| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ekaterina V Pershina, Irina Yu Chernomorets, Dmitry A Fedorov, Vladimir I Arkhipo. Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175959. |
in the hippocampus of these animals, the level of expression of genes characterizing glutamatergic synaptic transmission (grin2b, gria1, eaat2) did not differ from the level in control animals, as well as the expression of genes characterizing neuroinflammation (il1b, tgf beta 1, aif1, and gfap). |
2023-05-14 |
2023-08-14 |
rat |
| Isabel Carreras, Younghun Jung, Jonathan Lopez-Benitez, Christina M Tognoni, Alpaslan Dedeogl. Fingolimod mitigates memory loss in a mouse model of Gulf War Illness amid decreasing the activation of microglia, protein kinase R, and NFκB. Neurotoxicology. 2023-05-09. PMID:37160207. |
immunohistochemical analysis of brain sections with antibodies to iba1 and gfap revealed that gwi mice had increased microglia activation in the hippocampal dentate gyrus, but no difference in reactive astrocytes was detected. |
2023-05-09 |
2023-08-14 |
mouse |
| Jian Lu, Xiaoyan Tao, Hongyu Dai, Sunan Gao, Hongmei Zho. Peripheral and cerebral inflammation induced by repeated anesthesia and surgery do not cause impairment of learning and memory in middle‑aged mice. Acta neurobiologiae experimentalis. vol 83. issue 1. 2023-04-20. PMID:37078813. |
up‑regulation of iba1 and gfap, respectively, indicated activation of microglia and astrocytes in the hippocampus. |
2023-04-20 |
2023-08-14 |
mouse |
| Wembley Rodrigues Vilela, Paula Maria Quaglio Bellozi, Victor Luna Picolo, Bruna Neves Cavadas, Keila Valentina Silva Marques, Louise Tavares Garcia Pereira, Ainhoa Rodriguez de Yurre Guirao, Angélica Amorim Amato, Kelly Grace Magalhães, Márcia Renata Mortari, Emiliano Horacio Medei, Jair Trapé Goulart, Andreza Fabro de Be. Early-life metabolic dysfunction impairs cognition and mitochondrial function in mice. The Journal of nutritional biochemistry. 2023-04-15. PMID:37061011. |
hfd+stz mice presented increased immunoreactivity for gfap and a trend towards a decrease in neun in the hippocampus. |
2023-04-15 |
2023-08-14 |
mouse |
| Saeideh Davari, Nicole D'Costa, Reza Ramezan, John G Mielk. Chronic Early-Life Social Isolation Enhances Spatial Memory in Male and Female Rats. Behavioural brain research. 2023-04-10. PMID:37037406. |
lastly, to determine whether celsi affected neural cell density, the expression of key neuronal and glial proteins (such as psd-95 and gfap, respectively) was assessed in isolated hippocampal tissue using immunoblotting. |
2023-04-10 |
2023-08-14 |
rat |
| Saeideh Davari, Nicole D'Costa, Reza Ramezan, John G Mielk. Chronic Early-Life Social Isolation Enhances Spatial Memory in Male and Female Rats. Behavioural brain research. 2023-04-10. PMID:37037406. |
however, housing condition did not seem to affect either stress-sensitive biometrics, or hippocampal gfap expression. |
2023-04-10 |
2023-08-14 |
rat |
| Bárbara Mota, Miguel Ramos, Sandra I Marques, Ana Silva, Pedro A Pereira, M Dulce Madeira, Nuno Mateus, Armando Cardos. Effects of High-Fat and High-Fat High-Sugar Diets in the Anxiety, Learning and Memory, and in the Hippocampus Neurogenesis and Neuroinflammation of Aged Rats. Nutrients. vol 15. issue 6. 2023-03-29. PMID:36986100. |
in aged rats, the hfhs diet impaired spatial learning, memory, and working memory and increased anxiety levels, associated with a reduction in the number of dcx cells and an increase in gfap cells in the hippocampus. |
