| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaojuan Yin, Lei Dong, Wei Wei, Yu Wang, Yannan Chai, Zhichun Fen. Effect of mouse nerve growth factor on the expression of glial fibrillary acidic protein in hippocampus of neonatal rats with hypoxic-ischemic brain damage. Experimental and therapeutic medicine. vol 5. issue 2. 2021-10-21. PMID:23408790. |
this study revealed that mngf increases the expression of gfap in the hippocampus of neonatal rats with hibd and therefore may have a role in the repair of hibd. |
2021-10-21 |
2023-08-12 |
mouse |
| Cuimei Liu, Yonggang Li, Pamela J Lein, Byron D For. Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP). Current neurobiology. vol 3. issue 2. 2021-10-21. PMID:24039349. |
gfap immunoreactivity increased in the hippocampus, and piriform/entorhinal cortex at 1 h, peaked between 4-8 h then decreased from 16 to 24 h. gfap labeling in the amygdala gradually increased over the 24 h period. |
2021-10-21 |
2023-08-12 |
rat |
| Cuimei Liu, Yonggang Li, Pamela J Lein, Byron D For. Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP). Current neurobiology. vol 3. issue 2. 2021-10-21. PMID:24039349. |
a large increase in gfap labeling was seen at 3-7 days following dfp administration in the hippocampus, piriform/entorhinal cortex and dorsolateral thalamus. |
2021-10-21 |
2023-08-12 |
rat |
| Cuimei Liu, Yonggang Li, Pamela J Lein, Byron D For. Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP). Current neurobiology. vol 3. issue 2. 2021-10-21. PMID:24039349. |
at 3 days post-dfp exposure, gfap immunoreactivity was totally absent in central areas of the hippocampus, piriform/entorhinal cortex and dorsolateral thalamus that contained numerous fluorojade b (fjb) labeled neurons. |
2021-10-21 |
2023-08-12 |
rat |
| Cuimei Liu, Yonggang Li, Pamela J Lein, Byron D For. Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP). Current neurobiology. vol 3. issue 2. 2021-10-21. PMID:24039349. |
the mrna expression of gfap in hippocampus slowly increased at 24 h following dfp administration then dramatically increased at 3 days. |
2021-10-21 |
2023-08-12 |
rat |
| Shafiq Ur Rahman, Tahir Ali, Qiang Hao, Kaiwu He, Weifen Li, Najeeb Ullah, Zaijun Zhang, Yuhua Jiang, Shupeng L. Xanthohumol Attenuates Lipopolysaccharide-Induced Depressive Like Behavior in Mice: Involvement of NF-κB/Nrf2 Signaling Pathways. Neurochemical research. vol 46. issue 12. 2021-10-21. PMID:34398408. |
immunofluorescence analysis showed that xn reduced activated gliosis via attenuation of iba-1 and gfap in hippocampus. |
2021-10-21 |
2023-08-13 |
mouse |
| R L Moretti, E N Dias, S G Kiel, M C M Augusto, P S Rodrigues, A C S Sampaio, L S Medeiros, M F M Martins, I B Suffredini, C V Cardoso, E F Bonda. Behavioral and morphological effects of resveratrol and curcumin in rats submitted to doxorubicin-induced cognitive impairment. Research in veterinary science. vol 140. 2021-10-15. PMID:34536813. |
dox-injected rats presented short-term and long-term memory impairments as seen in the nort at 3 and 24 h after habituation and increased gfap and iba1 expression, respectively, in astrocytes and microglia of the frontal cortex, hypothalamus and hippocampus. |
2021-10-15 |
2023-08-13 |
rat |
| Walaa Yehia Abdelzaher, Hanaa H Mohammed, Nermeen N Welson, Gaber El-Saber Batiha, Roua S Baty, Asmaa Mohamed Abdel-Azi. Rivaroxaban Modulates TLR4/Myd88/NF-Kβ Signaling Pathway in a Dose-Dependent Manner With Suppression of Oxidative Stress and Inflammation in an Experimental Model of Depression. Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630092. |
cums showed a significant decrease in hypothalamic neurotransmitters, hippocampal gsh, sod, bndf, and vegf-a with a significant increase in hippocampal mda, nox, nf-kβ, myd88, tlr4, tnf-α, and gfap immunoexpression. |
2021-10-12 |
2023-08-13 |
rat |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
meanwhile, we employed immunofluorescence staining to examine the levels of gfap and iba1 in the hippocampus. |
2021-10-12 |
2023-08-13 |
mouse |
| Zengyu Yao, Zhinan Zhang, Jiping Zhang, Xiaowen Cai, Zheng Zhong, Yong Huang, Shanshan Q. Electroacupuncture alleviated the depression-like behavior by regulating FGF2 and astrocytes in the hippocampus of rats with chronic unpredictable mild stress. Brain research bulletin. vol 169. 2021-10-07. PMID:33434624. |
the results showed that ea and paroxetine could improve depression-like behavior in cums rats, and up-regulated the expression level of fgf2 in the hippocampus, increased gfap protein expression and the mean optical density of gfap-immunoreactive astrocyte (gfap-ir astrocyte). |
2021-10-07 |
2023-08-13 |
rat |
| Tunahan Kirabali, Ruslan Rust, Serena Rigotti, Alessandro Siccoli, Roger M Nitsch, Luka Kuli. Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:32866303. |
post-mortem human cortical and hippocampal samples derived from ad patients and non-demented elderly control individuals were immunostained using a panel of markers representing specific components of the nvu including collagen iv (basement membrane), pdgfr-β (pericytes), gfap (astrocytes), iba1 (microglia), mrc1 (perivascular macrophages) and lectin as an endothelial cell label. |
