| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroko Miyagishi, Minoru Tsuji, Atsumi Saito, Kazuya Miyagawa, Hiroshi Taked. Inhibitory effect of yokukansan on the decrease in the hippocampal excitatory amino acid transporter EAAT2 in stress-maladaptive mice. Journal of traditional and complementary medicine. vol 7. issue 4. 2020-10-01. PMID:29034181. |
western blot analysis revealed that the expression level of eaat2 was specifically decreased in the hippocampus of stress-maladaptive mice while there were no changes in the level of gfap, and this change was inhibited by chronic treatment with yks. |
2020-10-01 |
2023-08-13 |
mouse |
| Liping Chen, Chunhui Huang, Jieyi Shentu, Minjun Wang, Sicheng Yan, Fei Zhou, Zaijun Zhang, Chuang Wang, Yifan Han, Qinwen Wang, Wei Cu. Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:29234273. |
the mean optical density (od) with hyper-phosphorylated tau (ptau), glial fibrillary acidic protein (gfap) and cd45 positive staining in the hippocampus of 7bio-treated mice were significantly decreased compared to those of aβ oligomer-treated mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Maryam Anzabi, Maryam Ardalan, Nina K Iversen, Ali H Rafati, Brian Hansen, Leif Østergaar. Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29445328. |
glial fibrillary acid protein (gfap) immunostained hippocampal sections were examined by stereological techniques to detect differences in astrocyte morphology, and global spatial sampling method was used to quantify the length density of aquaporin-4 (aqp4) positive capillaries. |
2020-10-01 |
2023-08-13 |
mouse |
| Maryam Anzabi, Maryam Ardalan, Nina K Iversen, Ali H Rafati, Brian Hansen, Leif Østergaar. Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29445328. |
sah induced retraction of gfap positive astrocyte processes, accompanied by a significant reduction in the length density of aqp4 positive capillaries as well as narrowing of hippocampal capillaries. |
2020-10-01 |
2023-08-13 |
mouse |
| Jorge A Avila, Roseanna M Zanca, Denis Shor, Nicholas Paleologos, Amber A Alliger, Maria E Figueiredo-Pereira, Peter A Serran. Chronic voluntary oral methamphetamine induces deficits in spatial learning and hippocampal protein kinase Mzeta with enhanced astrogliosis and cyclooxygenase-2 levels. Heliyon. vol 4. issue 2. 2020-10-01. PMID:29560440. |
compared to controls, the voma paradigm also induced decreases in hippocampal levels of dopamine transporter (dat) and tyrosine hydroxylase (th), as well as increases in dopamine 1 receptor (d1r), glial fibrillary acidic protein (gfap) and cyclooxygenase-2 (cox-2), with a decrease in prostaglandins e2 (pge2) and d2 (pgd2). |
2020-10-01 |
2023-08-13 |
mouse |
| Huaiqing Luo, Yang Xiang, Xiangping Qu, Huijun Liu, Chi Liu, Guangyi Li, Li Han, Xiaoqun Qi. Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31040784. |
protein expression of apelin, apj, microglial marker (iba1), astroglia marker (gfap), interleukin 1 beta (il-1β), tumor necrosis factor-α (tnf-α), synaptophysin (syp), brain-derived neurotrophic factor (bdnf), trkb, phospho-trkb (p-trkb) in the hippocampus were examined by western blotting or immunohistochemistry. |
2020-10-01 |
2023-08-13 |
rat |
| Amjad Khan, Muhammad Ikram, Tahir Muhammad, Junsung Park, Myeong Ok Ki. Caffeine Modulates Cadmium-Induced Oxidative Stress, Neuroinflammation, and Cognitive Impairments by Regulating Nrf-2/HO-1 In Vivo and In Vitro. Journal of clinical medicine. vol 8. issue 5. 2020-10-01. PMID:31091792. |
similarly, caffeine ameliorated cd-mediated glial activation by reducing the expression of glial fibrillary acidic protein (gfap), ionized calcium-binding adapter molecule 1 (iba-1), and other inflammatory mediators in the cortical and hippocampal regions of the mouse brain. |
2020-10-01 |
2023-08-13 |
mouse |