2023-03-29 |
2023-08-14 |
human |
| Liana Shvachiy, Ângela Amaro-Leal, Tiago F Outeiro, Isabel Rocha, Vera Geralde. Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation. Cells. vol 12. issue 5. 2023-03-11. PMID:36899953. |
the expression of gfap, iba-1, neun and synaptophysin in the hippocampal dentate gyrus was assessed. |
2023-03-11 |
2023-08-14 |
rat |
| Liana Shvachiy, Ângela Amaro-Leal, Tiago F Outeiro, Isabel Rocha, Vera Geralde. Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation. Cells. vol 12. issue 5. 2023-03-11. PMID:36899953. |
we identified increases in gfap and iba1 markers together with presynaptic dysfunction in the hippocampus, concomitant with behavioral changes. |
2023-03-11 |
2023-08-14 |
rat |
| Guanlan Liu, Israr Khan, Yuxi Li, Yun Yang, Xuerui Lu, Yafei Wang, Junxiang Li, Chunjiang Zhan. Overcoming Anxiety Disorder by Probiotic Foods (Basel, Switzerland). vol 11. issue 22. 2023-03-08. PMID:36429192. |
lzu-j-tsl6 was able to effectively increase the gaba content in the mice hippocampus (p < 0.0001) and restore some markers related to anxiety such as brain-derived neurotrophic factor (bdnf), glial fibrillary acidic protein (gfap), and 5-hydroxytryptamine (5-ht). |
2023-03-08 |
2023-08-16 |
mouse |
| Abhishek Dahal, Karthivashan Govindarajan, Satyabrata Ka. Administration of kainic acid differentially alters astrocyte markers and transiently enhanced phospho-tau level in adult rat hippocampus. Neuroscience. 2023-02-22. PMID:36805001. |
our results reveal that levels/expression of various astrocyte markers such as gfap, vimentin, s100b, aldh1l1, but not gs, are increased in the hippocampus of ka-treated rats. |
2023-02-22 |
2023-08-14 |
human |
| Glauce Crivelaro Nascimento, Guilherme Lucas, Christie Ramos Andrade Leite-Paniss. Emerging role of microglia and astrocyte in the affective-motivational response induced by a rat model of persistent orofacial pain. Brain research bulletin. 2023-02-13. PMID:36781112. |
a significant increase in gfap and iba-1 expression was observed in the central nucleus of the amygdala, hippocampus and periaqueductal grey matter from day 3 to day 10 post-cfa injection. |
2023-02-13 |
2023-08-14 |
rat |
| Xiuli Zhang, Shivakumar Subbanna, Colin R O Williams, Stefanie Canals-Baker, John F Smiley, Donald A Wilson, Bhaskar C Das, Mariko Sait. Anti-inflammatory Action of BT75, a Novel RARα Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer's Disease. Neurochemical research. 2023-02-13. PMID:36781685. |
western blot results showed that bt75 decreased levels of neuronal nitric oxide synthase (nnos), gfap, and phosphorylated tau, and increased levels of synaptophysin in the hippocampus of icv-stz mice. |
2023-02-13 |
2023-08-14 |
mouse |
| Karina Maia Paiva, Rodrigo Freire Oliveira, Livia Helena Morais de Freitas, Acydália Madruga de Mendonça Florêncio de Melo, Gabriel Sousa da Rocha, Kalina Fernandes Freire, Jeferson de Souza Cavalcante, Paulo Leonardo Araújo de Gois Morais, José Rodolfo Lopes de Paiva Cavalcant. Physical exercise and flaxseed oil supplementation influence the glial plasticity in the rat hippocampus. Acta neurobiologiae experimentalis. vol 82. issue 4. 2023-02-07. PMID:36748968. |
the exercise program with flaxseed oil supplementation was able to alter the gfap expression in astrocytes in the ca1, ca3 and dentate gyrus regions of the hippocampus and modulate the behavioral aspects of memory and anxiety. |