2021-10-06 |
2023-08-13 |
human |
| Dalia A Mandour, M A Bendary, Amira E Alseme. Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid "hesperidin". Journal of molecular histology. vol 52. issue 5. 2021-10-04. PMID:34170456. |
in addition, sections of the hippocampus and prefrontal cortex revealed obvious histopathological changes, overexpression of p-tau protein and glial fibrillary acidic protein (gfap) with a decrease in the expression of synaptophysin (syn). |
2021-10-04 |
2023-08-13 |
rat |
| L K Friedman, H Peng, R J Zema. Cannabidiol reduces lesion volume and restores vestibulomotor and cognitive function following moderately severe traumatic brain injury. Experimental neurology. vol 346. 2021-10-04. PMID:34428457. |
post-injury administration of cbdi+ip greatly reduced defecation scores, lesion volume, the loss of neurons in the ipsilateral hippocampus, the number of injured neurons of the contralateral hippocampus, and reversed tbi-induced glial fibrillary acidic protein (gfap) upregulation which was superior to either cbd.ip or cbdi treatment alone. |
2021-10-04 |
2023-08-13 |
rat |
| Ala Albazal, Alireza-Azizzadeh Delshad, Mehrdad Roghan. Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation. Journal of chemical neuroanatomy. vol 112. 2021-09-30. PMID:33276072. |
besides, hippocampal level of acetylcholinesterase (ache), glial fibrillary acidic protein (gfap), nuclear factor-kappab (nf-κb), interleukin 6 (il-6) and tumor necrosis factor α (tnfα) decreased following melatonin treatment. |
2021-09-30 |
2023-08-13 |
rat |
| Yangliang Yang, Jing Yi, Mengzhi Pan, Baoji Hu, Hongwei Dua. Edaravone alleviated propofol-induced neural injury in developing rats by BDNF/TrkB pathway. Journal of cellular and molecular medicine. vol 25. issue 11. 2021-09-30. PMID:33932098. |
it was found out that propofol could produce inflammatory effects in the hippocampus by enhancing the astrogliosis (gfap) activation and elevating the level of neuronal nitric oxide synthase (nnos), pro-inflammatory cytokines interleukin-6 (il-6) and tumour necrosis factor-α (tnf-α). |
2021-09-30 |
2023-08-13 |
rat |
| Min Kyung Song, Yoon Ju Kim, Jae-Min Lee, Youn-Jung Ki. Neurovascular integrative effects of long-term environmental enrichment on chronic cerebral hypoperfusion rat model. Brain research bulletin. vol 163. 2021-09-29. PMID:32711044. |
neurovascular integrity was assessed based on immunoreactivity for glial fibrillary acidic protein (gfap), morphological changes in microvessels, and the expression of matrix metalloproteinase-9 (mmp-9) and zonula occludens-1 (zo-1) in the motor cortex and hippocampus. |
2021-09-29 |
2023-08-13 |
rat |
| Lucas Dos Reis Izolan, Douglas Marques da Silva, Helena Beatriz Larrosa Oliveira, Janaína Lucas de Oliveira Salomon, Caroline Portela Peruzzi, Solange C Garcia, Eliane Dallegrave, Caroline Zanotto, Elaine Elisabetsky, Carlos Alberto Gonçalves, Marcelo Dutra Arbo, Eduardo Luis Konrath, Mirna Bainy Lea. Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice. Neurochemical research. vol 46. issue 5. 2021-09-27. PMID:33544325. |
in addition, glial fibrillary acidic protein (gfap) and s100 calcium-binding protein b (s100b) levels were assessed in the frontal cortex and hippocampus, and dna damage was verified on blood cells. |
2021-09-27 |
2023-08-13 |
mouse |
| Isaac Deng, Michael D Wiese, Xin-Fu Zhou, Larisa Bobrovskay. The efficacy of systemic administration of lipopolysaccharide in modelling pre-motor Parkinson's disease in C57BL/6 mice. Neurotoxicology. vol 85. 2021-09-22. PMID:34097939. |
systemically administered lps induced increased glial markers gfap and iba-1 and oxidative stress marker 3-nitrotyrosine (3-nt) in the olfactory bulb, hippocampus, midbrain and cerebellum, and there were region specific changes in the expression of nfκb, il-1β, α-synuclein, th and bdnf proteins. |
2021-09-22 |
2023-08-13 |
mouse |
| Xiaofan Xiong, Lin Han, Meiyang Fan, Lingyu Zhang, Liying Liu, Chen Guo, Qiuhua Wu, Xiaofei Wang, Ruifang Sun, Lei Ni, Chen Huang, Juan Yan. Early maternal deprivation impairs learning and memory and alters hippocampal gene expression in adult male rats. Neurobiology of learning and memory. vol 183. 2021-09-22. PMID:34119613. |
in addition, glial fibrillary acidic protein (gfap) was also found reduced in adult hippocampus of md rats. |
2021-09-22 |
2023-08-13 |
rat |
| Wilma Helena Oliveira, Clarissa Figueiredo Braga, Deniele Bezerra Lós, Shyrlene Meiry Rocha Araújo, MariaEduarda Rocha França, Eduardo Duarte-Silva, Gabriel Barros Rodrigues, Sura Wanessa Santos Rocha, Christina Alves Peixot. Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice. Experimental brain research. vol 239. issue 9. 2021-09-21. PMID:34283253. |
moreover, the m200 group showed reduced gfap immunoreactivity in hippocampal dentate gyrus and ca1 compared with the stz group. |
2021-09-21 |
2023-08-13 |
mouse |