| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marwa Mohamed Atef, Marwa Nagy Emam, Rehab E Abo El Gheit, Eman M Elbeltagi, H A Alshenawy, Doaa A Radwan, Reham L Younis, Rania Nagi Abd-Ellati. Mechanistic Insights into Ameliorating Effect of Geraniol on D-Galactose Induced Memory Impairment in Rats. Neurochemical research. 2022-03-02. PMID:35235140. |
also, hippocampal histopathological assessment and immunohistochemical analysis of glial fibrillary acidic protein (gfap) and caspase-3 were performed. |
2022-03-02 |
2023-08-13 |
rat |
| Noorul Hasan, Saima Zameer, Abul Kalam Najmi, Suhel Parvez, Mohd Akhta. Roflumilast Reduces Pathological Symptoms of Sporadic Alzheimer's Disease in Rats Produced by Intracerebroventricular Streptozotocin by Inhibiting NF-κB/BACE-1 Mediated Aβ Production in the Hippocampus and Activating the cAMP/BDNF Signalling Pathway. Neurotoxicity research. 2022-02-22. PMID:35192144. |
rfm enhanced the levels of camp and brain-derived neurotrophic factors (bdnfs) while decreasing the expression of nuclear factor kappa b (nf-κb) and glial fibrillary acidic protein (gfap) in the hippocampus of icv-stz-infused rats. |
2022-02-22 |
2023-08-13 |
rat |
| Adriano Lama, Claudio Pirozzi, Ilenia Severi, Maria Grazia Morgese, Martina Senzacqua, Chiara Annunziata, Federica Comella, Filomena Del Piano, Stefania Schiavone, Stefania Petrosino, Maria Pina Mollica, Sabrina Diano, Luigia Trabace, Antonio Calignano, Antonio Giordano, Giuseppina Mattace Raso, Rosaria Mel. Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice. Brain, behavior, and immunity. 2022-02-17. PMID:35176443. |
moreover, pea attenuated the immunoreactivity of iba-1 and gfap and reduced pro-inflammatory pathways and cytokine production in both the hypothalamus and hippocampus. |
2022-02-17 |
2023-08-13 |
mouse |
| Eman M El Nashar, Walaa Obydah, Mansour A Alghamdi, Somaya Saad, Asmaa Yehia, Ayda Maryoud, Nedaa A Kiwan, Wardah A Alasmari, Abdelaziz M Hussei. Effects of Stevia rebaudiana Bertoni extracts in the rat model of epilepsy induced by pentylenetetrazol: Sirt-1, at the crossroads between inflammation and apoptosis. Journal of integrative neuroscience. vol 21. issue 1. 2022-02-15. PMID:35164457. |
also, in the hippocampus, the expression of il6 and bcl-2 at the mrna level and expression of sirt-1, p53, caspase-3, gfap, and nf-kb in ca3 hippocampal region by immunohistochemistry was investigated. |
2022-02-15 |
2023-08-13 |
rat |
| Eman M El Nashar, Walaa Obydah, Mansour A Alghamdi, Somaya Saad, Asmaa Yehia, Ayda Maryoud, Nedaa A Kiwan, Wardah A Alasmari, Abdelaziz M Hussei. Effects of Stevia rebaudiana Bertoni extracts in the rat model of epilepsy induced by pentylenetetrazol: Sirt-1, at the crossroads between inflammation and apoptosis. Journal of integrative neuroscience. vol 21. issue 1. 2022-02-15. PMID:35164457. |
also, ptz significantly increased mda, gfap, il-6, nf-kb, caspase-3, and p53 and significantly reduced sirt-1, tac, and bcl-2 in hippocampal tissues compared to the control group ( |
2022-02-15 |
2023-08-13 |
rat |
| Juan Wang, Feng Gao, Shuai Cui, Shaojie Yang, Fang Gao, Xuncui Wang, Guoqi Zh. Utility of 7,8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD. Pharmacological research. 2022-01-13. PMID:35026406. |
sps&s reduced the hippocampal expression of glial fibrillary acidic protein (gfap), a marker of astrocytes, and induced morphological changes in astrocytes. |
2022-01-13 |
2023-08-13 |
mouse |
| D W Svenson, Cameron J Davidson, Chitra Thakur, Scott E Bowe. ACUTE EXPOSURE TO ABUSE-LIKE CONCENTRATIONS OF TOLUENE INDUCES INFLAMMATION IN MOUSE LUNGS AND BRAIN. Journal of applied toxicology : JAT. 2022-01-07. PMID:34993988. |
gfap showed increased astrogliosis in the striatum with 2000 ppm toluene showing significantly higher expression than control (p < 0.05), and a marginal effect in the hippocampus. |
2022-01-07 |
2023-08-13 |
mouse |
