| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clémence Maupu, Julie Enderlin, Alexandre Igert, Myriam Oger, Stéphane Auvin, Rahma Hassan-Abdi, Nadia Soussi-Yanicostas, Xavier Brazzolotto, Florian Nachon, Grégory Dal Bo, Nina Dupui. Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice. Neurobiology of disease. vol 152. 2021-07-30. PMID:33529768. |
in order to compare these results to those obtained by ihc, we performed, classical iba1 (microglia/infiltrated macrophages) and gfap (astrocytes) ihc analysis in parallel, focusing on the hippocampus, a brain region affected by seizure activity and neurodegeneration. |
2021-07-30 |
2023-08-13 |
mouse |
| Gustavo A Chiprés-Tinajero, Miguel A Núñez-Ochoa, Laura Medina-Cej. Increased immunoreactivity of glutamate receptors, neuronal nuclear protein and glial fibrillary acidic protein in the hippocampus of epileptic rats with fast ripple activity. Experimental brain research. vol 239. issue 6. 2021-07-28. PMID:33909110. |
the animals were sacrificed on day 15, and fluorescence immunohistochemistry was carried out in the hippocampus for the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), n-methyl-d-aspartate (nmda) and mglu-r5 glutamate receptors as well as neuronal nuclear protein (neun) and glial fibrillary acidic protein (gfap). |
2021-07-28 |
2023-08-13 |
rat |
| Mary E Dail, Meghan L M Brino, Janice E Chamber. Effects of novel brain-penetrating oxime acetylcholinesterase reactivators on sarin surrogate-induced changes in rat brain gene expression. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33682265. |
our lab has invented a platform of phenoxyalkyl pyridinium oximes (us patent 9,277,937) that demonstrate the ability to cross the blood-brain barrier in in vivo rat tests with a sarin surrogate nitrophenyl isopropyl methylphosphonate (nimp) and provide evidence of brain penetration by reducing cessation time of seizure-like behaviors, accumulation of glial fibrillary acidic protein (gfap), and hippocampal neuropathology, as opposed to the currently approved oxime, 2-pyridine aldoxime methyl chloride (2-pam). |
2021-07-27 |
2023-08-13 |
rat |
| Hao Zhu, Yu Yang, Min Zhu, Xiao Shi, Le Ye, Song Zhang, Hongwei Fang, Wenjuan Y. Alteration in the expression of inflammatory cytokines in primary hippocampal astrocytes in response to MK-801 through ERK1/2 and PI3K signals. Cytokine. vol 138. 2021-07-26. PMID:33187817. |
our previous study showed that dizocilpine (mk-801) induced schizophrenia-like behavior in rats, enhanced gfap expression, and activated primary cultured hippocampal astrocytes. |
2021-07-26 |
2023-08-13 |
rat |
| Sameh M Farouk, Fatma A Gad, Rafa Almeer, Mohamed M Abdel-Daim, Mahmoud A Ema. Exploring the possible neuroprotective and antioxidant potency of lycopene against acrylamide-induced neurotoxicity in rats' brain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-07-22. PMID:33711552. |
moreover, marked histological alterations and astrocytosis were observed through the increased number of gfap immunopositively cells in cerebral, cerebellar and hippocampal tissues compared with the other groups. |
2021-07-22 |
2023-08-13 |
rat |
| Dounya Jalloul, Helene Hajjar, Rita Asdikian, Mariam Maawie, Leila Nasrallah, Yasser Medlej, Mouhamad Darwich, Nabil Karnib, Nada Lawand, Ronza Abdel Rassoul, Kevin K W Wang, Firas Kobeissy, Hala Darwish, Makram Obei. Potentiating Hemorrhage in a Periadolescent Rat Model of Closed-Head Traumatic Brain Injury Worsens Hyperexcitability but Not Behavioral Deficits. International journal of molecular sciences. vol 22. issue 12. 2021-07-19. PMID:34208666. |
compared to tbi rats, htbi rats had persistently higher eeg spiking and increased hippocampal gfap levels ( |
2021-07-19 |
2023-08-13 |
rat |
