b) and astrocytic dysfunction (recovering levels of gsh, glutamine synthetase and connexin-43). |
2022-12-24 |
2023-08-14 |
rat |
| Alia O Alia, Sohee Jeon, Jelena Popovic, Miranda A Salvo, Katherine R Sadleir, Robert Vassar, Leah K Cudd. Aberrant glial activation and synaptic defects in CaMKIIα-iCre and nestin-Cre transgenic mouse models. Scientific reports. vol 12. issue 1. 2022-12-21. PMID:36543864. |
increased gfap and iba1 levels were observed in hippocampal brain regions of 4-, 8- and 22-month-old camkiiα-icre mice compared to wt littermates. |
2022-12-21 |
2023-08-14 |
mouse |
| Ramya Balasubramanian, Mohd Rabi Bazaz, Tulasi Pasam, Naserunnisa Sharief, Laximan Velip, Gananadhamu Samanthula, Manoj P Dandeka. Involvement of Microbiome Gut-Brain Axis in Neuroprotective Effect of Quercetin in Mouse Model of Repeated Mild Traumatic Brain Injury. Neuromolecular medicine. 2022-12-09. PMID:36481824. |
quercetin treatment also restored the increased expression of gfap and decreased expression of occludin and doublecortin in the frontal cortex and hippocampus of rmtbi mice. |
2022-12-09 |
2023-08-14 |
mouse |
| Ying Zhang, Guiping Wang, Rui Li, Ruitong Liu, Zengli Yu, Zengli Zhang, Zhongxiao Wa. Trimethylamine N-oxide aggravated cognitive impairment from APP/PS1 mice and protective roles of voluntary exercise. Neurochemistry international. 2022-12-02. PMID:36460238. |
tmao group has significantly upregulated bace1 from both hippocampus and cortex, also increased cathepsin b, p-tau at ser396&ser404, gfap, p-nf-κb p65 in cortex, while reduced bdnf, synaptophysin and psd95 in hippocampus, also reduced occludin and zo-1 from cortex, and reduced occludin from colon. |
2022-12-02 |
2023-08-14 |
mouse |
| Mikaela Peglow Pinz, Renata Leivas de Oliveira, Caren Aline Ramson da Fonseca, Guilherme Teixeira Voss, Beatriz Pereira da Silva, Luis Fernando Barbosa Duarte, William Borges Domingues, Hadassa Gabriela Ortiz, Anne Suély Pinto Savall, Flavia Carla Meotti, Diego Alves, Vinicius Farias Campos, Simone Pinton, Ethel Antunes Wilhelm, Cristiane Luches. A Purine Derivative Containing an Organoselenium Group Protects Against Memory Impairment, Sensitivity to Nociception, Oxidative Damage, and Neuroinflammation in a Mouse Model of Alzheimer's Disease. Molecular neurobiology. 2022-11-25. PMID:36427137. |
aβ caused neuroinflammation with upregulation of glial fibrillary acidic protein (gfap) (in hippocampus), nuclear factor-κb (nf-κb), and the proinflammatory cytokines interferon-γ (ifn-γ) and tumor necrosis factor-α (tnf-α) in cerebral cortex and hippocampus. |
2022-11-25 |
2023-08-14 |
mouse |
| Mikaela Peglow Pinz, Renata Leivas de Oliveira, Caren Aline Ramson da Fonseca, Guilherme Teixeira Voss, Beatriz Pereira da Silva, Luis Fernando Barbosa Duarte, William Borges Domingues, Hadassa Gabriela Ortiz, Anne Suély Pinto Savall, Flavia Carla Meotti, Diego Alves, Vinicius Farias Campos, Simone Pinton, Ethel Antunes Wilhelm, Cristiane Luches. A Purine Derivative Containing an Organoselenium Group Protects Against Memory Impairment, Sensitivity to Nociception, Oxidative Damage, and Neuroinflammation in a Mouse Model of Alzheimer's Disease. Molecular neurobiology. 2022-11-25. PMID:36427137. |