| Shannon E Ronca, Jeanon Smith, Takaaki Koma, Magda M Miller, Nadezhda Yun, Kelly T Dineley, Slobodan Paessle. Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection. Frontiers in microbiology. vol 8. 2020-09-30. PMID:28223982. |
accompanying prepulse inhibition deficits, symptomatic animals exhibited thalamus damage as visualized with h&e staining, as well as increased gfap expression in the posterior complex of the thalamus and dentate gyrus of the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Scott A Ferguson, Benoit C Mouzon, Cillian Lynch, Carlyn Lungmus, Alexander Morin, Gogce Crynen, Benjamin Carper, Gayle Bieler, Elliott J Mufson, William Stewart, Michael Mullan, Fiona Crawfor. Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:29311903. |
pathologically, increases in iba-1 and gfap staining typically seen in this model of r-mtbi showed the expected increases with both injury and age, but phosphorylated tau stained with cp13 in the hippocampus (reduced in female sham mice compared to males) and phf1 in the cortex (reduced in female tbi mice compared to male tbi mice) showed the only histological signs of sex-dependent differences in these mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Hyun-Jin Tae, Il Jun Kang, Tae-Kyeong Lee, Jeong Hwi Cho, Jae-Chul Lee, Myoung Cheol Shin, Yoon Sung Kim, Jun Hwi Cho, Jong-Dai Kim, Ji Hyeon Ahn, Joon Ha Park, In-Shik Kim, Hyang-Ah Lee, Yang Hee Kim, Moo-Ho Won, Young Joo Le. Neuronal injury and tumor necrosis factor-alpha immunoreactivity in the rat hippocampus in the early period of asphyxia-induced cardiac arrest under normothermia. Neural regeneration research. vol 12. issue 12. 2020-09-30. PMID:29323039. |
we examined neuronal damage in the hippocampus using cresyl violet (cv) and fluore-jade b (f-j b) staining, and pro-inflammatory response using ionized calcium-binding adapter molecule 1 (iba-1), glial fibrillary acidic protein (gfap), and tumor necrosis factor-alpha (tnf-α) immunohistochemistry in the hippocampus after asphyxial ca in rats under normothermia. |
2020-09-30 |
2023-08-13 |
rat |
| Brigitte Ciapa, Sylvie Grano. Expression of Cyclin-D1 in Astrocytes Varies During Aging. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:29740309. |
finally, cells expressing cyclin-d1 but not gfap were also found scattered in the striatum and the ca1 region of the hippocampus, and at a high percentage in cortical layers of young and old mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Qian Sun, Ming Ying, Quan Ma, Zhijun Huang, Liangyu Zou, Jianjun Liu, Zhixiong Zhuang, Xifei Yan. Proteomic analysis of hippocampus in mice following long-term exposure to low levels of copper. Toxicology research. vol 5. issue 4. 2020-09-30. PMID:30090419. |
among these differentially expressed proteins, serine racemase (srr) and glial fibrillary acidic protein (gfap) were significantly down-regulated and up-regulated, respectively, in the hippocampus of copper-treated mice compared with the control mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Qian Sun, Ming Ying, Quan Ma, Zhijun Huang, Liangyu Zou, Jianjun Liu, Zhixiong Zhuang, Xifei Yan. Proteomic analysis of hippocampus in mice following long-term exposure to low levels of copper. Toxicology research. vol 5. issue 4. 2020-09-30. PMID:30090419. |
in summary, this study has identified a number of abnormally expressed proteins in the hippocampus of copper-treated mice, and the identified protein, such as srr, together with inflammatory responses, as evidenced by the increased expression of gfap, could contribute to memory impairment resulting from copper exposure. |
2020-09-30 |
2023-08-13 |
mouse |
| Sinéad Healy, Jill McMahon, Una FitzGeral. Seeing the wood for the trees: towards improved quantification of glial cells in central nervous system tissue. Neural regeneration research. vol 13. issue 9. 2020-09-30. PMID:30127105. |