| b' Volkan Solmaz, M\\xc3\\xbcmin Alper Erdo\\xc4\\x9fan, Alper Alnak, Ayfer Meral, Oytun Erba\\xc5\\x9. Erythropoietin shows gender dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide induced rat model of autism. Neuropeptides. vol 83. 2021-07-16. PMID:32736811.' |
histologically, hippocampal neuronal density and gfap expression were assessed. |
2021-07-16 |
2023-08-13 |
rat |
| Ayse Cigel, Oya Sayin, Seren Gulsen Gurgen, Atac Sonme. Long term neuroprotective effects of acute single dose MK-801treatment against traumatic brain injury in immature rats. Neuropeptides. vol 88. 2021-07-12. PMID:34098454. |
histopathological and immunohistochemical evaluations showed that treatment with mk-801 significantly ameliorated the trauma-induced hippocampal neuron loss and increased bdnf, ngf, nmda-r, gfap expressions in ca1, ca3, and dg hippocampal regions. |
2021-07-12 |
2023-08-13 |
rat |
| E P G Vazi, F Holanda, N A Santos, C V Cardoso, M F M Martins, E F Bonda. Short-term systemic methotrexate administration in rats induces astrogliosis and microgliosis. Research in veterinary science. vol 138. 2021-07-08. PMID:34091228. |
on the 5th day, brain samples were collected for hematoxylin-eosin and luxol fast blue staining techniques, as well as for immunohistochemical staining for glial fibrillary acidic protein (gfap) expression in astrocytes and iba1 (ionized calcium binding adaptor molecule 1) for microglia in the frontal cortex, hippocampus, hypothalamus and molecular/granular layers of the cerebellum. |
2021-07-08 |
2023-08-13 |
rat |
| Minzhen Deng, Liping Huang, Xiaoqin Zhong, Manting Huan. Dynamic Changes of Beclin-1 in the Hippocampus of Male Mice with Vascular Dementia at Different Time Points. Journal of molecular neuroscience : MN. vol 70. issue 10. 2021-06-29. PMID:32468217. |
the expression of beclin-1, lc3b, p62, bcl-2, bax, bace1, gfap, mbp and et-1 mrna were determined by rt-pcr; the expression of beclin-1 was detected by western blot and immunofluorescence; the pathological characteristics of the hippocampus were observed by haematoxylin-eosin (he) staining; and the correlation of beclin-1 with other vd-related proteins was analysed by pearson's correlation. |
2021-06-29 |
2023-08-13 |
mouse |
| Jéssica M Bonato, Erika Meyer, Patrícia S B de Mendonça, Humberto Milani, Jos Prickaerts, Rúbia Maria Weffort de Oliveir. Roflumilast protects against spatial memory impairments and exerts anti-inflammatory effects after transient global cerebral ischemia. The European journal of neuroscience. vol 53. issue 4. 2021-06-28. PMID:33340424. |
also, increases in the protein expression of the phosphorylated response element-binding protein (pcreb) and inflammatory markers such as the glial fibrillary acidic protein (gfap) and ionized calcium-binding adaptor molecule 1 (iba-1), were detected in the hippocampus in tgci rats. |
2021-06-28 |
2023-08-13 |
rat |
| Kun Niu, Jia-Lin Qin, Guo-Fang Lu, Jian Guo, John P Williams, Jian-Xiong A. Dexmedetomidine Reverses Postoperative Spatial Memory Deficit by Targeting Surf1 and Cytochrome c. Neuroscience. vol 466. 2021-06-22. PMID:33895343. |
dexmedetomidine appears to reverse surgery-induced behavior, mitigate the higher density of iba-1 and gfap, and downregulate the expression of surf1 and cytochrome c protein in the hippocampus of rats in a pnd model. |
2021-06-22 |
2023-08-13 |
human |
| Rafael Bandeira Fabres, Nathalia Lima Montes, Yahi de Menezes Camboim, Samir Khal de Souza, Fabrício Nicola, Isadora D'Ávila Tassinari, Maria Flavia Marques Ribeiro, Carlos Alexandre Netto, Luciano Stürmer de Frag. Long-Lasting Actions of Progesterone Protect the Neonatal Brain Following Hypoxia-Ischemia. Cellular and molecular neurobiology. vol 40. issue 8. 2021-06-21. PMID:32170571. |
at p14 (7 days following hi), the volumes of lesion of the cerebral hemisphere and the hippocampus ipsilateral to the cerebral ischemia were evaluated, along with p-akt, cleaved caspase-3 and gfap expression in the hippocampus. |