| Michelle R Dickerson, Susan F Murphy, Michael J Urban, Zakar White, Pamela J VandeVor. Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma. Frontiers in behavioral neuroscience. vol 15. 2021-12-27. PMID:34955781. |
these behaviors were also correlated with astrocyte pathology (glial-fibrillary acid protein, gfap) and dendritic alterations (microtubule-associated proteins, map2) within the hippocampus and mc regions at 52 weeks. |
2021-12-27 |
2023-08-13 |
rat |
| Yin Yuxiong, Xiang Xujin, Tang Yi, Chen Ya, Li Yujuan, Hu Shanshan, Wang Huiwe. Brain-specific TRAF7 deletion ameliorates traumatic brain injury by suppressing MEKK3-regulated glial inflammation and neuronal death. International immunopharmacology. vol 103. 2021-12-25. PMID:34953447. |
moreover, the aberrant activation of astrocyte and microglia in cortex and hippocampus of tbi mice was significantly restrained by traf7 conditional knockout in brain, as indicated by the increased expression of gfap and iba1. |
2021-12-25 |
2023-08-13 |
mouse |
| Matthew G Frank, Kathy H Nguyen, Jayson B Ball, Shelby Hopkins, Tel Kelley, Michael V Baratta, Monika Fleshner, Steven F Maie. SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: evidence of PAMP-like properties. Brain, behavior, and immunity. 2021-12-16. PMID:34915155. |
s1 increased and/or modulated neuroimmune gene expression (iba1, cd11b, mhciiα, cd200r1, gfap, tlr2, tlr4, nlrp3, il1b, hmgb1) and protein levels (ifnγ, il-1β, tnf, cxcl1, il-2, il-10), which varied across brain regions (hypothalamus, hippocampus, and frontal cortex) and time (24h and 7d) post-s1 treatment. |
2021-12-16 |
2023-08-13 |
human |
| Yanyu Ding, Bo Liu, Yang Zhang, Fang Fang, Xueyan Li, Song Wang, Jiyue We. Hydrogen sulphide protects mice against the mutual aggravation of cerebral ischaemia/reperfusion injury and colitis. European journal of pharmacology. vol 914. 2021-12-11. PMID:34871558. |
the results revealed that cerebral i/r induced brain damage and a marked increase in glial fibrillary acidic protein (gfap) expression and upregulation of rho-associated coiled coil-forming protein kinase (rhoa/rock) pathway in mouse hippocampal tissues. |
2021-12-11 |
2023-08-13 |
mouse |
| Diulle Spat Peres, Maria Carolina Theisen, Maria Fernanda Pessano Fialho, Diéssica Padilha Dalenogare, Patrícia Rodrigues, Sabrina Qader Kudsi, Laura de Barros Bernardes, Náthaly Andrighetto Ruviaro da Silva, Débora Denardin Lückemeyer, Tuane Bazanella Sampaio, Gabriele Cheiran Pereira, Fernanda Kulinski Mello, Juliano Ferreira, Guilherme Vargas Bochi, Sara Marchesan Oliveira, Caren Tatiane de David Antoniazzi, Gabriela Trevisa. TRPA1 involvement in depression- and anxiety-like behaviors in a progressive multiple sclerosis model in mice. Brain research bulletin. vol 175. 2021-12-10. PMID:34280479. |
the neuroinflammatory markers (aif1, gfap, il-1β, il-17, and tnf-α) were increased in mice's hippocampus. |
2021-12-10 |
2023-08-13 |
mouse |
| Rita Asdikian, Helene Hajjar, Sana Alturk, Jean-Pierre Asdikian, Fatima Jaafar, Houssein Salah, Yara Mrad, Farah Issa, Michel Almardini, Fatima Nourelddine, Ronza Abdel Rassoul, Houssam Al-Koussa, Makram Obei. Hippocampal injury and learning deficits following non-convulsive status epilepticus in periadolescent rats. Epilepsy & behavior : E&B. vol 125. 2021-12-10. PMID:34788732. |
histological analyses were performed at p52 to assess hippocampal neuronal densities, as well as potential reactive astrocytosis and synaptic dysfunction with gfap (glial fibrillary acidic protein) and synaptophysin (syp) staining, respectively. |
2021-12-10 |
2023-08-13 |
rat |
| Rita Asdikian, Helene Hajjar, Sana Alturk, Jean-Pierre Asdikian, Fatima Jaafar, Houssein Salah, Yara Mrad, Farah Issa, Michel Almardini, Fatima Nourelddine, Ronza Abdel Rassoul, Houssam Al-Koussa, Makram Obei. Hippocampal injury and learning deficits following non-convulsive status epilepticus in periadolescent rats. Epilepsy & behavior : E&B. vol 125. 2021-12-10. PMID:34788732. |