describing how we identified the maximum intensity projection as the best of six tested for two dimensional (2d)-rendering of three-dimensional (3d) images derived from a series of z-stacked micrographs, the review summarises our comparison of 16 global and 9 local algorithms for their ability to accurately quantify the expression of astrocytic glial fibrillary acidic protein (gfap), microglial ionized calcium binding adapter molecule 1 (iba1) and oligodendrocyte lineage olig2 within fixed cultured rat hippocampal brain slices. |
2020-09-30 |
2023-08-13 |
rat |
| Raul Chavez-Valdez, Amin Mottahedin, Linnea Stridh, Tracylyn R Yellowhair, Lauren L Jantzie, Frances J Northington, Carina Mallar. Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study. Frontiers in physiology. vol 10. 2020-09-30. PMID:30971945. |
a second group of pups were killed at 24 h (p9) or 7 days (p15) after poly i:c to assess astrocytic (gfap) and microglia (iba1) activation in the hippocampus, thalamus and cortex using immunohistochemistry, and gene and protein expression of cytokines/chemokines using real time rt-pcr and msd, respectively (4-6/group). |
2020-09-30 |
2023-08-13 |
mouse |
| Jianwei Lin, Shiyu Gao, Tianqi Wang, Yan Shen, Wenyu Yang, Yan Li, Haiyan H. Ginsenoside Rb1 improves learning and memory ability through its anti-inflammatory effect in Aβ American journal of translational research. vol 11. issue 5. 2020-09-29. PMID:31217866. |
ginsenoside rb1 improves learning and memory ability through its anti-inflammatory effect in aβ this study measured amyloid-beta (aβ), interleukin-1 beta (il-1β), and glial fibrillary acidic protein (gfap) expression in the hippocampus of alzheimer's disease (ad) rat models to elucidate the mechanism of anti-inflammatory effect of ginsenoside rb1 in ad. |
2020-09-29 |
2023-08-13 |
rat |
| Erica Zamberletti, Marina Gabaglio, Marie Woolley-Roberts, Sharon Bingham, Tiziana Rubino, Daniela Parolar. Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31447649. |
prenatal vpa exposure increased cb1 receptor, faah and magl levels, enhanced gfap, cd11b, and tnfα levels and triggered microglia activation restricted to the hippocampus. |
2020-09-29 |
2023-08-13 |
rat |
| Gholam-Reza Mahmoudiasl, Hojjat Allah Abbaszadeh, Mostafa Rezaei-Tavirani, Mohammad-Amin Abdollahifar, Yousef Sadeghi, Maryam Sadat Khoramgah, Somayeh Niknazar, Shahram Darab. Postmortem Study of Molecular and Histological Changes in the CA1 Hippocampal Region of Chronic Methamphetamine User. Iranian journal of pharmaceutical research : IJPR. vol 18. issue 4. 2020-09-28. PMID:32184870. |
western blotting and immunohistochemistry assay showed overexpression of gfap and iba-1 protein in the ca1 hippocampal region of meth users' brain. |
2020-09-28 |
2023-08-13 |
human |
| Gholam-Reza Mahmoudiasl, Hojjat Allah Abbaszadeh, Mostafa Rezaei-Tavirani, Mohammad-Amin Abdollahifar, Yousef Sadeghi, Maryam Sadat Khoramgah, Somayeh Niknazar, Shahram Darab. Postmortem Study of Molecular and Histological Changes in the CA1 Hippocampal Region of Chronic Methamphetamine User. Iranian journal of pharmaceutical research : IJPR. vol 18. issue 4. 2020-09-28. PMID:32184870. |
chronic meth use can induce gfap and iba-1 upregulation and neuronal apoptosis in the ca1 region of the postmortem hippocampus. |
2020-09-28 |
2023-08-13 |
human |
| Yabei Song, Caiyun Cao, Qiuyue Xu, Simeng Gu, Fushun Wang, Xi Huang, Shijun Xu, Erxi Wu, Jason H Huan. Piperine Attenuates TBI-Induced Seizures via Inhibiting Cytokine-Activated Reactive Astrogliosis. Frontiers in neurology. vol 11. 2020-09-28. PMID:32655468. |
our data show that piperine treatment can reduce the degree of cerebral edema, down-regulate tnf-α, il-1β, and bdnf, decrease the reactivity of gfap in the hippocampus, and inhibit tbi-induced seizures. |
2020-09-28 |
2023-08-13 |
mouse |