anti-neuroinflammatory effects of fsp were demonstrated by a decrease in the expression of gfap and nf-κb in the hippocampus, as well as a decrease in proinflammatory cytokines in both the hippocampus and cerebral cortex fsp protected against oxidative stress by decreasing oxidant levels and lipid peroxidation and by increasing ho-1 and prdx1 expressions in the hippocampus of mice. |
2022-11-25 |
2023-08-14 |
mouse |
| Cai Zhang, Baiping Liu, Jodi Pawluski, Harry W M Steinbusch, U Kirthana Kunikullaya, Cai Son. The effect of chronic stress on behaviors, inflammation and lymphocyte subtypes in male and female rats. Behavioural brain research. 2022-11-22. PMID:36414104. |
results show that cums increased anhedonia and anxiety-like behaviors, along with increased serum corticosterone, hippocampal pro-inflammatory factors, cd11b, ifn-γ, il-6 and il-17, but decreased cd4, cd25, cd4/cd8 ratio, gfap, 5-hydroxytryptamine (5-ht) and ne concentrations, regardless of sex. |
2022-11-22 |
2023-08-14 |
rat |
| Shveta V Parekh, Lydia O Adams, Gillian A Barkell, Donald T Lysl. MDMA administration attenuates hippocampal IL-β immunoreactivity and subsequent stress-enhanced fear learning: An animal model of PTSD. Brain, behavior, & immunity - health. vol 26. 2022-11-17. PMID:36388136. |
the current studies test the hypothesis that mdma is capable of attenuating sefl and inducing alterations in expression of tnf-α, il-1β, glial fibrillary acidic protein (gfap), an astrocyte specific marker, and ionized calcium-binding adapter molecule -1 (iba-1), a microglial specific marker, in the dorsal hippocampus (dh) following a severe stressor in male animals. |
2022-11-17 |
2023-08-14 |
Not clear |
| Samuel Treviño, Alfonso Díaz, Getsemaní González-López, Jorge Guevar. Differential biochemical-inflammatory patterns in the astrocyte-neuron axis of the hippocampus and frontal cortex in Wistar rats with metabolic syndrome induced by high fat or carbohydrate diets. Journal of chemical neuroanatomy. vol 126. 2022-11-14. PMID:36374648. |
after 3 months, we evaluated zoometry, a serum bioclinical profile, and in the hippocampus and frontal cortex, we performed biochemical assays (concentration of lactate, glutamate, fatty acids, and asat, alat, and ldh activity), immunoreactivity tests (gfap, cox2, cd36, and bdnf), and immunoassays (tnf-α, il-1β, il-6, and pge2). |
2022-11-14 |
2023-08-14 |
rat |
| Yan Sun, Haiyan Zhu, Rongrong Cheng, Zhengquan Tang, Min Zhan. Outer membrane protein Amuc_1100 of Akkermansia muciniphila alleviates antibiotic-induced anxiety and depression-like behavior in mice. Physiology & behavior. 2022-11-06. PMID:36336146. |
in addition, the brain derived neurotrophic factor / tropomyosin receptor kinase b (bdnf/trkb) signaling pathway was altered, glial fibrillary acidic protein (gfap) expression increased, and c-fos protein expression decreased in the hippocampus of antibiotic-treated mice. |
2022-11-06 |
2023-08-14 |
mouse |
| Alexandra V Griflyuk, Tatyana Y Postnikova, Aleksey V Zaitse. Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293077. |
prolonged febrile seizures impair synaptic plasticity and alter developmental pattern of glial fibrillary acidic protein (gfap)-immunoreactive astrocytes in the hippocampus of young rats. |
2022-10-27 |
2023-08-14 |
rat |
| Chen Hong, Zhi Wang, Si-Li Zheng, Wen-Jun Hu, Shu-Na Wang, Yan Zhao, Chao-Yu Mia. Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice. Acta pharmacologica Sinica. 2022-10-13. PMID:36229598. |