2023-02-07 |
2023-08-14 |
rat |
| Wataru Nagata, Akiho Koizumi, Keiichi Nakagawa, Sayaka Takahashi, Mari Gotoh, Yasushi Satoh, Toshiaki Ishizuk. Treatment with lysophosphatidic acid prevents microglial activation and depression-like behaviours in a murine model of neuropsychiatric systemic lupus erythematosus. Clinical and experimental immunology. 2023-01-31. PMID:36718978. |
the expression levels of tmem119, cd68, gfap, and caspase-3 in the hippocampus and prefrontal cortex of mrl/lpr mice were significantly higher than those in mrl/+ mice. |
2023-01-31 |
2023-08-14 |
mouse |
| Ekaterina Kurilova, Maria Sidorova, Oksana Tuchin. Single Prolonged Stress Decreases the Level of Adult Hippocampal Neurogenesis in C57BL/6, but Not in House Mice. Current issues in molecular biology. vol 45. issue 1. 2023-01-20. PMID:36661521. |
the susceptibility of mice to single prolonged stress was assessed by behavior phenotyping in the open field and elevated plus maze, the level of neuroinflammation in the hippocampus was estimated by real-time pcr to tnfα, il-1β, il-6, il-10, iba1 and gfap, as well as immunohistochemical analysis of microglial morphology and mean fluorescence intensity for gfap+ cells. |
2023-01-20 |
2023-08-14 |
mouse |
| Ekaterina Kurilova, Maria Sidorova, Oksana Tuchin. Single Prolonged Stress Decreases the Level of Adult Hippocampal Neurogenesis in C57BL/6, but Not in House Mice. Current issues in molecular biology. vol 45. issue 1. 2023-01-20. PMID:36661521. |
expression levels of iba1 in the hippocampus did not change significantly after single prolonged stress, however gfap expression increased substantially in stressed c57bl/6 mice. |
2023-01-20 |
2023-08-14 |
mouse |
| Varun Rawat, Clifford L Eastman, Radhika Amaradhi, Avijit Banik, Jason S Fender, Raymond J Dingledine, Raimondo D'Ambrosio, Thota Ganes. Temporal Expression of Neuroinflammatory and Oxidative Stress Markers and Prostaglandin E2 Receptor EP2 Antagonist Effect in a Rat Model of Epileptogenesis. ACS pharmacology & translational science. vol 6. issue 1. 2023-01-19. PMID:36654746. |
fpi results in increased mrna expression of inflammatory mediators including cyclooxygenase-2 (cox-2) and prostanoid receptor ep2, marker of oxidative stress (nox2), astrogliosis (gfap), and microgliosis (cd11b) in ipsilateral cortex and hippocampus. |
2023-01-19 |
2023-08-14 |
rat |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. |
2023-01-14 |
2023-08-14 |
human |
| Rehab M El-Sayed, Mohamed N Fawzy, Hala F Zaki, Enas A Abd El-Halei. Neuroprotection impact of biochanin A against pentylenetetrazol-kindled mice: Targeting NLRP3 inflammasome/TXNIP pathway and autophagy modulation. International immunopharmacology. vol 115. 2023-01-14. PMID:36640710. |
biochanin a pretreatment significantly reduced the severity of epileptogenesis by 51.7% and downregulated the histological changes in the ca3 region of the hippocampus by 42% along with displaying antioxidant/anti-inflammatory efficacy through upregulated hemeoxygenase-1 (ho-1) and, erythroid 2-related factor 2 (nrf2) levels in the brain by 1.9-fold and 2-fold respectively, parallel to reduction of malondialdehyde (mda), myeloperoxidase (mpo), glial fibrillary acidic protein (gfap) and l-glutamate/il-1β/txnib/nlrp3 axis. |
2023-01-14 |
2023-08-14 |
mouse |