2021-06-21 |
2023-08-13 |
rat |
| Rafael Bandeira Fabres, Nathalia Lima Montes, Yahi de Menezes Camboim, Samir Khal de Souza, Fabrício Nicola, Isadora D'Ávila Tassinari, Maria Flavia Marques Ribeiro, Carlos Alexandre Netto, Luciano Stürmer de Frag. Long-Lasting Actions of Progesterone Protect the Neonatal Brain Following Hypoxia-Ischemia. Cellular and molecular neurobiology. vol 40. issue 8. 2021-06-21. PMID:32170571. |
moreover, when administered after hi, prog was able to increase p-akt expression and reduce both cleaved caspase-3 and gfap expression in the hippocampus. |
2021-06-21 |
2023-08-13 |
rat |
| Lei Wu, Xiangfei Liu, Yunke Huang, Chao Lu, Jialing Zhou, Ping Ren, Xi Huan. Antidepressant-like Effect of Merazin Hydrate Depends on NO/ERK by Suppressing Its Downstream NF-κB or Nonactivating CREB/BDNF in Mouse Hippocampus. ACS chemical neuroscience. vol 11. issue 16. 2021-06-18. PMID:32644793. |
mh also normalized the expressions of gfap and ib-1 in dentate gyrus in the hippocampus and inflammatory factors such as il-1β, il-10, and tnf-α in serum. |
2021-06-18 |
2023-08-13 |
mouse |
| Asmaa F Khafaga, Sara E El-Kazaz, Ahmed E Noreldi. Boswellia serrata suppress fipronil-induced neuronal necrosis and neurobehavioral alterations via promoted inhibition of oxidative/inflammatory/apoptotic pathways. The Science of the total environment. vol 785. 2021-06-10. PMID:33933775. |
in addition, significant (p > 0.05) promotion in neurobehaviours, histopathologic imaging of the cerebral, cerebellar, and hippocampal regions, and immunohistochemical expression of caspase-3 and glial fibrillary acidic protein (gfap) were also reported in the bse-treated groups in a dose-dependent manner. |
2021-06-10 |
2023-08-13 |
rat |
| Oluwole Ojo Alese, Cleopatra Rakgantsho, Nombuso V Mkhize, Simo Zulu, Musa V Mabandl. Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy. Brain research bulletin. vol 155. 2021-06-03. PMID:31837458. |
we also observed it effect on the hippocampal glial fibrillary acidic protein (gfap), synaptophysin and metabotropic glutamate receptor 3 (mglur3) expression measured with immunofluorescence, li cor tissue florescence and immunohistochemistry respectively. |
2021-06-03 |
2023-08-13 |
rat |
| Oluwole Ojo Alese, Cleopatra Rakgantsho, Nombuso V Mkhize, Simo Zulu, Musa V Mabandl. Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy. Brain research bulletin. vol 155. 2021-06-03. PMID:31837458. |
the hippocampal gfap, synaptophysin and mglur3 expressions where upregulated in ptz rats with pfs history when compared to ptz rats alone.these findings indicated that pfs may increase the severity of epilepsy and alter brain expression of gfap, synaptophysin and mglur3 proteins. |
2021-06-03 |
2023-08-13 |
rat |
| Manuel Narváez, Yuniesky Andrade-Talavera, Ismael Valladolid-Acebes, Magnus Fredriksson, Pia Siegele, Alejandro Hernandez-Sosa, André Fisahn, Kjell Fuxe, Dasiel O Borroto-Escuel. Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations. Neuropharmacology. vol 170. 2021-06-03. PMID:32229140. |
localization of hippocampal fgfr1-5-ht1ar heterocomplexes in astrocytes was found using in situ proximity ligation assay combined with immunohistochemistry using glial fibrillary acidic protein (gfap) immunoreactivity as a marker for astroglia. |
2021-06-03 |
2023-08-13 |
Not clear |
| Shuwen Liu, Yu Su, Bixi Sun, Rubin Hao, Siqi Pan, Xiaoshu Gao, Xinyue Dong, Ahmed Mohammed Ismail, Bing Ha. Luteolin Protects Against CIRI, Potentially via Regulation of the SIRT3/AMPK/mTOR Signaling Pathway. Neurochemical research. vol 45. issue 10. 2021-06-01. PMID:32809175. |
at the same time, luteolin significantly reduced the number of gfap and iba-1 positive glial cells in the hippocampus while enhanced the scavenging of oxygen free radicals and the activity of sod in mitochondria. |
2021-06-01 |
2023-08-13 |
rat |