compared to controls, both the ska and rka groups had higher hippocampal gfap levels (p < 0.05). |
2021-12-10 |
2023-08-13 |
rat |
| Ingrid Prata Mendonça, Igor Henrique Rodrigues de Paiva, Eduardo Pereira Duarte-Silva, Michel Gomes de Melo, Rodrigo Soares da Silva, Wilma Helena de Oliveira, Belmira Lara da Silveira Andrade da Costa, Christina Alves Peixot. Metformin and fluoxetine improve depressive-like behavior in a murine model of Parkinsońs disease through the modulation of neuroinflammation, neurogenesis and neuroplasticity. International immunopharmacology. vol 102. 2021-12-10. PMID:34890997. |
metformin and fluoxetine also reduced iba-1 and gfap positive cells in the hippocampus. |
2021-12-10 |
2023-08-13 |
mouse |
| Alinny Rosendo Isaac, Patricia Coelho de Velasco, Karla Yasmin Dias Fraga, Maria das Graças Tavares-do-Carmo, Raquel Maria Pereira Campos, Fabio Arturo Iannotti, Roberta Verde, Danyelly Bruneska Gondim Martins, Thaysa Aragão Santos, Bruna Klippel Ferreira, Fernando Garcia de Mello, Vincenzo Di Marzo, Belmira Lara da Silveira Andrade-da-Costa, Ricardo Augusto de Melo Rei. Maternal omega-3 intake differentially affects the endocannabinoid system in the progeny`s neocortex and hippocampus: Impact on synaptic markers. The Journal of nutritional biochemistry. vol 96. 2021-12-04. PMID:34038760. |
additionally, total gfap isoform expression was increased in both cortex and hippocampus in neonates of the n-3def group. |
2021-12-04 |
2023-08-13 |
rat |
| A V Morgun, E D Osipova, E B Boitsova, A N Shuvaev, N A Malinovskaya, A I Mosiagina, A B Salmin. Neurogenic Potential of Implanted Neurospheres Is Regulated by Optogenetic Stimulation of Hippocampal Astrocytes Ex Vivo. Bulletin of experimental biology and medicine. vol 170. issue 6. 2021-11-26. PMID:33893948. |
the electrophysiological characteristics of the hippocampus and expression of molecules involved in the mechanisms of activation of astrocytes and microglia (gfap, cd38, c3/c3b, cx43, cd11b, and cd18) were evaluated. |
2021-11-26 |
2023-08-13 |
mouse |
| Yun-Tao Zhao, Lulu Zhang, Haowen Yin, Ling Shen, Wenjing Zheng, Kun Zhang, Jian Zeng, Chuanyin Hu, You Li. Hydroxytyrosol alleviates oxidative stress and neuroinflammation and enhances hippocampal neurotrophic signaling to improve stress-induced depressive behaviors in mice. Food & function. vol 12. issue 12. 2021-11-23. PMID:33998633. |
the expression level of glial fibrillary acidic protein (gfap) and the number of gfap-immunoreactive astrocytes in the hippocampus were significantly augmented by ht. |
2021-11-23 |
2023-08-13 |
mouse |
| Huei Gau Chuang, NurNaznee Hirni Abd Aziz, Jia Hui Wong, Muzaimi Mustapha, Jafri Malin Abdullah, Zamzuri Idris, Zuraidah Abdullah, Aziza Alrafiah, Sangu Muthuraj. Role of toll-like receptor 4 antagonist Lipopolysaccharide-Rhodobacter sphaeroides on acute stress-induced voluntary ethanol preference and drinking behaviour: In vivo Swiss Albino mouse model. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 45. 2021-11-22. PMID:32014377. |
morphological analysis showed no significant change in the prefrontal cortex and hippocampus among all groups, while immunoreactivity analysis showed higher expression of c-fos in prefrontal cortex and hippocampus, higher tlr4 expression in the prefrontal cortex and glial fibrillary acidic protein (gfap) in hippocampus among stressed-animals. |
2021-11-22 |
2023-08-13 |
mouse |
| Eman S Said, Asmaa M Elsayed, Laila A Rashed, Eman H Nadwa, Njood A Alsuhaibani, Batool S Alfuraih, Rania H Mahmou. Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations. European journal of pharmacology. vol 912. 2021-11-22. PMID:34547248. |
histological and immunohistochemical techniques were performed in hippocampus using h&e, cresyl violet stain, anti gfap and anti cox-2 immunostain. |
2021-11-22 |
2023-08-13 |
mouse |