furthermore, metrnl knockout significantly reduced hippocampal bdnf, trkb, and glial fibrillary acidic protein (gfap) levels in the d-gal-induced aging mice. |
2022-10-13 |
2023-08-14 |
mouse |
| Qi Li, Yuqian Zhao, Chuanchuan Shi, Xuemin Son. IL-33 Alleviates Postoperative Cognitive Impairment by Inhibiting Hippocampal Inflammation and Upregulating Excitatory Synaptic Number in Aged Mice. Brain sciences. vol 12. issue 9. 2022-09-23. PMID:36138980. |
immunofluorescence was used to detect the density of il-33 and glial fibrillary acidic protein (gfap) co-localization, ionized calcium-binding adapter molecule 1, vesicular glutamate transporter 1 (vglut1) and postsynaptic density protein-95 (psd95) co-localization in the hippocampus. |
2022-09-23 |
2023-08-14 |
mouse |
| Cuihong Jiang, Shuang Zheng, Tengfei Chen, Wenqiang Li, Chencheng Zhang, Shina Gu, Huicong Ren, Huanhuan, Jinggui Song, Zhaohui Zhan. Repetitive Transcranial Magnetic Stimulation Improves Depression-like Behavior in Rats by Promoting Neural Stem Cell Proliferation and Differentiation. Neuroscience. 2022-09-18. PMID:36116556. |
these behavioral deficits were accompanied by decreased numbers of astrocytes in the hippocampus, decreased expression of glial fibrillary acidic protein (gfap), increased numbers of neural stem cells (nscs), and increased expression of nestin protein. |
2022-09-18 |
2023-08-14 |
rat |
| Runan Yang, Jingjian Yang, Zijing Li, Ruichen Su, Lifang Zou, Lin Li, Xiumei Xu, Guilin Li, Shuangmei Liu, Shangdong Liang, Changshui X. Pinocembrin Inhibits P2X4 Receptor-Mediated Pyroptosis in Hippocampus to Alleviate the Behaviours of Chronic Pain and Depression Comorbidity in Rats. Molecular neurobiology. 2022-09-10. PMID:36088500. |
in the model rats, the mrna and protein levels of the p2x4 receptor in the hippocampus were increased, and the coexpression of p2x4 and the astrocyte marker glial fibrillary acidic protein (gfap) in the hippocampus was increased. |
2022-09-10 |
2023-08-14 |
rat |
| Leonardo C Souza, Marcos K Andrade, Evellyn M Azevedo, Daniele C Ramos, Ellen L Bail, Maria A B F Vita. Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer's Disease. Neurotoxicity research. 2022-08-27. PMID:36029454. |
in the present study, we investigated the effects of andro in the icv-stz model relative to short-term spatial memory (object location test (olt) and y maze test), short-term recognition memory (object recognition test (ort)), locomotor activity (open field test (oft)), expression of amyloid precursor protein (app), and activation of astrocytes (glial fibrillary acidic protein (gfap) expression) and microglia (ionized calcium-binding adapter molecule-1 (iba-1) immunohistochemistry) in the prefrontal cortex (pfc) and hippocampus (hip). |
2022-08-27 |
2023-08-14 |
rat |
| Heba M A Khalil, Dina B Mahmoud, Riham A El-Shiekh, Alaa F Bakr, Amira A Boseila, Sally Mehanna, Reham A Naggar, Hesham A Eliw. Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats. AAPS PharmSciTech. vol 23. issue 7. 2022-08-26. PMID:36028598. |
in addition, hp.snesns augmented the immunohistochemical expression of cortical and hippocampal glial fibrillary acidic protein (gfap) levels while downregulating the cortical bcl-2-associated x protein (bax) expression levels. |
2022-08-26 |
2023-08-14 |
rat |